| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina S Boksha, Tatyana A Prokhorova, Elena B Tereshkina, Olga K Savushkina, Gulnur Sh Burbaev. Protein Phosphorylation Signaling Cascades in Autism: The Role of mTOR Pathway. Biochemistry. Biokhimiia. vol 86. issue 5. 2021-07-09. PMID:33993859. |
protein phosphorylation signaling cascades in autism: the role of mtor pathway. |
2021-07-09 |
2023-08-13 |
Not clear |
| Matthew S Binder, Dalton G Jones, Samantha L Hodges, Joaquin N Lug. NS-Pten adult knockout mice display both quantitative and qualitative changes in urine-induced ultrasonic vocalizations. Behavioural brain research. vol 378. 2021-04-28. PMID:31586563. |
the ns-pten knockout (ko) mouse exhibits hyperactivity of the mammalian target of rapamycin (mtor) and is a model of autism spectrum disorder (asd). |
2021-04-28 |
2023-08-13 |
mouse |
| Daniel Rial, Emma Puighermanal, Marine Chazalon, Emmanuel Valjent, Serge N Schiffmann, Alban de Kerchove d'Exaerd. Mammalian Target of Rapamycin-RhoA Signaling Impairments in Direct Striatal Projection Neurons Induce Altered Behaviors and Striatal Physiology in Mice. Biological psychiatry. vol 88. issue 12. 2021-03-08. PMID:32711953. |
as an integrator of molecular pathways, mtor (mammalian target of rapamycin) has been associated with diseases including neurodevelopmental, psychiatric, and neurodegenerative disorders such as autism spectrum disorder, schizophrenia, and huntington's disease. |
2021-03-08 |
2023-08-13 |
mouse |
| Hans O Kalkman, Dominik Feuerbac. Microglia M2A Polarization as Potential Link between Food Allergy and Autism Spectrum Disorders. Pharmaceuticals (Basel, Switzerland). vol 10. issue 4. 2020-10-01. PMID:29232822. |
activation of mtor is an effect that is also common to several of the genetic forms of autism. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Shigemi Yoshihar. Contribution of Transferrin and Ceruloplasmin Neurotransmission and Oxidant/Antioxidant Status to the Effects of Everolimus: A Case Series. Cureus. vol 12. issue 2. 2020-09-28. PMID:32071825. |
as everolimus regulates iron homeostasis and increased copper levels suppress mtor signaling, everolimus improved autism symptoms with increased serum levels of cp and tf via homeostatic control of mtor activity, accompanied with the considerable overlap of oxidant-antioxidant systems, such as tap and creatine. |
2020-09-28 |
2023-08-13 |
Not clear |
| A Mühlebner, A Bongaarts, H B Sarnat, T Scholl, E Aronic. New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives. Journal of anatomy. vol 235. issue 3. 2020-09-11. PMID:30901081. |
constitutive activation of mtor signalling represents a shared pathogenic mechanism in a group of developmental malformations that have histopathological and clinical features in common, such as epilepsy, autism and other comorbidities. |
2020-09-11 |
2023-08-13 |
Not clear |
| Chao Tai, Che-Wei Chang, Gui-Qiu Yu, Isabel Lopez, Xinxing Yu, Xin Wang, Weikun Guo, Lennart Muck. Tau Reduction Prevents Key Features of Autism in Mouse Models. Neuron. vol 106. issue 3. 2020-08-24. PMID:32126198. |
similar to a proportion of people with autism, both models have epilepsy, abnormally enlarged brains, and overactivation of the phosphatidylinositol 3-kinase (pi3k)/akt (protein kinase b)/ mammalian target of rapamycin (mtor) signaling pathway. |
2020-08-24 |
2023-08-13 |
mouse |
| Ekaterina A Trifonova, Alexandra I Klimenko, Zakhar S Mustafin, Sergey A Lashin, Alex V Kocheto. The mTOR Signaling Pathway Activity and Vitamin D Availability Control the Expression of Most Autism Predisposition Genes. International journal of molecular sciences. vol 20. issue 24. 2020-04-29. PMID:31847491. |
the mtor signaling pathway activity and vitamin d availability control the expression of most autism predisposition genes. |
2020-04-29 |
2023-08-13 |
Not clear |
| Ekaterina A Trifonova, Alexandra I Klimenko, Zakhar S Mustafin, Sergey A Lashin, Alex V Kocheto. The mTOR Signaling Pathway Activity and Vitamin D Availability Control the Expression of Most Autism Predisposition Genes. International journal of molecular sciences. vol 20. issue 24. 2020-04-29. PMID:31847491. |
a significant part of both syndromic and idiopathic autism cases can be attributed to disorders caused by the mechanistic target of rapamycin (mtor)-dependent translation deregulation. |
