| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R N Mustafin, E K Khusnutdinov. Involvement of transposable elements in Alzheimer's disease pathogenesis. Vavilovskii zhurnal genetiki i selektsii. vol 28. issue 2. 2024-04-29. PMID:38680184. |
study of mirna involvement in alzheimer's disease pathogenesis is relevant, since the associations of protein-coding genes (apoe4, abca7, bin1, clu, cr1, picalm, trem2) with the disease revealed as a result of gwas make it difficult to explain its complex pathogenesis. |
2024-04-29 |
2024-05-01 |
human |
| Lena Duchateau, Nicole Wawrzyniak, Kristel Sleeger. The ABC's of Alzheimer risk gene ABCA7. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556850. |
the abc's of alzheimer risk gene abca7. |
2024-04-01 |
2024-04-03 |
Not clear |
| Lena Duchateau, Nicole Wawrzyniak, Kristel Sleeger. The ABC's of Alzheimer risk gene ABCA7. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556850. |
highlights: alzheimer's risk-increasing variants in abca7 can be found in up to 7% of ad patients. |
2024-04-01 |
2024-04-03 |
Not clear |
| Claire A Butler, Adrian Mendoza Arvilla, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Narges Rezaie, Heidi Y Liang, Dominic Javonillo, Annie Thach, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Angela Gomez-Arboledas, Caden M Henningfield, Lindsay A Hohsfield, Mark Mapstone, Andrea J Tenner, Frank M LaFerla, Ali Mortazavi, Grant R MacGregor, Kim N Gree. The Abca7 Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-20. PMID:38506634. |
the abca7 variants in abca7, a member of the abc transporter superfamily, have been associated with increased risk for developing late onset alzheimer's disease (load). |
2024-03-20 |
2024-03-23 |
Not clear |
| Holly N Cukier, Shaina A Simon, Eugene Tang, Charles G Golightly, Mayra Juliana Laverde-Paz, Larry Deon Adams, Takiyah D Starks, Jeffery M Vance, Michael L Cuccaro, Jonathan L Haines, Goldie S Byrd, Margaret A Pericak-Vance, Derek M Dykxhoor. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem cell research. vol 76. 2024-02-29. PMID:38422817. |
generation of an induced pluripotent stem cell line (umi043-a) from an african american patient with alzheimer's disease carrying an abca7 deletion (p.arg578alafs). |
2024-02-29 |
2024-03-03 |
Not clear |
| Holly N Cukier, Shaina A Simon, Eugene Tang, Charles G Golightly, Mayra Juliana Laverde-Paz, Larry Deon Adams, Takiyah D Starks, Jeffery M Vance, Michael L Cuccaro, Jonathan L Haines, Goldie S Byrd, Margaret A Pericak-Vance, Derek M Dykxhoor. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem cell research. vol 76. 2024-02-29. PMID:38422817. |
the atp-binding cassette, subfamily a (abc1), member 7 (abca7) gene is associated with alzheimer's disease (ad) risk in populations of african, asian, and european ancestry |
2024-02-29 |
2024-03-03 |
Not clear |
| Keiji Kawatani, Marie-Louise Holm, Skylar C Starling, Yuka A Martens, Jing Zhao, Wenyan Lu, Yingxue Ren, Zonghua Li, Peizhou Jiang, Yangying Jiang, Samantha K Baker, Ni Wang, Bhaskar Roy, Tammee M Parsons, Ralph B Perkerson, Hanmei Bao, Xianlin Han, Guojun Bu, Takahisa Kanekiy. ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism. Molecular psychiatry. 2023-12-22. PMID:38135757. |
abca7 loss-of-function variants are associated with increased risk of alzheimer's disease (ad). |
2023-12-22 |
2023-12-25 |
human |
| Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy M J Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleeger. CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response. Alzheimer's research & therapy. vol 15. issue 1. 2023-11-10. PMID:37946268. |
the alzheimer's disease (ad) risk gene abca7 has suggested functions in lipid metabolism and the immune system. |
2023-11-10 |
2023-11-20 |
Not clear |
| Joel P Wiener, Sindy Desire, Viktor Garliyev, Nicholas Lyssenko Iii, Domenico Praticò, Nicholas N Lyssenk. Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA. Cells. vol 12. issue 17. 2023-09-08. PMID:37681876. |
adenosine triphosphate-binding cassette transporter subfamily a member 7 (abca7) is a major risk factor for alzheimer's disease. |
2023-09-08 |
2023-10-07 |
human |
| Jiale Gan, Hui Zhou, Chao Liu, Liangjuan Fan. PSEN2 and ABCA7 variants causing early-onset preclinical pathological changes in Alzheimer's disease: a case report and literature review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-01-26. PMID:36701017. |
psen2 and abca7 variants causing early-onset preclinical pathological changes in alzheimer's disease: a case report and literature review. |
