| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcos Vinícius Vidor, Eduardo Schneider Vitola, Cibele Edom Bandeira, Alexandre Ribeiro Martins, Maria Eduarda de Araujo Tavares, Renata Basso Cupertino, Alana Castro Panzenhagen, Bruna Santos da Silva, Isabel Ghirardi Falkenberg, Pedro Olavo Barreto, Stefania Pigatto Teche, Felipe Almeida Picon, Luis Augusto Rohde, Diego L Rovaris, Claiton Henrique Dotto Bau, Eugenio Horacio Greve. Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder. European archives of psychiatry and clinical neuroscience. 2024-05-16. PMID:38753191. |
lower concentrations of glutamate in the posterior cingulate cortex suggest that a glutamatergic imbalance within the posterior cingulate cortex might play a role in the pathogenesis of adhd. |
2024-05-16 |
2024-05-27 |
Not clear |
| Fabrizio Turiaco, Chiara Cullotta, Federica Mannino, Antonio Bruno, Francesco Squadrito, Giovanni Pallio, Natasha Irrer. Attention Deficit Hyperactivity Disorder (ADHD) and Polyphenols: A Systematic Review. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338814. |
thus, a neuroinflammatory state may influence the neurotransmitters pathways, such as the noradrenergic, glutamatergic, serotoninergic, and, in particular, dopaminergic ones, whose impairment is strongly associated with attention deficit hyperactivity disorder (adhd). |
2024-02-10 |
2024-02-12 |
Not clear |
| Ebru Ulu, Esra Demirci, Elif Funda Sener, Sevgi Özmen, Melike Kevser Gul, Reyhan Tahtasakal, Fatma Da. Role of Glutamate Receptor-related Biomarkers in the Etiopathogenesis of ADHD. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 22. issue 1. 2024-01-22. PMID:38247414. |
however, cyclin-dependent kinase 5 (cdk5), microtubule-associated protein-2 (map2), guanylate kinase-associated protein (gkap), and postsynaptic density 95 (psd95), all of which are biomarkers involved in neurodevelopmental processes closely related to glutamatergic pathways, have not previously been studied in patients with adhd. |
2024-01-22 |
2024-01-24 |
Not clear |
| Mahasweta Chatterjee, Sharmistha Saha, Sayanti Shom, Nilanjana Dutta, Swagata Sinha, Kanchan Mukhopadhya. Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands. Scientific reports. vol 13. issue 1. 2023-11-14. PMID:37964012. |
this indicates that down-regulated glutamatergic system may have an effect on adhd etiology and treatment efficacy warranting further in-depth investigation. |
2023-11-14 |
2023-11-20 |
human |
| Mahasweta Chatterjee, Sharmistha Saha, Sayanti Shom, Nilanjana Dutta, Swagata Sinha, Kanchan Mukhopadhya. Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands. Scientific reports. vol 13. issue 1. 2023-11-14. PMID:37964012. |
glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of indian adhd probands. |
2023-11-14 |
2023-11-20 |
human |
| Gustavo Sudre, Derek E Gildea, Gauri G Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K Auluck, Laura Elnitski, Andreas D Baxevanis, Stefano Marenco, Philip Sha. Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder. Molecular psychiatry. 2022-11-15. PMID:36380233. |
significant downregulation emerged of neurotransmitter gene pathways, particularly glutamatergic, in keeping with models that implicate these neurotransmitters in adhd. |
2022-11-15 |
2023-08-14 |
Not clear |
| Marcos Vinícius Vidor, Alana Castro Panzenhagen, Alexandre Ribeiro Martins, Renata Basso Cupertino, Cibele Edom Bandeira, Felipe Almeida Picon, Bruna Santos da Silva, Eduardo Schneider Vitola, Luis Augusto Rohde, Diego Luiz Rovaris, Claiton Henrique Dotto Bau, Eugênio Horácio Greve. Emerging findings of glutamate-glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies. European archives of psychiatry and clinical neuroscience. 2022-03-24. PMID:35322293. |
results of this meta-analysis provided an overall map of the brain regions evaluated so far, addressed the role of glutamatergic metabolites in the pathophysiology of adhd, and pointed to new perspectives for consistent use of the tool in the field. |
2022-03-24 |
2023-08-13 |
Not clear |
| Yuichi Hiraoka, Kaori Sugiyama, Daiki Nagaoka, Iku Tsutsui-Kimura, Kenji F Tanaka, Kohichi Tanak. Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder. Biochemical and biophysical research communications. vol 567. 2021-11-18. PMID:34166912. |
although animal models and human brain imaging studies indicate a significant role for glutamatergic dysfunction in adhd, there is no direct evidence that glutamatergic dysfunction is sufficient to induce adhd-like symptoms. |
2021-11-18 |
2023-08-13 |
mouse |
| Yuichi Hiraoka, Kaori Sugiyama, Daiki Nagaoka, Iku Tsutsui-Kimura, Kenji F Tanaka, Kohichi Tanak. Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder. Biochemical and biophysical research communications. vol 567. 2021-11-18. PMID:34166912. |
these findings indicate that glutamatergic dysfunction due to glt1 deficiency, a mechanism distinct from the dopaminergic deficit hypothesis of adhd, underlies adhd-like symptoms. |
2021-11-18 |
2023-08-13 |
mouse |
| Anatoly V Skalny, Anna L Mazaletskaya, Irina P Zaitseva, Andrey A Skalny, Demetrios A Spandidos, Aristidis Tsatsakis, Yulia N Lobanova, Margarita G Skalnaya, Michael Aschner, Alexey A Tinko. Alterations in serum amino acid profiles in children with attention deficit/hyperactivity disorder. Biomedical reports. vol 14. issue 5. 2021-04-02. PMID:33786176. |
