| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dabing Li, Qiangwen Pan, Yewei Xiao, Kehui H. Advances in the study of phencyclidine-induced schizophrenia-like animal models and the underlying neural mechanisms. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-07-22. PMID:39039065. |
nondopaminergic pathophysiology, particularly excessive glutamate release induced by nmdar hypofunction in the prefrontal cortex (pfc), may play a key role in the development of pcp-induced sz-like symptoms. |
2024-07-22 |
2024-07-25 |
Not clear |
| M Flavia Barbano, Jia Qi, Emma Chen, Uzma Mohammad, Orlando Espinoza, Marcos Candido, Huiling Wang, Bing Liu, Suyun Hahn, François Vautier, Marisela Morale. VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-06-26. PMID:38926603. |
increased nac dopamine release from ventral tegmental area (vta) inputs is critical to psychostimulant self-administration and nac glutamate release from prelimbic prefrontal cortex (pfc) inputs synapsing on medium spiny neurons (msns) is critical to reinstatement of psychostimulant-seeking after extinction. |
2024-06-26 |
2024-06-29 |
mouse |
| Nastran Kabiri-Samani, Hossein Amini-Khoei, Mohammad Rahimi-Madiseh, Antoni Sureda, Zahra Lorigooin. Trigonelline as an anticonvulsant agent: mechanistic insights into NMDA receptor expression and oxidative stress balance. Scientific reports. vol 14. issue 1. 2024-06-20. PMID:38902338. |
therefore, this study was performed to determine trg's anticonvulsant effects, focusing on its potential effects on n-methyl-d-aspartate (nmda) receptors, a type of glutamate receptor, and oxidative stress state in the prefrontal cortex (pfc) in ptz-induced seizure in mice. |
2024-06-20 |
2024-06-23 |
mouse |
| Abhinav Singh, Maryam Sarwat, Sangeetha Gupt. Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder. Current pharmaceutical design. 2024-06-07. PMID:38847247. |
alterations in the circuits, including the prefrontal cortex, striatum, and limbic system, regulate mood and cause variation in several crucial neurotransmitters, including serotonin, dopamine, gaba, and glutamate. |
2024-06-07 |
2024-06-10 |
Not clear |
| Charlotte M Crisp, Angad Sahni, Sze W Pang, Lucy D Vanes, Timea Szentgyorgyi, Bruno Averbeck, Rosalyn J Moran, Sukhwinder S Shergil. Deterioration in cognitive control related mPFC function underlying development of treatment resistance in early psychosis. Scientific reports. vol 14. issue 1. 2024-06-05. PMID:38839828. |
changes in cognitive control related activity (in prefrontal cortex and acc) over time were compared between treatment-resistant and treatment-responsive groups and related to glutamate. |
2024-06-05 |
2024-06-08 |
human |
| Sinead M O'Donovan, Dan Shan, Xiaojun Wu, Jae Hyuk Choi, Robert E McCullumsmit. Dysregulated Transcript Expression but Not Function of the Glutamate Transporter EAAT2 in the Dorsolateral Prefrontal Cortex in Schizophrenia. Schizophrenia bulletin. 2024-06-02. PMID:38825587. |
dysregulated transcript expression but not function of the glutamate transporter eaat2 in the dorsolateral prefrontal cortex in schizophrenia. |
2024-06-02 |
2024-06-05 |
human |
| Yuchen Qin, Weiyu Huang, Zijiang Wang, Chunting Wang, Chen Wang, Meng Zhang, Shengting Wu, Gaoyang Wang, Fenghong Zha. 1,2-Dichloroethane causes anxiety and cognitive dysfunction in mice by disturbing GABA metabolism and inhibiting the cAMP-PKA-CREB signaling pathway. Ecotoxicology and environmental safety. vol 279. 2024-05-17. PMID:38759534. |
the contents of γ-aminobutyric acid (gaba) and glutamine (gln) in mice's prefrontal cortex decreased, whereas that of glutamate (glu) increased. |
2024-05-17 |
2024-05-27 |
mouse |
| Shane E Ehrhardt, Yohan Wards, Reuben Rideaux, Małgorzata Marjańska, Jin Jin, Martijn A Cloos, Dinesh K Deelchand, Helge J Zöllner, Muhammad G Saleh, Steve C N Hui, Tonima Ali, Thomas B Shaw, Markus Barth, Jason B Mattingley, Hannah L Filmer, Paul E Du. Neurochemical predictors of generalised learning induced by brain stimulation and training. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-26. PMID:38531634. |
critically, the transferred benefits associated with right prefrontal tdcs were predicted by pre-training concentrations of glutamate in the prefrontal cortex. |
2024-03-26 |
2024-03-29 |
Not clear |
| Tristan Hurzeler, Joshua Watt, Warren Logge, Ellen Towers, Anastasia Suraev, Nicholas Lintzeris, Paul Haber, Kirsten C Morle. Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review. Journal of cannabis research. vol 6. issue 1. 2024-03-21. PMID:38509580. |
the results suggest that cbd modulates γ-aminobutyric acid and glutamate signaling in the basal ganglia and dorso-medial prefrontal cortex. |
2024-03-21 |
2024-03-23 |
human |
| Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mour. Chronic social defeat stress induces the down-regulation of the Nedd4L-GLT-1 ubiquitination pathway in the prefrontal cortex of mice. Journal of neurochemistry. 2024-03-18. PMID:38497582. |
in terms of brain microdialysis, csds reduced depolarization-evoked glutamate release in the prefrontal cortex (pfc), which was reversed by a glutamate transporter 1 (glt-1) inhibitor. |
2024-03-18 |
2024-03-20 |
mouse |
| Nicola Johnstone, Kathrin Cohen Kados. Excitatory and inhibitory neurochemical markers of anxiety in young females. Developmental cognitive neuroscience. vol 66. 2024-03-06. PMID:38447470. |
