| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Kusunoki, Y Natsume, D Sato, H Tsutsui, T Miyata, K Tsutsumi, T Suga, Y Oshid. Luseogliflozin, A Sodium Glucose Co-transporter 2 Inhibitor, Alleviates Hepatic Impairment in Japanese Patients with Type 2 Diabetes. Drug research. vol 66. issue 11. 2017-03-29. PMID:27626603. |
in this study, luseogliflozin significantly improved both hba1c and body weight to similar extents in both the normal group and the elevated group, accompanied by marked reductions in the aspartate aminotransferase (ast), alanine aminotransferase (alt), and γ-glutamyl transpeptidase (γ-gtp) levels. |
2017-03-29 |
2023-08-13 |
Not clear |
| Keita Kirito, Minoru Sakamoto, Nobuyuki Enomot. Elevation of the Hepatitis B Virus DNA during the Treatment of Polycythemia Vera with the JAK Kinase Inhibitor Ruxolitinib. Internal medicine (Tokyo, Japan). vol 55. issue 10. 2017-03-28. PMID:27181544. |
we herein report the case of a polycythemia vera patient who showed an elevation of hbv-dna viral dna with an elevation of aspartate aminotransferase (ast) and alanine aminotransferase (alt) after the initiation of ruxolitinib. |
2017-03-28 |
2023-08-13 |
Not clear |
| Tom Clifford, Dean M Allerton, Meghan A Brown, Liam Harper, Steven Horsburgh, Karen M Keane, Emma J Stevenson, Glyn Howatso. Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 3. 2017-03-28. PMID:28165768. |
maximal isometric voluntary contractions (mivc), countermovement jumps (cmj), muscle soreness, serum cytokines, leucocytosis, creatine kinase (ck), high sensitivity c-reactive protein (hs-crp), and aspartate aminotransferase (ast) were measured pre, post, and 2 days after the marathon. |
2017-03-28 |
2023-08-13 |
Not clear |
| Hong-Wei Zhao, Zhen-Fang Zhang, Xuan Chai, Guang-Quan Li, He-Rong Cui, Hong-Bo Wang, Ya-Kun Meng, Hui-Min Liu, Jia-Bo Wang, Rui-Sheng Li, Zhao-Fang Bai, Xiao-He Xia. Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. International immunopharmacology. vol 36. 2017-03-27. PMID:27179304. |
after ccl4 alone, the fibrosis score was 20.2±0.8, and the level of alanine aminotransferase (alt), aspartate aminotransferase (ast), hydroxyproline content, and collagen i expression was elevated, but omt blunted these parameters. |
2017-03-27 |
2023-08-13 |
rat |
| Yunli Yu, Quanying Zhang, Wenjun Xu, Chengzhe Lv, Gang Ha. Population pharmacokinetic modeling of oxcarbazepine active metabolite in Chinese patients with epilepsy. European journal of drug metabolism and pharmacokinetics. vol 41. issue 4. 2017-03-24. PMID:25700977. |
the effect of age, gender, red blood cell count, red blood cell specific volume, hemoglobin (hgb), alanine aminotransferase (alt), aspartate aminotransferase (ast), blood urea nitrogen (bun), and serum creatine were analyzed. |
2017-03-24 |
2023-08-13 |
Not clear |
| Mina T Kelleni, Salwa A Ibrahim, Aly M Abdelrahma. Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis. Toxicology mechanisms and methods. vol 26. issue 5. 2017-03-24. PMID:27269004. |
pretreatment with captopril or telmisartan produced a significant hepatic protection manifested as a significant (p < 0.05) decrease in serum levels of alanine transferase (alt) and aspartate transferase (ast) and alkaline phosphatase (alp) enzymes; hepatic malondialdehyde (mda) and total nitrites and nitrates (nox) levels; as well as a significant increase in hepatic superoxide dismutase (sod) activity. |
2017-03-24 |
2023-08-13 |
rat |
| Awatef Elwej, Yousri Grojja, Imen Ghorbel, Ons Boudawara, Raoudha Jarraya, Tahia Boudawara, Najiba Zegha. Barium chloride induces redox status unbalance, upregulates cytokine genes expression and confers hepatotoxicity in rats-alleviation by pomegranate peel. Environmental science and pollution research international. vol 23. issue 8. 2017-03-23. PMID:26732703. |
