| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amit Tirosh, Ilan Shimo. Complications of acromegaly: thyroid and colon. Pituitary. vol 20. issue 1. 2017-07-10. PMID:27631334. |
in acromegaly the long-term exposure to high growth hormone (gh) and insulin-like growth factor-1 (igf-1) levels may result in specific complications in different human organs, including the thyroid gland and the colon. |
2017-07-10 |
2023-08-13 |
human |
| Iris Crespo, Elena Valassi, Susan M Web. Update on quality of life in patients with acromegaly. Pituitary. vol 20. issue 1. 2017-07-10. PMID:27730455. |
moreover, there is evidence that factors, such as radiotherapy or post-treatment gh deficiency also impair qol in patients diagnosed with acromegaly. |
2017-07-10 |
2023-08-13 |
Not clear |
| Lucio Vilar, Clarice Freitas Vilar, Ruy Lyra, Raissa Lyra, Luciana A Nave. Acromegaly: clinical features at diagnosis. Pituitary. vol 20. issue 1. 2017-07-10. PMID:27812777. |
acromegaly is a rare and underdiagnosed disorder caused, in more than 95% of cases, by a growth hormone (gh)-secreting pituitary adenoma. |
2017-07-10 |
2023-08-13 |
Not clear |
| Emmanuelle Kuhn, Philippe Chanso. Cabergoline in acromegaly. Pituitary. vol 20. issue 1. 2017-07-10. PMID:28025719. |
acromegaly, a rare disease due to growth hormone (gh) hypersecretion by a pituitary adenoma, is associated with severe comorbidity and premature death if not adequately treated. |
2017-07-10 |
2023-08-13 |
Not clear |
| Katharina Schilbach, Christian J Strasburger, Martin Bidlingmaie. Biochemical investigations in diagnosis and follow up of acromegaly. Pituitary. vol 20. issue 1. 2017-07-10. PMID:28168377. |
measurements of human growth hormone (gh) and insulin-like growth-factor i (igf-i) are cornerstones in the diagnosis of acromegaly. |
2017-07-10 |
2023-08-13 |
human |
| Katharina Schilbach, Christian J Strasburger, Martin Bidlingmaie. Biochemical investigations in diagnosis and follow up of acromegaly. Pituitary. vol 20. issue 1. 2017-07-10. PMID:28168377. |
management of acromegaly is particularly challenging in cases where discordant information is obtained from measurement of gh concentrations following oral glucose load and from measurement of igf-i. |
2017-07-10 |
2023-08-13 |
human |
| Jakob Dal, Katrine Lundby Høyer, Steen Bønløkke Pedersen, Nils Erik Magnusson, Peter Bjerring, Jan Frystyk, Niels Møller, Niels Jessen, Jens Otto Lunde Jørgense. Growth Hormone and Insulin Signaling in Acromegaly: Impact of Surgery Versus Somatostatin Analog Treatment. The Journal of clinical endocrinology and metabolism. vol 101. issue 10. 2017-06-30. PMID:27466699. |
somatostatin analogs (sas) used in acromegaly to suppress gh secretion and tumor growth also suppress insulin secretion and may impact gh signaling. |
2017-06-30 |
2023-08-13 |
Not clear |
| Moisés Mercado, Etual Espinosa, Claudia Ramíre. Current status and future directions of pharmacological therapy for acromegaly. Minerva endocrinologica. vol 41. issue 3. 2017-06-23. PMID:26485036. |
acromegaly can be approached pharmacologically by inhibiting gh secretion by the tumor (somatostatin analogues, dopamine agonists) or by antagonizing gh actions at its target tissues (gh receptor antagonists). |
2017-06-23 |
2023-08-13 |
Not clear |
| Ethem Turgay Cerit, Kemal Ağbaht, Özgür Demir, Mustafa Şahin, Vedia Tonyukuk Gedik, Cem Özcan, Demet Çorapçıoğl. DISCORDANCE BETWEEN GH AND IGF-1 LEVELS IN TURKISH ACROMEGALIC PATIENTS. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. vol 22. issue 12. 2017-06-20. PMID:27631850. |
discordance between insulin-like growth factor-1 (igf-1) and growth hormone (gh) levels is an important problem in the follow-up of patients diagnosed with acromegaly. |
2017-06-20 |
2023-08-13 |
Not clear |
| L I Astaf'eva, P L Kalinin, B A Kadashe. [Modern diagnosis and postoperative monitoring of acromegaly patients at a neurosurgical clinic]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko. vol 81. issue 1. 2017-06-14. PMID:28291214. |
acromegaly is a severe disease associated with chronic overproduction of the growth hormone (gh) and insulin-like growth factor-1 (igf-1), which is caused in most cases by pituitary adenoma. |
2017-06-14 |
2023-08-13 |
Not clear |
| Min Yu, David E Bruns, John A Jane, Ralf M Nass, Edward H Oldfield, Mary Lee Vance, Michael O Thorne. Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly. Clinical chemistry. vol 63. issue 2. 2017-05-22. PMID:27974387. |
in the immediate postoperative period following resection of growth hormone (gh)-secreting pituitary tumors, serum concentrations of gh have limited ability to predict remission of acromegaly. |
2017-05-22 |
2023-08-13 |
Not clear |
