| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerio Cervelli, Maria G Scioli, Pietro Gentile, Elena Doldo, Elena Bonanno, Luigi G Spagnoli, Augusto Orland. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem cells translational medicine. vol 1. issue 3. 2013-01-10. PMID:23197780. |
prp with insulin synergistically upregulated fibroblast growth factor receptor (fgfr) and downregulated epidermal growth factor receptor (erbb) expression; moreover, prp in association prevented insulin-induced insulin-like growth factor-1 receptor and insulin receptor downregulation. |
2013-01-10 |
2023-08-12 |
mouse |
| Valerio Cervelli, Maria G Scioli, Pietro Gentile, Elena Doldo, Elena Bonanno, Luigi G Spagnoli, Augusto Orland. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem cells translational medicine. vol 1. issue 3. 2013-01-10. PMID:23197780. |
our results ascertain that prp in association with insulin greatly potentiates adipogenesis in human ascs through a fgfr-1 and erbb2-regulated akt mechanism. |
2013-01-10 |
2023-08-12 |
mouse |
| Valerio Cervelli, Maria G Scioli, Pietro Gentile, Elena Doldo, Elena Bonanno, Luigi G Spagnoli, Augusto Orland. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem cells translational medicine. vol 1. issue 3. 2013-01-10. PMID:23197780. |
here we investigated the signaling pathways and effects of prp and human recombinant insulin on proliferation and adipogenic differentiation of ascs in vitro. |
2013-01-10 |
2023-08-12 |
mouse |
| Valerio Cervelli, Maria G Scioli, Pietro Gentile, Elena Doldo, Elena Bonanno, Luigi G Spagnoli, Augusto Orland. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem cells translational medicine. vol 1. issue 3. 2013-01-10. PMID:23197780. |
although prp alone did not increase adipogenesis, in association with insulin it prevented asc proliferative arrest, greatly enhanced intracytoplasmic lipid accumulation, strongly increased serine/threonine kinase akt phosphorylation and mouse monoclonal anti-sterol regulatory element binding protein-1 accumulation, and downregulated erk-1 activity; adipogenic effects were markedly prevented by the akt inhibitor wortmannin. |
2013-01-10 |
2023-08-12 |
mouse |
| K Wada, Y Takiguchi, M Nakashim. Changes in Platelet Aggregation in Whole Blood, Plasma and Washed Platelets in Streptozotocin-induced Diabetic Rats: Time-dependent Change in the Antiaggregatory Activity of Diabetic Rat Plasma. Platelets. vol 4. issue 5. 2012-10-02. PMID:21043752. |
insulin treatment normalized aggregation in whole blood and prp and abolished the antiaggregatory activity of diabetic plasma. |
2012-10-02 |
2023-08-12 |
rat |
| Andrew M Lee, Johan F Paulsson, Justin Cruite, Abegail A Andaya, Matthew J Trifilo, Michael B A Oldston. Extraneural manifestations of prion infection in GPI-anchorless transgenic mice. Virology. vol 411. issue 1. 2011-04-04. PMID:21227476. |
islets contain abundant insulin and there is no abnormality in glucose metabolism in infected gpi⁻/⁻ prp tg mice. |
2011-04-04 |
2023-08-12 |
mouse |
| Maija I Mednieks, Andrew Szczepanski, Brett Clark, Arthur R Han. Protein expression in salivary glands of rats with streptozotocin diabetes. International journal of experimental pathology. vol 90. issue 4. 2009-09-16. PMID:19659899. |
electrophoresis and western blotting of tissue extracts of two secretory proteins showed that the response to dm and insulin treatment was gland specific: prp showed little change in the smg, but decreased in the parotid in dm and was partially restored after insulin treatment. |
2009-09-16 |
2023-08-12 |
rat |
| Michael R Sawaya, Shilpa Sambashivan, Rebecca Nelson, Magdalena I Ivanova, Stuart A Sievers, Marcin I Apostol, Michael J Thompson, Melinda Balbirnie, Jed J W Wiltzius, Heather T McFarlane, Anders Ø Madsen, Christian Riekel, David Eisenber. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature. vol 447. issue 7143. 2007-06-07. PMID:17468747. |
these include segments from the alzheimer's amyloid-beta and tau proteins, the prp prion protein, insulin, islet amyloid polypeptide (iapp), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. |
2007-06-07 |
2023-08-12 |
Not clear |
| W M Amselgruber, M Büttner, T Schlegel, M Schweiger, E Pfaf. The normal cellular prion protein (PrPc) is strongly expressed in bovine endocrine pancreas. Histochemistry and cell biology. vol 125. issue 4. 2007-05-09. PMID:16208484. |
using immunostained serial sections and specific antibodies against bovine prp(c), insulin, glucagon, somatostatin, chromogranin a and chromogranin b we found that prp(c) is highly expressed in all endocrine cells of fetal and adult pancreatic islets with a particular strong expression in a-cells. |
