| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Abdulkadir, Douglas Londono, Derek Gordon, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Lonneke Elzerman, Carolin Fremer, Odette Fründt, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Ewgeni Jakubovski, Young Key Kim, Young Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Pablo Mir, Astrid Morer, Kirsten Müller-Vahl, Alexander Münchau, Tara L Murphy, Kerstin J Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Robert A King, Jay A Tischfield, Gary A Heiman, Pieter J Hoekstra, Andrea Dietric. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. European archives of psychiatry and clinical neuroscience. vol 268. issue 3. 2018-09-11. PMID:28555406. |
17 were candidate snps implicated in ts and 2 were implicated in obsessive-compulsive disorder (ocd) or autism spectrum disorder (asd); 142 were tagging snps from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top snps from ts gwas; and 13 top snps from attention-deficit/hyperactivity disorder, ocd, or asd gwas. |
2018-09-11 |
2023-08-13 |
Not clear |
| Maximiliano Rapanelli, Luciana Romina Frick, Meiyu Xu, Stephanie Mary Groman, Kantiya Jindachomthong, Nobuaki Tamamaki, Chiyoko Tanahira, Jane Rebecca Taylor, Christopher Pittenge. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological psychiatry. vol 82. issue 3. 2018-04-02. PMID:28347488. |
interneuronal pathology is implicated in many neuropsychiatric disorders, including autism spectrum disorder (asd) and tourette syndrome (ts). |
2018-04-02 |
2023-08-13 |
mouse |
| Maximiliano Rapanelli, Luciana Romina Frick, Christopher Pittenge. The Role of Interneurons in Autism and Tourette Syndrome. Trends in neurosciences. vol 40. issue 7. 2018-02-26. PMID:28578790. |
in abnormalities are linked to two pediatric psychiatric disorders with high comorbidity: autism spectrum disorder (asd) and tourette syndrome (ts). |
2018-02-26 |
2023-08-13 |
Not clear |
| C Wright, J H Shin, A Rajpurohit, A Deep-Soboslay, L Collado-Torres, N J Brandon, T M Hyde, J E Kleinman, A E Jaffe, A J Cross, D R Weinberge. Altered expression of histamine signaling genes in autism spectrum disorder. Translational psychiatry. vol 7. issue 5. 2018-02-20. PMID:28485729. |
although not well studied in autism spectrum disorder (asd), the hs is implicated in many neurological disorders, some of which share comorbidity with asd, including tourette syndrome (ts). |
2018-02-20 |
2023-08-13 |
human |
| Luciana Frick, Maximiliano Rapanelli, Eeman Abbasi, Hiroshi Ohtsu, Christopher Pittenge. Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27381299. |
microglial abnormalities are implicated in a range of neuropsychiatric pathology, including tourette syndrome (ts) and autism. |
2018-01-11 |
2023-08-13 |
mouse |
| Miho Kawaida, Tokiya Abe, Toshio Nakanishi, Yoko Miyahara, Hiroyuki Yamagishi, Michiie Sakamoto, Taketo Yamad. A case of Timothy syndrome with adrenal medullary dystrophy. Pathology international. vol 66. issue 10. 2017-03-17. PMID:27593853. |
recently, ts has been associated with autism and other psychological disorders. |
2017-03-17 |
2023-08-13 |
Not clear |
| Vinson Diep, Laurie H Seave. Long QT syndrome with craniofacial, digital, and neurologic features: Is it useful to distinguish between Timothy syndrome types 1 and 2? American journal of medical genetics. Part A. vol 167A. issue 11. 2016-08-28. PMID:26227324. |
timothy syndrome (ts) is a rare genetic condition that associates long qt syndrome, structural heart defects, dysmorphic facial features, syndactyly, seizures, developmental delay, and autism. |
2016-08-28 |
2023-08-13 |
Not clear |
| Janet K Kern, David A Geier, Paul G King, Lisa K Sykes, Jyutika A Mehta, Mark R Geie. Shared Brain Connectivity Issues, Symptoms, and Comorbidities in Autism Spectrum Disorder, Attention Deficit/Hyperactivity Disorder, and Tourette Syndrome. Brain connectivity. vol 5. issue 6. 2016-04-28. PMID:25602622. |
the prevalence of neurodevelopmental disorders, including autism spectrum disorder (asd), attention deficit/hyperactivity disorder (adhd), and tourette syndrome (ts), has increased over the past two decades. |
2016-04-28 |
2023-08-13 |
Not clear |
| David J Segar, Yosef G Chodakiewitz, Radmehr Torabi, G Rees Cosgrov. Deep brain stimulation for the obsessive-compulsive and Tourette-like symptoms of Kleefstra syndrome. Neurosurgical focus. vol 38. issue 6. 2016-03-31. PMID:26030700. |
a 24-year-old female patient with childhood hypotonia, developmental delay, and diagnoses of autism spectrum disorder, ocd, and ts refractory to medical management underwent the placement of bilateral ventral capsule/ventral striatum (vc/vs) dbs leads, with clinical improvement. |
2016-03-31 |
2023-08-13 |
Not clear |
| Davide Martino, Panagiotis Zis, Maura Buttiglion. The role of immune mechanisms in Tourette syndrome. Brain research. vol 1617. 2016-03-11. PMID:24845720. |
