| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Hayashi, Joseph B Lesnak, Ashley N Plumb, Adam J Janowski, Angela F Smith, Joslyn K Hill, Kathleen A Sluk. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961342. |
bdnf messenger ribonucleic acid (mrna) was significantly increased in l4-l6 dorsal root ganglion (drg), but not the spinal dorsal horn or gastrocnemius muscle, 24hr after induction of the model in either male or female mice. |
2023-11-14 |
2023-11-20 |
mouse |
| Kazuhiro Hayashi, Joseph B Lesnak, Ashley N Plumb, Adam J Janowski, Angela F Smith, Joslyn K Hill, Kathleen A Sluk. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961342. |
bdnf protein expression via immunohistochemistry was significantly increased in l4-l6 spinal dorsal horn and retrogradely labelled muscle afferent drg neurons, at 24hr after induction of the model in both sexes. |
2023-11-14 |
2023-11-20 |
mouse |
| Tomoki Yamaguchi, Siamak Salavatian, Yuki Kuwabara, Abigail Hellman, Bradley K Taylor, Kimberly Howard-Quijano, Aman Mahaja. Thoracic Dorsal Root Ganglion Application of Resiniferatoxin Reduces Myocardial Ischemia-Induced Ventricular Arrhythmias. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893094. |
the activation of trpv1 drg neurons triggers the spinal dorsal horn and the sympathetic preganglionic neurons in the spinal intermediolateral column, which results in sympathoexcitation. |
2023-10-30 |
2023-11-08 |
Not clear |
| Vikram Thakur, Mayra A Gonzalez, Maria Parada, Robert D Martinez, Munmun Chattopadhya. Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy. Molecular neurobiology. 2023-10-24. PMID:37875708. |
the results demonstrate that fk228 treatment can alleviate thermal hyperalgesia and mechanical allodynia significantly along with changes in the expression of hdacs in the dorsal root ganglia (drg) and spinal cord dorsal horn neurons of diabetic animals. |
2023-10-24 |
2023-11-08 |
mouse |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. |
2023-08-14 |
2023-08-16 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. |
2023-08-14 |
2023-08-16 |
Not clear |
| Sahibpreet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jagg. Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms. Fundamental & clinical pharmacology. 2023-07-04. PMID:37401197. |
the activation of the ephrin b/ephb system in the dorsal root ganglion and dorsal horn of the spinal cord may be essential in initiating and maintaining neuropathic pain. |
2023-07-04 |
2023-08-14 |
Not clear |
| Shih-Hung Wang, Shu-Hung Huang, Meng-Chien Hsieh, I-Cheng Lu, Ping-Ruey Chou, Ming-Hong Tai, Sheng-Hua W. Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-\\xce\\xbaB Signaling Pathway. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982452. |
immunofluorescence in the spinal cord dorsal horn and dorsal root ganglion revealed that tlr4 overexpression in pac- and pac/lps-treated rats was significantly downregulated after hbot and tak-242. |
2023-03-29 |
2023-08-14 |
rat |
| Hayate Javed, Aishwarya Mary Johnson, Anil Kumar Challagandla, Bright Starling Emerald, Safa Sheha. Cutaneous Injection of Resiniferatoxin Completely Alleviates and Prevents Nerve-Injury-Induced Neuropathic Pain. Cells. vol 11. issue 24. 2022-12-23. PMID:36552812. |
the results showed that intraplantar injection of rtx (0.002%, 100 \xc2\xb5l) (1) completely reversed the development of chronic thermal and mechanical hypersensitivity; (2) completely prevented the development of nerve-injury-induced thermal and mechanical hypersensitivity when applied one week earlier; (3) caused downregulation of nociceptive pain markers, including trpv1, ib4 and cgrp, and upregulation of vip in the ipsilateral dorsal horn of spinal cord and dorsal root ganglion (drg) immunohistochemically and a significant reduction in the expression of trpv1 mrna and protein in the ipsilateral drg using western blot and qrt-pcr techniques; (4) caused downregulation of pgp 9.5- and cgrp-immunoreactivity in the injected skin; (5) produced significant suppression of c-fos expression, as a neuronal activity marker, in the spinal neurons in response to a second intraplantar rtx injection two weeks later. |
2022-12-23 |
2023-08-14 |
rat |
