| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Smrithi Prem, Bharati Dev, Cynthia Peng, Monal Mehta, Rohan Alibutud, Robert J Connacher, Madeline St Thomas, Xiaofeng Zhou, Paul Matteson, Jinchuan Xing, James H Millonig, Emanuel DiCicco-Bloo. Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells. eLife. vol 13. 2024-03-25. PMID:38525876. |
dysregulation of mtor signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells. |
2024-03-25 |
2024-03-27 |
Not clear |
| Smrithi Prem, Bharati Dev, Cynthia Peng, Monal Mehta, Rohan Alibutud, Robert J Connacher, Madeline St Thomas, Xiaofeng Zhou, Paul Matteson, Jinchuan Xing, James H Millonig, Emanuel DiCicco-Bloo. Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells. eLife. vol 13. 2024-03-25. PMID:38525876. |
surprisingly despite the genetic heterogeneity, hundreds of shared p-peptides were identified between autism subtypes including the mtor pathway. |
2024-03-25 |
2024-03-27 |
Not clear |
| Smrithi Prem, Bharati Dev, Cynthia Peng, Monal Mehta, Rohan Alibutud, Robert J Connacher, Madeline St Thomas, Xiaofeng Zhou, Paul Matteson, Jinchuan Xing, James H Millonig, Emanuel DiCicco-Bloo. Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells. eLife. vol 13. 2024-03-25. PMID:38525876. |
mtor signaling alterations were confirmed in all npcs across both asd-subtypes, and mtor modulation rescued asd phenotypes and reproduced autism npc associated phenotypes in control npcs. |
2024-03-25 |
2024-03-27 |
Not clear |
| Paolo Curatolo, Mirte Scheper, Leonardo Emberti Gialloreti, Nicola Specchio, Eleonora Aronic. Is tuberous sclerosis complex-associated autism a preventable and treatable disorder? World journal of pediatrics : WJP. 2023-10-25. PMID:37878130. |
the mtor pathway plays a crucial role in several brain processes leading to tsc-related epilepsy, intellectual disability, and autism spectrum disorder (asd). |
2023-10-25 |
2023-11-08 |
Not clear |
| E A Trifonova, A A Kotliarova, A V Kocheto. [Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000653. |
a significant part of both syndromic and idiopathic autism is associated with translational deregulation dependent on the mechanistic target of rapamycin (mtor). |
2023-03-31 |
2023-08-14 |
Not clear |
| E A Trifonova, A A Kotliarova, A V Kocheto. [Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000653. |
in this review, we present both bioinformatic and experimental data that link the mtor signaling pathway to maternal autoantibody related autism and childhood autoimmune neuropsychiatric disorders such as sydenham's chorea and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (pandas). |
2023-03-31 |
2023-08-14 |
Not clear |
| Shilu Deepa Thomas, Niraj Kumar Jha, Shreesh Ojha, Bassem Sade. mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838876. |
mtor signaling disruption and its association with the development of autism spectrum disorder. |
2023-02-25 |
2023-08-14 |
Not clear |
| Mary Dusing, Candi L LaSarge, Angela White, Lilian G Jerow, Christina Gross, Steve C Danze. Neurovascular development in eNeuro. 2023-02-09. PMID:36759189. |
neurovascular development in hyperactivation of the mtor signaling pathway is linked to more than a dozen neurological diseases, causing a range of pathologies, including excess neuronal growth, disrupted neuronal migration, cortical dysplasia, epilepsy and autism. |
2023-02-09 |
2023-08-14 |
Not clear |
| Li-Hua Cao, Hong-Juan He, Yuan-Yuan Zhao, Zhen-Zhen Wang, Xing-Yuan Jia, Kamal Srivastava, Ming-San Miao, Xiu-Min L. Food Allergy-Induced Autism-Like Behavior is Associated with Gut Microbiota and Brain mTOR Signaling. Journal of asthma and allergy. vol 15. 2022-05-23. PMID:35603013. |
we sought to test the association of gut microbiota and mammalian/mechanistic target of rapamycin (mtor) signaling with cow's milk allergy (cma)-induced autism pathogenesis. |
2022-05-23 |
2023-08-13 |
Not clear |
| Siddharth Srivastava, Booil Jo, Bo Zhang, Thomas Frazier, Anne Snow Gallagher, Fleming Peck, April R Levin, Sangeeta Mondal, Zetan Li, Rajna Filip-Dhima, Gregory Geisel, Kira A Dies, Amelia Diplock, Charis Eng, Rabi Hanna, Mustafa Sahin, Antonio Harda. A randomized controlled trial of Everolimus for neurocognitive symptoms in PTEN hamartoma tumor syndrome. Human molecular genetics. 2022-05-20. PMID:35594551. |
no placebo-controlled studies have examined mtor inhibition on cognition and behavior in humans with phts with/without autism. |
2022-05-20 |
2023-08-13 |
Not clear |
| Baojiang Wang, Yueyuan Qin, Qunyan Wu, Xi Li, Dongying Xie, Zhongying Zhao, Shan Dua. mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder. Frontiers in immunology. vol 13. 2022-04-15. PMID:35422816. |
mtor signaling pathway regulates the release of proinflammatory molecule ccl5 implicated in the pathogenesis of autism spectrum disorder. |
2022-04-15 |
2023-08-13 |
Not clear |
