| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae-Gyun Choi, Sheu-Ran Choi, Dong-Wook Kang, Jaehyuk Kim, Jin Bong Park, Hyun-Woo Ki. Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice. Neurochemistry international. vol 146. 2021-06-18. PMID:33744374. |
either intraperitoneal or intrathecal administration of the ace inhibitors, captopril and enalapril for 10 days significantly increased the paw withdrawal frequency to innocuous mechanical stimuli and the levels of sp in both the lumbar drg and the sdh region of the spinal cord dorsal horn. |
2021-06-18 |
2023-08-13 |
mouse |
| Jae-Gyun Choi, Sheu-Ran Choi, Dong-Wook Kang, Jaehyuk Kim, Jin Bong Park, Hyun-Woo Ki. Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice. Neurochemistry international. vol 146. 2021-06-18. PMID:33744374. |
these findings demonstrate that inhibition of ace increases the levels of sp in both the lumbar drg and spinal cord dorsal horn, ultimately contributing to the induction of mechanical allodynia in mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Jang Hyuk Cho, Dong Gyu Le. Translocation of AMPA Receptors in the Dorsal Horn of the Spinal Cord Corresponding to Long-term Depression Following Pulsed Radiofrequency Stimulation at the Dorsal Root Ganglion. Pain medicine (Malden, Mass.). vol 21. issue 9. 2021-05-14. PMID:31794026. |
translocation of ampa receptors in the dorsal horn of the spinal cord corresponding to long-term depression following pulsed radiofrequency stimulation at the dorsal root ganglion. |
2021-05-14 |
2023-08-13 |
Not clear |
| Michela Campolo, Marika Lanza, Irene Paterniti, Alessia Filippone, Alessio Ardizzone, Giovanna Casili, Sarah A Scuderi, Caterina Puglisi, Marzia Mare, Lorenzo Memeo, Salvatore Cuzzocrea, Emanuela Esposit. PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis. International journal of molecular sciences. vol 22. issue 8. 2021-05-13. PMID:33920318. |
our results demonstrated that pea-oxa, more than peaum, reduced the development of hypersensitivity in rats; this was associated with the reduction in hyperactivation of glia cells and the increased production of proinflammatory cytokines in the dorsal horn of the spinal cord, accompanied by an upregulation of neurotrophic factors in the dorsal root ganglia (drg). |
2021-05-13 |
2023-08-13 |
rat |
| Kun-Wu Yang, Pu-Wei Yuan, Bo Dong, Jing-Jie Fan, Ying-Ying Wang, Hui Liu, Xin Chai, Jie Zhen. [Effects of electroacupuncture on pain behavior and pain-related factors in spinal cord dorsal horn and dorsal root ganglia of rats with knee osteoarthritis]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 10. 2021-04-02. PMID:33788448. |
to observe the effect of electroacupuncture(ea) on the pain behavior and prostaglandin e2 (pge2), calcitonin gene-related peptide (cgrp) and substance p (sp) in the spinal cord dorsal horn and dorsal root ganglia (drg) of rats with knee osteoarthritis (koa), so as to explore the mechanisms of ea underlying improvement of chronic pain in koa rats. |
2021-04-02 |
2023-08-13 |
rat |
| Sanjay Kumar, Manjula Vinaya. NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation. Neurochemistry international. vol 134. 2021-02-23. PMID:31891736. |
peripheral nociceptive inputs activate the primary afferents via release of various chemical mediators which are potentially capable of mediating signals from neuron to glia in drg and subsequently in spinal cord dorsal horn. |
2021-02-23 |
2023-08-13 |
mouse |
| Sanjay Kumar, Manjula Vinaya. NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation. Neurochemistry international. vol 134. 2021-02-23. PMID:31891736. |
thus, the present study was focused to investigate the effect of ml171 on erk1/2 signaling, glial activation, and crosstalk between neuron and glia in drg and dorsal horn of the spinal cord of lumbar region (l3-l5) in a mouse model of formalin induced acute nociception. |
2021-02-23 |
2023-08-13 |
mouse |
| Sanjay Kumar, Manjula Vinaya. NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation. Neurochemistry international. vol 134. 2021-02-23. PMID:31891736. |
immunofluorescence and western blot analysis demonstrated decreased levels of nociceptive mediators like p-erk1/2, p-nfκb p65, iba1 and gfap in drg as well as in spinal cord dorsal horn; supporting anti-nociceptive potential of ml171. |
2021-02-23 |
2023-08-13 |
mouse |
| Melissa Jones, Jie Wen, Prabhuanand Selvaraj, Mikiei Tanaka, Sean Moran, Yumin Zhan. Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618769. |
accumulation of astrocytes and microglia in spinal cord dorsal horn and infiltration of macrophages into the dorsal root ganglion and sciatic nerve were reduced by drug treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Aubin Moutal, Shizhen Luo, Tally M Largent-Milnes, Todd W Vanderah, Rajesh Khann. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiology of pain (Cambridge, Mass.). vol 5. 2020-10-01. PMID:31080913. |