| Sylvie Cornet, Denis Carr\\xc3\\xa9, Lorenzo Limana, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Steven Evans, Stephane Lezmi, Mikhail Kaliniche. Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. Scientific reports. vol 12. issue 1. 2022-12-13. PMID:36513684. |
in abobont-a-treated animals cleaved snap25 was absent in the skin and drg, but present in the ipsilateral dorsal horn of the spinal cord. |
2022-12-13 |
2023-08-14 |
Not clear |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
as a crucial huntington-associated protein, hap1 is enriched in normal spinal dorsal horn and dorsal root ganglia (drg) where are regarded as "primary sensory center", indicating its potential functions in pain process. |
2022-12-12 |
2023-08-14 |
mouse |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
here, we discovered that hap1 level was greatly increased in the dorsal horn and drg under acute and chronic pain conditions. |
2022-12-12 |
2023-08-14 |
mouse |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
collectively, our results suggest that hap1 in dorsal horn and drg neurons regulates cav1.2 surface expression, which in turn reduces neuronal excitability, bdnf secretion and inflammatory responses and ultimately influences neuropathic pain progression. |
2022-12-12 |
2023-08-14 |
mouse |
| Xuan Lu, Lunhao Chen, Chao Jiang, Kelei Cao, Zhihua Gao, Yue Wan. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2022-09-28. PMID:36170151. |
we found that nerve root compression using degenerated np tissues can initiate remarkable and persistent sciatica, with increased and prolonged macrophage infiltration in dorsal root ganglia (drg) and significant activation of microglia in the spinal dorsal horn. |
2022-09-28 |
2023-08-14 |
mouse |
| Jing Wang, Feng Zhou, Susu Zhang, Mao Mao, Shanwu Feng, Xian Wan. Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain. Neuroscience letters. 2022-02-12. PMID:35149198. |
western blot and immunohistochemistry suggested that a cumulative dosage of ptx (8 mg/kg) upregulated trpv1 expression in the lumbar drg and spinal dorsal horn (sdh) at day 14 post treatment. |
2022-02-12 |
2023-08-13 |
rat |
| Aleyah E Goins, Kimberly Gomez, Dongzhi Ran, Mitra Afaghpour-Becklund, Rajesh Khanna, Sascha R A Alle. Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain. Pflugers Archiv : European journal of physiology. 2022-01-20. PMID:35048187. |
transcriptomics studies have shown that slc7a5 and its binding partner slc3a2 are expressed in neurons of the dorsal root ganglia (drg) and spinal dorsal horn, which are critical to the initiation and maintenance of nociception and pathophysiology of chronic pain. |
2022-01-20 |
2023-08-13 |
Not clear |
| Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian X. KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34464689. |
our results showed that snl led to a significant increase in kdm6b mrna and protein in the ipsilateral l4/5 dorsal root ganglia (drg) and spinal dorsal horn; and this increase correlated a markedly reduction in the level of h3k27me3 methylation in the same tissue. |
2021-12-09 |
2023-08-13 |
rat |
| Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian X. KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34464689. |
double immunofluorescence staining revealed that the kdm6b expressed in myelinated a- and unmyelinated c-fibers in the drg; and located in neuronal cells, astrocytes, and microglia in the dorsal horn. |
2021-12-09 |
2023-08-13 |
rat |
| Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian X. KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34464689. |
together, our results indicate that snl-induced upregulation of kdm6b via demethylating h3k27me3 facilitates the binding of stat3 with il-6 promoter, and subsequently mediated-increase in the expression of il-6 in the drg and dorsal horn contributes to the development and maintenance of neuropathic pain. |
2021-12-09 |
2023-08-13 |
rat |
| Pascale Vergne-Salle, Philippe Berti. Chronic pain and neuroinflammation. Joint bone spine. vol 88. issue 6. 2021-11-22. PMID:34022418. |
these afferent fibers release neurotransmitters in the dorsal root ganglion and dorsal horn of the spinal cord, capable of activating microglia, which are the local immune cells. |
2021-11-22 |
2023-08-13 |
Not clear |