| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Ping Guan, Ji-Xing Nan, Xue-Jun Jin, Qing-Hao Jin, Kyung Chell Kwak, Kyu-yun Chai, Zhe-Shan Qua. Protective effects of chalcone derivatives for acute liver injury in mice. Archives of pharmacal research. vol 28. issue 1. 2005-06-17. PMID:15742813. |
thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels in serum. |
2005-06-17 |
2023-08-12 |
mouse |
| Ekrem Orbay, Mehmet Sargin, Haluk Sargin, Hülya Gözü, Oya Uygur Bayramiçli, All Yayl. Addition of rosiglitazone to glimepirid and metformin combination therapy in type 2 diabetes. Endocrine journal. vol 51. issue 6. 2005-06-16. PMID:15644569. |
secondary efficacy parameters included the mean changes from baseline to the end of the study in fasting plasma glucose (fpg) and insulin levels, as well as total cholesterol, hdl-c, ldl-c, triglycerides, alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels. |
2005-06-16 |
2023-08-12 |
Not clear |
| Ekrem Orbay, Mehmet Sargin, Haluk Sargin, Hülya Gözü, Oya Uygur Bayramiçli, All Yayl. Addition of rosiglitazone to glimepirid and metformin combination therapy in type 2 diabetes. Endocrine journal. vol 51. issue 6. 2005-06-16. PMID:15644569. |
no one experienced elevations of alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels greater than 2.5 times the upper limit of the reference range. |
2005-06-16 |
2023-08-12 |
Not clear |
| A K Nyarko, L K N Okine, R K Wedzi, P A Addo, M Ofosuhen. Subchronic toxicity studies of the antidiabetic herbal preparation ADD-199 in the rat: absence of organ toxicity and modulation of cytochrome P450. Journal of ethnopharmacology. vol 97. issue 2. 2005-06-13. PMID:15707772. |
add-199 did not affect plasma aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp) and albumin or creatinine kinase (ck) levels. |
2005-06-13 |
2023-08-12 |
rat |
| Maha Abdelrahman, Marika Collin, Christoph Thiemerman. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. Shock (Augusta, Ga.). vol 22. issue 6. 2005-06-08. PMID:15545828. |
hemorrhage and resuscitation resulted in an increase in serum levels of (a) urea and creatinine and, hence renal dysfunction; alanine aminotransferase (alt) and aspartate aminotransferase (ast) and, hence, hepatic injury. |
2005-06-08 |
2023-08-12 |
rat |
| Ender Içen, Ferah Armutçu, Kemal Büyükgüzel, Ahmet Güre. Biochemical stress indicators of greater wax moth exposure to organophosphorus insecticides. Journal of economic entomology. vol 98. issue 2. 2005-06-07. PMID:15889724. |
we therefore investigated alterations in lipid peroxidation product, malondialdehyde (mda) content, and alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities, in conjunction with ache activity as biochemical stress indicators in greater wax moth, galleria mellonella (l.) larvae for ops methyl parathion (mp) and ethyl parathion (ep). |
2005-06-07 |
2023-08-12 |
Not clear |
| Baburao Koneru, Adrian Fisher, Yan He, Kenneth M Klein, Joan Skurnick, Dorian J Wilson, Andrew N de la Torre, Anand Merchant, Rakesh Arora, Arun K Samant. Ischemic preconditioning in deceased donor liver transplantation: a prospective randomized clinical trial of safety and efficacy. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 11. issue 2. 2005-05-31. PMID:15666380. |
safety was assessed by measurement of heart rate, blood pressure, and visual inspection of abdominal organs during recovery, and efficacy by recipient aminotransferases (aspartate aminotransferase [ast] and alanine aminotransferase [alt], both measured in u/l), total bilirubin, and international normalized ratio of prothrombin time (inr) after transplantation. |
2005-05-31 |
2023-08-12 |
Not clear |
| Javier Carbone, Elizabeth Sarmiento, Eduardo Fernández-Cru. [Overwhelming course of HCV disease in patients with hypogammaglobulinemia associated with cellular immunity deficiency]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru. vol 25. issue 1. 2005-05-31. PMID:15818419. |
five of the six patients had a positive overwhelming course (crp) for hcv and all have changes in their hepatic biochemistry during the exposure period [ analine aminotransferase (alt) (from 280 to 2720 u/l) and aspartate aminotransferase (ast) (from 400 to 2600) u/l)]. |
2005-05-31 |
2023-08-12 |
Not clear |
| Lysandro P Borges, Vanessa Corralo Borges, Angelica Venturini Moro, Cristina Wayne Nogueira, Joao Batista Teixeira Rocha, Gilson Zen. Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats. Toxicology. vol 210. issue 1. 2005-05-27. PMID:15804453. |
the parameters that indicate tissue damage such as plasma alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma-glutamyl transferase (ggt), alpha-fetoprotein (afp), creatinine and urea were determined. |
2005-05-27 |
2023-08-12 |
rat |
| Göksel Sener, Ozer Sehirli, Sule Cetinel, Berrak G Yeğen, Nursal Gedik, Gül Ayanoğlu-Dülge. Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice. Journal of applied toxicology : JAT. vol 25. issue 1. 2005-05-26. PMID:15669031. |
blood urea nitrogen, serum creatinine, alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels in blood and glutathione (gsh) and malondialdehyde (mda) levels, myeloperoxidase (mpo) activity and collagen contents in liver and kidney tissues were measured. |
2005-05-26 |
2023-08-12 |
mouse |
| Anwarul Hassan Gilani, Sheikh Yaeesh, Qamar Jamal, M Nabeel Ghayu. Hepatoprotective activity of aqueous-methanol extract of Artemisia vulgaris. Phytotherapy research : PTR. vol 19. issue 2. 2005-05-26. PMID:15852491. |