a spared nerve injury (sni) increased expression of a cyclin dependent kinase 5 (cdk5)-phosphorylated form of crmp2 in the dorsal horn of the spinal cord and the dorsal root ganglia (drg) in the ipsilateral (injured) versus the contralateral (non-injured) sites. |
2020-10-01 |
2023-08-13 |
rat |
| Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A Sortino, Santina Chiechi. Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:29104538. |
also a reduced expression of the epigenetic modifying enzyme, histone deacetylase 2 (hdac2), in dorsal root ganglia (drg) and dorsal horn (dh) together with an increase histone 3 acetylation (h3) level was observed in females but not in males. |
2020-09-30 |
2023-08-13 |
mouse |
| Jamie K Moy, Arkady Khoutorsky, Marina N Asiedu, Gregory Dussor, Theodore J Pric. eIF4E Phosphorylation Influences Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:29467623. |
brain-derived neurotrophic factor (bdnf) signaling from nociceptors in the drg to spinal dorsal horn neurons is an important mediator of hyperalgesic priming. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jamie K Moy, Jasper L Kuhn, Thomas A Szabo-Pardi, Grishma Pradhan, Theodore J Pric. eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model. Neurobiology of pain (Cambridge, Mass.). vol 4. 2020-09-30. PMID:30211343. |
this signaling pathway controls changes in excitability that drive acute pain sensitization as well as the translation of mrnas, such as brain-derived neurotrophic factor (bdnf), that enhance plasticity between dorsal root ganglion (drg) nociceptors and second order neurons in the spinal dorsal horn. |
2020-09-30 |
2023-08-13 |
mouse |
| Etsuro Ito, Rei Shima, Tohru Yoshiok. A novel role of oxytocin: Oxytocin-induced well-being in humans. Biophysics and physicobiology. vol 16. 2020-09-30. PMID:31608203. |
we previously reported that oxytocin can induce pain relief and described the possibility how oxytocin in the dorsal horn and/or the dorsal root ganglion relieves joint and muscle pain. |
2020-09-30 |
2023-08-13 |
human |
| Jian-Ling Gao, Ke Peng, Meng-Wei Shen, Yong-Heng Hou, Xiao-Bo Qian, Xiao-Wen Meng, Fu-Hai Ji, Li-Na Wang, Jian-Ping Yan. Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2. The journal of pain. vol 20. issue 12. 2020-09-22. PMID:31085334. |
wnk1 expression and distribution in the lumbar spinal cord dorsal horn and dorsal root ganglion were examined. |
2020-09-22 |
2023-08-13 |
rat |
| Jian-Ling Gao, Ke Peng, Meng-Wei Shen, Yong-Heng Hou, Xiao-Bo Qian, Xiao-Wen Meng, Fu-Hai Ji, Li-Na Wang, Jian-Ping Yan. Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2. The journal of pain. vol 20. issue 12. 2020-09-22. PMID:31085334. |
bcp rats exhibited significant mechanical allodynia, with increased wnk1 expression in the dorsal horn and dorsal root ganglion neurons, elevated spak/osr1 and nkcc1 expression in the dorsal root ganglion, and decreased kcc2 expression in the dorsal horn. |
2020-09-22 |
2023-08-13 |
rat |
| Xiaobing Yu, Hongju Liu, Katherine A Hamel, Maelig G Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M Braz, Allan I Basbau. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nature communications. vol 11. issue 1. 2020-04-23. PMID:31937758. |
paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (drg). |
2020-04-23 |
2023-08-13 |
mouse |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 38. issue 2. 2020-02-10. PMID:31538672. |
we assessed hyperalgesia, histopathological changes, immunoreactive (-ir) neurons for calcitonin gene-related peptide and activating transcription factor 3 in drg, and immunoreactive neurons for ionized-calcium-binding adaptor molecule 1 (iba1) in the dorsal horn of the spinal cord. |
2020-02-10 |
2023-08-13 |
rat |
| Hsien-Yin Liao, Ching-Liang Hsieh, Chun-Ping Huang, Yi-Wen Li. Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29142219. |
in cfa-injected mice, a dramatic increase was observed in the expression of the following proteins in the dorsal root ganglion and spinal cord dorsal horn: the astrocytic marker gfap, s100b, rage, ppkcε, cox-2, perk, and pnfκb. |
2019-07-03 |
2023-08-13 |
mouse |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 11. 2019-05-09. PMID:29888808. |
we measured the local production of tnf-α, immunoreactive (-ir) neurons for calcitonin gene-related peptide (cgrp), and growth associated protein-43 (gap-43) in drg, and immunoreactive neurons for ionized-calcium-binding adaptor molecule-1 (iba-1) in the dorsal horn of spinal cord, on post-induction days 7, 14, 28, 42, and 56 (n = 5 rats/group/time point). |
2019-05-09 |
2023-08-13 |
rat |