| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luigi Ferini-Strambi, Michael Hensley, Maria Salson. Decoding Causal Links Between Sleep Apnea and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 1. 2021-09-13. PMID:33459636. |
obstructive sleep apnea (osa) and alzheimer's disease (ad) are two common chronic diseases with a well-documented association. |
2021-09-13 |
2023-08-13 |
Not clear |
| Mariana Fernandes, Fabio Placidi, Nicola Biagio Mercuri, Claudio Liguor. The Importance of Diagnosing and the Clinical Potential of Treating Obstructive Sleep Apnea to Delay Mild Cognitive Impairment and Alzheimer's Disease: A Special Focus on Cognitive Performance. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-08-10. PMID:34368635. |
obstructive sleep apnea (osa) is a highly frequent sleep disorder in the middle-aged and older population, and it has been associated with an increased risk of developing cognitive decline and dementia, including mild cognitive impairment (mci) and alzheimer's disease (ad). |
2021-08-10 |
2023-08-13 |
Not clear |
| Pamela Barletta, Alexandre R Abreu, Alberto R Ramos, Salim I Dib, Carlos Torre, Alejandro D Chedia. Role of Obstructive Sleep Apnea in Cognitive Impairment. International journal of head and neck surgery. vol 10. issue 3. 2021-07-27. PMID:34305353. |
emerging science suggest that untreated and undertreated osa increases the risk of developing cognitive impairment, including vascular dementia and neurodegenerative disorders, like alzheimer's disease. |
2021-07-27 |
2023-08-13 |
Not clear |
| A Targa, F Dakterzada, I D Benítez, D de Gonzalo-Calvo, A Moncusí-Moix, R López, M Pujol, A Arias, J de Batlle, M Sánchez-de-la-Torre, F Barbé, Gerard Piñol-Ripol. Circulating MicroRNA Profile Associated with Obstructive Sleep Apnea in Alzheimer's Disease. Molecular neurobiology. vol 57. issue 11. 2021-06-29. PMID:32720075. |
the diagnosis of obstructive sleep apnea (osa) in alzheimer's disease (ad) by polysomnography (psg) is challenging due to the required collaboration of the patients. |
2021-06-29 |
2023-08-13 |
Not clear |
| Carmen Jorge, Adriano Targa, Iván David Benítez, Faride Dakterzada, Gerard Torres, Olga Minguez, Anna Carnes, Montse Pujol, Aurora Gibert, Ricard López, Anna Michela Gaeta, Mireia Dalmases, Ramón Farré, Manuel Sánchez-de-la-Torre, Ferran Barbé, Gerard Piñol-Ripol. Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease. The European respiratory journal. vol 56. issue 5. 2021-06-21. PMID:32554539. |
we evaluated the influence of untreated obstructive sleep apnoea (osa) on the magnitude of cognitive decline and on several cognitive subdomains in patients with mild-to-moderate alzheimer's disease.in this single-centre study, 144 patients were recruited prospectively from a cognitive impairment unit and underwent overnight polysomnography.the mean±sd change in the alzheimer's disease assessment scale cognitive subscale (adas-cog) score at 12 months was 3.19±5.61 in the non-osa group and 0.08±5.62 in the osa group, with an intergroup difference of -3.36 (95% ci 0.19-0.16; p=0.002). |
2021-06-21 |
2023-08-13 |
Not clear |
| Mónica Díaz-Román, Matias M Pulopulos, Miguel Baquero, Alicia Salvador, Ana Cuevas, Inés Ferrer, Oana Ciopat, Enriqueta Góme. Obstructive sleep apnea and Alzheimer's disease-related cerebrospinal fluid biomarkers in mild cognitive impairment. Sleep. vol 44. issue 1. 2021-04-26. PMID:32728730. |
previous studies have demonstrated that sleep-breathing disorders, and especially obstructive sleep apnea (osa), can be observed in patients with a higher risk of progression to alzheimer's disease (ad). |
2021-04-26 |
2023-08-13 |
Not clear |
| Jessica E Owen, Bryndis Benediktsdottir, Elizabeth Cook, Isleifur Olafsson, Thorarinn Gislason, Stephen R Robinso. Alzheimer's disease neuropathology in the hippocampus and brainstem of people with obstructive sleep apnea. Sleep. vol 44. issue 3. 2021-04-26. PMID:32954401. |