exposure of rats to barium caused oxidative stress in the liver as evidenced by an increase in malondialdehyde (mda), lipid hydroperoxides (loohs), h2o2 and advanced oxidation protein product (aopp) levels, and lactate dehydrogenase (ldh), gamma glutamyl transpeptidase (ggt), alanine aminotransferase (ast) and aspartate aminotransferase (alt) activities, a decrease in catalase (cat) and glutathione peroxidase (gpx) activities, glutathion (gsh), non-protein thiol (npsh), vitamin c levels, and mn-sod gene expression. |
2017-03-23 |
2023-08-13 |
rat |
| Shu-Lin Chen, Ning Xue, Mian-Tao Wu, Hao Chen, Xia He, Jian-Pei Li, Wan-Li Liu, Shu-Qin Da. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27598151. |
influence of preoperative serum aspartate aminotransferase (ast) level on the prognosis of patients with non-small cell lung cancer. |
2017-03-23 |
2023-08-13 |
human |
| Shu-Lin Chen, Ning Xue, Mian-Tao Wu, Hao Chen, Xia He, Jian-Pei Li, Wan-Li Liu, Shu-Qin Da. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27598151. |
the purpose of this work is to analyze preoperative serum aspartate aminotransferase (ast) levels and their effect on the prognosis of patients with non-small cell lung cancer (nsclc) after surgical operation. |
2017-03-23 |
2023-08-13 |
human |
| Gitte S Jensen, Cassandra Drapeau, Miki Lenninger, Kathleen F Benso. Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation. Journal of medicinal food. vol 19. issue 7. 2017-03-22. PMID:27362442. |
serum levels of aspartate transaminase (ast) showed a significant reduction after 2 weeks of ace consumption (p < .001), in contrast to placebo where no changes were seen; the difference in ast levels between the two groups was significant at 2 weeks (p < .02). |
2017-03-22 |
2023-08-13 |
Not clear |
| Yan Wen Dai, Chang Cheng Zhang, Hai Xia Zhao, Jing Zhi Wan, Li Li Deng, Zhi Yong Zhou, Yao Yan Dun, Chao Qi Liu, Ding Yuan, Ting Wan. Chikusetsusaponin V attenuates lipopolysaccharide-induced liver injury in mice. Immunopharmacology and immunotoxicology. vol 38. issue 3. 2017-03-21. PMID:26981791. |
our results showed that csv significantly attenuated elevation of alanine transaminase (alt) and aspartate aminotransferase (ast) levels and improved liver histopathological changes in lps-induced mice. |
2017-03-21 |
2023-08-13 |
mouse |
| Diao He, Zhen Guo, Jun-Liang Pu, Dao-Feng Zheng, Xu-Fu Wei, Rui Liu, Cheng-Yong Tang, Zhong-Jun W. Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo. International immunopharmacology. vol 35. 2017-03-21. PMID:27064547. |
in vivo assays revealed that resveratrol reduced levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), and liver pathological changes, while it alleviated hepatocyte apoptosis, negatively mediated the production of tnf-α and il-1β in serum, and reversed tlr4/nf-κb signaling pathway caused by hepatic ischemia/reperfusion stimulation in liver tissues. |
2017-03-21 |
2023-08-13 |
rat |
| Chun-Mu Miao, Kun He, Pei-Zhi Li, Zuo-Jin Liu, Xi-Wen Zhu, Zhi-Bing Ou, Xiong-Zhong Ruan, Jian-Ping Gong, Chang-An Li. LXRα represses LPS-induced inflammatory responses by competing with IRF3 for GRIP1 in Kupffer cells. International immunopharmacology. vol 35. 2017-03-21. PMID:27085678. |
in the t0901317+lps group, the serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), and tumor necrosis factor alpha (tnf-α) were lower, while the serum level of interleukin-10 (il-10) was higher. |
2017-03-21 |
2023-08-13 |
mouse |
| Dan Yan, Hai-Ling Liu, Zhong-Jian Yu, Yong-Hong Huang, Dian Gao, Hua Hao, Shou-Sheng Liao, Fang-Yun Xu, Xiao-Yan Zho. BML-111 Protected LPS/D-GalN-Induced Acute Liver Injury in Rats. International journal of molecular sciences. vol 17. issue 7. 2017-03-21. PMID:27420055. |
the activities of aspartate aminotransferase (ast) and alanine aminotransferase (alt) in serum were detected to evaluate the functions of the liver. |
2017-03-21 |
2023-08-13 |
rat |