within the bayesian framework, we found that gaba increased and glutamate decreased with age, negative associations between anxiety and glutamate and gaba ratios in the dorsolateral prefrontal cortex, and a positive relationship of gaba with anxiety levels. |
2024-03-06 |
2024-03-09 |
Not clear |
| Wirginia Krzyściak, Beata Bystrowska, Paulina Karcz, Robert Chrzan, Amira Bryll, Aleksander Turek, Paulina Mazur, Natalia Śmierciak, Marta Szwajca, Paulina Donicz, Katarzyna Furman, Fabio Pilato, Tamas Kozicz, Tadeusz Popiela, Maciej Pileck. Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396971. |
the strongest correlations with the level of blood lactate and cortisol were demonstrated by brain glutamate, n-acetylaspartate and the concentrations of glutamate and glutamine, creatine and phosphocreatine in the prefrontal cortex. |
2024-02-24 |
2024-02-26 |
human |
| Qiu-Yi Dong, Yun-Bin Cao, Hui-Wei Huang, Dan Li, Yanqin Lin, Hua-Jun Che. Metabolic disorder and functional disturbance in the central executive network in minimal hepatic encephalopathy. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 2. 2024-02-16. PMID:38365269. |
minimal hepatic encephalopathy patients had decreased myo-inositol / total creatine and choline / total creatine and increased glutamate and glutamine complex / total creatine in right dorsolateral prefrontal cortex (all p ≤ 0.020); decreased static functional connectivity between bilateral dorsolateral prefrontal cortex and between right dorsolateral prefrontal cortex and lateral-inferior temporal cortex (p ≤ 0.001); increased frequency and mean dwell time in state-1 (p ≤ 0.001), which exhibited weakest functional connectivity. |
2024-02-16 |
2024-02-19 |
Not clear |
| Christopher J E Denning, Lauren E Madory, Jessica N Herbert, Ryan A Cabrera, Karen K Szumlinsk. Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339206. |
relative to naïve controls, ma-experienced mice exhibited several changes in the expression of certain glutamate receptor-related proteins and their downstream effectors within the ventral and dorsal areas of the prefrontal cortex, the hippocampus, and the amygdala, many of which were sex-selective. |
2024-02-10 |
2024-02-12 |
mouse |
| Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabac. Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242425. |
levels of noradrenaline (na), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), glutamate (glu) and gaba were assessed in the prefrontal cortex (pfc). |
2024-01-19 |
2024-01-22 |
rat |
| Mahum T Siddiqi, Dhruba Podder, Amanda R Pahng, Alexandria C Athanason, Tali Nadav, Chelsea Cates-Gatto, Max Kreifeldt, Candice Contet, Amanda J Roberts, Scott Edwards, Marisa Roberto, Florence P Varodaya. Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. Addiction neuroscience. vol 9. 2023-12-28. PMID:38152067. |
pfc glutamate neurotransmission is mostly mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic receptors (ampars); however preclinical studies have mostly focused on other receptor subtypes. |
2023-12-28 |
2023-12-30 |
mouse |
| María Elena Quintanilla, Paola Morales, Daniela Santapau, Alba Ávila, Carolina Ponce, Pablo Berrios-Cárcamo, Belén Olivares, Javiera Gallardo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezque. Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069404. |
we show that wistar-derived outbred uchb rats selected for their high alcohol preference additionally develop: (i) a preference for oral ingestion of morphine over water, resulting in morphine intake of 15 mg/kg/day; (ii) marked opioid dependence, as evidenced by the generation of strong withdrawal signs upon naloxone administration; (iii) prefrontal cortex alterations known to be associated with the loss of control over drug intake, namely, demyelination, axonal degeneration, and a reduction in glutamate transporter glt-1 levels; and (iv) glial striatal neuroinflammation and brain oxidative stress, as previously reported for chronic alcohol and chronic nicotine use. |
2023-12-09 |
2023-12-17 |
rat |
| Luis Gerardo Balcazar-Ochoa, Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Claudia Gómez-Acevedo, Omar Francisco Carrasco, Raúl Sampieri-Cabrera, Anahí Chavarría, Abimael González-Hernánde. Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System. Archives of medical research. vol 55. issue 1. 2023-12-01. PMID:38039802. |
studies have revealed that clav can increase glt-1 expression in the nucleus accumbens (nacc), medial prefrontal cortex (pfc), and spinal cord of rodents, to affect glutamate and dopaminergic neurotransmission, and exert an anti-inflammatory effect by modulating the levels of the cytokines tnf-α and interleukin 10 (il-10). |
2023-12-01 |
2023-12-10 |
Not clear |
| Xiao Hu, Hui-Ling Zhao, Nurhumar Kurban, Yu Qin, Xi Chen, Su-Ying Cui, Yong-He Zhan. Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia. eNeuro. vol 10. issue 11. 2023-11-23. PMID:37989582. |
reduction of bdnf levels and biphasic changes in glutamate release in the prefrontal cortex correlate with susceptibility to chronic stress-induced anhedonia. |
2023-11-23 |
2023-11-28 |
rat |
| Xiao Hu, Hui-Ling Zhao, Nurhumar Kurban, Yu Qin, Xi Chen, Su-Ying Cui, Yong-He Zhan. Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia. eNeuro. vol 10. issue 11. 2023-11-23. PMID:37989582. |
the present study investigated effects of chronic mild stress (cms) for 14, 21, and 35 d on anhedonia-like behavior and glutamate synapses in the pfc. |
2023-11-23 |
2023-11-28 |
rat |