| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shahira M Ezzat, Hossam M Abdallah, Ghada A Fawzy, Shohda A El-Maragh. Hepatoprotective constituents of Torilis radiata Moench (Apiaceae). Natural product research. vol 26. issue 3. 2012-04-11. PMID:21867456. |
the hepatoprotection of the ae and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (alt), aspartate amino transferase (ast), lactate dehydrogenase (ldh)), a reduction in the inflammatory markers (tumour necrosis-α (tnf-α), nitric oxide (no), n-acetyl-β-d-glucosaminidase (nag) and myloperoxidase (mpo) in serum) and restoration of the oxidant balance by decreasing the serum and hepatic malondialdehyde (mda) levels, along with increasing the activity of hepatic catalase (cat), glutathione peroxidase (gshpx) and the non-enzymatic antioxidant glutathione (gsh). |
2012-04-11 |
2023-08-12 |
cat |
| Yusuke Kawamura, Yasuji Arase, Kenji Ikeda, Yuya Seko, Norihiro Imai, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yuki Ohmoto, Kazuhisa Amakawa, Hiroshi Tsuji, Hiromitsu Kumad. Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma. The American journal of gastroenterology. vol 107. issue 2. 2012-04-10. PMID:22008893. |
the aim of this study was to determine the incidence and risk factors of hepatocellular carcinoma (hcc), and to elucidate the utility of two non-invasive predictive procedures for liver fibrosis: the aspartate aminotransferase (ast) to platelet ratio index (apri) and the bard score (which includes the following three variables: body mass index, ast/alanine aminotransferase ratio, and diabetes) in the prediction of hcc in a large population of japanese patients with non-alcoholic fatty liver disease (nafld). |
2012-04-10 |
2023-08-12 |
Not clear |
| Mineyoshi Hiyoshi, Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto, Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri, Keizo Ohnaka, Sadao Suzuki, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajim. Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity. Gene. vol 496. issue 2. 2012-04-09. PMID:22293393. |
thus, we hypothesized that (1) the comt gene contributes to liver homeostasis and (2) a comt polymorphism (rs4680: val158met) causing thermolability of enzymatic activity affects liver enzymes (e.g., aspartate aminotransferase (ast), alanine aminotransferase (alt) and gamma-glutamyl transpeptidase (γ-gt)) in serum. |
2012-04-09 |
2023-08-12 |
human |
| C D M Witjes, J N M IJzermans, A A van der Eijk, B E Hansen, C Verhoef, R A de Ma. Quantitative HBV DNA and AST are strong predictors for survival after HCC detection in chronic HBV patients. The Netherlands journal of medicine. vol 69. issue 11. 2012-04-05. PMID:22279629. |
the group of 37 patients (38%) who had a high viral load contained more hbeag-positive patients, had lower serum albumin levels and higher serum aspartate aminotransferase (ast ) and alanine aminotransferase (alt ) levels. |
2012-04-05 |
2023-08-12 |
Not clear |
| Bo Liu, Xianping Ge, Jun Xie, Pao Xu, Yijin He, Yanting Cui, Jianhua Ming, Qunlan Zhou, Liangkun Pa. Effects of anthraquinone extract from Rheum officinale Bail on the physiological responses and HSP70 gene expression of Megalobrama amblycephala under Aeromonas hydrophila infection. Fish & shellfish immunology. vol 32. issue 1. 2012-04-02. PMID:21362482. |
we then challenged the fish with a. hydrophila and recorded mortality and changes in serum cortisol, lysozyme, alkaline phosphatase (alp), total protein, aspartate aminotransferase (ast), alanine aminotransferase (alt), and hepatic catalase (cat), superoxide dismutase (sod), malondialdehyde (mda) and the relative expression of heat shock protein 70 (hsp70) mrna for a period of 5 d. |
2012-04-02 |
2023-08-12 |
cat |
| E G Kamel, M A El-Emam, S S M Mahmoud, F M Fouda, F E Bayaum. Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban. Parasitology international. vol 60. issue 4. 2012-04-02. PMID:21740980. |
