| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min-Hyeon Park, Jae-Won Kim, Young-Hui Yang, Soon-Beom Hong, Subin Park, Hyejin Kang, Boong-Nyun Kim, Min-Sup Shin, Hee Jeong Yoo, Soo-Churl Ch. Regional brain perfusion before and after treatment with methylphenidate may be associated with the G1287A polymorphism of the norepinephrine transporter gene in children with attention-deficit/hyperactivity disorder. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22405810. |
dysregulation of the noradrenergic system may be involved in the pathophysiology of attention-deficit/hyperactivity disorder (adhd). |
2012-09-14 |
2023-08-12 |
human |
| Soyoun Kim, Irina Bobeica, Nao J Gamo, Amy F T Arnsten, Daeyeol Le. Effects of α-2A adrenergic receptor agonist on time and risk preference in primates. Psychopharmacology. vol 219. issue 2. 2012-05-01. PMID:21979441. |
in particular, the α-2a noradrenergic system is known to have a key influence on prefrontal cortical circuits, and medications that stimulate this receptor are currently in use for the treatment of adhd. |
2012-05-01 |
2023-08-12 |
Not clear |
| Jeffery R Wickens, Brian I Hyland, Gail Trip. Animal models to guide clinical drug development in ADHD: lost in translation? British journal of pharmacology. vol 164. issue 4. 2012-03-25. PMID:21480864. |
the involvement of dopaminergic and noradrenergic systems in the pathophysiology of adhd is probable. |
2012-03-25 |
2023-08-12 |
human |
| T J Renner, T T Nguyen, M Romanos, S Walitza, C Röser, A Reif, H Schäfer, A Warnke, M Gerlach, K P Lesc. No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample. Attention deficit and hyperactivity disorders. vol 3. issue 3. 2012-01-05. PMID:21739117. |
noradrenergic neurotransmission influences executive functions, attentional performance, and general alertness, involving neuronal networks affected in attention deficit/hyperactivity disorder (adhd). |
2012-01-05 |
2023-08-12 |
Not clear |
| Dong-Ho Song, Kyungun Jhung, Jungeun Song, Keun-Ah Cheo. The 1287 G/A polymorphism of the norepinephrine transporter gene (NET) is involved in commission errors in Korean children with attention deficit hyperactivity disorder. Behavioral and brain functions : BBF. vol 7. 2011-09-20. PMID:21569456. |
previous evidence supports the role of noradrenergic systems in adhd, and norepinephrine transporter (net) is critical in regulating the noradrenergic system. |
2011-09-20 |
2023-08-12 |
Not clear |
| b' Bogus\\xc5\\x82awa Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [Immunological and endocrinological pattern in ADHD etiopathogenesis]. Przeglad lekarski. vol 67. issue 11. 2011-08-30. PMID:21442976.' |
recently, it has been postulated that the reduced activity of the dopaminergic and noradrenergic systems play a crucial role in adhd pathogenesis. |
2011-08-30 |
2023-08-12 |
Not clear |
| b' Bogus\\xc5\\x82awa Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [Immunological and endocrinological pattern in ADHD etiopathogenesis]. Przeglad lekarski. vol 67. issue 11. 2011-08-30. PMID:21442976.' |
it is evidenced by the fact that drugs intensifying the noradrenergic and dopaminergic transmission are the most successful for adhd treatment. |
2011-08-30 |
2023-08-12 |
Not clear |
| Forough Riahi, Mehdi Tehrani-Doost, Zahra Shahrivar, Javad Alaghband-Ra. Efficacy of reboxetine in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled clinical trial. Human psychopharmacology. vol 25. issue 7-8. 2011-08-25. PMID:21312292. |
the main aim of this study is to evaluate the efficacy of reboxetine, a specific noradrenergic reuptake inhibitor, in adults with attention-deficit/hyperactivity disorder (adhd). |
2011-08-25 |
2023-08-12 |
Not clear |
| Terje Sagvolde. Impulsiveness, overactivity, and poorer sustained attention improve by chronic treatment with low doses of l-amphetamine in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Behavioral and brain functions : BBF. vol 7. 2011-08-02. PMID:21450079. |
there is no biological marker, but there is considerable evidence to suggest that adhd behavior is associated with poor dopaminergic and noradrenergic modulation of neuronal circuits that involve the frontal lobes. |
2011-08-02 |
2023-08-12 |
rat |
| Soo-Churl Cho, Hyo-Won Kim, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Seockhoon Chung, Dae-Yeon Cho, Sun-Woo Jung, Hee Jeong Yoo, In-Won Chung, Un-Sun Chung, Jung-Woo So. Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253413. |
brain-derived neurotrophic factor (bdnf), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in adhd development. |
2011-07-14 |
2023-08-12 |
Not clear |