2020-04-29 |
2023-08-13 |
Not clear |
| Ekaterina A Trifonova, Alexandra I Klimenko, Zakhar S Mustafin, Sergey A Lashin, Alex V Kocheto. The mTOR Signaling Pathway Activity and Vitamin D Availability Control the Expression of Most Autism Predisposition Genes. International journal of molecular sciences. vol 20. issue 24. 2020-04-29. PMID:31847491. |
we hypothesized that genetic and/or environment mtor hyperactivation, including provocation by vitamin d deficiency, might be a common mechanism controlling the expressivity of most autism predisposition genes and even core symptoms of autism. |
2020-04-29 |
2023-08-13 |
Not clear |
| Maya A Rhine, Jennifer M Parrott, Maria N Schultz, Tatiana M Kazdoba, Jacqueline N Crawle. Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism. Autism research : official journal of the International Society for Autism Research. vol 12. issue 3. 2020-04-17. PMID:30653853. |
btbr is an inbred strain model of forms of idiopathic autism in which reduced inhibitory neurotransmission and excessive mtor signaling have been reported. |
2020-04-17 |
2023-08-13 |
mouse |
| Candi L LaSarge, Raymund Y K Pun, Zhiqing Gu, Victor R Santos, Steve C Danze. Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? Experimental neurology. vol 321. 2020-02-28. PMID:31377403. |
hyperactivation of the mechanistic target of rapamycin (mtor) pathway is associated with epilepsy, autism and brain growth abnormalities in humans. |
2020-02-28 |
2023-08-13 |
mouse |
| Harsha Ganesan, Venkatesh Balasubramanian, Mahalaxmi Iyer, Anila Venugopal, Mohana Devi Subramaniam, Ssang-Goo Cho, Balachandar Vellingir. mTOR signalling pathway - A root cause for idiopathic autism? BMB reports. vol 52. issue 7. 2020-02-04. PMID:31186084. |
mtor signalling pathway - a root cause for idiopathic autism? |
2020-02-04 |
2023-08-13 |
Not clear |
| Harsha Ganesan, Venkatesh Balasubramanian, Mahalaxmi Iyer, Anila Venugopal, Mohana Devi Subramaniam, Ssang-Goo Cho, Balachandar Vellingir. mTOR signalling pathway - A root cause for idiopathic autism? BMB reports. vol 52. issue 7. 2020-02-04. PMID:31186084. |
the present review highlights, underlying mechanism of mtor and its role in altered signalling cascades as a triggering factor in the onset of idiopathic autism. |
2020-02-04 |
2023-08-13 |
Not clear |
| Arti B Patel, Irene Tsilioni, Susan E Leeman, Theoharis C Theoharide. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 45. 2019-11-20. PMID:27663735. |
neurotensin stimulates sortilin and mtor in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. |
2019-11-20 |
2023-08-13 |
human |
| Correction for Patel et al., Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 45. 2019-11-20. PMID:27803332. |
correction for patel et al., neurotensin stimulates sortilin and mtor in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. |
2019-11-20 |
2023-08-13 |
human |
| Guo-Xia Sheng, Ke-Wen Jian. [Research advances in the role of mTOR signaling pathway in autism spectrum disorder]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 21. issue 7. 2019-07-23. PMID:31315775. |
[research advances in the role of mtor signaling pathway in autism spectrum disorder]. |
2019-07-23 |
2023-08-13 |
Not clear |
| Guo-Xia Sheng, Ke-Wen Jian. [Research advances in the role of mTOR signaling pathway in autism spectrum disorder]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 21. issue 7. 2019-07-23. PMID:31315775. |
dysregulation of the mtor signaling pathway is generally considered to be related to the pathogenesis of autism spectrum disorder (asd); meanwhile, the mtor inhibitor can ameliorate the symptoms of asd. |
2019-07-23 |
2023-08-13 |
Not clear |
| Kellen D Winden, Darius Ebrahimi-Fakhari, Mustafa Sahi. Abnormal mTOR Activation in Autism. Annual review of neuroscience. vol 41. 2019-06-13. PMID:29490194. |
abnormal mtor activation in autism. |
2019-06-13 |
2023-08-13 |
Not clear |
| Eleonora Rosina, Barbara Battan, Martina Siracusano, Lorena Di Criscio, Fiona Hollis, Laura Pacini, Paolo Curatolo, Claudia Bagn. Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism. Translational psychiatry. vol 9. issue 1. 2019-06-12. PMID:30705255. |
disruption of mtor and mapk pathways correlates with severity in idiopathic autism. |
2019-06-12 |
2023-08-13 |
human |