with analogy to autism, genetic and early life environmental factors could foster the involvement of immune mechanisms to the abnormal developmental trajectories postulated in ts, as well as lead to systemic immune dysregulation in this condition. |
2016-03-11 |
2023-08-13 |
human |
| S Raza, A Harker, S Richards, B Kolb, R Gib. Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid. Behavioural brain research. vol 282. 2015-09-21. PMID:25557797. |
massage therapy, or tactile stimulation (ts), early in life has repeatedly been shown to be an effective, low-cost, therapeutic approach in ameliorating the cognitive, social, and emotional symptoms of autism. |
2015-09-21 |
2023-08-13 |
rat |
| S Raza, A Harker, S Richards, B Kolb, R Gib. Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid. Behavioural brain research. vol 282. 2015-09-21. PMID:25557797. |
while early ts treatment attenuates many of the behavioral aberrations among children with autism, the neuroanatomical correlates driving such changes are unknown. |
2015-09-21 |
2023-08-13 |
rat |
| S Raza, A Harker, S Richards, B Kolb, R Gib. Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid. Behavioural brain research. vol 282. 2015-09-21. PMID:25557797. |
the present study assessed the therapeutic effects of early ts treatment on behavior and neuroanatomy using the valproic acid (vpa) rodent model of autism. |
2015-09-21 |
2023-08-13 |
rat |
| Refugio A Martinez, Jason L Stein, Anne-Rachel F Krostag, Angelique M Nelson, John S Marken, Vilas Menon, Ryan C May, Zizhen Yao, Ajamete Kaykas, Daniel H Geschwind, Joshua S Grimle. Genome engineering of isogenic human ES cells to model autism disorders. Nucleic acids research. vol 43. issue 10. 2015-08-17. PMID:25765640. |
of particular interest are the spectrum of autism disorders, some of which are monogenic such as timothy syndrome (ts); others are multigenic such as the microdeletion and microduplication syndromes of the 16p11.2 chromosomal locus. |
2015-08-17 |
2023-08-13 |
human |
| E S Gershon, K Grennan, J Busnello, J A Badner, F Ovsiew, S Memon, N Alliey-Rodriguez, J Cooper, B Romanos, C Li. A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain. Molecular psychiatry. vol 19. issue 8. 2015-05-11. PMID:23979604. |
however, ts also includes cognitive impairment, autism and major developmental delays in many of the patients. |
2015-05-11 |
2023-08-12 |
human |
| Linea Melchior, Birgitte Bertelsen, Nanette Mol Debes, Camilla Groth, Liselotte Skov, Jens D Mikkelsen, Karen Brøndum-Nielsen, Zeynep Tüme. Microduplication of 15q13.3 and Xq21.31 in a family with Tourette syndrome and comorbidities. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 162B. issue 8. 2014-10-22. PMID:23894120. |
identification of rare copy number variations (cnvs) as susceptibility factors in several neuropsychiatric disorders such as attention deficit-hyperactivity disorder (adhd), autism and schizophrenia, suggests involvement of these rare structural changes also in ts etiology. |
2014-10-22 |
2023-08-12 |
Not clear |
| Mady Hornig, W Ian Lipki. Immune-mediated animal models of Tourette syndrome. Neuroscience and biobehavioral reviews. vol 37. issue 6. 2014-01-10. PMID:23313649. |
an autoimmune diathesis has been proposed in tourette syndrome (ts) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia nervosa. |
2014-01-10 |
2023-08-12 |
mouse |
| Vassilis N Panagopoulos, Deanna J Greene, Meghan C Campbell, Kevin J Blac. Towards objectively quantifying sensory hypersensitivity: a pilot study of the "Ariana effect". PeerJ. vol 1. 2013-08-13. PMID:23940834. |
sh is common in tourette syndrome (ts) and autism, and methods to quantify sh may lead to better understanding of these disorders. |
2013-08-13 |
2023-08-12 |
human |
| Masayuki Yazawa, Ricardo E Dolmetsc. Modeling Timothy syndrome with iPS cells. Journal of cardiovascular translational research. vol 6. issue 1. 2013-07-02. PMID:23299782. |
to circumvent this issue, we have developed a method using human-induced pluripotent stem cells to generate cardiomyocytes from individuals with timothy syndrome (ts), a genetic disorder characterized by qt prolongation, ventricular tachycardia, and autism. |
2013-07-02 |
2023-08-12 |
human |
| Jane Gillis, Elena Burashnikov, Charles Antzelevitch, Susan Blaser, Gil Gross, Lesley Turner, Riyana Babul-Hirji, David Chitaya. Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: expanding the spectrum of Timothy syndrome. American journal of medical genetics. Part A. vol 158A. issue 1. 2013-06-20. PMID:22106044. |
timothy syndrome (ts) is an autosomal dominant condition with the constellation of features including prolonged qt interval, hand and foot abnormalities, and mental retardation or autism. |
2013-06-20 |
2023-08-12 |
Not clear |