| A Golimstok, J I Rojas, M Romano, M C Zurru, D Doctorovich, E Cristian. Previous adult attention-deficit and hyperactivity disorder symptoms and risk of dementia with Lewy bodies: a case-control study. European journal of neurology. vol 18. issue 1. 2011-05-25. PMID:20491888. |
previous reports have shown that in dementia with lewy body (dlb) and attention-deficit and hyperactivity disorder (adhd) a hypodopaminergic and noradrenergic substrate seems to play a central role in developing the diseases. |
2011-05-25 |
2023-08-12 |
Not clear |
| Yoosook Joung, Chun-Hyung Kim, Jisook Moon, Won-Seok Jang, Jaewon Yang, Dongwon Shin, Soonyoung Lee, Kwang-Soo Ki. Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19685476. |
recent studies showing the improvement of adhd symptoms obtained with the highly selective noradrenergic reuptake inhibitor, atomoxetine, demonstrate that the noradrenergic system plays the role of pathophysiology in this disorder. |
2010-12-20 |
2023-08-12 |
human |
| Boong-Nyun Kim, Jae-Won Kim, Hyejin Kang, Soo-Churl Cho, Min-Sup Shin, Hee-Jeong Yoo, Soon-Beom Hong, Dong Soo Le. Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder. Journal of psychiatry & neuroscience : JPN. vol 35. issue 5. 2010-12-13. PMID:20731965. |
neurobiologic studies have suggested that dysregulation of central noradrenergic systems may be involved in the pathophysiology of attention deficit hyperactivity disorder (adhd), and it has been hypothesized that genetic changes in the norepinephrine pathways might contribute to dysfunction of the prefrontal cortex circuits in adhd. |
2010-12-13 |
2023-08-12 |
Not clear |
| Fukie Niijima, Hiroko Saito, Shigeo Murai, Yuichiro Arai, Osamu Nakagawasai, Koichi Tan-No, Hiromi Watanabe, Hajime Hiraga, Takeshi Tadan. Effects of atomoxetine on levels of monoamines and related substances in discrete brain regions in mice intermittently deprived of rapid eye movement sleep. Biological & pharmaceutical bulletin. vol 33. issue 4. 2010-11-12. PMID:20410595. |
an imbalance between noradrenergic and dopaminergic systems is implicated in hyperactivity disorders, such as attention deficit/hyperactivity disorder (adhd). |
2010-11-12 |
2023-08-12 |
mouse |
| Timothy E Wilens, Thomas J Spence. Understanding attention-deficit/hyperactivity disorder from childhood to adulthood. Postgraduate medicine. vol 122. issue 5. 2010-11-08. PMID:20861593. |
pharmacotherapy, including stimulants, noradrenergic agents, α-agonists, and antidepressants, plays a fundamental role in the long-term management of adhd. |
2010-11-08 |
2023-08-12 |
Not clear |
| Soo-Churl Cho, Hyo-Won Kim, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Dae-Yeon Cho, Seockhoon Chung, Sun-Woo Jung, Hee Jeong Yoo, In-Won Chung, Un-Sun Chung, Jung-Woo So. Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20576502. |
neurotrophin-3 (ntf3), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, has been identified as a factor in the development of adhd. |
2010-11-02 |
2023-08-12 |
Not clear |
| Veronika Engert, Jens C Pruessne. Dopaminergic and noradrenergic contributions to functionality in ADHD: the role of methylphenidate. Current neuropharmacology. vol 6. issue 4. 2010-06-11. PMID:19587853. |
dopaminergic and noradrenergic contributions to functionality in adhd: the role of methylphenidate. |
2010-06-11 |
2023-08-12 |
Not clear |
| Veronika Engert, Jens C Pruessne. Dopaminergic and noradrenergic contributions to functionality in ADHD: the role of methylphenidate. Current neuropharmacology. vol 6. issue 4. 2010-06-11. PMID:19587853. |
methylphenidate (mph), a psychostimulant affecting both the dopaminergic and the noradrenergic systems, is one of the most frequently prescribed treatments for adhd. |
2010-06-11 |
2023-08-12 |
Not clear |
| Javier Quintero, M Navas, A Fernández, T Orti. Advances in attention deficit hyperactivity disorder.What does neuroimaging provide us with? Actas espanolas de psiquiatria. vol 37. issue 6. 2010-05-20. PMID:20066587. |
structural and functional imaging studies suggest that the adhd pathophysiology would be conditioned by a dysfunction in the fronto-subcortical pathways, as well as imbalances in the dopaminergic and noradrenergic systems. |
2010-05-20 |
2023-08-12 |
Not clear |
| Courtney A Ficks, Irwin D Waldma. Gene-environment interactions in attention-deficit/hyperactivity disorder. Current psychiatry reports. vol 11. issue 5. 2010-01-04. PMID:19785980. |
genetic associations with adhd have been found in the dopaminergic, serotonergic, and noradrenergic neurotransmitter systems, but findings are inconsistent across studies. |
2010-01-04 |
2023-08-12 |
Not clear |