people with osa can experience memory deficits and have reduced hippocampal volume; these features are also characteristic of alzheimer's disease (ad), where they are accompanied by neurofibrillary tangles (nfts) and amyloid beta (aβ) plaques in the hippocampus and brainstem. |
2021-04-26 |
2023-08-13 |
Not clear |
| Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Anne Obst, Beate Stubbe, Mohamad Habes, András Szentkirályi, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Völzke, Helena U Zacharias, Hans J Grab. Associations between sleep apnea and advanced brain aging in a large-scale population study. Sleep. vol 44. issue 3. 2021-04-26. PMID:33017007. |
advanced brain aging is commonly regarded as a risk factor for neurodegenerative diseases, for example, alzheimer's dementia, and it was suggested that sleep disorders such as obstructive sleep apnea (osa) are significantly contributing factors to these neurodegenerative processes. |
2021-04-26 |
2023-08-13 |
human |
| Omonigho M Bubu, Ogie Q Umasabor-Bubu, Arlener D Turner, Ankit Parekh, Anna E Mullins, Korey Kam, Madeline K Birckbichler, Fahad Mukhtar, Alfred K Mbah, Natasha J Williams, David M Rapoport, Mony de Leon, Girardin Jean-Louis, Indu Ayappa, Andrew W Varga, Ricardo S Osori. Self-reported obstructive sleep apnea, amyloid and tau burden, and Alzheimer's disease time-dependent progression. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-04-10. PMID:33090679. |
obstructive sleep apnea (osa) is associated with alzheimer's disease (ad) biomarkers in cognitively normal (cn) and mild cognitive impaired (mci) participants. |
2021-04-10 |
2023-08-13 |
human |
| Omonigho M Bubu, Andreia G Andrade, Ogie Q Umasabor-Bubu, Megan M Hogan, Arlener D Turner, Mony J de Leon, Gbenga Ogedegbe, Indu Ayappa, Girardin Jean-Louis G, Melinda L Jackson, Andrew W Varga, Ricardo S Osori. Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research. Sleep medicine reviews. vol 50. 2021-02-08. PMID:31881487. |
increasing evidence links cognitive-decline and alzheimer's disease (ad) to various sleep disorders, including obstructive sleep apnea (osa). |
2021-02-08 |
2023-08-13 |
Not clear |
| Chih-Yun Kuo, Hung-Ta Hsiao, Ing-Hsien Lo, Tomas Nikola. Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review. Frontiers in aging neuroscience. vol 12. 2021-01-26. PMID:33488381. |
obstructive sleep apnea (osa) and alzheimer's disease (ad) are common in the elderly population. |
2021-01-26 |
2023-08-13 |
Not clear |
| Anna Michela Gaeta, Ivan D Benítez, Carmen Jorge, Gerard Torres, Faride Dakterzada, Olga Minguez, Raquel Huerto, Montse Pujol, Anna Carnes, Mireia Dalmases, Aurora Gibert, Ramón Farré, Manuel Sanchez de la Torres, Ferran Barbé, Gerard Piñol-Ripol. Prevalence of obstructive sleep apnea in Alzheimer's disease patients. Journal of neurology. vol 267. issue 4. 2021-01-01. PMID:31832828. |
to assess the prevalence of obstructive sleep apnea (osa) in patients with mild-moderate alzheimer's disease (ad) and to evaluate cognitive characteristics according to the severity of osa. |
2021-01-01 |
2023-08-13 |
Not clear |
| Dora Polsek, Diana Cash, Mattia Veronese, Katarina Ilic, Tobias C Wood, Milan Milosevic, Svjetlana Kalanj-Bognar, Mary J Morrell, Steve C R Williams, Srecko Gajovic, Guy D Leschziner, Dinko Mitrecic, Ivana Rosenzwei. The innate immune toll-like-receptor-2 modulates the depressogenic and anorexiolytic neuroinflammatory response in obstructive sleep apnoea. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32651433. |
the increased awareness of obstructive sleep apnoea's (osa) links to alzheimer's disease and major psychiatric disorders has recently directed an intensified search for their potential shared mechanisms. |
2020-12-08 |
2023-08-13 |
mouse |
