| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Krogsgaard-Larsen, H Mikkelsen, P Jacobsen, E Falch, D R Curtis, M J Peet, J D Lea. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. Journal of medicinal chemistry. vol 26. issue 6. 1983-07-08. PMID:6304315. |
the thio analogues of the gaba (gamma-aminobutyric acid) agonist thip (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), the gaba uptake inhibitor thpo (4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol), and the glycine antagonist thaz (5,6,7,8-tetrahydro-4h-isoxazolo[4,5-d]azepin-3-ol) have been synthesized and tested biologically on single neurons in the cat spinal cord and in vitro by using synaptic membrane preparations obtained from rat brains. |
1983-07-08 |
2023-08-12 |
rat |
| A Goldinger, W E Mülle. Stereospecific interaction of bicuculline with specific [3H]strychnine binding to rat spinal cord synaptosomal membranes. Neuroscience letters. vol 16. issue 1. 1983-06-17. PMID:6302570. |
the gamma-aminobutyric acid (gaba) antagonist (+/-)-bicuculline inhibits specific [3h]strychnine binding to postsynaptic glycine receptor sites in rat spinal cord synaptosomal membranes with an inhibition constant of about 5 microm, which is fairly similar to its inhibition constant reported for the gaba receptor. |
1983-06-17 |
2023-08-12 |
rat |
| A Goldinger, W E Mülle. Stereospecific interaction of bicuculline with specific [3H]strychnine binding to rat spinal cord synaptosomal membranes. Neuroscience letters. vol 16. issue 1. 1983-06-17. PMID:6302570. |
besides an unspecific effect at the glycine receptor, the results could suggest that the glycine and the gaba receptors are located close together in spinal cord membranes, so that the antagonist states of both receptors may be able to interfere with each other in some mechanistic way. |
1983-06-17 |
2023-08-12 |
rat |
| D Graham, F Pfeiffer, H Bet. Photoaffinity-labelling of the glycine receptor of rat spinal cord. European journal of biochemistry. vol 131. issue 3. 1983-06-10. PMID:6301811. |
spinal cord membranes photoaffinity-labelled with the gamma-aminobutyric acid receptor ligand [3h]flunitrazepam, however, gave a single polypeptide with a relative molecular mass of 5- 0000. |
1983-06-10 |
2023-08-12 |
rat |
| L W Hayne. Neuronal and glial localization of acetylcholinesterase and GABA transaminase in organized cultures of developing rat spinal cord. Experientia. vol 39. issue 2. 1983-05-27. PMID:6832304. |
neuronal and glial localization of acetylcholinesterase and gaba transaminase in organized cultures of developing rat spinal cord. |
1983-05-27 |
2023-08-12 |
rat |
| S C Datta, K L Mukherje. Changes in free amino acid levels in developing human foetal brain regions. Journal of neurochemistry. vol 40. issue 4. 1983-05-05. PMID:6834045. |
striking developmental changes were found in the levels of aspartic acid in medulla-pons and spinal cord, glycine in the spinal cord, gamma-aminobutyric acid in the cerebral cortex, glutamic acid in the cerebral cortex, midbrain, and spinal cord, and taurine in the medulla-pons and spinal cord. |
1983-05-05 |
2023-08-12 |
human |
| A Nistri, C Bert. Caffeine-induced potentiation of GABA effects on frog spinal cord: an electrophysiological study. Brain research. vol 258. issue 2. 1983-04-15. PMID:6600642. |
caffeine-induced potentiation of gaba effects on frog spinal cord: an electrophysiological study. |
1983-04-15 |
2023-08-12 |
Not clear |
| J C Hackman, D Auslander, V Grayson, R A Davidof. GABA 'desensitization' of frog primary afferent fibers. Brain research. vol 253. issue 1-2. 1983-03-24. PMID:6295548. |
gaba (gamma-aminobutyric acid) depolarizes the terminals of primary afferent fibers of the in vitro hemisected frog spinal cord. |
1983-03-24 |
2023-08-12 |
Not clear |
| M Chavko, J Martiniak, M Luxová, J Marsal. Free amino acids in the dog spinal cord during prolonged ischaemia. Physiologia Bohemoslovaca. vol 31. issue 5. 1983-02-25. PMID:6217471. |
the authors studied the effect of 40 and 80 minutes' occlusion of the abdominal aorta on the aspartic acid, glutamic acid, glutamine, glycine and gamma-aminobutyric acid concentration in the sacral, lumbar, thoracic and cervical segments of the dog spinal cord. |
1983-02-25 |
2023-08-12 |
dog |
| R C Frere, R L Macdonald, A B Youn. GABA binding and bicuculline in spinal cord and cortical membranes from adult rat and from mouse neurons in cell culture. Brain research. vol 244. issue 1. 1982-12-02. PMID:6288176. |
