| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
alzheimer's disease (ad) is characterized by the spread of tau pathology throughout the cerebral cortex. |
2021-06-23 |
2023-08-13 |
Not clear |
| Santosh R D'Mell. When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer's and Huntington's Disease. International journal of molecular sciences. vol 22. issue 11. 2021-06-23. PMID:34072862. |
alzheimer's disease (ad) is a mostly sporadic brain disorder characterized by cognitive decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex whereas huntington's disease (hd) is a monogenic inherited disorder characterized by motor abnormalities and psychiatric disturbances resulting from selective neurodegeneration in the striatum. |
2021-06-23 |
2023-08-13 |
Not clear |
| Joseph M Schul. The Potential of Induced Pluripotent Stem Cells to Treat and Model Alzheimer's Disease. Stem cells international. vol 2021. 2021-06-15. PMID:34122554. |
an estimated 6.2 million americans aged 65 or older are currently living with alzheimer's disease (ad), a neurodegenerative disease that disrupts an individual's ability to function independently through the degeneration of key regions in the brain, including but not limited to the hippocampus, the prefrontal cortex, and the motor cortex. |
2021-06-15 |
2023-08-13 |
human |
| Mohammad Amani, Julie C Lauterborn, Aliza A Le, Brittney M Cox, Weisheng Wang, Julian Quintanilla, Conor D Cox, Christine M Gall, Gary Lync. Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 10. 2021-06-11. PMID:33514675. |
why layers ii/iii of entorhinal cortex (ec) deteriorate in advance of other regions during the earliest stages of alzheimer's disease is poorly understood. |
2021-06-11 |
2023-08-13 |
mouse |
| V N Salkov, R M Khudoerko. [The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases]. Arkhiv patologii. vol 83. issue 3. 2021-05-28. PMID:34041898. |
the accumulation of ions of these metals in the brain structures leads to chronic intoxication that is manifested by the morphological signs that are typical for alzheimer's disease, such as deposits of β-amyloid and τ-protein mainly in the frontal and temporal regions of the cortex, and for parkinson's disease, such as degeneration of dopamine neurons in the substantia nigra and their accumulation of α-synuclein. |
2021-05-28 |
2023-08-13 |
human |
| Mariona Jové, Natàlia Mota-Martorell, Pascual Torres, Victoria Ayala, Manuel Portero-Otin, Isidro Ferrer, Reinald Pamplon. The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology. Life (Basel, Switzerland). vol 11. issue 5. 2021-05-27. PMID:33923074. |
current shreds of evidence point to the entorhinal cortex (ec) as the origin of the alzheimer's disease (ad) pathology in the cerebrum. |
2021-05-27 |
2023-08-13 |
Not clear |
| Masahiko Takaya, Kazunari Ishii, Kazumasa Saigoh, Osamu Shirakaw. Longitudinal study of primary progressive aphasia in a patient with pathologically diagnosed Alzheimer's disease: a case report. Journal of medical case reports. vol 15. issue 1. 2021-05-27. PMID:34034805. |
alzheimer's disease is a neurodegenerative disease involving the deposition of pathologic amyloid-β and tau protein in the cerebral cortex. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yilei Song, Xiangyu Wang, Xingrong Wang, Jianze Wang, Qiulian Hao, Jifu Hao, Xueqin Ho. Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration. Oxidative medicine and cellular longevity. vol 2021. 2021-05-18. PMID:33564364. |
ost-ne improved the spatial memory ability, increased the acetylcholine content in the cerebral cortex, and decreased the activity of acetylcholinesterase in the hippocampus of alzheimer's disease model mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. |
the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. |
2021-05-18 |
2023-08-13 |
mouse |
| Virginie Bottero, Dallen Powers, Ashna Yalamanchi, James P Quinn, Judith A Potashki. Key Disease Mechanisms Linked to Alzheimer's Disease in the Entorhinal Cortex. International journal of molecular sciences. vol 22. issue 8. 2021-05-13. PMID:33920138. |
key disease mechanisms linked to alzheimer's disease in the entorhinal cortex. |
2021-05-13 |
2023-08-13 |
Not clear |
| Miao Sun, Kai Ma, Jie Wen, Guangxian Wang, Changliang Zhang, Qi Li, Xiaofeng Bao, Hui Wan. A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 73. issue 3. 2021-05-10. PMID:31884474. |
