| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shubha S Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian Sd Robert. Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney international. 2024-03-30. PMID:38554992. |
all biopsies were evaluated for glomeruli with segmental capillary occlusion by matrix ("not otherwise specified", nos lesion), simple capsular adhesion without capillary occlusion (adh), tip lesions, and podocyte hypertrophy (ph). |
2024-03-30 |
2024-04-02 |
Not clear |
| Mark P Keller, Chris O'Connor, Markus Bitzer, Kathryn L Schueler, Donald S Stapleton, Christopher H Emfinger, Aimee Teo Broman, Jeffrey B Hodgin, Alan D Atti. Genetic analysis of obesity-induced diabetic nephropathy in BTBR mice. Diabetes. 2023-11-07. PMID:37935024. |
we isolated kidneys from 460 f2 mice and histologically scored them for percent mesangial matrix and glomerular volume (∼50 glomeruli per mouse), yielding ∼45,000 distinct measures in total. |
2023-11-07 |
2023-11-20 |
mouse |
| Yoshihito Nihei, Hitoshi Suzuki, Yusuke Suzuk. Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy. Frontiers in immunology. vol 14. 2023-04-28. PMID:37114051. |
igan is characterized by the deposition of iga and complement c3, often with igg and/or igm, in the glomerular mesangial region, followed by mesangial cell proliferation and excessive synthesis of extracellular matrix in glomeruli. |
2023-04-28 |
2023-08-14 |
Not clear |
| Alexei V Mikhailov, Yixi Liu, Heng-Jie Cheng, Jen-Jar Lin, Che Ping Chen. Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice. Heliyon. vol 8. issue 11. 2022-11-22. PMID:36411910. |
mesangial matrix measurements were performed on trichrome-stained paraffin sections using a trainable segmentation method based on weka (waikato environment for knowledge analysis) image j-fiji plugin (tws plugin), and the electron micrographs of the whole glomeruli stitched from individual 4800x partial glomerular images. |
2022-11-22 |
2023-08-14 |
mouse |
| Hayato Sasaki, Nobuya Sasak. Tensin 2-deficient nephropathy - mechanosensitive nephropathy, genetic susceptibility. Experimental animals. 2022-04-21. PMID:35444113. |
loss of tns2 leads to the development of glomerular basement membrane lesions and abnormal accumulation of extracellular matrix in maturing glomeruli during the early postnatal stages. |
2022-04-21 |
2023-08-13 |
Not clear |
| Shuxia Wan. Role of upstream stimulatory factor 2 in diabetic nephropathy. Frontiers in biology. vol 10. issue 3. 2021-09-30. PMID:26494984. |
importantly, usf2 transgenic (tg) mice demonstrate a specific increase in renal renin expression and angiotensin ii (angii) levels in kidney and exhibit increased urinary albumin excretion and extracellular matrix deposition in glomeruli, supporting a role for usf2 in the development of diabetic nephropathy. |
2021-09-30 |
2023-08-13 |
mouse |
| Boyan Woychyshyn, Joan Papillon, Julie Guillemette, José R Navarro-Betancourt, Andrey V Cybulsk. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice. American journal of physiology. Renal physiology. vol 318. issue 6. 2020-10-07. PMID:32308020. |
glomeruli of adriamycin-treated slk ko mice showed diffuse increases in the matrix and sclerosis as well as collapse of the actin cytoskeleton. |
2020-10-07 |
2023-08-13 |
mouse |
| Manish R Balwani, Vivek B Kute, Pankaj R Shah, Pawan Wakhare, Hargovind L Trived. Secondary renal amyloidosis in a patient of pulmonary tuberculosis and common variable immunodeficiency. Journal of nephropharmacology. vol 4. issue 2. 2020-09-30. PMID:28197481. |
glomeruli showed variable widening of mesangial regions with deposition of periodic schiff stain (pas) pale positive of pink matrix showing apple green birefringence on congo-red staining. |
2020-09-30 |
2023-08-13 |
Not clear |
| Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneu. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 34. issue 4. 2020-01-06. PMID:29931336. |
diabetes elevates nox4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation. |
2020-01-06 |
2023-08-13 |
mouse |
| Hiroyuki Ono, Hideharu Abe, Akiko Sakurai, Arisa Ochi, Tatsuya Tominaga, Masanori Tamaki, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Masayuki Kohashi, Toshio Do. Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30002389. |
extracellular matrix (ecm) protein overexpression and smad1 activation were observed in the glomeruli of db/db mice but were suppressed in the glomeruli of smad3 |
2019-11-25 |
2023-08-13 |
mouse |
| Martin Höhne, Christian K Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M Altintas, Bernhard Schermer, Thomas Reinheckel, Heike Göbel, Jochen Reiser, Tobias B Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C Liebau, Bodo B Beck, Thomas Benzing, Andreas Beyer, Markus M Rinsche. Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney international. vol 93. issue 6. 2018-12-17. PMID:29530281. |
