| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Orly Lazarov, Carolyn Holland. Hippocampal neurogenesis: Learning to remember. Progress in neurobiology. vol 138-140. 2016-12-13. PMID:26855369. |
it has become increasingly clear that while neuronal cell loss in the entorhinal cortex and hippocampus occurs in alzheimer's disease, it is preceded by a long period of deficits in the connectivity of the hippocampal formation that contributes to the vulnerability of these circuits. |
2016-12-13 |
2023-08-13 |
Not clear |
| Orly Lazarov, Carolyn Holland. Hippocampal neurogenesis: Learning to remember. Progress in neurobiology. vol 138-140. 2016-12-13. PMID:26855369. |
this review will examine the evidence suggesting that hippocampal neurogenesis plays a role in cognitive function that is affected in alzheimer's disease, will discuss the cognitive assessments used for the detection of alzheimer's disease in humans and rodent models of familial alzheimer's disease, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia. |
2016-12-13 |
2023-08-13 |
Not clear |
| V Frazzini, S Guarnieri, M Bomba, R Navarra, C Morabito, M A Mariggiò, S L Sens. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model. Cell death & disease. vol 7. 2016-12-13. PMID:26890139. |
altered kv2.1 functioning promotes increased excitability in hippocampal neurons of an alzheimer's disease mouse model. |
2016-12-13 |
2023-08-13 |
mouse |
| V Frazzini, S Guarnieri, M Bomba, R Navarra, C Morabito, M A Mariggiò, S L Sens. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model. Cell death & disease. vol 7. 2016-12-13. PMID:26890139. |
we investigated kv2.1 currents and its relation to the intrinsic synaptic activity of hippocampal neurons from 3xtg-ad (triple transgenic mouse model of alzheimer's disease) mice, a widely employed preclinical ad model. |
2016-12-13 |
2023-08-13 |
mouse |
| Wasco Wruck, Friederike Schröter, James Adjay. Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26890743. |
meta-analysis of transcriptome data related to hippocampus biopsies and ipsc-derived neuronal cells from alzheimer's disease patients reveals an association with foxa1 and foxa2 gene regulatory networks. |
2016-12-13 |
2023-08-13 |
Not clear |
| Printha Wijesinghe, S K Shankar, Yasha T Chickabasaviah, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa, K Sunil Kumara, Kamani Samarasinghe, Yoo Hun Suh, H W Steinbusch, K Ranil D De Silv. Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples. Current Alzheimer research. vol 13. issue 3. 2016-12-13. PMID:26906356. |
alzheimer related pathologies were not different among elders, however, in colombo males, neurofibrillary tangle grade was significantly higher in the region of hippocampus (odds ratio = 1.46, 95% confidence interval = 0.07-0.7) and at risk in midbrain substantia nigra (p = 0.075). |
2016-12-13 |
2023-08-13 |
Not clear |
| Yan-Qiu Cui, Qi Wang, Dong-Mei Zhang, Jun-Ya Wang, Bing Xiao, Yan Zheng, Xiao-Min Wan. Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice. Current Alzheimer research. vol 13. issue 3. 2016-12-13. PMID:26906357. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by aggregation of amyloid-β (aβ) peptide in the hippocampus and cortex of brain. |
2016-12-13 |
2023-08-13 |
mouse |
| Eduardo J Fernandez-Perez, Christian Peters, Luis G Aguay. Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation. Current pharmaceutical design. vol 22. issue 10. 2016-12-13. PMID:26972288. |
it is well accepted that cortical and hippocampal synaptic densities are reduced in alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Michelle K Lupton, Lachlan Strike, Narelle K Hansell, Wei Wen, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Katie L McMahon, Greig I de Zubicaray, Amelia A Assareh, Andrew Simmons, Petroula Proitsi, John F Powell, Grant W Montgomery, Derrek P Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, Henry Brodaty, David Ames, Julian N Trollor, Nicholas G Martin, Paul M Thompson, Perminder S Sachdev, Margaret J Wrigh. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973105. |
the effect of increased genetic risk for alzheimer's disease on hippocampal and amygdala volume. |
2016-12-13 |
2023-08-13 |
Not clear |
| Michelle K Lupton, Lachlan Strike, Narelle K Hansell, Wei Wen, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Katie L McMahon, Greig I de Zubicaray, Amelia A Assareh, Andrew Simmons, Petroula Proitsi, John F Powell, Grant W Montgomery, Derrek P Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, Henry Brodaty, David Ames, Julian N Trollor, Nicholas G Martin, Paul M Thompson, Perminder S Sachdev, Margaret J Wrigh. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973105. |
reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Stefano Delli Pizzi, Raffaella Franciotti, Giovanna Bubbico, Astrid Thomas, Marco Onofrj, Laura Bonann. Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973109. |
atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with lewy bodies and alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Stefano Delli Pizzi, Raffaella Franciotti, Giovanna Bubbico, Astrid Thomas, Marco Onofrj, Laura Bonann. Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973109. |
specific alterations of the different hippocampal subfields and adjacent extrahippocampal structures could differently contribute to the pathophysiology of alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2016-12-13 |
2023-08-13 |
Not clear |
| Evan Fletcher, Sylvia Villeneuve, Pauline Maillard, Danielle Harvey, Bruce Reed, William Jagust, Charles DeCarl. β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973117. |
use of hippocampal volume in prior studies was based on the notion that limbic circuit degeneration is an early manifestation of the alzheimer's disease (ad) pathophysiology. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jennifer L Au, Nina Weishaupt, Hayley J Nell, Shawn N Whitehead, David F Cechett. Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke. Journal of visualized experiments : JoVE. issue 109. 2016-12-13. PMID:27022854. |
motor and hippocampal dependent spatial learning and reference memory assessment in a transgenic rat model of alzheimer's disease with stroke. |
2016-12-13 |
2023-08-13 |
rat |
| Kyungha Shin, Yeseul Cha, Kwang Sei Kim, Ehn-Kyoung Choi, Youngjin Choi, Haiyu Guo, Young-Hwan Ban, Jong-Choon Kim, Dongsun Park, Yun-Bae Ki. Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Unconditioned Fear in Rats with Amygdala Injury. Behavioural neurology. vol 2016. 2016-12-13. PMID:27087745. |
we previously demonstrated that f3.chat human neural stem cells (nscs) overexpressing choline acetyltransferase (chat) improve cognitive function of alzheimer's disease model rats with hippocampal or cholinergic nerve injuries by increasing acetylcholine (ach) level. |
2016-12-13 |
2023-08-13 |
human |
| Maite Mendioroz, Naiara Celarain, Miren Altuna, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Idoya Rubio, Rosa Larumbe, María Elena Erro, Iván Méndez, Carmen Echávarr. CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease. Alzheimer's research & therapy. vol 8. issue 1. 2016-12-13. PMID:27094739. |
crtc1 gene is differentially methylated in the human hippocampus in alzheimer's disease. |
2016-12-13 |
2023-08-13 |
human |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
evidence for an imbalance between tau o-glcnacylation and phosphorylation in the hippocampus of a mouse model of alzheimer's disease. |
2016-11-11 |
2023-08-13 |
mouse |
| Sinéad M Ryan, Yvonne M Nola. Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate? Neuroscience and biobehavioral reviews. vol 61. 2016-11-09. PMID:26695382. |
dysregulation of hippocampal neurogenesis has been shown to be an important mechanism underlying the cognitive impairment associated with normal aging, as well as the cognitive deficits evident in preclinical models of alzheimer's disease and other neurodegenerative diseases. |
2016-11-09 |
2023-08-13 |
Not clear |
| Avi Ohry, Octavian Bud. Teofil Simchowicz (1879-1957): the scientist who coined senile plaques in neuropathology. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 56. issue 4. 2016-11-07. PMID:26743308. |
simchowicz coined the terms senile plaques, senile index, and granulovacuolar degeneration - discovered in the hippocampus in patients with alzheimer's disease, and described the nasomental reflex. |
2016-11-07 |
2023-08-13 |
Not clear |
| Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, M Mallar Chakravarty, Fernando Caravaggio, Hiroyoshi Takeuchi, Philip Gerretsen, Yusuke Iwata, Raihaan Patel, Benoit H Mulsant, Ariel Graff-Guerrer. Depressive Symptoms and Small Hippocampal Volume Accelerate the Progression to Dementia from Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 49. issue 3. 2016-11-01. PMID:26519442. |
using data from alzheimer's disease neuroimaging initiative, we examined 2-year follow-up data from 38 dep+amci patients and 38 matched dep-amci patients and compared their ages of conversion from amci to ad and trajectories of progressive hippocampal volume changes. |
2016-11-01 |
2023-08-13 |
Not clear |