| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Motofumi Sasaki, Kenichi Shikata, Shinichi Okada, Satoshi Miyamoto, Shingo Nishishita, Hitomi Usui Kataoka, Chikage Sato, Jun Wada, Daisuke Ogawa, Hirofumi Makin. The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration. Acta medica Okayama. vol 65. issue 2. 2011-05-19. PMID:21519365. |
the 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. |
2011-05-19 |
2023-08-12 |
mouse |
| Nadja Herbach, Irene Schairer, Andreas Blutke, Sabine Kautz, Angela Siebert, Burkhard Göke, Eckhard Wolf, Ruediger Wank. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. American journal of physiology. Renal physiology. vol 296. issue 4. 2009-06-02. PMID:19211686. |
early renal changes of transgenic mice consisted of podocyte hypertrophy, reduced numerical volume density of podocytes in glomeruli, and homogenous thickening of the glomerular basement membrane, followed by renal and glomerular hypertrophy as well as mesangial expansion and matrix accumulation. |
2009-06-02 |
2023-08-12 |
mouse |
| Denise W Wong, Gavin Y Oudit, Heather Reich, Zamaneh Kassiri, Joyce Zhou, Qiao C Liu, Peter H Backx, Josef M Penninger, Andrew M Herzenberg, James W Schole. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American journal of pathology. vol 171. issue 2. 2007-09-13. PMID:17600118. |
ace2(-/y)ins2(wt/c96y) mice were the only group to exhibit increased mesangial matrix scores and glomerular basement membrane thicknesses compared with ace2(+/y)ins2(wt/wt) mice, accompanied by increased fibronectin and alpha-smooth muscle actin immunostaining in the glomeruli of ace2(-/y) ins2(wt/c96y) mice. |
2007-09-13 |
2023-08-12 |
mouse |
| Eiji Sugaru, Tsutomu Nakagawa, Michiko Ono-Kishino, Jun Nagamine, Teruhisa Tokunaga, Makoto Kitoh, W Ewan Hume, Ryu Nagata, Mutsuo Taij. SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice. American journal of physiology. Renal physiology. vol 290. issue 4. 2006-04-13. PMID:16278277. |
previously, we demonstrated that 5-chloro-2-{(1e)-3-[2-(4-methoxybenzoyl)-4-methyl-1h-pyrrol-1-yl]prop-1-en-1-yl}-n-(methylsulfonyl)benzamide (smp-534) reduces extracellular matrix (ecm) production induced by transforming growth factor-beta (tgf-beta) in vitro and prevents the accumulation of ecm in glomeruli in rat thy-1 nephritis models. |
2006-04-13 |
2023-08-12 |
mouse |
| Agnieszka Pedrycz, Marcin Wieczorski, Krystyna Czern. Histological and histochemical assessment of the effects of a single dose adriamycin on fetal rat kidney. Acta histochemica. vol 107. issue 3. 2005-11-08. PMID:15964613. |
it induces increased amounts of pas(+)-positive mesangial matrix, glomerulosclerosis, dilatation of the urinary space and thickening of basement membranes in glomeruli. |
2005-11-08 |
2023-08-12 |
rat |
| Ciro Esposito, Bina Parrilla, Andreana De Mauri, Flavia Cornacchia, Gianluca Fasoli, Annalisa Foschi, Tiziana Mazzullo, Annarita Plati, Roberta Scudellaro, Antonio Dal Canto. Hepatocyte growth factor (HGF) modulates matrix turnover in human glomeruli. Kidney international. vol 67. issue 6. 2005-08-09. PMID:15882257. |
hepatocyte growth factor (hgf) modulates matrix turnover in human glomeruli. |
2005-08-09 |
2023-08-12 |
human |
| Ciro Esposito, Bina Parrilla, Andreana De Mauri, Flavia Cornacchia, Gianluca Fasoli, Annalisa Foschi, Tiziana Mazzullo, Annarita Plati, Roberta Scudellaro, Antonio Dal Canto. Hepatocyte growth factor (HGF) modulates matrix turnover in human glomeruli. Kidney international. vol 67. issue 6. 2005-08-09. PMID:15882257. |