in single glomeruli from two different mouse models of sclerotic glomerular disease, we identified a coherent protein expression module consisting of extracellular matrix protein deposition (reflecting glomerular sclerosis), glomerular albumin (reflecting proteinuria) and lamp1, a lysosomal protein. |
2018-12-17 |
2023-08-13 |
mouse |
| Anika Langenfurth, Song Gu, Verena Bautze, Caiyi Zhang, Julia E Neumann, Ulrich Schüller, Kristin Stock, Susanne A Wolf, Anna-Maria Maier, Giorgia Mastrella, Andrew Pak, Hongwei Cheng, Roland E Kälin, Kenn Holmbeck, Jörg Strotmann, Helmut Kettenmann, Rainer Glas. Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream. Scientific reports. vol 6. 2018-05-16. PMID:27573347. |
we here report that membrane type-1 matrix metalloproteinase (mt1-mmp) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the ob, reduced numbers of olfactory glomeruli and reduced ob-size without alterations in svz neurogenesis. |
2018-05-16 |
2023-08-13 |
mouse |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology. vol 767. 2016-10-05. PMID:26481166. |
recent studies have shown that calcineurin plays a central role in hypertrophy and extracellular matrix (ecm) accumulation in glomeruli at the early stages of diabetic nephropathy. |
2016-10-05 |
2023-08-13 |
rat |
| P Anil Kumar, Gavin I Welsh, Moin A Saleem, Ram K Meno. Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus. Frontiers in endocrinology. vol 5. 2014-10-13. PMID:25309512. |
histological alterations in dm include early hypertrophy of glomerular and tubular components, subsequent thickening of basement membrane in glomeruli and tubules, progressive accumulation of extracellular matrix proteins in the glomerular mesangium and loss of podocytes, together constituting a clinical condition referred to as diabetic nephropathy (dn). |
2014-10-13 |
2023-08-13 |
Not clear |
| Kirankumar Katta, Miriam Boersema, Saritha Adepu, Heleen Rienstra, Johanna W A M Celie, Rik Mencke, Grietje Molema, Harry van Goor, Jo H M Berden, Gerjan Navis, Jan-Luuk Hillebrands, Jacob van den Bor. Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction. The American journal of pathology. vol 183. issue 5. 2014-06-10. PMID:24035513. |
in glomeruli and neointimae of allografts, selective induction of the matrix heparan sulfate proteoglycan perlecan was observed, along with massive accumulation of fibroblast growth factor 2 (fgf2). |
2014-06-10 |
2023-08-12 |
rat |
| Michio Hayashi, Akihiro Tojo, Tatsuo Shimosawa, Toshiro Fujit. The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice. Journal of diabetes research. vol 2013. 2014-01-28. PMID:23957015. |
glomerular mesangial matrix expansion was more severe in the diabetic amko mice than in the diabetic wild mice and exhibited a positive correlation with the degree of lipid peroxidation products in the glomeruli. |
2014-01-28 |
2023-08-12 |
mouse |
| Yetao Wang, Yoshiko Murakami, Teruhito Yasui, Shigeharu Wakana, Hitoshi Kikutani, Taroh Kinoshita, Yusuke Maed. Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity. The Journal of biological chemistry. vol 288. issue 35. 2013-12-10. PMID:23864655. |
we report here that a significant number of aged pgap3(-/-) mice developed autoimmune-like symptoms, such as increased anti-dna antibodies, spontaneous germinal center formation, and enlarged renal glomeruli with deposition of immune complexes and matrix expansion. |
2013-12-10 |
2023-08-12 |
mouse |
| Yi Lin, Makoto Kuro-o, Zhongjie Su. Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology. vol 154. issue 10. 2013-11-25. PMID:23928372. |
klotho deficiency in kl(+/-) mutant mice exacerbated stz-induced increases in urine albumin, blood urea nitrogen, expansion of mesangial matrix in renal glomeruli, and kidney hypertrophy, suggesting a protective role of klotho in kidney function and structure. |
2013-11-25 |
2023-08-12 |
mouse |
| Mohamed A Saleh, Jennifer S Pollock, David M Polloc. Distinct actions of endothelin A-selective versus combined endothelin A/B receptor antagonists in early diabetic kidney disease. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21471190. |
hyperglycemia led to significant proteinuria, increased glomerular permeability to albumin (p(alb)), nephrinuria, and an increase in total matrix metalloprotease (mmp) and transforming growth factor-β1 (tgf-β1) activities in glomeruli. |
2011-08-30 |
2023-08-12 |
rat |
| Toshikazu Araoka, Hideharu Abe, Tatsuya Tominaga, Akira Mima, Takeshi Matsubara, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Toshio Do. Transcription factor 7-like 2 (TCF7L2) regulates activin receptor-like kinase 1 (ALK1)/Smad1 pathway for development of diabetic nephropathy. Molecules and cells. vol 30. issue 3. 2011-05-20. PMID:20803090. |
the inos transgenic mice (inos-tgm), which developed diabetic glomerulosclerosis resembling human diabetic nephropathy, exhibited markedly increased expressions of alk1, tcf7l2, smad1, psmad1, and α-sma in glomeruli in association with mesangial matrix expansion. |
2011-05-20 |
2023-08-12 |
mouse |