| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johanna Inhyang Kim, Jae Hyun Yoo, Dohyun Kim, Bumseok Jeong, Bung-Nyun Ki. The effects of GRIN2B and DRD4 gene variants on local functional connectivity in attention-deficit/hyperactivity disorder. Brain imaging and behavior. vol 12. issue 1. 2018-08-27. PMID:28258362. |
based on the interplay between dopaminergic and glutamatergic systems, n-methyl-d-asparate (nmda) receptor genes are thought to be involved in the pathophysiology of adhd. |
2018-08-27 |
2023-08-13 |
human |
| Jia Cheng, Aiyi Liu, Michael Y Shi, Zhen Ya. Disrupted Glutamatergic Transmission in Prefrontal Cortex Contributes to Behavioral Abnormality in an Animal Model of ADHD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28176786. |
disrupted glutamatergic transmission in prefrontal cortex contributes to behavioral abnormality in an animal model of adhd. |
2018-04-24 |
2023-08-13 |
rat |
| Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R Li, Walter K Kraft, Hakon Hakonarso. Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling. Nature communications. vol 9. issue 1. 2018-02-02. PMID:29339723. |
the glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (adhd). |
2018-02-02 |
2023-08-13 |
human |
| Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R Li, Walter K Kraft, Hakon Hakonarso. Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling. Nature communications. vol 9. issue 1. 2018-02-02. PMID:29339723. |
fasoracetam in adolescents with adhd and glutamatergic gene network variants disrupting mglur neurotransmitter signaling. |
2018-02-02 |
2023-08-13 |
human |
| Ruu-Fen Tzang, Yue-Cune Chang, Guochuan E Tsai, Hsien-Yuan Lan. Sarcosine treatment for oppositional defiant disorder symptoms of attention deficit hyperactivity disorder children. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27443598. |
sarcosine, a glycine transporter-1 inhibitor, may also play a role in treating adhd by modulating the glutamatergic neurotransmission system through activating n-methyl-d-aspartate type glutamate receptors. |
2017-12-28 |
2023-08-13 |
Not clear |
| Jilly Naaijen, Natalie J Forde, David J Lythgoe, Sophie E A Akkermans, Thaira J C Openneer, Andrea Dietrich, Marcel P Zwiers, Pieter J Hoekstra, Jan K Buitelaa. Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder. NeuroImage. Clinical. vol 13. 2017-11-17. PMID:27909683. |
both tourette's disorder (td) and attention-deficit/hyperactivity disorder (adhd) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. |
2017-11-17 |
2023-08-13 |
Not clear |
| J Naaijen, J Bralten, G Poelmans, J C Glennon, B Franke, J K Buitelaa. Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28072412. |
glutamatergic and gabaergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in adhd and autism. |
2017-11-16 |
2023-08-13 |
Not clear |
| J Naaijen, J Bralten, G Poelmans, J C Glennon, B Franke, J K Buitelaa. Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28072412. |
common variants within glutamatergic and gabaergic genes were investigated using the magma software in an adhd case-only sample (n=931), in which we assessed asd symptoms and response inhibition on a stop task. |
2017-11-16 |
2023-08-13 |
Not clear |
| Estela M Bruxel, Glaucia C Akutagava-Martins, Angélica Salatino-Oliveira, Julia P Genro, Cristian P Zeni, Guilherme V Polanczyk, Rodrigo Chazan, Marcelo Schmitz, Luis A Rohde, Mara H Hut. GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171. issue 8. 2017-09-21. PMID:27530595. |
recent studies suggest a role for γ-aminobutyric acid (gaba) on adhd hyperactive/impulsive symptoms due to behavioral disinhibition resulting from inappropriate modulation of both glutamatergic and gabaergic signaling. |
2017-09-21 |
2023-08-13 |
Not clear |
| Toni-Lee Sterley, Fleur M Howells, Jacqueline J Dimatelis, Vivienne A Russel. Genetic predisposition and early life experience interact to determine glutamate transporter (GLT1) and solute carrier family 12 member 5 (KCC2) levels in rat hippocampus. Metabolic brain disease. vol 31. issue 1. 2016-10-17. PMID:26464063. |
these data suggest significant involvement of glutamatergic and gabaergic transmission in the neuropathophysiology of adhd, and implicates changes in glutamatergic transmission as a result of early life stress. |
2016-10-17 |
2023-08-13 |
rat |
| Jane Pei-Chen Chang, Hsien-Yuan Lane, Guochuan E Tsa. Attention deficit hyperactivity disorder and N-methyl-D-aspartate (NMDA) dysregulation. Current pharmaceutical design. vol 20. issue 32. 2016-03-29. PMID:24410567. |
the review also addresses the development of novel treatments for adhd via modulation of glutamatergic system, particularly the nmda/glycine site. |
2016-03-29 |
2023-08-12 |
Not clear |
| Glaucia Chiyoko Akutagava-Martins, Angelica Salatino-Oliveira, Julia P Genro, Verônica Contini, Guilherme Polanczyk, Cristian Zeni, Rodrigo Chazan, Christian Kieling, Luciana Anselmi, Ana M B Menezes, Eugênio H Grevet, Claiton H D Bau, Luis A Rohde, Mara H Hut. Glutamatergic copy number variants and their role in attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 165B. issue 6. 2015-03-30. PMID:24985920. |
taken together, our results suggest a role for glutamate in adhd as cnvs in the glutamatergic genes investigated herein were associated with cognitive and clinical characteristics of adhd individuals. |
