| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Liu, Jia Cheng, Yi Su, Ning Ji, Qian Gao, Haimei Li, Li Yang, Li Sun, Qiujin Qian, Yufeng Wan. Deficiency of Sustained Attention in ADHD and Its Potential Genetic Contributor MAOA. Journal of attention disorders. vol 22. issue 9. 2019-09-18. PMID:25784069. |
to investigate the genetic contributors to adhd sustained attention deficit among noradrenergic genes responsible for the synthesis (dopamine-β-hydroxylase gene, dbh), transport (norepinephrine transporter gene, net1), reception (alpha-2a adrenergic receptor gene, adra2a), and metabolism (monoamine oxidase a gene, maoa) of noradrenalin (ne). |
2019-09-18 |
2023-08-13 |
Not clear |
| Jochen Bauer, Anne Werner, Waldemar Kohl, Harald Kugel, Anna Shushakova, Anya Pedersen, Patricia Ohrman. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 19. issue 7. 2019-01-14. PMID:27973969. |
attention-deficit/hyperactivity disorder (adhd) is closely linked to the dysregulation of dopaminergic and noradrenergic neurotransmission in the fronto-striatal neural network, including the anterior cingulate cortex (acc) and the dorsolateral prefrontal cortex (dlpfc). |
2019-01-14 |
2023-08-13 |
Not clear |
| David J Mokler, Christine E Miller, Jill A McGaugh. Evidence for a role of corticopetal, noradrenergic systems in the development of executive function. Neurobiology of learning and memory. vol 143. 2018-05-24. PMID:28219751. |
adhd, may result primarily from increases in cortical norepinephrine (ne) and that cortical noradrenergic systems mature across adolescence. |
2018-05-24 |
2023-08-13 |
rat |
| Honghai Zhang, Haiting Zhao, Hua-Jun Fen. Atomoxetine, a norepinephrine reuptake inhibitor, reduces seizure-induced respiratory arrest. Epilepsy & behavior : E&B. vol 73. 2018-03-26. PMID:28605634. |
our data suggest that the noradrenergic signaling is importantly involved in s-ira, and that atomoxetine, a medication widely used to treat attention deficit hyperactivity disorder (adhd), is potentially useful to prevent sudep. |
2018-03-26 |
2023-08-13 |
mouse |
| Ruu-Fen Tzang, Yue-Cune Chang, Guochuan E Tsai, Hsien-Yuan Lan. Sarcosine treatment for oppositional defiant disorder symptoms of attention deficit hyperactivity disorder children. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27443598. |
methylphenidate, a stimulant that activates dopaminergic and noradrenergic function, is an important agent in the treatment of attention deficit hyperactivity disorder (adhd). |
2017-12-28 |
2023-08-13 |
Not clear |
| James T McCracken, James J McGough, Sandra K Loo, Jennifer Levitt, Melissa Del'Homme, Jennifer Cowen, Alexandra Sturm, Fiona Whelan, Gerhard Hellemann, Catherine Sugar, Robert M Bilde. Combined Stimulant and Guanfacine Administration in Attention-Deficit/Hyperactivity Disorder: A Controlled, Comparative Study. Journal of the American Academy of Child and Adolescent Psychiatry. vol 55. issue 8. 2017-12-19. PMID:27453079. |
because models of attention-deficit/hyperactivity disorder (adhd) therapeutics emphasize benefits of both enhanced dopaminergic and noradrenergic signaling, strategies to enhance d1 and α2a agonism may yield enhanced clinical and cognitive responses. |
2017-12-19 |
2023-08-13 |
Not clear |
| Sandra K Loo, Robert M Bilder, Alexander L Cho, Alexandra Sturm, Jennifer Cowen, Patricia Walshaw, Jennifer Levitt, Melissa Del'Homme, John Piacentini, James J McGough, James T McCracke. Effects of d-Methylphenidate, Guanfacine, and Their Combination on Electroencephalogram Resting State Spectral Power in Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 55. issue 8. 2017-12-19. PMID:27453081. |
noradrenergic agents are increasingly used as adhd monotherapies or adjuncts for suboptimal stimulant response, yet knowledge of their cortical effects is limited. |
2017-12-19 |
2023-08-13 |
Not clear |
| Jesus-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarat. Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy. Experimental neurology. vol 289. 2017-05-15. PMID:28013000. |
these findings suggest that endogenous galanin, acting through galr1 may be involved in the pathophysiology of epilepsy-associated depression and adhd via inhibiting rn-pfc serotonergic and lc-pfc noradrenergic transmissions respectively. |
2017-05-15 |
2023-08-13 |
human |
| Victoria A Reed, Jan K Buitelaar, Ernie Anand, Kathleen Ann Day, Tamás Treuer, Himanshu P Upadhyaya, David R Coghill, Ludmila A Kryzhanovskaya, Nicola C Savil. The Safety of Atomoxetine for the Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Comprehensive Review of Over a Decade of Research. CNS drugs. vol 30. issue 7. 2017-04-11. PMID:27290715. |
