| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma L Twait, Lotte Gerritsen, Justine E F Moonen, Inge M W Verberk, Charlotte E Teunissen, Pieter Jelle Visser, Wiesje M van der Flier, Mirjam I Geerling. Plasma Markers of Alzheimer's Disease Pathology, Neuronal Injury, and Astrocytic Activation and MRI Load of Vascular Pathology and Neurodegeneration: The SMART-MR Study. Journal of the American Heart Association. 2024-02-14. PMID:38353228. |
plasma biomarkers for alzheimer's disease-related pathology have recently emerged, including aβ (amyloid-beta), p-tau (phosphorylated tau), nfl (neurofilament light), and gfap (glial fibrillary acidic protein). |
2024-02-14 |
2024-02-16 |
Not clear |
| Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty McAleese, Lauren Walker, Fiona E LeBeau, Johannes Attems, Tiago F Outeiro, Alan Thomas, David J Kos. Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change. Acta neuropathologica. vol 147. issue 1. 2024-02-14. PMID:38353753. |
employing frozen and fixed frontal cortex grey and white matter tissue from non-ad controls (con; n = 39) and alzheimer's disease (ad) cases (n = 21), biochemical and immunohistochemical (ihc) measures of aβ and at-8 phosphorylated tau were assessed. |
2024-02-14 |
2024-02-16 |
Not clear |
| Benjamin S Zide, Nancy J Donovan, Soyoung Lee, Sukriti Nag, David A Bennett, Heidi I L Jacob. Social activity mediates locus coeruleus tangle-related cognition in older adults. Molecular psychiatry. 2024-02-14. PMID:38355788. |
conversely, accumulation of tau tangles in the brainstem locus coeruleus nuclei is recently studied as a very early marker of alzheimer's disease (ad) pathogenesis and cognitive vulnerability, even among older adults without cognitive impairment or significant cerebral ad pathologies. |
2024-02-14 |
2024-02-17 |
Not clear |
| Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Syed Misbahul Hasan, Rufaida Wasim, Shubhrat Maheshwari, Juber Akhtar, Suvaiv Sheikh, Vishal Kumar Vishwakarm. Targeting Abnormal Tau Phosphorylation for Alzheimer's Therapeutics. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2024-02-13. PMID:38350636. |
targeting abnormal tau phosphorylation for alzheimer's therapeutics. |
2024-02-13 |
2024-02-16 |
Not clear |
| Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månber. CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration. Molecular neurodegeneration. vol 19. issue 1. 2024-02-13. PMID:38350954. |
amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with alzheimer's disease (ad). |
2024-02-13 |
2024-02-16 |
Not clear |
| Aaron T Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Prat. O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology. 2024-02-12. PMID:38347213. |
amyloid-forming proteins such α-synuclein and tau, which are implicated in alzheimer's and parkinson's disease, can form different fibril structures or strains with distinct toxic properties, seeding activities and pathology. |
2024-02-12 |
2024-02-15 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Göt. Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular brain. vol 17. issue 1. 2024-02-12. PMID:38347594. |
the most studied of these modifications is phosphorylation, which affects tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in alzheimer's disease and primary tauopathies. |
2024-02-12 |
2024-02-15 |
Not clear |
| Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases. Cell & bioscience. vol 14. issue 1. 2024-02-12. PMID:38347638. |
for example, the main pathological features of alzheimer's disease are the aggregation of beta-amyloid protein and abnormal phosphorylation of tau protein. |
2024-02-12 |
2024-02-15 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
impaired sleep is associated with tau deposition on impaired sleep is commonly associated with alzheimer's disease (ad), although the underlying mechanisms remain unclear. |
2024-02-11 |
2024-02-14 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
using data from the alzheimer's disease neuroimaging initiative, we investigated whether a medical history of impaired sleep, informant-reported nighttime behaviors, and sleep-affecting medications are associated with beta-amyloid and tau deposition on pet and cognitive change, cross-sectionally and longitudinally. |
2024-02-11 |
2024-02-14 |
Not clear |
| D M Sithara Dissanayaka, Vijay Jayasena, Stephanie R Rainey-Smith, Ralph N Martins, W M A D Binosha Fernand. The Role of Diet and Gut Microbiota in Alzheimer's Disease. Nutrients. vol 16. issue 3. 2024-02-10. PMID:38337696. |
alzheimer's disease (ad), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (aβ) plaques and hyperphosphorylated tau tangles. |
2024-02-10 |
2024-02-12 |
Not clear |
| Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H Chen. Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338484. |
the molecular events of protein misfolding and self-aggregation of tau and amylin are associated with the progression of alzheimer's and diabetes, respectively. |
2024-02-10 |
2024-02-12 |
Not clear |
| Tânia Soares Martins, Steven Pelech, Maria Ferreira, Beatriz Pinho, Kevin Leandro, Luís Pereira de Almeida, Benedict Breitling, Niels Hansen, Hermann Esselmann, Jens Wiltfang, Odete A B da Cruz E Silva, Ana Gabriela Henrique. Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338863. |
phosphorylation plays a key role in alzheimer's disease (ad) pathogenesis, impacting distinct processes such as amyloid-beta (aβ) peptide production and tau phosphorylation. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
the associations of phosphorylated tau 181 and tau 231 levels in plasma and cerebrospinal fluid with cognitive function in alzheimer's disease: a systematic review and meta-analysis. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
cerebrospinal fluid (csf) or blood biomarkers like phosphorylated tau proteins (p-tau) are used to detect alzheimer's disease (ad) early. |
2024-02-10 |
2024-02-12 |
Not clear |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
generation of tau dephosphorylation-targeting chimeras for the treatment of alzheimer's disease and related tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in alzheimer's disease (ad) and many other tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Ki. Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity. Translational psychiatry. vol 14. issue 1. 2024-02-10. PMID:38341444. |
we compared tau burden measured by pet, brain volume assessed by mri, cross-sectional cognitive function, longitudinal cognitive decline and polygenic risk score (prs) between pet/plasma groups (pet-/plasma-, pet-/plasma+, pet+/plasma-, pet+/plasma+) using alzheimer's disease neuroimaging initiative database. |
2024-02-10 |
2024-02-14 |
human |
| Corrina S Fonseca, Suzanne L Baker, Lindsey Dobyns, Mustafa Janabi, William J Jagust, Theresa M Harriso. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-09. PMID:38334195. |
amyloid beta (aβ) and tau pathology are cross-sectionally associated with atrophy and cognitive decline in aging and alzheimer's disease (ad). |
2024-02-09 |
2024-02-11 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
impact of apoe on amyloid and tau accumulation in argyrophilic grain disease and alzheimer's disease. |
2024-02-09 |
2024-02-12 |
Not clear |