| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Wang, Xin Men, Xiaodong Huang, Xiaoxiao Qiu, Weilong Wang, Jin Zhou, Zhenfeng Zho. Unraveling the signaling network between dysregulated microRNA and mRNA expression in sevoflurane-induced developmental neurotoxicity in rat. Heliyon. vol 10. issue 13. 2024-07-19. PMID:39027541. |
overall, this study suggests that the dysregulation of the mirna-mrna signaling network induced by sevoflurane may contribute to neurodevelopmental toxicity in the hippocampus of rats and be associated with long-term cognitive dysfunction. |
2024-07-19 |
2024-07-21 |
rat |
| Run-Qi Li, Wei-Wen Zhu, Cheng Li, Ke-Bin Zhan, Ping Zhang, Fan Xiao, Jia-Mei Jiang, Wei Zo. Hippocampal Warburg effect Mediates Hydrogen Sulfide-Ameliorated Diabetes-Associated Cognitive Dysfunction: Involving Promotion of Hippocampal Synaptic Plasticity. Neuroscience research. 2024-07-18. PMID:39025266. |
hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: involving promotion of hippocampal synaptic plasticity. |
2024-07-18 |
2024-07-21 |
Not clear |
| Mahvash Nikpendar, Mohammad Javanbakht, Hamidreza Moosavian, Sepideh Sajjadi, Yalda Nilipour, Toktam Moosavian, Mahsa Fazl. Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats. Diabetology & metabolic syndrome. vol 16. issue 1. 2024-07-16. PMID:39004753. |
however, little is known about the short-term and long-term effects of repeated episodes of acute severe hypoglycemia on the brain, particularly in relation to hippocampal damage and cognitive dysfunction. |
2024-07-16 |
2024-07-18 |
rat |
| Yujia Liu, Xue Han, Yan Su, Yiming Zhou, Minhui Xu, Jiyan Xu, Zhengliang Ma, Xiaoping Gu, Tianjiao Xi. Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice. Neural regeneration research. 2024-07-12. PMID:38993135. |
to identify the signaling mechanisms contributing to postoperative cognitive dysfunction, we first conducted gene ontology and kyoto encyclopedia of genes and genomes pathway enrichment analyses of the gene expression omnibus gse95426 dataset, which consists of mrnas and long non-coding rnas differentially expressed in mouse hippocampus 3 days after tibial fracture. |
2024-07-12 |
2024-07-14 |
mouse |
| Yayu Chen, Gen Wei, Xiaojin Feng, Enjun Lei, Lieliang Zhan. Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat. Experimental neurology. vol 379. 2024-07-06. PMID:38823674. |
dexmedetomidine enhances mitophagy via pink1 to alleviate hippocampal neuronal pyroptosis and improve postoperative cognitive dysfunction in elderly rat. |
2024-07-06 |
2024-07-12 |
rat |
| Min-Nan Lu, Dan Wang, Chen-Jun Ye, Guo-Ji Yan, Jing-Feng Song, Xin-Ying Shi, Shan-Shan Li, Li-Na Liu, Hui-Xiang Zhang, Xiao-Han Dong, Tao Hu, Xu-Yang Wang, Yan-Bin Xiyan. Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF. Molecular neurobiology. 2024-07-04. PMID:38965172. |
previous works have demonstrated that aβ pathology induced aberrant elevation in the levels and excessive enzymatic hydrolysis of voltage-gated sodium channel type 2 beta subunit (navβ2) in the brain of ad models, accompanied by alteration in excitability of hippocampal neurons, synaptic deficits, and subsequently, cognitive dysfunction. |
2024-07-04 |
2024-07-11 |
mouse |
| Lihua Wang, Mingjie Li, Bing Liu, Ruihan Zheng, Xinyi Zhang, Shuoyi Y. Corrigendum to "miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway" [Brain Res. Bull. 212 (2024) 15 212 110953]. Brain research bulletin. 2024-06-25. PMID:38918140. |
corrigendum to "mir-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the sirt1/nrf2 pathway" [brain res. |
2024-06-25 |
2024-06-29 |
Not clear |
| Zheng Lei, Jie Wan, Jing-Jing Han, Chun-Yan Zhang, Hao-Tian Wang, Ding-Jie Zhou, Yu Chen, He Huan. Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2024-06-17. PMID:38886876. |
spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction. |
2024-06-17 |
2024-06-21 |
rat |
| Yu Cai, Lu-Wan Wang, Jing Wu, Zi-Wei Chen, Xue-Feng Yu, Fu-He Liu, Da-Peng Ga. Fasudil alleviates alcohol-induced cognitive deficits and hippocampal morphology injury partly by altering the assembly of the actin cytoskeleton and microtubules. Behavioural brain research. 2024-06-03. PMID:38830386. |
fasudil, a rho kinase (rock) inhibitor, has established neuroprotective properties; however, its impact on alcohol-induced cognitive dysfunction and hippocampal structural damage remains unelucidated. |
2024-06-03 |
2024-06-06 |
mouse |
| Cheng Zhu, Jiaxi Xu, Jixin Lin, Jiahong Liu, Enyan Y. Double-strand-break repair protein rad21 homolog/Synaptotagmin-7 alleviates Alzheimer's disease in mice by promoting M2 polarization of microglia. Brain research bulletin. 2024-06-03. PMID:38830486. |
