All Relations between Alzheimer Disease and bche

Publication Sentence Publish Date Extraction Date Species
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. the present research suggests that taxifolin has a strong ability to bind and inhibit ache and bche and could be used to manage neuron-associated problems; however, further research is required to explore taxifolin's neurological therapeutic potential using animal models of alzheimer's disease. 2024-02-10 2024-02-12 Not clear
Hormoz Pourtaher, Yasaman Mohammadi, Alireza Hasaninejad, Aida Iraj. Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: RSC medicinal chemistry. vol 15. issue 1. 2024-01-29. PMID:38283217. next, the biological potencies of the newly synthesized spiroindolinone-pyrazole derivatives against ache and bche as alzheimer's disease-related targets were determined. 2024-01-29 2024-01-31 Not clear
Sang Hee Lee, Rosa Purgatorio, Francesco Samarelli, Marco Catto, Nunzio Denora, Maria Grazia Morgese, Paolo Tucci, Luigia Trabace, Hye Won Kim, Hyun Soo Park, Sang Eun Kim, Byung Chul Lee, Modesto de Candia, Cosimo D Altomar. Radiosynthesis and whole-body distribution in mice of a Archiv der Pharmazie. 2023-12-29. PMID:38158335. radiosynthesis and whole-body distribution in mice of a recently, the azepino[4,3-b]indole-1-one derivative 1 showed in vitro nanomolar inhibition against butyrylcholinesterase (bche), the che isoform that plays a role in the progression and pathophysiology of alzheimer's disease (ad), and protects against n-methyl- d-aspartate-induced neuronal toxicity. 2023-12-29 2024-01-05 mouse
Yueyao Jiang, Haizhen Cui, Qian Y. A novel near-infrared fluorescent probe for high-sensitivity detection of butyrylcholinesterase in various pathological states. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 308. 2023-12-24. PMID:38142494. butyrylcholinesterase (bche) is a crucial hydrolytic enzyme predominantly synthesized in the liver, playing a significant role in conditions like liver disorders, diabetes, alzheimer's disease, and fat metabolism regulation. 2023-12-24 2023-12-27 human
Saira Naseem, Samra Khan, Safdar Hussain, Muhammad Usman Mirza, Muhammad Ashraf, Zahid Shafiq, John F Tran. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2023-11-10. PMID:37948312. this study delineates the design and synthesis of a series of xanthene-based thiosemicarbazones that show low μm inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), crucial enzymes associated with, among others, alzheimer's disease (ad) pathology. 2023-11-10 2023-11-20 Not clear
Hai Duc Nguye. Journal of biomolecular structure & dynamics. 2023-09-19. PMID:37723904. increasing evidence indicates that heterocyclic molecules possess properties against butyrylcholinesterase (bche) enzymatic activity, which is a potential therapeutic target for alzheimer's disease (ad). 2023-09-19 2023-10-07 Not clear
Javier Avendaño-Godoy, Arnoldo Miranda, Sigrid Mennickent, Carolina Gómez-Gaet. Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation. Journal of pharmaceutical sciences. 2023-08-26. PMID:37595752. rivastigmine is an acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitor drug approved by the us food and drug administration (fda) for the treatment of mild to moderate dementia of alzheimer's type. 2023-08-26 2023-09-07 rat
Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang, Yao Chen, Haopeng Su. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. 2023-08-10. PMID:37561893. design, synthesis, and proof of concept of balanced dual inhibitors of butyrylcholinesterase (bche) and histone deacetylase 6 (hdac6) for the treatment of alzheimer's disease. 2023-08-10 2023-08-16 Not clear
Lei Wang, Tianyu Sun, Zhenqi Wang, Hui Liu, Weimin Qiu, Xu Tang, Huanchao Guo, Peng Yang, Yao Chen, Haopeng Su. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. 2023-08-10. PMID:37561893. concomitant inhibition of butyrylcholinesterase (bche) and histone deacetylase 6 (hdac6) is supposed to be effective in the treatment of alzheimer's disease (ad). 2023-08-10 2023-08-16 Not clear
Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. 2023-07-05 2023-08-14 human
Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). 2023-05-27 2023-08-14 Not clear
Hui Dong, Le Zhao, Tao Wang, Yanan Chen, Wanqing Hao, Ziyi Zhang, Yizhao Hao, Cunliang Zhang, Xiuhua Wei, Yintang Zhang, Yanli Zhou, Maotian X. Dual-Mode Ratiometric Electrochemical and Turn-On Fluorescent Detection of Butyrylcholinesterase Utilizing a Single Probe for the Diagnosis of Alzheimer's Disease. Analytical chemistry. 2023-05-16. PMID:37192372. the probe re-bche was synthesized in a single step and demonstrated dual mode response toward butyrylcholinesterase (bche), a promising biomarker of alzheimer's disease (ad). 2023-05-16 2023-08-14 Not clear
b' Milena Mlaki\\xc4\\x87, Ema \\xc4\\x90ur\\xc4\\x8devi\\xc4\\x87, Ilijana Odak, Danijela Bari\\xc4\\x87, Ines Juri\\xc4\\x8devi\\xc4\\x87, Ivana \\xc5\\xa0agud, Franko Bur\\xc4\\x8dul, Zlata Lasi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Irena \\xc5\\xa0kori\\xc4\\x8. Thieno-Thiazolostilbenes, Thienobenzo-Thiazoles, and Naphtho-Oxazoles: Computational Study and Cholinesterase Inhibitory Activity. Molecules (Basel, Switzerland). vol 28. issue 9. 2023-05-14. PMID:37175190.' these results are significant as bche has been attracting growing attention due to its positive role in the treatment of alzheimer's disease. 2023-05-14 2023-08-14 Not clear
Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. in diseases such as alzheimer, in which elevated bche and impaired lipid levels are observed, the lipolytic activity of bche might be involved. 2023-05-02 2023-08-14 Not clear
b' Nesrin Korkmaz, Dursun K\\xc4\\xb1sa, \\xc3\\x96zlem Kaplan, Nazan G\\xc3\\xb6k\\xc5\\x9fen Tosun, Aykut \\xc3\\x96zg\\xc3\\xbcr, Rizvan \\xc4\\xb0mamo\\xc4\\x9flu, Ahmet Karada\\xc4\\x9. A Silver Compound with Potential Applications as an Anticancer, Antibacterial, Antifungal, and Anti-Alzheimer. Chemistry & biodiversity. 2023-04-28. PMID:37116090.' experimental results show that the compound has inhibitory potential with an ic50 value of 178.10 µm for the bche (butyrylcholinesterase) enzyme, which has a vital role in the progression of alzheimer's disease. 2023-04-28 2023-08-14 Not clear
Tuan Xu, Shuaizhang Li, Andrew J Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huan. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening. Journal of chemical information and modeling. 2023-04-03. PMID:37011147. acetylcholinesterase (ache) and butyrylcholinesterase (bche) play important roles in human neurodegenerative disorders such as alzheimer's disease. 2023-04-03 2023-08-14 human
Filip Pidany, Jana Kroustkova, Abdullah Al Mamun, Daniela Suchankova, Xavier Brazzolotto, Florian Nachon, Fabien Chantegreil, Rafael Dolezal, Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Vladimir Finger, Martin Kufa, Ondrej Soukup, Daniel Jun, Jaroslav Jenco, Jiri Kunes, Lucie Novakova, Jan Korabecny, Lucie Cahlikov. Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation. European journal of medicinal chemistry. vol 252. 2023-03-30. PMID:36996715. butyrylcholinesterase (bche) is one of the most frequently implicated enzymes in the advanced stage of alzheimer's disease (ad). 2023-03-30 2023-08-14 human
b' Toma\\xc5\\xbe Trobec, Monika C \\xc5\\xbdu\\xc5\\xbeek, Kristina Sep\\xc4\\x8di\\xc4\\x87, Jerneja Kladnik, Iztok Turel, Robert Frange\\xc5\\xb. Novel Organoruthenium(II) Complex C1 Selectively Inhibits Butyrylcholinesterase without Side Effects on Neuromuscular Transmission. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769002.' enzyme butyrylcholinesterase (bche) shows increased activity in some brain regions after progression of alzheimer's disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. 2023-02-11 2023-08-14 Not clear
Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. 2023-01-21 2023-08-14 Not clear
Ashraf K El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keu. Identification of New Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678580. identification of new monoamine oxidase-b (mao-b), acetylcholinesterase (ache), and butyrylcholinesterase (bche) have been considered target enzymes of depression and neurodegenerative diseases, including alzheimer's disease (ad). 2023-01-21 2023-08-14 Not clear