this study aims to detect the antischistosomal properties of the plants' chenopodium ambrosioides, conyza dioscorides and sesbania sesban methanol extract against schistosoma mansoni in infected mice, including determination of total protein and albumin levels and the activities of alanine and aspartate transaminases (alt, ast) and acid and alkaline phosphatases (acp and akp) enzymes in the serum of infected treated mice. |
2012-04-02 |
2023-08-12 |
mouse |
| Lutz P Breitling, Volker Arndt, Christoph Drath, Hermann Brenne. Liver enzymes: interaction analysis of smoking with alcohol consumption or BMI, comparing AST and ALT to γ-GT. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132177. |
the present work aimed to provide further insights by examining similar interactions pertaining to aspartate and alanine transaminase (ast, alt), routine liver markers less prone to enzyme induction. |
2012-04-02 |
2023-08-12 |
Not clear |
| Dympna M Kelly, Hiroaki Shiba, Shunichi Nakagawa, Samuel Irefin, Bijan Eghtesad, Cristiano Quintini, Federico Aucejo, Koji Hashimoto, John J Fung, Charles Mille. Hepatic blood flow plays an important role in ischemia-reperfusion injury. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 17. issue 12. 2012-03-28. PMID:21858913. |
ir injury was defined by the aspartate aminotransferase (ast) level on postoperative day (pod) 2, and the patients were divided into 3 groups: (1) mild ir injury [ast < 500 u/l; n = 160 (51%)], (2) moderate ir injury [ast = 500-1000 u/l; n = 85 (27%)], and (3) severe ir injury [ast > 1000 u/l; n = 67 (21%)]. |
2012-03-28 |
2023-08-12 |
Not clear |
| Takashi Ashino, Jinko Sugiuchi, Junna Uehara, Yumiko Naito-Yamamoto, Sachiyo Kenmotsu, Yoichiro Iwakura, Seiji Shioda, Satoshi Numazawa, Takemi Yoshid. Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1. The Journal of toxicological sciences. vol 36. issue 5. 2012-03-27. PMID:22008538. |
cocaine (75 mg/kg) markedly increased serum alanine amino transferase (alt) (4,130 iu/l) and aspartate amino transferase (ast) (1,730 iu/l) activities at 16 hr after treatment, and induced hepatic necrosis surrounding central veins in mice. |
2012-03-27 |
2023-08-12 |
mouse |
| Rabiea Bilal, Manzar Zakaria, Ahmad Usman, Azam Zi. Comparison of simvastatin with Eugenia Jambolana fruit pulp in their effects on alanine transferase, aspartate aminotransferase and creatinine phosphokinase levels of hyperlipidaemic rats. JPMA. The Journal of the Pakistan Medical Association. vol 61. issue 12. 2012-03-27. PMID:22355964. |
to compare the effects of eugenia jambolana fruit extract with simvastatin on liver enzymes, aspartate aminotransferase (ast), alanine transferase (alt) and muscle enzyme creatinine phosphokinase (cpk) in diet induced hyperlipidaemic rats. |
2012-03-27 |
2023-08-12 |
rat |
| Mostafa M Shahshahani, Sahar Azizahari, Tahere Soori, Saeed Manavi, Kamran Balighi, Maryam Daneshpazhooh, Cheida S Davatchi, Nasife Esmail. Hepatotoxicity and liver enzyme alteration in patients with immunobullous diseases receiving immunosuppressive therapy. The Journal of dermatology. vol 38. issue 12. 2012-03-25. PMID:21981904. |
aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (alp) plasma levels were recorded before the start of treatment and every week under treatment (up to 3 weeks). |
2012-03-25 |
2023-08-12 |
Not clear |
| Giuseppe Banfi, Alessandra Colombini, Giovanni Lombardi, Anna Lubkowsk. Metabolic markers in sports medicine. Advances in clinical chemistry. vol 56. 2012-03-25. PMID:22397027. |
in liver metabolism, the interpretation of serum aminotransferases concentration in athletes should consider the release of aspartate aminotransferase (ast) from muscle and of alanine aminotransferase (alt) mainly from the liver, when bilirubin can be elevated because of continuous hemolysis, which is typical of exercise. |
2012-03-25 |
2023-08-12 |
human |
| Subramaniyan Jayakumar, Arumugam Madankumar, Selvamani Asokkumar, Subramanian Raghunandhakumar, Krishnan Gokula dhas, Sattu Kamaraj, Michael Georget Josephine Divya, Thiruvengadam Devak. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Molecular and cellular biochemistry. vol 360. issue 1-2. 2012-03-22. PMID:21879312. |