syt7, which was the most significantly differentially expressed gene in the rna-sequencing, was found to be reduced in ad-like mice, and overexpression of syt7 alleviated cognitive dysfunction and attenuated neuroinflammation and neuronal loss in the hippocampal tissues of mice with ad. |
2024-06-03 |
2024-06-06 |
mouse |
| Guangsen Wu, Yichao Ou, Zhanpeng Feng, Zhiwei Xiong, Kai Li, Mengjie Che, Songtao Qi, Mingfeng Zho. Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition. Translational psychiatry. vol 14. issue 1. 2024-05-25. PMID:38796566. |
oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal erk signaling and aβ deposition. |
2024-05-25 |
2024-05-31 |
Not clear |
| Guangsen Wu, Yichao Ou, Zhanpeng Feng, Zhiwei Xiong, Kai Li, Mengjie Che, Songtao Qi, Mingfeng Zho. Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition. Translational psychiatry. vol 14. issue 1. 2024-05-25. PMID:38796566. |
our findings suggest that cognitive dysfunction after hypothalamic injury may be caused by erk hyperphosphorylation in the hippocampal region resulting from a decrease in the number of oxytocin neurons, which in turn causes β-amyloid deposition. |
2024-05-25 |
2024-05-31 |
Not clear |
| Zhengdong Yang, You Wu, Jun Tang, Renhuai Liu, Zongping Fang, Binxiao S. [Cannabinoid receptor 1 agonist arachidonyl-2'-chloroethylamide (ACEA) improves sepsis-associated encephalopathy by inhibiting inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 4. 2024-05-06. PMID:38710516. |
compared to the control group, the lps group showed significant increases in mrna of inflammatory factors such as il-6, tnf-α, and il-1β, together with significant increases in il-6 and tnf-α protein levels in the hippocampus, a decrease in nissl bodies in the ca1 region, and significant cognitive dysfunction. |
2024-05-06 |
2024-05-27 |
mouse |
| Liang Chen, Zhifeng Yue, Ziyu Liu, Huaqin Liu, Jin Zhang, Fengjiao Zhang, Tao Hu, Jianfeng F. The Impact of Nrf2 Knockout on the Neuroprotective Effects of Dexmedetomidine in a Mice Model of Cognitive Impairment. Behavioural brain research. 2024-05-01. PMID:38692357. |
our research findings suggest that dex enhances the expression of nqo1, ho-1, psd95, and syp proteins in hippocampal tissue, inhibits microglial proliferation, reduces pro-inflammatory cytokines il-1β and tnf-ɑ, increases anti-inflammatory cytokine il-10, and improves dendritic spine density, thereby alleviating cognitive dysfunction induced by lps. |
2024-05-01 |
2024-05-04 |
mouse |
| Saurabh Tiwari, Phoolmala, Shweta Goyal, Ranjeet Kumar Yadav, Rajnish Kumar Chaturved. Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions. Molecular neurobiology. 2024-04-18. PMID:38635025. |
bisphenol-f and bisphenol-s (bpf and bps) impair the stemness of neural stem cells and neuronal fate decision in the hippocampus leading to cognitive dysfunctions. |
2024-04-18 |
2024-04-20 |
Not clear |
| Lihua Wang, Mingjie Li, Bing Liu, Ruihan Zheng, Xinyi Zhang, Shuoyi Y. miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway. Brain research bulletin. 2024-04-18. PMID:38636610. |
mir-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the sirt1/nrf2 pathway. |
2024-04-18 |
2024-04-21 |
Not clear |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Ming Wang, Binyuan Xu, Yangmei Xie, Ge Yao, Yinghui Che. Mir155hg Accelerates Hippocampal Neuron Injury in Convulsive Status Epilepticus by Inhibiting Microglial Phagocytosis. Neurochemical research. 2024-03-30. PMID:38555337. |
convulsive status epilepticus (cse) is a common critical neurological condition that can lead to irreversible hippocampal neuron damage and cognitive dysfunction. |
2024-03-30 |
2024-04-02 |
rat |
| Evelini Plácido, David J Koss, Tiago Fleming Outeiro, Patricia S Brocard. Altered hippocampal doublecortin expression in Parkinson's disease. Journal of neurochemistry. 2024-03-14. PMID:38485468. |
in summary, we provide evidence supporting that the process of hippocampal adult neurogenesis is likely to be compromised in pd patients before cognitive dysfunction, shedding light on potential mechanisms contributing to the neuropsychiatric symptoms observed in affected individuals. |
2024-03-14 |
2024-03-17 |
human |
| Jianxiong Gui, Mingdan Xie, Lingman Wang, Bing Tian, Benke Liu, Hengsheng Chen, Li Cheng, Dishu Huang, Ziyao Han, Xiaoyue Yang, Jie Liu, Li Jian. Protective effects of docosahexaenoic acid supplementation on cognitive dysfunction and hippocampal synaptic plasticity impairment induced by early postnatal PM2.5 exposure in young rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-09. PMID:38459987. |
protective effects of docosahexaenoic acid supplementation on cognitive dysfunction and hippocampal synaptic plasticity impairment induced by early postnatal pm2.5 exposure in young rats. |
2024-03-09 |
2024-03-12 |
rat |