the present study evaluated the effect of hgf on the extracellular matrix turnover and on c-met receptor in human glomeruli. |
2005-08-09 |
2023-08-12 |
human |
| Gary Strike. HGF and extracellular matrix turnover in normal human glomeruli ex vivo. Kidney international. vol 67. issue 6. 2005-08-09. PMID:15882298. |
hgf and extracellular matrix turnover in normal human glomeruli ex vivo. |
2005-08-09 |
2023-08-12 |
human |
| S V McLennan, X Y Wang, V Moreno, D K Yue, S M Twig. Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology. vol 145. issue 12. 2004-12-23. PMID:15345671. |
in vivo studies of glomeruli from diabetic and control rats showed that intensive insulin treatment prevented the increase in expression of ctgf and timp-1 and attenuated the decreased matrix degradation seen in diabetes. |
2004-12-23 |
2023-08-12 |
human |
| Jun Soma, Kozo Sato, Tsutomu Sakuma, Hirotaka Saito, Hiroshi Sato, Toshinobu Sato, Acha Abbas, Pierre Aucouturie. Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 43. issue 1. 2004-04-14. PMID:14712467. |
the authors describe a 54-year-old woman presenting with proteinuria, hematuria, and hypocomplementemia whose renal biopsy results showed diffuse increase in mesangial matrix and nodular formations in several glomeruli with the deposition of immunoglobulin gamma3-heavy-chain and complement components c1q and c3 in the glomeruli and on the tubular basement membranes, without associated light-chain deposits. |
2004-04-14 |
2023-08-12 |
Not clear |
| C Esposito, B Parilla, A De Mauri, F Cornacchia, G Fasoli, A Foschi, T Mazzullo, A R Plati, R Scudellaro, A Dal Canto. [Hepatocyte growth factor (HGF) reduces the expression of profibrotic factors in human isolated glomeruli]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 20. issue 4. 2004-01-15. PMID:14523898. |
the aim of the present study was to evaluate the effect of hgf on the mrna levels of molecules involved in the extracellular matrix turnover and of the c-met receptor in isolated human glomeruli. |
2004-01-15 |
2023-08-12 |
human |
| Jeng-Bin Huang, Wu-Chang Yang, Ching-Chung Hu, An-Han Yang, Chih-Ching Li. IgA deficiency with membranous glomerulonephritis: a case report and review. Journal of nephrology. vol 16. issue 1. 2003-07-23. PMID:12649548. |
percutaneous renal needle biopsy showed diffuse global thickening and rigidity of glomerular capillary walls, mildly diffuse segmental expansion of mesangial matrix, focal and cortical scar with segmental obsolescence of glomeruli. |
2003-07-23 |
2023-08-12 |
Not clear |
| Akira Yabuki, Syusaku Suzuki, Mitsuharu Matsumoto, Hayao Nishinakagaw. Life span and renal morphological characterization of the SAMP1//Ka mouse. Experimental animals. vol 51. issue 1. 2002-07-29. PMID:11871156. |
at 12 months old, glomerular lesions with expansion of the mesangial matrix and thickening of the basement membrane as well as scar lesions in the outer cortex appeared, and amyloid was deposited in the interstitium or glomeruli from 18 months of age. |
2002-07-29 |
2023-08-12 |
mouse |
| Heinrich M Regele, Edith Fillipovic, Brigitte Langer, Helga Poczewki, Ilse Kraxberger, Reginald E Bittner, Dontscho Kerjaschk. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. Journal of the American Society of Nephrology : JASN. vol 11. issue 3. 2000-03-23. PMID:10703664. |
because the major dg binding partners in the gbm (laminin, agrin, perlecan), and the intracellular dystrophin analogue utrophin are also present in glomeruli, it appears that podocytes adhere to the gbm via dg complexes, similar to muscle fibers in which actin is linked via dystrophin and dg to the extracellular matrix. |
