All Relations between Amyotrophic Lateral Sclerosis and spinal cord

Publication Sentence Publish Date Extraction Date Species
Arsh Ketabforoush, Meifang Wang, Catherine L Smith, William David Arnold, Nicole L Nichol. Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation. Journal of visualized experiments : JoVE. issue 206. 2024-05-06. PMID:38709037. loss of ventilatory muscle function is a consequence of motor neuron injury and neurodegeneration (e.g., cervical spinal cord injury and amyotrophic lateral sclerosis, respectively). 2024-05-06 2024-05-08 rat
Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotte. Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology. 2024-05-04. PMID:38703371. pathogenic variants in the ubqln2 gene cause x-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. 2024-05-04 2024-05-07 Not clear
Priya Singh, Paul Belliveau, Jennifer Towle, Andrea Elena Neculau, Lorena Dim. Edaravone Oral Suspension: A Neuroprotective Agent to Treat Amyotrophic Lateral Sclerosis. American journal of therapeutics. vol 31. issue 3. 2024-05-01. PMID:38691665. amyotrophic lateral sclerosis (als) is characterized by loss of motor neurons due to degeneration of nerve cells within the brain and spinal cord. 2024-05-01 2024-05-04 Not clear
Aparna Thulasidharan, Lovleen Garg, Shweta Tendulkar, Girish S Ratnaparkh. Age-dependent dynamics of neuronal VAPB Neurobiology of disease. 2024-04-28. PMID:38679111. age-dependent dynamics of neuronal vapb amyotrophic lateral sclerosis (als) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. 2024-04-28 2024-05-01 human
Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. mitochondrial and nuclear dna variants in amyotrophic lateral sclerosis: enrichment in the mitochondrial control region and sirtuin pathway genes in spinal cord tissue. 2024-04-27 2024-04-29 human
Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. amyotrophic lateral sclerosis (als) is a progressive disease with prevalent mitochondrial dysfunctions affecting both upper and lower motor neurons in the motor cortex, brainstem, and spinal cord. 2024-04-27 2024-04-29 human
Faisal A Alzahrani, Yasir M Riza, Thamir M Eid, Reema Almotairi, Lea Scherschinski, Jessica Contreras, Muhammed Nadeem, Sylvia E Perez, Sudhanshu P Raikwar, Ruchira M Jha, Mark C Preul, Andrew F Ducruet, Michael T Lawton, Kanchan Bhatia, Naseem Akhter, Saif Ahma. Exosomes in Vascular/Neurological Disorders and the Road Ahead. Cells. vol 13. issue 8. 2024-04-26. PMID:38667285. neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), stroke, and aneurysms, are characterized by the abnormal accumulation and aggregation of disease-causing proteins in the brain and spinal cord. 2024-04-26 2024-04-28 Not clear
David Gonzalez, Xiomara Cuenca, Miguel L Allend. Knockdown of Frontiers in cellular neuroscience. vol 18. 2024-04-22. PMID:38644973. knockdown of amyotrophic lateral sclerosis (als) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. 2024-04-22 2024-04-24 mouse
Gaurav Deepak Patel, Lichao Liu, Ailian Li, Yun-Hsuan Yang, Chia-Chi Shen, Beate Brand-Saberi, Xuesong Yan. Mesenchymal stem cell-based therapies for treating well-studied neurological disorders: a systematic review. Frontiers in medicine. vol 11. 2024-04-11. PMID:38601118. millions of people across the globe are affected by conditions like amyotrophic lateral sclerosis (als), parkinson's disease (pd), multiple sclerosis (ms), spinal cord injury (sci), and traumatic brain injury (tbi), although most occurrences are common in the elderly population. 2024-04-11 2024-04-13 Not clear
Makoto Urushitani, Hitoshi Warita, Naoki Atsuta, Yuishin Izumi, Osamu Kano, Toshio Shimizu, Yuki Nakayama, Yugo Narita, Hiroyuki Nodera, Takuji Fujita, Koichi Mizoguchi, Mitsuya Morita, Masashi Aok. The clinical practice guideline for the management of amyotrophic lateral sclerosis in Japan-update 2023. Rinsho shinkeigaku = Clinical neurology. 2024-03-24. PMID:38522911. amyotrophic lateral sclerosis (als) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and motor neurons in the brainstem and spinal cord. 2024-03-24 2024-03-27 Not clear