gaba binding and bicuculline in spinal cord and cortical membranes from adult rat and from mouse neurons in cell culture. |
1982-12-02 |
2023-08-12 |
mouse |
| L M Nowak, A B Young, R L Macdonal. GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture. Brain research. vol 244. issue 1. 1982-12-02. PMID:6288177. |
gaba and bicuculline actions on mouse spinal cord and cortical neurons in cell culture. |
1982-12-02 |
2023-08-12 |
mouse |
| L M Nowak, A B Young, R L Macdonal. GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture. Brain research. vol 244. issue 1. 1982-12-02. PMID:6288177. |
the neutral amino acid gamma-aminobutyric acid (gaba) produced membrane hyperpolarization and increased membrane chloride ion conductance of spinal cord (sc) and cortical (ctx) neurons in cell culture. |
1982-12-02 |
2023-08-12 |
mouse |
| R Capek, B Espli. Excitability of primary afferents in feline spinal cord: taurine, homotaurine, and gamma-aminobutyric acid compared. Canadian journal of physiology and pharmacology. vol 60. issue 6. 1982-12-02. PMID:7116229. |
excitability of primary afferents in feline spinal cord: taurine, homotaurine, and gamma-aminobutyric acid compared. |
1982-12-02 |
2023-08-12 |
Not clear |
| R P Barber, J E Vaughn, E Robert. The cytoarchitecture of GABAergic neurons in rat spinal cord. Brain research. vol 238. issue 2. 1982-09-10. PMID:7046873. |
glutamic acid decarboxylase (gad), the enzyme that synthesizes the transmitter gamma-aminobutyric acid (gaba), has previously been localized within synaptic terminals in rat spinal cord by immunocytochemistry. |
1982-09-10 |
2023-08-12 |
rat |
| R P Barber, J E Vaughn, E Robert. The cytoarchitecture of GABAergic neurons in rat spinal cord. Brain research. vol 238. issue 2. 1982-09-10. PMID:7046873. |
in the present study, gad was localized within the somata and dendrites of gaba neurons following colchicine injections into rat lumbar spinal cord. |
1982-09-10 |
2023-08-12 |
rat |
| R P Barber, J E Vaughn, E Robert. The cytoarchitecture of GABAergic neurons in rat spinal cord. Brain research. vol 238. issue 2. 1982-09-10. PMID:7046873. |
the widespread distribution of gaba neurons in spinal cord was suggestive of diverse functions for these cells, encompassing conventional synaptic roles and, perhaps, an involvement in hormonally modulated communication via gabaergic, csf-contacting neurons. |
1982-09-10 |
2023-08-12 |
rat |
| K Saito, M Goto, H Fukud. Postnatal development of the GABA system in the rat spinal cord. Japanese journal of pharmacology. vol 32. issue 1. 1982-08-26. PMID:6283213. |
to assess the postnatal development of the gaba system in the rat spinal cord, gaba levels and gad activity, as well as specific [3h]-muscimol binding, were determined in the dorsal and ventral areas. |
1982-08-26 |
2023-08-12 |
rat |
| A Rustioni, M Cueno. Selective retrograde transport of D-aspartate in spinal interneurons and cortical neurons of rats. Brain research. vol 236. issue 1. 1982-06-24. PMID:6175376. |
retrograde labeling of neuronal elements in the brain and spinal cord has been investigated by autoradiographic techniques following injections of d-[3h]aspartate (asp), [3h] gamma-aminobutyric acid (gaba) or horseradish peroxidase (hrp) in the medulla and spinal cord of rats. |
1982-06-24 |
2023-08-12 |
rat |
| J M Wojtowicz, R A Nicol. Selective action of piretanide on primary afferent GABA responses in the frog spinal cord. Brain research. vol 236. issue 1. 1982-06-24. PMID:6279234. |
selective action of piretanide on primary afferent gaba responses in the frog spinal cord. |
1982-06-24 |
2023-08-12 |
Not clear |
| D B Malakhovskaia, G E Sviderskai. [Effect of GABA on motor activity in the rat during the early postnatal period]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 32. issue 1. 1982-05-27. PMID:7064553. |
it is suggested that a possible mechanism of the observed effect of gaba consists in the deepening of presynaptic inhibition, which results, during the earlier stages of postnatal ontogeny, in intensifying the autorhythmical activity of spinal motor centres, whereas during the later stages, when the autorhythmical activity of the spinal cord is replaced by reflex excitatory mechanisms, in depressing the latter. |
1982-05-27 |
2023-08-12 |
rat |