alzheimer's disease (ad) is a neurodegenerative process characterized by loss of neurons in the hippocampus and cerebral cortex, leading to progressive cognitive decline. |
2021-05-10 |
2023-08-13 |
Not clear |
| Angela M Crist, Kelly M Hinkle, Xue Wang, Christina M Moloney, Billie J Matchett, Sydney A Labuzan, Isabelle Frankenhauser, Nkem O Azu, Amanda M Liesinger, Elizabeth R Lesser, Daniel J Serie, Zachary S Quicksall, Tulsi A Patel, Troy P Carnwath, Michael DeTure, Xiaojia Tang, Ronald C Petersen, Ranjan Duara, Neill R Graff-Radford, Mariet Allen, Minerva M Carrasquillo, Hu Li, Owen A Ross, Nilüfer Ertekin-Taner, Dennis W Dickson, Yan W Asmann, Rickey E Carter, Melissa E Murra. Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-05-10. PMID:33875655. |
the hippocampus and cortex are selectively vulnerable in alzheimer's disease (ad), however the degree of involvement of the different brain regions differs among patients. |
2021-05-10 |
2023-08-13 |
human |
| b' Martina Parizkova, Ondrej Lerch, Ross Andel, Jana Kalinova, Hana Markova, Martin Vyhnalek, Jakub Hort, Jan Lacz\\xc3\\xb. Spatial Pattern Separation in Early Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 76. issue 1. 2021-05-07. PMID:32444544.' |
the hippocampus, entorhinal cortex, and basal forebrain are among the first brain structures affected by alzheimer's disease (ad). |
2021-05-07 |
2023-08-13 |
Not clear |
| Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong La. Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer's disease. Neural regeneration research. vol 16. issue 4. 2021-04-29. PMID:33063739. |
melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of alzheimer's disease. |
2021-04-29 |
2023-08-13 |
rat |
| Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong La. Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer's disease. Neural regeneration research. vol 16. issue 4. 2021-04-29. PMID:33063739. |
these findings suggest that melatonin can improve microvessel abnormalities in the cerebral cortex and hippocampus by lowering the expression of vascular endothelial growth factor and its receptors, thereby improving the cognitive function of patients with alzheimer's disease. |
2021-04-29 |
2023-08-13 |
rat |
| Richard D Semb. Perspective: The Potential Role of Circulating Lysophosphatidylcholine in Neuroprotection against Alzheimer Disease. Advances in nutrition (Bethesda, Md.). vol 11. issue 4. 2021-04-27. PMID:32190891. |
alzheimer disease (ad), the most common cause of dementia, is a progressive disorder involving cognitive impairment, loss of learning and memory, and neurodegeneration affecting wide areas of the cerebral cortex and hippocampus. |
2021-04-27 |
2023-08-13 |
Not clear |
| Decheng Bi, Lijun Yao, Zhijian Lin, Lianli Chi, Hui Li, Hong Xu, Xiubo Du, Qiong Liu, Zhangli Hu, Jun Lu, Xu X. Unsaturated mannuronate oligosaccharide ameliorates β-amyloid pathology through autophagy in Alzheimer's disease cell models. Carbohydrate polymers. vol 251. 2021-04-23. PMID:33142656. |
in this study, we investigated for the first time the potential therapeutic effect of mos on alzheimer's disease (ad) and its molecular mechanism in n2a-sw cells and 3×tg-ad primary cortex neurons. |
2021-04-23 |
2023-08-13 |
Not clear |
| E J Fernández-Pérez, S Gallegos, L Armijo-Weingart, A Araya, N O Riffo-Lepe, F Cayuman, L G Aguay. Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model. Scientific reports. vol 10. issue 1. 2021-04-22. PMID:33177601. |
several previous studies showed that hippocampus and cortex are affected in alzheimer's disease (ad). |
2021-04-22 |
2023-08-13 |
mouse |
| Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, Loghman Firoozpour, Kouros Divsalar, Ali Asadipour, Tahmineh Akbarzadeh, Alireza Foroumad. Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 Heliyon. vol 7. issue 4. 2021-04-21. PMID:33869871. |
design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 alzheimer's disease (ad), is among the most growing neurodegenerative diseases, which is mainly caused by the acetylcholine neurotransmitter loss in the hippocampus and cortex. |
2021-04-21 |
2023-08-13 |
Not clear |
| Jelena Djordjevic, Subir Roy Chowdhury, Wanda M Snow, Claudia Perez, Chris Cadonic, Paul Fernyhough, Benedict C Albens. Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer's Mice. Cells. vol 9. issue 6. 2021-03-31. PMID:32599904. |
early onset of sex-dependent mitochondrial deficits in the cortex of 3xtg alzheimer's mice. |
2021-03-31 |
2023-08-13 |
mouse |