| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| Ying Chen, Weiting Zhang, Qi Li, Huanfang Xie, Shuaishuai Xing, Xin Lu, Weiping Lyu, Baichen Xiong, Yuanyuan Wang, Wei Qu, Wenyuan Liu, Heng Chi, Xiaolong Zhang, Feng Feng, Haopeng Su. Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 272. 2024-05-05. PMID:38704944. |
discovery of 4-benzylpiperazinequinoline bche inhibitor that suppresses neuroinflammation for the treatment of alzheimer's disease. |
2024-05-05 |
2024-05-08 |
Not clear |
| Ying Chen, Weiting Zhang, Qi Li, Huanfang Xie, Shuaishuai Xing, Xin Lu, Weiping Lyu, Baichen Xiong, Yuanyuan Wang, Wei Qu, Wenyuan Liu, Heng Chi, Xiaolong Zhang, Feng Feng, Haopeng Su. Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 272. 2024-05-05. PMID:38704944. |
butyrylcholinesterase (bche) has attracted wide interest as a promising target in alzheimer's disease (ad) investigation. |
2024-05-05 |
2024-05-08 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Hao Li, Xiao-Dong Li, Chao-Hua Yan, Zhen-Hua Ni, Mu-Han Lü, Li-Wei Zou, Ling Yan. Rational design of a near-infrared fluorescent probe for monitoring butyrylcholinesterase activity and its application in development of inhibitors. Frontiers in bioengineering and biotechnology. vol 12. 2024-04-19. PMID:38638318. |
butyrylcholinesterase (bche) is widely expressed in multiple tissues and has a vital role in several key human disorders, such as alzheimer's disease and tumorigenesis. |
2024-04-19 |
2024-04-21 |
human |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Francesco Samarelli, Rosa Purgatorio, Gianfranco Lopopolo, Caterina Deruvo, Marco Catto, Michael Andresini, Antonio Carrieri, Orazio Nicolotti, Annalisa De Palma, Daniela Valeria Miniero, Modesto de Candia, Cosimo D Altomar. Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults. European journal of medicinal chemistry. vol 270. 2024-04-05. PMID:38579622. |
due to the putative role of butyrylcholinesterase (bche) in regulation of acetylcholine levels and functions in the late stages of the alzheimer's disease (ad), the potential of selective inhibitors (bcheis) has been envisaged as an alternative to administration of acetylcholinesterase inhibitors (acheis). |
2024-04-05 |
2024-04-10 |
Not clear |
| Sabrina Lekmine, Ouided Benslama, Hichem Tahraoui, Mohammad Shamsul Ola, Aicha Laouani, Kenza Kadi, Antonio Ignacio Martín-García, Ahmad Al. Anti-Cholinergic Effects of the Phenolic Extract from the Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543134. |
cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), hold pivotal significance in alzheimer's disease (ad) treatment. |
2024-03-28 |
2024-03-30 |
Not clear |
| Lei Wang, Tianyu Sun, Tengfei Zhen, Wei Li, Huajing Yang, Suyu Wang, Feng Feng, Yao Chen, Haopeng Su. Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer's Disease. Journal of medicinal chemistry. 2024-03-28. PMID:38546542. |
butyrylcholinesterase (bche) is a promising biomarker and effective therapeutic target for alzheimer's disease (ad). |
2024-03-28 |
2024-03-30 |
Not clear |
| Mustafa Kemal Ozalp, Patricia A Vignaux, Ana C Puhl, Thomas R Lane, Fabio Urbina, Sean Ekin. Sequential Contrastive and Deep Learning Models to Identify Selective Butyrylcholinesterase Inhibitors. Journal of chemical information and modeling. 2024-03-27. PMID:38532612. |
butyrylcholinesterase (bche) is a target of interest in late-stage alzheimer's disease (ad) where selective bche inhibitors (bis) may offer symptomatic treatment without the harsh side effects of acetylcholinesterase (ache) inhibitors. |
2024-03-27 |
2024-03-29 |
Not clear |