administration of den to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), and gamma glutamyl transpeptidase (γgt). |
2012-03-22 |
2023-08-12 |
rat |
| Haiqing Shen, Coleen Damcott, Scott R Shuldiner, Sumbul Chai, Rongze Yang, Hong Hu, Quince Gibson, Kathleen A Ryan, Braxton D Mitchell, Da-Wei Gon. Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. Journal of human genetics. vol 56. issue 11. 2012-03-22. PMID:21900944. |
we carried out a genome-wide association study of serum aspartate aminotransferase (ast) activity in 866 amish participants of the heredity and phenotype intervention heart study and identified significant association of ast activity with a cluster of single nucleotide polymorphisms located on chromosome 10q24.1 (peak association was rs17109512; p=2.80e-14), in the vicinity of got1, the gene encoding cytosolic ast (cast). |
2012-03-22 |
2023-08-12 |
human |
| Wei Li, Ming Zhang, Yi-Nan Zheng, Jing Li, Ying-Ping Wang, Yun-Jing Wang, Jian Gu, Ying Jin, Hui Wang, Li Che. Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice. Molecules (Basel, Switzerland). vol 16. issue 12. 2012-03-20. PMID:22146371. |
during the study on hepatoprotective in a mice model of chronic liver injury, pdg or g-m1 supplement significantly ameliorated the ccl(4)-induced liver lesions, lowered the serum levels of select hepatic enzyme markers (alanine aminotransferase, alt, and aspartate aminotransferase, ast) and malondialdehyde and increased the activity of superoxide dismutase in liver. |
2012-03-20 |
2023-08-12 |
mouse |
| Hossam H Abbas, Wafaa T Abba. Assessment study on the use of Pawpaw; Carica papaya seeds to control Oreochromis niloticus breeding. Pakistan journal of biological sciences : PJBS. vol 14. issue 24. 2012-03-20. PMID:22335051. |
also the high dose revealed a significant increase in the leukocytes (wbcs) count, serum glucose, total protein, aspartate aminotransferase (ast), alanine aminotransferase (alt), creatinine and uric acid levels. |
2012-03-20 |
2023-08-12 |
Not clear |
| Mahdi Banaee, Antoni Sureda, Ali Reza Mirvaghefi, Golam Reza Rafe. Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss). Fish physiology and biochemistry. vol 37. issue 4. 2012-03-16. PMID:21519846. |
plasma alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), alkaline phosphatase (alp), creatine kinase (ck), glucose, total protein, creatinine, triglyceride, cholesterol, urea, uric acid and liver cellular total antioxidant, and protein content were measured after 7, 14, and 28 days of silymarin treatment. |
2012-03-16 |
2023-08-12 |
Not clear |
| Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwaha. Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration. Chemico-biological interactions. vol 195. issue 2. 2012-03-15. PMID:22178775. |
serum levels of aspartate (ast), alanine (alt) transaminases, pro-inflammatory interleukin-6 (il-6), tumor necrosis factor-alpha (tnf-α) and anti-inflammatory interleukin-10 (il-10) in the rats exposed to ethanol induced ulceration have been altered. |
2012-03-15 |
2023-08-12 |
rat |
| Sathish Priya, Paramasivan Vijayalakshmi, Palani Vivekanandan, Sivanesan Karthikeya. Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats. Toxicology and industrial health. vol 27. issue 10. 2012-03-08. PMID:21558131. |
caused a significant increase in the levels of the serum marker enzymes (aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), glutamyl transpeptidase (γ-gt)) and a subsequent decrease in ast, alt, alp and increase in ldh and γ-gt in the liver tissue indicating hepatocellular damage. |
2012-03-08 |
2023-08-12 |
rat |
| S Y Ozsoy, B Ozsoy, Z Ozyildiz, I Ayteki. Protective effect of L-carnitine on experimental lead toxicity in rats: a clinical, histopathological and immunohistochemical study. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 86. issue 6. 2012-03-07. PMID:21039307. |
blood samples were obtained from the jugular vein for hemoglobin (hb), hematocrit (hct), red blood cells (rbc), white blood cells (wbc), platelets (plt), aspartate aminotransferase (ast), alanine aminotransferase (alt) and creatinine. |
2012-03-07 |
2023-08-12 |
rat |