atomoxetine is a noradrenergic reuptake inhibitor prescribed for attention-deficit/hyperactivity disorder (adhd) that first gained approval in the usa in 2002 and has been authorized in 97 countries worldwide. |
2017-04-11 |
2023-08-13 |
Not clear |
| Adrian L Loprest. Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. Attention deficit and hyperactivity disorders. vol 7. issue 4. 2016-08-31. PMID:25894292. |
attention deficit hyperactivity disorder (adhd) has a complex aetiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited. |
2016-08-31 |
2023-08-13 |
Not clear |
| Ming-Tao Yang, Dai-Hua Lu, Jui-Ching Chen, Wen-Mei F. Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD. Psychopharmacology. vol 232. issue 20. 2016-05-13. PMID:26228972. |
dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (adhd). |
2016-05-13 |
2023-08-13 |
rat |
| Sucharita S Somkuwar, Kathleen M Kantak, Linda P Dwoski. Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder. Journal of neuroscience methods. vol 252. 2016-04-27. PMID:25680322. |
thus, the current study implicates increased net function in ofc as an underlying mechanism for reduced noradrenergic transmission in ofc, and consequently, the behavioral deficits associated with adhd. |
2016-04-27 |
2023-08-13 |
rat |
| Ivana D'Andrea, Valentina Fardella, Stefania Fardella, Fabio Pallante, Alessandra Ghigo, Roberta Iacobucci, Angelo Maffei, Emilio Hirsch, Giuseppe Lembo, Daniela Carneval. Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. EMBO molecular medicine. vol 7. issue 7. 2016-03-21. PMID:25882071. |
moreover, we demonstrate that the adhd phenotype depends on a dysregulation of creb signaling exerted by a kinase-independent pi3kγ-pde4d interaction in the noradrenergic neurons of the locus coeruleus, thus uncovering new tools for mechanistic and therapeutic research in adhd. |
2016-03-21 |
2023-08-13 |
mouse |
| Daniel J Walker, Oren Mason, David B Clemow, Kathleen A Da. Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder. Postgraduate medicine. vol 127. issue 7. 2015-11-25. PMID:26343377. |
atomoxetine (atx), a nonstimulant, selective noradrenergic reuptake inhibitor, was approved in the united states in 2002 for the treatment of adhd in children and adolescents, as well as adults. |
2015-11-25 |
2023-08-13 |
Not clear |
| Kazuaki Kawaura, Jun-ichi Karasawa, Shigeyuki Chaki, Hirohiko Hikich. Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder. Behavioural brain research. vol 270. 2015-08-14. PMID:24882610. |
however, the roles of noradrenergic systems, which are involved in the pathophysiology of adhd, have not been investigated in this model. |
2015-08-14 |
2023-08-13 |
rat |
| Yia-Ping Liu, Teng-Shun Huang, Che-Se Tung, Chen-Cheng Li. Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25151304. |
atomoxetine, a noradrenaline reuptake inhibitor (nri), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (adhd), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (dnab)-lesioned condition has not been examined. |
2015-07-31 |
2023-08-13 |
rat |
| Ann Childress, Floyd R Salle. Pozanicline for the treatment of attention-deficit/hyperactivity disorder. Expert opinion on investigational drugs. vol 23. issue 11. 2015-06-15. PMID:25196198. |
medications currently used for the treatment of adhd enhance dopaminergic and/or noradrenergic transmission. |
2015-06-15 |
2023-08-13 |
Not clear |
| Blair A Johnston, Benson Mwangi, Keith Matthews, David Coghill, Kerstin Konrad, J Douglas Steel. Brainstem abnormalities in attention deficit hyperactivity disorder support high accuracy individual diagnostic classification. Human brain mapping. vol 35. issue 10. 2015-05-20. PMID:24819333. |
high accuracy prediction was supported by a region of reduced white matter in the brainstem, associated with a pons volumetric reduction in adhd, adjacent to the noradrenergic locus coeruleus and dopaminergic ventral tegmental area nuclei. |
2015-05-20 |
2023-08-13 |
human |
| Blair A Johnston, Benson Mwangi, Keith Matthews, David Coghill, Kerstin Konrad, J Douglas Steel. Brainstem abnormalities in attention deficit hyperactivity disorder support high accuracy individual diagnostic classification. Human brain mapping. vol 35. issue 10. 2015-05-20. PMID:24819333. |
medications used to treat adhd modify dopaminergic and noradrenergic function. |
2015-05-20 |
2023-08-13 |
human |
| Martijn Arns, J Leon Keneman. Neurofeedback in ADHD and insomnia: vigilance stabilization through sleep spindles and circadian networks. Neuroscience and biobehavioral reviews. vol 44. 2015-03-30. PMID:23099283. |
this nucleus has been shown to project to the noradrenergic locus coeruleus (lc) thereby explaining the vigilance stabilizing effects of such treatments in adhd. |
2015-03-30 |
2023-08-12 |
Not clear |