| Ahmad Movahedpour, Omid Vakili, Masoomeh Khalifeh, Pegah Mousavi, Amir Mahmoodzadeh, Mortaza Taheri-Anganeh, Saeed Razmeh, Zahra Shabaninejad, Fatemeh Yousefi, Hamid Behrouj, Hassan Ghasemi, Seyyed Hossein Khatam. Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy. Cell biochemistry and function. 2022-03-08. PMID:35258097. |
in this context, recent evaluations have revealed that mtor inhibitors could be potential targets to defeat a group of neurological disorders, and thus, a number of clinical trials are investigating their efficacy in treating dementia, autism, epilepsy, stroke, and brain injury, as irritating neurological defects. |
2022-03-08 |
2023-08-13 |
Not clear |
| Ekaterina A Trifonova, Zakhar S Mustafin, Sergey A Lashin, Alex V Kocheto. Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055151. |
a significant part of both syndromic and idiopathic autism cases could be attributed to disorders caused by mammalian target of rapamycin (mtor)-dependent translation deregulation. |
2022-01-21 |
2023-08-13 |
Not clear |
| Elisa Colombo, Guilherme Horta, Mona K Roesler, Natascha Ihbe, Stuti Chhabra, Konstantin Radyushkin, Giovanni Di Liberto, Mario Kreutzfeldt, Sven Schumann, Jakob von Engelhardt, Doron Merkler, Christian Behl, Thomas Mittmann, Albrecht M Clement, Ari Waisman, Michael J Schmeisse. The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 47. 2021-12-11. PMID:34782467. |
by providing evidence that cyld can modulate mechanistic target of rapamycin (mtor) signaling and autophagy at the synapse, we propose that synaptic k63-linked ubiquitination processes could be fundamental in understanding the pathomechanisms underlying autism spectrum disorder. |
2021-12-11 |
2023-08-13 |
mouse |
| Verica Vasic, Mattson S O Jones, Denise Haslinger, Lisa S Knaus, Michael J Schmeisser, Gaia Novarino, Andreas G Chiocchett. Translating the Role of mTOR- and RAS-Associated Signalopathies in Autism Spectrum Disorder: Models, Mechanisms and Treatment. Genes. vol 12. issue 11. 2021-11-30. PMID:34828352. |
mutations affecting mtor or ras signaling underlie defined syndromes (the so-called mtoropathies and rasopathies) with high risk for autism spectrum disorder (asd). |
2021-11-30 |
2023-08-13 |
human |
| Jian-Wei Zhu, Ming-Ming Zou, Yi-Fei Li, Wen-Jin Chen, Ji-Chuan Liu, Hong Chen, Li-Pao Fang, Yan Zhang, Zhao-Tao Wang, Ji-Bo Chen, Wenhui Huang, Shen Li, Wei-Qiang Jia, Qin-Qin Wang, Xue-Chu Zhen, Chun-Feng Liu, Shao Li, Zhi-Cheng Xiao, Guo-Qiang Xu, Jens C Schwamborn, Melitta Schachner, Quan-Hong Ma, Ru-Xiang X. Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 5. 2021-11-16. PMID:31828304. |
hyperactive mtor is an essential pathological mechanism in autism spectrum disorder (asd). |
2021-11-16 |
2023-08-13 |
mouse |
| Shira Mencer, Maryam Kartawy, Felix Lendenfeld, Huda Soluh, Manish Kumar Tripathi, Igor Khaliulin, Haitham Ama. Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34535637. |
proteomics of autism and alzheimer's mouse models reveal common alterations in mtor signaling pathway. |
2021-10-11 |
2023-08-13 |
mouse |
| Tomas Petrasek, Iveta Vojtechova, Ondrej Klovrza, Klara Tuckova, Cestmir Vejmola, Jakub Rak, Anna Sulakova, Daniel Kaping, Nadine Bernhardt, Petrus J de Vries, Jakub Otahal, Robert Walterei. mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus. Journal of neurodevelopmental disorders. vol 13. issue 1. 2021-08-26. PMID:33863288. |
tuberous sclerosis complex (tsc), a multi-system genetic disorder often associated with autism spectrum disorder (asd), is caused by mutations of tsc1 or tsc2, which lead to constitutive overactivation of mammalian target of rapamycin (mtor). |
2021-08-26 |
2023-08-13 |
Not clear |
| Rebecca L Poole, Philippa D K Curry, Ruta Marcinkute, Carole Brewer, David Coman, Emma Hobson, Diana Johnson, Sally Ann Lynch, Anand Saggar, Claire Searle, Ingrid Scurr, Peter D Turnpenny, Pradeep Vasudevan, Katrina Tatton-Brow. Delineating the Smith-Kingsmore syndrome phenotype: Investigation of 16 patients with the MTOR c.5395G > A p.(Glu1799Lys) missense variant. American journal of medical genetics. Part A. vol 185. issue 8. 2021-08-23. PMID:34032352. |
smith-kingsmore syndrome (sks) is a rare genetic syndrome associated with megalencephaly, a variable intellectual disability, autism spectrum disorder, and mtor gain of function variants. |
2021-08-23 |
2023-08-13 |
Not clear |
| Masashi Mizuguchi, Maki Ohsawa, Hirofumi Kashii, Atsushi Sat. Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment. International journal of molecular sciences. vol 22. issue 13. 2021-07-23. PMID:34206526. |
molecular target therapy with mtor inhibitors has recently been proved to be efficacious for epilepsy in human tsc patients, and for autism in tsc model mice, indicating the possibility for pharmacological treatment of developmental synaptic disorders. |
2021-07-23 |
2023-08-13 |
mouse |