| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Phillips, Lucas Pozzo-Mille. Dendritic spine dysgenesis in autism related disorders. Neuroscience letters. vol 601. 2015-10-21. PMID:25578949. |
by examining molecular signaling pathways, synaptic deficits, and spine dysgenesis in experimental mouse models of autism related disorders we find strong evidence for mtor to be a critical point of convergence and promising therapeutic target. |
2015-10-21 |
2023-08-13 |
mouse |
| Da Yong Le. Roles of mTOR Signaling in Brain Development. Experimental neurobiology. vol 24. issue 3. 2015-09-28. PMID:26412966. |
the abnormalities in the activity of mtor and its downstream signaling molecules in neural stem cells result in severe defects of brain developmental processes causing a significant number of brain disorders, such as pediatric brain tumors, autism, seizure, learning disability and mental retardation. |
2015-09-28 |
2023-08-13 |
Not clear |
| Hidetoshi Kassai, Yuki Sugaya, Shoko Noda, Kazuki Nakao, Tatsuya Maeda, Masanobu Kano, Atsu Aib. Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell reports. vol 7. issue 5. 2015-08-21. PMID:24857653. |
mammalian target of rapamycin (mtor) has been implicated in human neurological diseases such as tuberous sclerosis complex (tsc), neurodegeneration, and autism. |
2015-08-21 |
2023-08-13 |
mouse |
| Jonathan O Lipton, Mustafa Sahi. The neurology of mTOR. Neuron. vol 84. issue 2. 2015-01-21. PMID:25374355. |
the importance of mtor signaling to brain function is underscored by the myriad disorders in which mtor pathway dysfunction is implicated, such as autism, epilepsy, and neurodegenerative disorders. |
2015-01-21 |
2023-08-13 |
Not clear |
| Matt Kaeberlei. mTOR Inhibition: From Aging to Autism and Beyond. Scientifica. vol 2013. 2014-06-24. PMID:24379984. |
mtor inhibition: from aging to autism and beyond. |
2014-06-24 |
2023-08-12 |
Not clear |
| Juan José García-Peñas, Inmaculada Carreras-Sááe. [Autism, epilepsy and tuberous sclerosis complex: a functional model linked to mTOR pathway]. Revista de neurologia. vol 56 Suppl 1. 2013-10-28. PMID:23446718. |
[autism, epilepsy and tuberous sclerosis complex: a functional model linked to mtor pathway]. |
2013-10-28 |
2023-08-12 |
Not clear |
| Anya Alayev, Marina K Hol. mTOR signaling for biological control and cancer. Journal of cellular physiology. vol 228. issue 8. 2013-06-24. PMID:23460185. |
we also discuss the role of mtor and its downstream effectors in cancer, obesity and diabetes, and autism. |
2013-06-24 |
2023-08-12 |
Not clear |
| Hansen Wang, Laurie C Doerin. Reversing autism by targeting downstream mTOR signaling. Frontiers in cellular neuroscience. vol 7. 2013-03-28. PMID:23533374. |
reversing autism by targeting downstream mtor signaling. |
2013-03-28 |
2023-08-12 |
Not clear |
| Matthew C Weston, Hongmei Chen, John W Swan. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895726. |
mtor signaling is hyperactive in neurological syndromes in both humans and mouse models that are characterized by epilepsy, autism, and cognitive disturbances. |
2012-11-02 |
2023-08-12 |
mouse |
| Delia M Talos, Hongyu Sun, Xiangping Zhou, Erin C Fitzgerald, Michele C Jackson, Peter M Klein, Victor J Lan, Annelise Joseph, Frances E Jense. The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. PloS one. vol 7. issue 5. 2012-09-17. PMID:22567115. |
the mammalian target of rapamycin (mtor) modulates protein translation and is dysregulated in tuberous sclerosis complex, a disorder characterized by epilepsy and autism. |
2012-09-17 |
2023-08-12 |
rat |
| Paolo Curatolo, Valerio Napolioni, Romina Moaver. Autism spectrum disorders in tuberous sclerosis: pathogenetic pathways and implications for treatment. Journal of child neurology. vol 25. issue 7. 2010-10-25. PMID:20207609. |
the dysregulation of intracellular signaling through the activation of mtor pathway could play a direct role in determining susceptibility to autism. |
2010-10-25 |
2023-08-12 |
Not clear |
| M Neves-Pereira, B Müller, D Massie, J H G Williams, P C M O'Brien, A Hughes, S-B Shen, David St Clair, Z Miedzybrodzk. Deregulation of EIF4E: a novel mechanism for autism. Journal of medical genetics. vol 46. issue 11. 2010-02-12. PMID:19556253. |
eif4e mediated translation is the final common process modulated by the mammalian target of rapamycin (mtor), pten and fragile x mental retardation protein (fmrp) pathways, which are implicated in autism. |
2010-02-12 |
2023-08-12 |
Not clear |