Jiaying Shi, Zhaokun Wang, Ming Yi, Shengyu Xie, Xinyue Zhang, Dachang Tao, Yunqiang Liu, Yuan Yan. Evidence based on Mendelian randomization and colocalization analysis strengthens causal relationships between structural changes in specific brain regions and risk of amyotrophic lateral sclerosis. Frontiers in neuroscience. vol 18. 2024-03-20. PMID:38505770. amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by the degeneration of motor neurons in the brain and spinal cord with a poor prognosis. 2024-03-20 2024-03-23 Not clear
LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. 2024-03-19 2024-03-21 human
Lynn George, BreAnna Cameron, Lauryn Torres-Hernandez, Virginia Montague, Karen Lewis, Heidi Smith, James Fox, Xueshui Guo, Robert G Kal. Titin is a nucleolar protein in neurons. Research square. 2024-03-18. PMID:38496572. additionally, we show that the levels of both titin mrna and protein are altered in the spinal cord of sod1g93a mice, a commonly used model of amyotrophic lateral sclerosis, indicating that titin mediated nucleolar events may in fact contribute to the pathobiology of disease. 2024-03-18 2024-03-20 mouse
Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. 2024-03-13 2024-03-16 mouse
Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Laura Sander, Eva Kesenheimer, Nicole Naumann, Tanja Haas, Philipp Madoerin, Nathalie Braun, Christoph Neuwirth, Markus Weber, Kathleen Jahn, Ludwig Kappos, Cristina Granziera, Kathi Schweikert, Michael Sinnreich, Oliver Bieri, Regina Schlaege. Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. European journal of neurology. 2024-03-11. PMID:38465478. cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. 2024-03-11 2024-03-14 Not clear
Ingrid L Peterson, Austin D Thompson, Natalie E Scholpa, Tally Largent-Milnes, Rick G Schnellman. Isolation and monoculture of functional primary astrocytes from the adult mouse spinal cord. Frontiers in neuroscience. vol 18. 2024-03-04. PMID:38435055. astrocytes are a widely heterogenic cell population that play major roles in central nervous system (cns) homeostasis and neurotransmission, as well as in various neuropathologies, including spinal cord injury (sci), traumatic brain injury, and neurodegenerative diseases, such as amyotrophic lateral sclerosis. 2024-03-04 2024-03-06 mouse
Cyril Jones Jagaraj, Sina Shadfar, Sara Assar Kashani, Sayanthooran Saravanabavan, Fabiha Farzana, Julie D Atki. Molecular hallmarks of ageing in amyotrophic lateral sclerosis. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-03-02. PMID:38430277. amyotrophic lateral sclerosis (als) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain, brainstem, and spinal cord. 2024-03-02 2024-03-04 Not clear
Andrée-Anne Berthiaume, Sherif M Reda, Kayla N Kleist, Sharay E Setti, Wei Wu, Jewel L Johnston, Robert W Taylor, Liana R Stein, Hans J Moebius, Kevin J Churc. ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS. Frontiers in neuroscience. vol 18. 2024-02-23. PMID:38389786. amyotrophic lateral sclerosis (als), a progressive and fatal neurodegenerative disorder, primarily affects the motor neurons of the brain and spinal cord. 2024-02-23 2024-02-25 Not clear
Mohammad Mohasin Miah, Maliha Afroj Zinnia, Nuzhat Tabassum, Abul Bashar Mir Md Khademul Isla. Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-02-21. PMID:38381392. sporadic amyotrophic lateral sclerosis (sals) is a severe neurodegenerative disease characterized by continuous diminution of motor neurons in the brain and spinal cord. 2024-02-21 2024-02-23 Not clear
Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi X. Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis. Reviews in the neurosciences. 2024-02-21. PMID:38381656. amyotrophic lateral sclerosis (als) is a rare neurodegenerative disease which damages upper and lower motor neurons (umn and lmn) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related umn and lmn, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. 2024-02-21 2024-02-24 Not clear