| Ming-Wei Liu, Rong Liu, Hai-Yin Wu, Wei Zhang, Jing Xia, Min-Na Dong, Wen Yu, Qiang Wang, Feng-Mei Xie, Rui Wang, Yun-Qiao Huang, Chuan-Yun Qia. Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression. International journal of molecular medicine. vol 38. issue 5. 2017-03-21. PMID:27666960. |
the effects of xbj on d-gal- and lps-induced expression of tumor necrosis factor (tnf)‑alpha‑induced protein 8-like 2 (tipe2), nuclear factor-κb (nf-κb), matrix metalloproteinase-9 (mmp-9) and heme oxygenase-1 (ho-1) as well as mitogen-activated protein kinase (mapk) signaling was examined using reverse transcription-quantitative polymerase chain reaction (rt-qpcr), western blot analysis, immunofluorescence, as well as by analysing the serum levels of pro-inflammatory cytokines and the transaminases, alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2017-03-21 |
2023-08-13 |
rat |
| Hadiseh Dadras, Mohammad Reza Hayatbakhsh, William L Shelton, Amin Golpou. Effects of dietary administration of Rose hip and Safflower on growth performance, haematological, biochemical parameters and innate immune response of Beluga, Huso huso (Linnaeus, 1758). Fish & shellfish immunology. vol 59. 2017-03-21. PMID:27773731. |
the serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels were significantly lower in supplemented diet groups compared with the control. |
2017-03-21 |
2023-08-13 |
Not clear |
| Liya Liu, Jinyan Zhao, Ying Li, Yun Wan, Jiumao Lin, Aling Shen, Wei Xu, Huang Li, Yuchen Zhang, Jianfeng Xu, Jun Peng, Zhenfeng Hon. Artemisia capillaris formula inhibits hepatic steatosis via an miR‑122‑induced decrease in fatty acid synthase expression in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-03-20. PMID:27081834. |
serum alanine transaminase (alt), aspartate aminotransferase (ast), triglycerides (tg), total cholesterol (tc), high‑density lipoprotein cholesterol (hdl‑c), low‑density lipoprotein cholesterol (ldl‑c), and steatotic hepg2 human liver carcinoma cell tc and tg levels were measured. |
2017-03-20 |
2023-08-13 |
human |
| Kazeem A Akinwumi, Olabode O Osifeso, Afusat J Jubril, Ayobami W Adedoja, Elizabeth T Ogunbiyi, Fumilayo M Adebo, Idayat O Adesina, Oyeronke A Odunol. Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats. Journal of medicinal food. vol 19. issue 5. 2017-03-20. PMID:27152977. |
the frequency of micronucleated polychromatic erythrocytes (mpces) was monitored in bone marrow cells, while induction of aspartate aminotransferase (ast), alanine aminotransferase (alt), creatinine levels, and hematological parameters were assessed in the plasma. |
2017-03-20 |
2023-08-13 |
human |
| Yeonjung Ha, Jung Bok Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Hyun-Ki Yoon, Yong Moon Shin, Han Chu Le. Validation and reappraisal of the assessment for retreatment with transarterial chemoembolization score for unresectable non-metastatic hepatocellular carcinoma in a hepatitis b virus-endemic region. European radiology. vol 26. issue 10. 2017-03-17. PMID:26747261. |
to validate and reappraise the assessment for retreatment with transarterial chemoembolization (art) score comprising three parameters (>25 % increase in aspartate aminotransferase [ast], increase in child-pugh score and tumour response), determined prior to subsequent transarterial chemoembolization (tace). |
2017-03-17 |
2023-08-13 |
Not clear |
| Nor Aijratul Asikin Mohamad Shalan, Noordin M Mustapha, Suhaila Mohame. Chronic toxicity evaluation of Morinda citrifolia fruit and leaf in mice. Regulatory toxicology and pharmacology : RTP. vol 83. 2017-03-17. PMID:27871867. |
the 6 months study showed the fruit extract produced chronic toxicity effects at the high dose of 2 mg/ml drinking water, evidenced through deteriorated liver histology (hepatocyte necrosis), reduced liver length, increased liver injury marker ast (aspartate aminotransferase) and albumin reduction, injury symptoms (hypoactivity, excessive grooming, sunken eyes and hunched posture) and 40% mortality within 3 months. |
2017-03-17 |
2023-08-13 |
mouse |