| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soichiro Tokeshi, Miyako Suzuki-Narita, Ikuko Tajiri, Kazuhide Inage, Jun Takeuchi, Takahito Arai, Yuya Kawarai, Hiroakira Terakawa, Seiji Ohtori, Sumihisa Orit. Comparison of effects of intra-articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-11-11. PMID:39528346. |
the percentage of iba-1 positive microglia in the spinal dorsal horn and of fg + cgrp-labeled cells among fg-positive cells in the dorsal root ganglion were evaluated by immunohistochemical staining. |
2024-11-11 |
2024-11-17 |
rat |
| Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Den. SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. International journal of biological macromolecules. 2024-10-30. PMID:39476923. |
the absence of setd2 in the drg potentiated neuronal excitability and increased presynaptic nmdar activity in the spinal dorsal horn. |
2024-10-30 |
2024-11-02 |
Not clear |
| Jie Zhang, Yijing Jiang, Zijian Zhang, Shilin Li, Haowen Fan, Jinhua Gu, Renfang Mao, Xiaohong X. Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases. Expert reviews in molecular medicine. vol 26. 2024-10-08. PMID:39375839. |
the expression of rgmb is transcriptionally regulated by dorsal root ganglion 11 (drg11), which is a transcription factor expressed in embryonic drg and dorsal horn neurons and plays an important role in the development of sensory circuits. |
2024-10-08 |
2024-10-10 |
human |
| Krishna Ghosh, Yuying Huang, Shao-Rui Chen, Hui-Lin Pa. Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone deacetylase HDAC2 in dorsal root ganglia. The Journal of biological chemistry. 2024-10-02. PMID:39357831. |
nerve injury causes sustained upregulation of α2δ-1 (encoded by the cacna2d1 gene) in the dorsal root ganglion (drg), contributing to pain hypersensitivity by directly interacting with and augmenting presynaptic nmda receptor activity in the spinal dorsal horn. |
2024-10-02 |
2024-10-05 |
rat |
| Zhi-Chuan Sun, Wen-Juan Han, Zhi-Wei Dou, Na Lu, Xu Wang, Fu-Dong Wang, Sui-Bin Ma, Zhi-Cheng Tian, Hang Xian, Wan-Neng Liu, Ying-Ying Liu, Wen-Bin Wu, Wen-Guang Chu, Huan Guo, Fei Wang, Hui Ding, Yuan-Ying Liu, Hui-Ren Tao, Marc Freichel, Lutz Birnbaumer, Zhen-Zhen Li, Rou-Gang Xie, Sheng-Xi Wu, Ceng Lu. TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-28. PMID:39340833. |
it is shown that in mice and human, trpc3 and trpc6 are upregulated in drg and spinal dorsal horn under pathological states. |
2024-09-28 |
2024-10-01 |
mouse |
| Adham Farah, Ryan Patel, Piotr Poplawski, Benjamin J Wastie, Mandy Tseng, Allison M Barry, Omar Daifallah, Akash Dubb, Ivan Paul, Hoi Lao Cheng, Faisal Feroz, Yuhe Su, Marva Chan, Hanns Ulrich Zeilhofer, Theodore Price, David L Bennett, Kirsty Bannister, John M Dawe. A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity. Brain : a journal of neurology. 2024-09-20. PMID:39301592. |
we show that lgi1 is highly expressed in drg and spinal cord dorsal horn neurons in both mouse and human. |
2024-09-20 |
2024-09-22 |
mouse |
| Taro Koike, Tenga Sato, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yosuke Nakano, Hikaru Iwashita, Yuki Sato, Yukie Hirahara, Masaaki Kitad. CD34 distribution in C-fiber low threshold mechanoreceptors in the mouse dorsal root ganglion and spinal cord. Brain research. 2024-09-10. PMID:39255903. |
at c4 and l1 levels of the dorsal horn, cd34 was observed in the entire region of lamina iiiv, however, in c8 and l4 levels of the dorsal horn cd34 was not detected in the medial part of lamina iiiv, which receives neural inputs from drg neurons that innervate palm or sole skin. |
2024-09-10 |
2024-09-13 |
mouse |
| Vittoria Borgonetti, Martina Morozzi, Nicoletta Galeott. Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain. Neuropharmacology. 2024-08-19. PMID:39159835. |
an increase of the itch neuropeptide b-type natriuretic peptide (bnp) in neun+ cells, of its downstream effector interleukin 17 (il17) along with increased perk1/2 levels occurred in the spinal cord dorsal horn and drg. |
2024-08-19 |
2024-08-22 |
mouse |
| Zheng Niu, Shu-Ting Qu, Ling Zhang, Jia-Hao Dai, Ke Wang, Yun Liu, Long Chen, Yu Song, Ren Sun, Zhen-Hua Xu, Hai-Long Zhan. Trim14-IκBα signaling regulates chronic inflammatory pain in rats and osteoarthritis patients. Neuroscience. 2024-05-02. PMID:38697463. |
furthermore, cfa-induced inflammatory pain rat model showed that trim14 was significantly increased in the l3-5 spinal dorsal horn (sdh) and dorsal root ganglion (drg), and in turn the inhibitor of nuclear factor kappa-b isoform α (iκbα) was decreased after trim14 elevation. |
2024-05-02 |
2024-05-05 |
rat |