| Shuaishuai Xing, Xu Tang, Leyan Wang, Jun Wang, Bingbing Lv, Xiaolong Wang, Can Guo, Ye Zhao, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Su. Optimizing drug-like properties of selective butyrylcholinesterase inhibitors for cognitive improvement: Enhancing aqueous solubility by disrupting molecular plane. European journal of medicinal chemistry. vol 268. 2024-03-07. PMID:38452730. |
most recently, worldwide interest in butyrylcholinesterase (bche) as a potential target for treating alzheimer's disease (ad) has increased. |
2024-03-07 |
2024-03-10 |
Not clear |
| Xin Lu, Yueqing Li, Qianwen Guan, Huajing Yang, Yijun Liu, Chenxi Du, Lei Wang, Qinghua Wang, Yuqiong Pei, Liang Wu, Haopeng Sun, Yao Che. Discovery, Structure-Based Modification, ACS chemical neuroscience. 2024-03-07. PMID:38453668. |
discovery, structure-based modification, for the potential therapy of alzheimer's disease (ad), butyrylcholinesterase (bche) has gradually gained worldwide interest in the progression of ad. |
2024-03-07 |
2024-03-10 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
the present research suggests that taxifolin has a strong ability to bind and inhibit ache and bche and could be used to manage neuron-associated problems; however, further research is required to explore taxifolin's neurological therapeutic potential using animal models of alzheimer's disease. |
2024-02-10 |
2024-02-12 |
Not clear |
| Hormoz Pourtaher, Yasaman Mohammadi, Alireza Hasaninejad, Aida Iraj. Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: RSC medicinal chemistry. vol 15. issue 1. 2024-01-29. PMID:38283217. |
next, the biological potencies of the newly synthesized spiroindolinone-pyrazole derivatives against ache and bche as alzheimer's disease-related targets were determined. |
2024-01-29 |
2024-01-31 |
Not clear |
| Sang Hee Lee, Rosa Purgatorio, Francesco Samarelli, Marco Catto, Nunzio Denora, Maria Grazia Morgese, Paolo Tucci, Luigia Trabace, Hye Won Kim, Hyun Soo Park, Sang Eun Kim, Byung Chul Lee, Modesto de Candia, Cosimo D Altomar. Radiosynthesis and whole-body distribution in mice of a Archiv der Pharmazie. 2023-12-29. PMID:38158335. |
radiosynthesis and whole-body distribution in mice of a recently, the azepino[4,3-b]indole-1-one derivative 1 showed in vitro nanomolar inhibition against butyrylcholinesterase (bche), the che isoform that plays a role in the progression and pathophysiology of alzheimer's disease (ad), and protects against n-methyl- d-aspartate-induced neuronal toxicity. |
2023-12-29 |
2024-01-05 |
mouse |
| Yueyao Jiang, Haizhen Cui, Qian Y. A novel near-infrared fluorescent probe for high-sensitivity detection of butyrylcholinesterase in various pathological states. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 308. 2023-12-24. PMID:38142494. |
butyrylcholinesterase (bche) is a crucial hydrolytic enzyme predominantly synthesized in the liver, playing a significant role in conditions like liver disorders, diabetes, alzheimer's disease, and fat metabolism regulation. |
2023-12-24 |
2023-12-27 |
human |
| Saira Naseem, Samra Khan, Safdar Hussain, Muhammad Usman Mirza, Muhammad Ashraf, Zahid Shafiq, John F Tran. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2023-11-10. PMID:37948312. |
this study delineates the design and synthesis of a series of xanthene-based thiosemicarbazones that show low μm inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), crucial enzymes associated with, among others, alzheimer's disease (ad) pathology. |
2023-11-10 |
2023-11-20 |
Not clear |
| Hai Duc Nguye. Journal of biomolecular structure & dynamics. 2023-09-19. PMID:37723904. |
increasing evidence indicates that heterocyclic molecules possess properties against butyrylcholinesterase (bche) enzymatic activity, which is a potential therapeutic target for alzheimer's disease (ad). |
2023-09-19 |
2023-10-07 |
Not clear |