2007-05-09 |
2023-08-12 |
cattle |
| M Yngen, N Li, P Hjemdahl, N H Wallé. Insulin enhances platelet activation in vitro. Thrombosis research. vol 104. issue 2. 2002-02-14. PMID:11672752. |
insulin (30 or 300 microu/ml) also enhanced adp-induced platelet aggregation in prp (p<.01 or p<.001; n=14). |
2002-02-14 |
2023-08-12 |
Not clear |
| M Yngen, N Li, P Hjemdahl, N H Wallé. Insulin enhances platelet activation in vitro. Thrombosis research. vol 104. issue 2. 2002-02-14. PMID:11672752. |
the effect of insulin (30 or 300 microu/ml, incubated for 3 min) on platelet aggregation was studied using born aggregometry in platelet-rich plasma (prp). |
2002-02-14 |
2023-08-12 |
Not clear |
| C Kuwahara, A Kubosaki, T Nishimura, Y Nasu, Y Nakamura, K Saeki, Y Matsumoto, T Onoder. Enhanced expression of cellular prion protein gene by insulin or nerve growth factor in immortalized mouse neuronal precursor cell lines. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679279. |
treatment with nerve growth factor (ngf) and insulin induced cell differentiation and enhanced expression of prp gene (prnp) mrna and protein. |
2000-03-22 |
2023-08-12 |
mouse |
| A Szczepanski, M I Mednieks, A R Han. Expression and distribution of parotid secretory proteins in experimental diabetes. European journal of morphology. vol 36 Suppl. 1999-01-15. PMID:9825930. |
the response to insulin treatment was variable: amylase and psp labeling were partly restored, but prp and aeg labeling showed little change. |
1999-01-15 |
2023-08-12 |
rat |
| L C Stewart, R Deslauriers, V V Kupriyano. Relationships between cytosolic [ATP], [ATP]/[ADP] and ionic fluxes in the perfused rat heart: A 31P, 23Na and 87Rb NMR study. Journal of molecular and cellular cardiology. vol 26. issue 10. 1995-03-27. PMID:7869398. |
during dg + insulin treatment the pressure-rate product (prp) decreased by half and was restored upon insulin washout to 80% of its initial value both in the presence and in the absence of the shift reagent [5 mm dy (triethylenetetraminehexaacetate)3-]. |
1995-03-27 |
2023-08-12 |
rat |
| M Trovati, P Massucco, L Mattiello, E Mularoni, F Cavalot, G Anfoss. Insulin increases guanosine-3',5'-cyclic monophosphate in human platelets. A mechanism involved in the insulin anti-aggregating effect. Diabetes. vol 43. issue 8. 1994-08-22. PMID:7518780. |
to investigate whether insulin reduces platelet aggregability through a modulation of the guanosine-3',5'-cyclic monophosphate (cgmp) concentrations, we determined by a radioimmunoassay the cgmp values in the platelet-rich plasma (prp) obtained from 17 healthy volunteers and incubated for 3 min with different concentrations of human recombinant insulin (0, 240, 480, 720, 960, and 1,920 pm). |
1994-08-22 |
2023-08-12 |
human |
| M Trovati, G Anfossi, F Cavalot, P Massucco, E Mularoni, G Emanuell. Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. Diabetes. vol 37. issue 6. 1988-08-04. PMID:2838353. |
for the in vitro investigation, we evaluated whether insulin affects platelet function at a physiological hormone concentration by incubating the platelet-rich plasma (prp) of fasting subjects with human regular insulin at the final concentration of 40 microu/ml for 30 min; we observed a significant reduction of platelet sensitivity to all the aggregating agents employed, i.e., adp, platelet-activating factor (paf), epinephrine, collagen, and na+ arachidonate. |
1988-08-04 |
2023-08-11 |
human |
| M Trovati, G Anfossi, F Cavalot, P Massucco, E Mularoni, G Emanuell. Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. Diabetes. vol 37. issue 6. 1988-08-04. PMID:2838353. |
to investigate whether the insulin effect on platelets is dose dependent, we incubated the prp of fasting subjects with different concentrations of human regular insulin (40, 80, 120, and 160 microu/ml) for 5 min, and we observed that the insulin-induced reduction of platelet sensitivity to aggregating agents is a dose-dependent phenomenon. |
1988-08-04 |
2023-08-11 |
human |
| M Trovati, G Anfossi, F Cavalot, S Vitali, P Massucco, E Mularoni, P Schinco, G Tamponi, G Emanuell. Studies on mechanisms involved in hypoglycemia-induced platelet activation. Diabetes. vol 35. issue 7. 1986-07-30. PMID:2941327. |
to further elucidate the mechanisms of hypoglycemia-induced platelet activation, we incubated in vitro platelet-rich plasma (prp) of seven fasting healthy subjects with the same concentrations of insulin, epinephrine, glucagon, growth hormone, and cortisol measured in vivo during insulin-induced hypoglycemia. |
1986-07-30 |
2023-08-11 |
human |