2000-03-23 |
2023-08-12 |
human |
| K Sebeková, J Dämmrich, Z Krivosíková, A Heidlan. The effect of oral protease administration in the rat remnant kidney model. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 199. issue 3. 2000-02-14. PMID:10639701. |
the protein/dna ratio in isolated glomeruli and tubules, as an estimate of glomerular matrix accumulation and hypertrophy of tubules, was enhanced in 5/6 nx groups and a tendency towards lower values was observed after e treatment. |
2000-02-14 |
2023-08-12 |
rat |
| L P Adhikary, T Yamamoto, M Isome, Y Nakano, K Kawasaki, E Yaoita, I Kihar. Expression profile of extracellular matrix and its regulatory proteins during the process of interstitial fibrosis after anti-glomerular basement membrane antibody-induced glomerular sclerosis in Sprague-Dawley rats. Pathology international. vol 49. issue 8. 2000-01-05. PMID:10504539. |
accumulation of fibronectin, collagen type i and type iv was noted in the interstitium by immunofluorescence microscopy in association with enhanced expression of mrna for these ecm components and their regulatory molecules such as matrix metalloproteinase (mmp2), tissue inhibitor of metalloproteinase (timp)-1 and tgf-beta1 both in glomeruli and cortex. |
2000-01-05 |
2023-08-12 |
rat |
| C Mohan, L Morel, P Yang, H Watanabe, B Croker, G Gilkeson, E K Wakelan. Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies. The Journal of clinical investigation. vol 103. issue 12. 1999-07-07. PMID:10377175. |
in contrast to these monocongenics, the present study reveals that b6.nzmc1|c7 mice, bicongenic for sle1 and sle3, exhibit splenomegaly, significantly expanded populations of activated b and cd4(+) t cells, and a robust, variegated igg autoantibody response targeting multiple components of chromatin (including double-stranded dna), intact glomeruli, and basement membrane matrix antigens. |
1999-07-07 |
2023-08-12 |
mouse |
| T Matsumae, S Jimi, N Uesugi, S Takebayashi, S Nait. Clinical and morphometrical interrelationships in patients with overt nephropathy induced by non-insulin-dependent diabetes mellitus. A light- and electron-microscopy study. Nephron. vol 81. issue 1. 1999-03-03. PMID:9884418. |
using standard stereological methods, the glomerular filtration surface area per nephron (s-filt/neph), mesangial volume per glomerulus (v-mes/glom), mesangial matrix volume per glomerulus (v-mm/glom) and the width of the glomerular basement membrane (gbm) were measured in nonoccluded glomeruli. |
1999-03-03 |
2023-08-12 |
Not clear |
| M Yagi, S Kato, T Nishitoba, H Sato, N Kobayashi, N Iinuma, N Nagan. Effects of chitosan-coated dialdehyde cellulose, a newly developed oral adsorbent, on glomerulonephritis induced by anti-Thy-1 antibody in rats. Nephron. vol 78. issue 4. 1998-06-04. PMID:9578070. |
the proliferation of mesangial cells and an accumulation of extracellular matrix components such as type i collagen and fibronectin were observed in the glomeruli 9 days after ox-7 injection; these were improved in rats fed a diet containing chitosan dac (10% content) for 9 days compared with those in rats fed a normal diet. |
1998-06-04 |
2023-08-12 |
rat |
| J P Li, T Akiba, F Marum. Long-term, low-dose, cadmium-induced nephropathy with renal osteopathy in ovariectomized rats. The Journal of toxicological sciences. vol 22. issue 3. 1997-11-24. PMID:9279821. |
sclerosis and collapse of the glomeruli were observed in the cd groups with no proliferation in mesangial cells or matrix. |
1997-11-24 |
2023-08-12 |
rat |