| LuminiŢa Nicoleta Cima, Simona Vasilica Fica, Alice Ioana Albu, Ioana Maria Lambrescu, Ioana SmărăndiŢa Lăcău, Bogdan Ovidiu Popescu, Mihaela Gherghiceanu, Corin Virgil Badiu, Carmen Gabriela Barb. Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy in acromegalic patient with severe headache. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 57. issue 3. 2017-05-01. PMID:28002537. |
acromegaly was caused by a growth hormone (gh) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. |
2017-05-01 |
2023-08-13 |
Not clear |
| Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, John J Kopchic. Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynologia Polska. vol 67. issue 4. 2017-04-12. PMID:27387246. |
while ample experimental evidence supports a role of the gh-igf system in tumour promotion and progression, with several of its components being currently tested as central targets for cancer therapy, the strength of evidence from patients with acromegaly, gh deficiency, or treated with gh is much weaker. |
2017-04-12 |
2023-08-13 |
human |
| Laura B Butz, Stephen E Sullivan, William F Chandler, Ariel L Barka. "Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era. Pituitary. vol 19. issue 6. 2017-04-05. PMID:27497970. |
"micromegaly": an update on the prevalence of acromegaly with apparently normal gh secretion in the modern era. |
2017-04-05 |
2023-08-13 |
Not clear |
| Laura B Butz, Stephen E Sullivan, William F Chandler, Ariel L Barka. "Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era. Pituitary. vol 19. issue 6. 2017-04-05. PMID:27497970. |
approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma igf-1 levels, but apparently "normal" 24-h mean plasma gh levels. |
2017-04-05 |
2023-08-13 |
Not clear |
| Laura B Butz, Stephen E Sullivan, William F Chandler, Ariel L Barka. "Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era. Pituitary. vol 19. issue 6. 2017-04-05. PMID:27497970. |
the current study served to update the data for patients with acromegaly referred to our facility, after increasing awareness of this "normal" gh subpopulation throughout the medical community. |
2017-04-05 |
2023-08-13 |
Not clear |
| V Touskova, J Klouckova, V Durovcova, Z Lacinova, P Kavalkova, P Trachta, M Kosak, M Mraz, D Haluzikova, V Hana, J Marek, M Krsek, M Haluzi. The possible role of mRNA expression changes of GH/IGF-1/insulin axis components in subcutaneous adipose tissue in metabolic disturbances of patients with acromegaly. Physiological research. vol 65. issue 3. 2017-03-30. PMID:27070751. |
we explored the effect of chronically elevated circulating levels of growth hormone (gh)/insulin-like-growth-factor-1 (igf-1) on mrna expression of gh/igf-1/insulin axis components and p85alpha subunit of phosphoinositide-3-kinase (p85alpha) in subcutaneous adipose tissue (scat) of patients with active acromegaly and compared these findings with healthy control subjects in order to find its possible relationships with insulin resistance and body composition changes. |
2017-03-30 |
2023-08-13 |
human |
| V Touskova, J Klouckova, V Durovcova, Z Lacinova, P Kavalkova, P Trachta, M Kosak, M Mraz, D Haluzikova, V Hana, J Marek, M Krsek, M Haluzi. The possible role of mRNA expression changes of GH/IGF-1/insulin axis components in subcutaneous adipose tissue in metabolic disturbances of patients with acromegaly. Physiological research. vol 65. issue 3. 2017-03-30. PMID:27070751. |
in scat, patients with acromegaly had significantly increased igf-1 and igf-binding protein-3 (igfbp-3) expression that both positively correlated with serum gh. |
2017-03-30 |
2023-08-13 |
human |
| V Touskova, J Klouckova, V Durovcova, Z Lacinova, P Kavalkova, P Trachta, M Kosak, M Mraz, D Haluzikova, V Hana, J Marek, M Krsek, M Haluzi. The possible role of mRNA expression changes of GH/IGF-1/insulin axis components in subcutaneous adipose tissue in metabolic disturbances of patients with acromegaly. Physiological research. vol 65. issue 3. 2017-03-30. PMID:27070751. |
our data suggest that gh overproduction in acromegaly group increases igf-1 and igfbp-3 expression in scat while it does not affect scat p85alpha expression. |
2017-03-30 |
2023-08-13 |
human |
| N C van Varsseveld, C C van Bunderen, A A M Franken, H P F Koppeschaar, A J van der Lely, M L Dren. Fractures in pituitary adenoma patients from the Dutch National Registry of Growth Hormone Treatment in Adults. Pituitary. vol 19. issue 4. 2017-03-22. PMID:27048484. |
the aim of this study was to investigate characteristics and fracture occurrence at start of (baseline) and during long-term gh replacement therapy in ghd adults previously treated for cushing's disease (cd) or acromegaly, compared to patients with previous nonfunctioning pituitary adenoma (nfpa). |
2017-03-22 |
2023-08-13 |
Not clear |