| Qiang Zhang, Ran Ding, Yuanjie Li, Dan Qiao, Jiamin Kang, Linyue Zong, Yun Li, Yuan Yuan, Yang Jiao, Chunyan Wang, Yonghao Yu, Linlin Zhang, Yize L. Euchromatin histone-lysine N-methyltransferase 2 regulates the expression of potassium-sodium-activated channel subfamily T member 1 in primary sensory neurons and contributes to remifentanil-induced pain sensitivity. Brain research bulletin. 2024-04-26. PMID:38670469. |
g9a overexpression decreased slo2.2-mediated leak current and increased excitability in the small-diameter drg neurons and laminal ii small-diameter neurons in the spinal dorsal horn, which was implicated in peripheral and central sensitization. |
2024-04-26 |
2024-04-29 |
Not clear |
| Ri Chen, Xueru Xu, Youfen Yu, Yanqin Chen, Chun Lin, Rongguo Li. High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI. Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402335. |
four different voltages (45 v, 65 v, 85 v, and 100 v) of prf on drg significantly alleviated the sni-induced nep, reduced the levels of activating transcription factor 3 (atf3) in drg, improved the ultrastructure of drg, and promoted autophagy in spinal microglia to varying degrees and partially reversed the increased expression of tnf-α and the reduced expression of il-10 in spinal cord dorsal horn (scdh). |
2024-02-24 |
2024-02-27 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
this study used an in vivo rat annulus fibrosus (af) injury-driven discogenic pain model to investigate the acute and chronic changes in ivd degeneration and spinal inflammation, as well as sensitization, inflammation, and remodeling in dorsal root ganglion (drg) and spinal cord (sc) dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |
| Lunhao Chen, Chao Jiang, Qian Xu, Jiale Jin, Sigen A, Xi Wang, Xiaolin Li, Yaling Hu, Huankun Sun, Xuan Lu, Shumin Duan, Zhihua Gao, Wenxin Wang, Yue Wan. Biphasic release of betamethasone from an injectable HA hydrogel implant for alleviating lumbar disc herniation induced sciatica. Acta biomaterialia. 2024-01-20. PMID:38244658. |
in a mouse model of ldh, the epidural administration of bd/bp@ha efficiently alleviated ldh-induced sciatica for at least 10 days by inhibiting the activation of macrophages and microglia in dorsal root ganglion and spinal dorsal horn, respectively. |
2024-01-20 |
2024-01-23 |
mouse |
| Kazuhiro Hayashi, Joseph B Lesnak, Ashley N Plumb, Adam J Janowski, Angela F Smith, Joslyn K Hill, Kathleen A Sluk. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961342. |
bdnf messenger ribonucleic acid (mrna) was significantly increased in l4-l6 dorsal root ganglion (drg), but not the spinal dorsal horn or gastrocnemius muscle, 24hr after induction of the model in either male or female mice. |
2023-11-14 |
2023-11-20 |
mouse |
| Kazuhiro Hayashi, Joseph B Lesnak, Ashley N Plumb, Adam J Janowski, Angela F Smith, Joslyn K Hill, Kathleen A Sluk. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961342. |
bdnf protein expression via immunohistochemistry was significantly increased in l4-l6 spinal dorsal horn and retrogradely labelled muscle afferent drg neurons, at 24hr after induction of the model in both sexes. |
2023-11-14 |
2023-11-20 |
mouse |
| Tomoki Yamaguchi, Siamak Salavatian, Yuki Kuwabara, Abigail Hellman, Bradley K Taylor, Kimberly Howard-Quijano, Aman Mahaja. Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893094. |
the activation of trpv1 drg neurons triggers the spinal dorsal horn and the sympathetic preganglionic neurons in the spinal intermediolateral column, which results in sympathoexcitation. |
2023-10-30 |
2023-11-08 |
Not clear |
| Vikram Thakur, Mayra A Gonzalez, Maria Parada, Robert D Martinez, Munmun Chattopadhya. Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy. Molecular neurobiology. 2023-10-24. PMID:37875708. |
the results demonstrate that fk228 treatment can alleviate thermal hyperalgesia and mechanical allodynia significantly along with changes in the expression of hdacs in the dorsal root ganglia (drg) and spinal cord dorsal horn neurons of diabetic animals. |
2023-10-24 |
2023-11-08 |
mouse |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. |
2023-08-14 |
2023-08-16 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. |
2023-08-14 |
2023-08-16 |
Not clear |
| Sahibpreet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jagg. Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms. Fundamental & clinical pharmacology. 2023-07-04. PMID:37401197. |
the activation of the ephrin b/ephb system in the dorsal root ganglion and dorsal horn of the spinal cord may be essential in initiating and maintaining neuropathic pain. |
2023-07-04 |
2023-08-14 |
Not clear |