2015-03-30 |
2023-08-13 |
human |
| Karen Dineen Wagne. Timely topics in pediatric psychiatry. The Journal of clinical psychiatry. vol 75. issue 11. 2015-02-09. PMID:25470084. |
this section of focus on childhood and adolescent mental health presents findings on an array of topics including inflammation and child and adolescent depression, glutamatergic dysregulation and pediatric psychiatric disorders, predictors of bipolar disorder in children with attention-deficit/hyperactivity disorder (adhd), and the continuum between obsessive-compulsive personality disorder (ocpd) and obsessive-compulsive disorder (ocd). |
2015-02-09 |
2023-08-13 |
Not clear |
| Patrick T Udvardi, Karl J Föhr, Carolin Henes, Stefan Liebau, Jens Dreyhaupt, Tobias M Boeckers, Andrea G Ludolp. Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study. Drug design, development and therapy. vol 7. 2014-08-29. PMID:24348020. |
these alterations might contribute to atomoxetine's clinical effects in the treatment of adhd, a neurodevelopmental disorder in which synaptic processes and especially a dysregulated glutamatergic metabolism seem to be involved. |
2014-08-29 |
2023-08-12 |
rat |
| Qin Hong, Lei Yang, Min Zhang, Xiao-Qin Pan, Mei Guo, Li Fei, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Ch. Increased locomotor activity and non-selective attention and impaired learning ability in SD rats after lentiviral vector-mediated RNA interference of Homer 1a in the brain. International journal of medical sciences. vol 10. issue 1. 2013-07-12. PMID:23289010. |
our previous studies found that homer 1a, a scaffolding protein localized at the post-synaptic density (psd) of glutamatergic excitatory synapses, is significantly down-regulated in the brain of spontaneous hypertensive rats (shr), an animal model of attention deficit hyperactivity disorder (adhd). |
2013-07-12 |
2023-08-12 |
rat |
| Susanne Karch, Felix Segmiller, Irmgard Hantschk, Anja Cerovecki, Markus Opgen-Rhein, Bettina Hock, Sascha Dargel, Gregor Leicht, Kristina Hennig-Fast, Michael Riedel, Oliver Pogarel. Increased γ oscillations during voluntary selection processes in adult patients with attention deficit/hyperactivity disorder. Journal of psychiatric research. vol 46. issue 11. 2013-04-05. PMID:22921861. |
given that gamma-band responses have been related to gabaergic and glutamatergic responses these results may indicate accordant dysfunction in patients with adhd. |
2013-04-05 |
2023-08-12 |
human |
| b' S Gonz\\xc3\\xa1lez, C Rangel-Barajas, M Peper, R Lorenzo, E Moreno, F Ciruela, J Borycz, J Ortiz, C Llu\\xc3\\xads, R Franco, P J McCormick, N D Volkow, M Rubinstein, B Floran, S Ferr\\xc3\\xa. Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21844870.' |
it is therefore postulated that dysfunctional d(2s)-d(4.7) heteromers may impair presynaptic dopaminergic control of corticostriatal glutamatergic neurotransmission and explain functional deficits associated with adhd. |
2012-11-07 |
2023-08-12 |
mouse |
| Margaretha Dramsdahl, Lars Ersland, Kerstin J Plessen, Jan Haavik, Kenneth Hugdahl, Karsten Spech. Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study. Frontiers in psychiatry. vol 2. 2012-10-02. PMID:22131979. |
impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (adhd) may be related to a prefrontal cortical glutamatergic deficit. |
2012-10-02 |
2023-08-12 |
Not clear |
| Josephine Elia, Joseph T Glessner, Kai Wang, Nagahide Takahashi, Corina J Shtir, Dexter Hadley, Patrick M A Sleiman, Haitao Zhang, Cecilia E Kim, Reid Robison, Gholson J Lyon, James H Flory, Jonathan P Bradfield, Marcin Imielinski, Cuiping Hou, Edward C Frackelton, Rosetta M Chiavacci, Takeshi Sakurai, Cara Rabin, Frank A Middleton, Kelly A Thomas, Maria Garris, Frank Mentch, Christine M Freitag, Hans-Christoph Steinhausen, Alexandre A Todorov, Andreas Reif, Aribert Rothenberger, Barbara Franke, Eric O Mick, Herbert Roeyers, Jan Buitelaar, Klaus-Peter Lesch, Tobias Banaschewski, Richard P Ebstein, Fernando Mulas, Robert D Oades, Joseph Sergeant, Edmund Sonuga-Barke, Tobias J Renner, Marcel Romanos, Jasmin Romanos, Andreas Warnke, Susanne Walitza, Jobst Meyer, Haukur Pálmason, Christiane Seitz, Sandra K Loo, Susan L Smalley, Joseph Biederman, Lindsey Kent, Philip Asherson, Richard J L Anney, J William Gaynor, Philip Shaw, Marcella Devoto, Peter S White, Struan F A Grant, Joseph D Buxbaum, Judith L Rapoport, Nigel M Williams, Stanley F Nelson, Stephen V Faraone, Hakon Hakonarso. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature genetics. vol 44. issue 1. 2012-02-27. PMID:22138692. |
we identified rare recurrent cnvs affecting glutamatergic neurotransmission genes that were overrepresented in multiple adhd cohorts. |
2012-02-27 |
2023-08-12 |
Not clear |
| Qin Hong, Yan-Ping Wang, Min Zhang, Xiao-Qin Pan, Mei Guo, Fei Li, Mei-Ling Tong, Rong-Hua Chen, Xi-Rong Guo, Xia Ch. Homer expression in the hippocampus of an animal model of attention-deficit/hyperactivity disorder. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21523321. |
we previously demonstrated differential expression of some isoforms of homer, a family of scaffolding proteins localized to the postsynaptic density of glutamatergic excitatory synapses, in the spontaneous hypertensive rat (shr), which is the most frequently used animal model of adhd. |
2011-09-30 |
2023-08-12 |
rat |