| Ming-Shao Tsai, Hsueh-Yu Li, Chung-Guei Huang, Robert Y L Wang, Li-Pang Chuang, Ning-Hung Chen, Chi-Hung Liu, Yao-Hsu Yang, Chia-Yen Liu, Cheng-Ming Hsu, Wen-Nuan Cheng, Li-Ang Le. Risk of Alzheimer's Disease in Obstructive Sleep Apnea Patients With or Without Treatment: Real-World Evidence. The Laryngoscope. vol 130. issue 9. 2020-12-07. PMID:32045010. |
to assess the risk of alzheimer's disease (ad) in patients with obstructive sleep apnea (osa) with or without treatment based on real-world evidence. |
2020-12-07 |
2023-08-13 |
Not clear |
| Batsheva R Rubin, Teresa A Milner, Virginia M Pickel, Christal G Coleman, Jose Marques-Lopes, Tracey A Van Kempen, Syed Faraz Kazim, Bruce S McEwen, Jason D Gray, Ana C Pereir. Sex and age differentially affect GABAergic neurons in the mouse prefrontal cortex and hippocampus following chronic intermittent hypoxia. Experimental neurology. vol 325. 2020-10-23. PMID:31837319. |
obstructive sleep apnea (osa), a chronic sleep disorder characterized by repetitive reduction or cessation of airflow during sleep, is widely prevalent and is associated with adverse neurocognitive sequelae including increased risk of alzheimer's disease (ad). |
2020-10-23 |
2023-08-13 |
mouse |
| Hsueh-Yu Li, Ming-Shao Tsai, Chung-Guei Huang, Robert Y L Wang, Li-Pang Chuang, Ning-Hung Chen, Chi-Hung Liu, Cheng-Ming Hsu, Wen-Nuan Cheng, Li-Ang Le. Alterations in Alzheimer's Disease-Associated Gene Expression in Severe Obstructive Sleep Apnea Patients. Journal of clinical medicine. vol 8. issue 9. 2020-10-01. PMID:31480626. |
obstructive sleep apnea (osa) increases the risk of alzheimer's disease (ad), and inflammation may be involved in the early pathogenesis of ad in patients with osa. |
2020-10-01 |
2023-08-13 |
Not clear |
| Luigi Ferini-Strambi, Giulia Elisabetta Lombardi, Sara Marelli, Andrea Galbiat. Neurological Deficits in Obstructive Sleep Apnea. Current treatment options in neurology. vol 19. issue 4. 2020-09-30. PMID:28374233. |
osa may accelerate the onset of mild cognitive impairment and alzheimer's disease (ad) and might also represent an independent risk factor for parkinson's disease (pd). |
2020-09-30 |
2023-08-13 |
Not clear |
| b' Maria Jos\\xc3\\xa9 Menal, Ignasi Jorba, Marta Torres, Josep M Montserrat, David Gozal, Anna Colell, Gerard Pi\\xc3\\xb1ol-Ripoll, Daniel Navajas, Isaac Almendros, Ramon Farr\\xc3\\xa. Alzheimer\'s Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea. Frontiers in neurology. vol 9. 2020-09-29. PMID:29403429.' |
evidence from patients and animal models suggests that obstructive sleep apnea (osa) may increase the risk of alzheimer's disease (ad) and that ad is associated with reduced brain tissue stiffness. |
2020-09-29 |
2023-08-13 |
mouse |
| Carme Jorge, Ivan Benítez, Gerard Torres, Faride Dakterzada, Olga Minguez, Raquel Huerto, Montse Pujol, Anna Carnes, Anna Michela Gaeta, Mireia Dalmases, Aurora Gibert, Manuel Sanchez de la Torres, Ferran Barbé, Gerard Piñol-Ripol. The STOP-Bang and Berlin questionnaires to identify obstructive sleep apnoea in Alzheimer's disease patients. Sleep medicine. vol 57. 2020-07-07. PMID:30897451. |
a close relationship between obstructive sleep apnoea (osa) and alzheimer's disease (ad) has been described in recent years. |
2020-07-07 |
2023-08-13 |
Not clear |
| Omonigho M Bubu, Elizabeth Pirraglia, Andreia G Andrade, Ram A Sharma, Sandra Gimenez-Badia, Ogie Q Umasabor-Bubu, Megan M Hogan, Amanda M Shim, Fahad Mukhtar, Nidhi Sharma, Alfred K Mbah, Azizi A Seixas, Korey Kam, Ferdinand Zizi, Amy R Borenstein, James A Mortimer, Kevin E Kip, David Morgan, Ivana Rosenzweig, Indu Ayappa, David M Rapoport, Girardin Jean-Louis, Andrew W Varga, Ricardo S Osori. Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes. Sleep. vol 42. issue 6. 2020-04-20. PMID:30794315. |
to determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (osa) on longitudinal changes in brain amyloid pet and csf biomarkers (aβ42, t-tau, and p-tau) in cognitively normal (nl), mild cognitive impairment (mci), and alzheimer's disease (ad) elderly. |
2020-04-20 |
2023-08-13 |
Not clear |