co-administration of d-galn (700 mg[sol ]kg) and lps (1 microg[sol ]kg) significantly (p < 0.05) raised the plasma levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast) in mice in the toxin group compared with the values in the control group. |
2005-05-26 |
2023-08-12 |
mouse |
| Choong-Yong Kim, Hyun-Sook Lee, Su-Cheol Han, Jeong-Doo Heo, Myung-Sang Kwon, Chang-Su Ha, Sang-Seop Ha. Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride. Journal of medical primatology. vol 34. issue 2. 2005-05-26. PMID:15860116. |
ketamine anesthesia also increased the serum activities of aspartate aminotransferase (ast), alanine aminotransferase (alt) and creatine phosphokinase (cpk), but reduced the serum concentrations of glucose, inorganic phosphate, sodium and potassium. |
2005-05-26 |
2023-08-12 |
monkey |
| Ki-Tae Ha, Sang-Ju Yoon, Dall-Yeong Choi, Dong-Wook Kim, June-Ki Kim, Cheorl-Ho Ki. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. Journal of ethnopharmacology. vol 96. issue 3. 2005-05-24. PMID:15619574. |
the pretreatment of lfe has shown to possess a significant protective effect by lowering the serum aspartate and alanine aminotransferase (ast and alt) and alkaline phosphatase (alp). |
2005-05-24 |
2023-08-12 |
rat |
| Yoko Aniya, Tomoyuki Koyama, Chika Miyagi, Manami Miyahira, Chiho Inomata, Shizuka Kinoshita, Toshio Ichib. Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biological & pharmaceutical bulletin. vol 28. issue 1. 2005-05-20. PMID:15635156. |
galactosamine (galn, 400 mg/kg) and lipopolysaccharide (lps, 0.5 microg/kg) induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) and of lipid peroxidation in liver homogenates was significantly depressed when the herbal extract was given intraperitoneally 1 and 15 h before galn and lps treatment. |
2005-05-20 |
2023-08-12 |
rat |
| Mari Yamaguchi, Aiko Yamauchi, Masuhiro Nishimura, Nobuhiko Ueda, Shinsaku Nait. Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats. Biological & pharmaceutical bulletin. vol 28. issue 1. 2005-05-20. PMID:15635179. |
after tpn administration for 4 d, serum aspartate aminotransferase (ast) levels in group 2 were significantly increased (p<0.01) compared with the other groups. |
2005-05-20 |
2023-08-12 |
rat |
| Kyoko Nomura, Eiji Yano, Toshiaki Shinozaki, Kazumi Tagaw. Efficacy and effectiveness of liver screening program to detect fatty liver in the periodic health check-ups. Journal of occupational health. vol 46. issue 6. 2005-05-19. PMID:15613764. |
the liver screening program to detect fatty liver was performed on 411 japanese workers utilizing serum aspartate aminotransferase (alt), alanine aminotransferase (ast), and gammaglutamyl transpeptidase (gamma-gtp). |
2005-05-19 |
2023-08-12 |
human |
| Richa Gupta, Swaran J S Flor. Protective value of Aloe vera against some toxic effects of arsenic in rats. Phytotherapy research : PTR. vol 19. issue 1. 2005-05-19. PMID:15799004. |
hepatic reduced gsh, oxidized glutathione (gssg) level remained unaltered, thiobarbituric acid reactive substance (tbars) level increased significantly while the activity of alkaline phosphatase (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt) and catalase decreased on arsenic exposure. |
2005-05-19 |
2023-08-12 |
rat |
| Matilde Marcellini, Vincenzo Di Ciommo, Francesco Callea, Rita Devito, Donatella Comparcola, Maria Rita Sartorelli, Giovanni Carelli, Francesco Carelli, Valerio Nobil. Treatment of Wilson's disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up study. The Journal of laboratory and clinical medicine. vol 145. issue 3. 2005-05-19. PMID:15871305. |
five years after the start of zinc treatment, we noted highly significant decreases in alanine aminotransferase (alt), aspartate aminotransferase (ast), and urinary copper excretion, but white blood cell counts did not vary significantly. |
2005-05-19 |
2023-08-12 |
Not clear |
| L Pari, P Muruga. Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity. Pharmacological research. vol 49. issue 5. 2005-05-17. PMID:14998559. |
the increased level of serum enzymes (aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp)), bilirubin, cholesterol, triglycerides, phospholipids, free fatty acids and plasma thiobarbituric acid reactive substances (tbars) and hydroperoxides observed in rats treated with erythromycin estolate were very much reduced in rats treated with thc and erythromycin estolate. |
2005-05-17 |
2023-08-12 |
rat |
| Maurice E Knuckles, Frank Inyang, Aramandla Rames. Acute and subchronic oral toxicity of fluoranthene in F-344 rats. Ecotoxicology and environmental safety. vol 59. issue 1. 2005-05-16. PMID:15261730. |
the toxicological endpoints examined included rat body and organ weights, as well as histopathological examinations of liver, kidney, stomach, prostate, testes, and ovaries; hematological parameters including red blood cell (rbc) counts, white blood cell (wbc) counts, hemoglobin (hgb) concentration, hematocrit (hct) concentration, mean corpuscular volume (mcv), mean corpuscular hemoglobin (mch) and mean corpuscular hemoglobin concentration (mchc); blood chemistry including alanine amino transferase (alt), aspartate amino transferase (ast), blood urea nitrogen (bun); and urine chemistry including glucose, bilirubin, specific gravity, ph, protein, urobilinogen, nitrite, occult blood, and leukocytes. |
2005-05-16 |
2023-08-12 |
rat |