2023-01-26 |
2023-08-14 |
Not clear |
| Mingfeng Guan, Yue Chai, Ran Yi, Yuewen Chen, Jacque P K Ip, Tao Ye, Yu Che. Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system. Stem cell research. vol 66. 2022-12-15. PMID:36521383. |
abca7 encodes an atp-binding cassette transporter, and its loss-of-function variants are associated with alzheimer's disease. |
2022-12-15 |
2023-08-14 |
human |
| Mingfeng Guan, Yue Chai, Ran Yi, Yuewen Chen, Jacque P K Ip, Tao Ye, Yu Che. Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system. Stem cell research. vol 66. 2022-12-15. PMID:36521383. |
to investigate the role of abca7 deficiency in the pathogenesis of alzheimer's disease, we generated a homozygous abca7-knockout induced pluripotent stem cell (ipsc) line using crispr/cas9-mediated gene editing. |
2022-12-15 |
2023-08-14 |
human |
| Chenlu Xu, Jia Zhang, Qinfeng Zhou, Juling Wang, Chenyang Liu, Yu Tian, Danni Huang, Huaizhuang Ye, Yongtang Ji. Exposure to a real traffic environment impairs brain cognition in aged mice. Environmental research. 2022-09-16. PMID:36113572. |
by screening the risk genes of alzheimer's disease, we found the mrna and protein levels of abca7 were down-regulated and those of pyk2 were up-regulated. |
2022-09-16 |
2023-08-14 |
mouse |
| Chong Jin, Brian Lee, Li Shen, Qi Lon. Integrating multi-omics summary data using a Mendelian randomization framework. Briefings in bioinformatics. 2022-09-12. PMID:36094096. |
the top hits of the analyses of multi-omics alzheimer's disease datasets include genes abca7 and atp1b1. |
2022-09-12 |
2023-08-14 |
Not clear |
| Jahangir Iqbal, Manuel D Suarez, Pradeep K Yadav, Meghan T Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M Brickman, José A Luchsinger, Kezhi Dai, Herman Moreno, M Mahmood Hussai. ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. The Journal of biological chemistry. 2022-08-25. PMID:36007616. |
since loss of function mutations in the abca7 gene exhibit strong associations with late-onset alzheimer's disease (load) across racial groups, we also studied the effects of abca7 deficiency in the mouse brain. |
2022-08-25 |
2023-08-14 |
mouse |
| b' Nicholas N Lyssenko, Xinghua Shi, Domenico Pratic\\xc3\\xb. The Alzheimer\'s disease GWAS risk alleles in the ABCA7 promoter and 5\' region reduce ABCA7 expression. Acta neuropathologica. 2022-06-27. PMID:35759012.' |
the alzheimer's disease gwas risk alleles in the abca7 promoter and 5' region reduce abca7 expression. |
2022-06-27 |
2023-08-14 |
Not clear |
| Antonino Picataggi, Amrith Rodrigues, Debra A Cromley, Hu Wang, Joel P Wiener, Viktor Garliyev, Jeffrey T Billheimer, Brian C Grabiner, Jessica A Hurt, Allen C Chen, Xianlin Han, Daniel J Rader, Domenico Praticò, Nicholas N Lyssenk. Specificity of ABCA7-mediated cell lipid efflux. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022-04-05. PMID:35381375. |
adenosine triphosphate-binding cassette transporter subfamily a member 7 (abca7) performs incompletely understood biochemical functions that affect pathogenesis of alzheimer's disease. |
2022-04-05 |
2023-08-13 |
Not clear |
| Liene Bossaerts, Elisabeth Hendrickx Van de Craen, Rita Cacace, Bob Asselbergh, Christine Van Broeckhove. Rare missense mutations in ABCA7 might increase Alzheimer's disease risk by plasma membrane exclusion. Acta neuropathologica communications. vol 10. issue 1. 2022-04-01. PMID:35361255. |
rare missense mutations in abca7 might increase alzheimer's disease risk by plasma membrane exclusion. |
2022-04-01 |
2023-08-13 |
Not clear |
| Liene Bossaerts, Elisabeth Hendrickx Van de Craen, Rita Cacace, Bob Asselbergh, Christine Van Broeckhove. Rare missense mutations in ABCA7 might increase Alzheimer's disease risk by plasma membrane exclusion. Acta neuropathologica communications. vol 10. issue 1. 2022-04-01. PMID:35361255. |
the adenosine triphosphate-binding cassette subfamily a member 7 gene (abca7) is associated with alzheimer's disease (ad) in large genome-wide association studies. |
2022-04-01 |
2023-08-13 |
Not clear |
| Liene Bossaerts, Elisabeth Hens, Rita Cacace, Bernard J Hanseeuw, Rik Vandenberghe, Patrick Cras, Peter Paul De Deyn, Sebastiaan Engelborghs, Christine Van Broeckhove. Rare missense mutations and compound heterozygous mutations in ABCA7 contribute to Alzheimer's disease in Belgian patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108979. |
rare missense mutations and compound heterozygous mutations in abca7 contribute to alzheimer's disease in belgian patients. |
2022-02-03 |
2023-08-13 |
Not clear |