the observed alterations in pro/hypro and gln/glu levels and ratios are likely associated with the coexisting connective tissue pathology and alterations in glutamatergic neurotransmission in adhd, respectively. |
2021-04-02 |
2023-08-13 |
human |
| Filip S Polli, Theis H Ipsen, Maitane Caballero-Puntiverio, Tina Becher Østerbøg, Susana Aznar, Jesper T Andreasen, Kristi A Kohlmeie. Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31916029. |
alterations in glutamatergic functioning in ca1 neurons parallel changes seen in the spontaneously hypertensive rat adhd model and likely contribute to the lower cognitive performance in the rcpt. |
2020-12-29 |
2023-08-13 |
mouse |
| Regina Waltes, Christine M Freitag, Timo Herlt, Thomas Lempp, Christiane Seitz, Haukur Palmason, Jobst Meyer, Andreas G Chiocchett. Impact of autism-associated genetic variants in interaction with environmental factors on ADHD comorbidities: an exploratory pilot study. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 12. 2020-08-17. PMID:31707462. |
this pilot study suggests that common asd variants of the glutamatergic system interact with prenatal and lifetime psychosocial risk factors influencing the risk for adhd common comorbidities and thus warrants replication in larger samples. |
2020-08-17 |
2023-08-13 |
Not clear |
| Geoffrey A Dunn, Joel T Nigg, Elinor L Sulliva. Neuroinflammation as a risk factor for attention deficit hyperactivity disorder. Pharmacology, biochemistry, and behavior. vol 182. 2020-02-25. PMID:31103523. |
alterations in neurotransmitter systems, including the dopaminergic, serotonergic and glutamatergic systems, are observed in adhd populations. |
2020-02-25 |
2023-08-13 |
human |
| Priyanka Purkayastha, Aruna Malapati, Perumal Yogeeswari, Dharmarajan Srira. A Review on GABA/Glutamate Pathway for Therapeutic Intervention of ASD and ADHD Current medicinal chemistry. vol 22. issue 15. 2019-11-20. PMID:25666800. |
this review focuses on the necessity for developing gaba enhancing and glutamate suppressing drug candidates and illustrates the role of gabaergic and glutamatergic system in cognition and memory impairment involved in neurodevelopmental disorders with emphasis on asd and adhd. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tirill Medin, Vidar Jensen, Øyvind Skare, Jon Storm-Mathisen, Øyvind Hvalby, Linda Hildegard Bergerse. Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD). Behavioural brain research. vol 360. 2019-05-02. PMID:30552946. |
a dysfunctional glutamatergic system may negatively affect learning abilities and underlie symptoms of attention-deficit/hyperactivity disorder (adhd). |
2019-05-02 |
2023-08-13 |
rat |
| R N Mustafin, R F Enikeeva, S B Malykh, R G Valinurov, E K Khusnutdinov. [Genetics and epigenetics of attention deficit hyperactivity disorder]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. 2019-03-25. PMID:30335081. |
association studies have shown the relationship between adhd and genes of dopaminergic (drd4, drd5, slc6a3), serotoninergic (htr1b, 5-httlpr), glutamatergic (mglur, ndrg2) systems, metabolic pathways (slc2a3, slc6a4, cdh13, cfod1, gfod1), membrane proteins (kchip1, itga1, snap-25) as well as tumour-suppressor (ndrg2, nf1) and cytokine genes. |
2019-03-25 |
2023-08-13 |
Not clear |
| Karen Müller Smit. Hyperactivity in mice lacking one allele of the glutamic acid decarboxylase 67 gene. Attention deficit and hyperactivity disorders. vol 10. issue 4. 2019-02-25. PMID:29556956. |
gabaergic interneuron loss, maturational delay or imbalance of glutamatergic to gabaergic signaling has been implicated in several neuropsychiatric disorders including tourette syndrome and attention-deficit/hyperactivity disorder (adhd). |
2019-02-25 |
2023-08-13 |
mouse |
| Edoardo Moretto, Luca Murru, Giuseppe Martano, Jenny Sassone, Maria Passafar. Glutamatergic synapses in neurodevelopmental disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt B. 2019-01-30. PMID:28935587. |
we summarize present knowledge on autism spectrum disorders (asd), intellectual disability (id), down syndrome (ds), rett syndrome (rs) and attention-deficit hyperactivity disorder (adhd), highlighting the involvement of glutamatergic synapses and receptors in these disorders. |
2019-01-30 |
2023-08-13 |
Not clear |
| Jochen Bauer, Anne Werner, Waldemar Kohl, Harald Kugel, Anna Shushakova, Anya Pedersen, Patricia Ohrman. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 19. issue 7. 2019-01-14. PMID:27973969. |
additionally, increasing evidence supports the involvement of the glutamatergic system in the pathophysiology of adhd. |
2019-01-14 |
2023-08-13 |
Not clear |
| Jochen Bauer, Anne Werner, Waldemar Kohl, Harald Kugel, Anna Shushakova, Anya Pedersen, Patricia Ohrman. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 19. issue 7. 2019-01-14. PMID:27973969. |
impulsivity, a core symptom in patients with adhd, has been repeatedly associated with glutamatergic neurotransmission, and pharmacological treatment of adhd has been shown to reduce glutamate levels in the prefrontal cortex. |
2019-01-14 |
2023-08-13 |
Not clear |