| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W G Zhang, Z Li. [The effects of fluoride and dexamethasone on the phenotypic development of osteoblast grown on the demineralized dental root surface] Shanghai kou qiang yi xue = Shanghai journal of stomatology. vol 7. issue 2. 2019-11-20. PMID:15071677. |
[the effects of fluoride and dexamethasone on the phenotypic development of osteoblast grown on the demineralized dental root surface] objective: to investigate the effects of the phenotypic development of osteoblast growing on the periodontitis affected root surface in the condition with fluoride and dexamethasone.methods:cell culture technique in vitro had been used to study the growth condition of mc3t3-e1 osteoblast line on the surf ace of cementum treated with various methods.results:the present study showed that osteoblast treated with fluoride and dexamethasone had a better cellular growth behavior.conclusion: the results demonstrated that demineralization procedure by citric acid might promote the osteoblasts attachment and growth on root surface; and dexamethasone and low dose fluoride were of benefit to maintain the phenotype of osteoblast as well as promote the maturation of bone-like matrix and increase the mineralization formation. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jeong Jin Min, Byung-Seop Shin, Jong-Hwan Lee, Yunseok Jeon, Dae Kyun Ryu, Sojin Kim, Young Hee Shi. Effects of Pravastatin on Type 1 Diabetic Rat Heart with or without Blood Glycemic Control. Journal of diabetes research. vol 2018. 2018-09-26. PMID:29682576. |
cardiac expression of collagen i/iii, matrix metalloproteinase (mmp)-2, mmp-9, and angiotensin-converting enzyme (ace)/ace2 was evaluated by immunohistochemistry and/or western blot. |
2018-09-26 |
2023-08-13 |
rat |
| Jeffrey Yim, Hyokeun Cho, Simon W Rabki. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 40. issue 2. 2018-06-27. PMID:29140729. |
abbreviations inducible nitric oxide synthase (inos), neutrophil cytosolic factor 1 (p47phox), adrenomedullin (adm), atrial natriuretic peptide (anp), osteopontin (opn/spp1), angiotensin converting enzyme (ace), monocyte chemotactic protein 1 (mcp-1), cytochrome b-245 beta polypeptide (gp91phox), intercellular adhesion molecule 1 (icam-1), transforming growth factor beta 1 (tgf-β1), connective tissue growth factor (ctgf), endothelin-1 (et-1), cytochrome b-245, alpha polypeptide (p22phox), endothelin receptor type b (etb/ednrb), brain natriuretic peptide (bnp), endothelin receptor type a (eta/ednra), matrix metallopeptidase 13 (mmp13), type i collagen (col1a1), matrix metallopeptidase 2 (mmp2), timp metallopeptidase inhibitor 1 (timp1), type iii collagen (col3a1), interleukin 1 beta (il-1β), beta myocin heavy chain (β-mhc), endothelin converting enzyme 1 (ece1) matrix metallopeptidase 14 (mmp14), angiotensinogen (agt), angiotensin ii receptor type 1 (at1r), cytochrome c oxidase i (cox1), fms-like tyrosine kinase 1 (flt1), timp metallopeptidase inhibitor 2 (timp2), phospholamban (pln), vascular cell adhesion molecule 1 (vcam1), extracellular matrix (ecm). |
2018-06-27 |
2023-08-13 |
rat |
| Kaizhong Yan, Yixin She. Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28765966. |
additionally, the expression levels of factors associated with osteoclast differentiation (receptor activator of nuclear factor κb ligand and osteoprotegerin), articular cartilage destruction [tumor necrosis factor‑α (tnf‑α) and matrix metalloproteinase 9] and osteoblast differentiation [runt related transcription factor 2 (runx2)], along with ras components (renin, renin‑receptor, angiotensin type 1 receptor (at1r), at2r, angiotensin converting enzyme (ace) and angiotensin ii (ang ii)] were detected in samples from the proximal tibias. |
2018-05-21 |
2023-08-13 |
rat |
| Na Li, Xin-Zhuang Zhang, Yan-Ru Wang, Liang Cao, Gang Ding, Zhen-Zhong Wang, Wei Xiao, Xiao-Jie X. [Mechanism of Tongsaimai tablet for atherosclerosis based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 9. 2018-05-17. PMID:28891622. |
targets network analysis showed that, the active compounds of tongsaimai tablets could regulate inflammation, stabilize plaque, protect vascular endothelial cell, regulate blood lipid and inhibit blood coagulation through acting on the main 22 target proteins, such as toll-like receptors (tlr1, tlr2), matrix metalloproteinase (mmp1, mmp2, mmp3, mmp9), angiotensin converting enzyme (ace), leukotriene a4 hydrolase (lta4-h), 5-lipoxidase (5-lox), peroxisome proliferators-activated receptors (pparα, pparγ). |
2018-05-17 |
2023-08-13 |
Not clear |
| O S Timoshenko, E V Kugaevskaya, T A Gureeva, L E Zavalishina, Yu Yu Andreeva, N I Solovуev. [Matrix metalloproteinases 2 and 9, their endogenous regulators, and angiotensin-converting enzyme in cervical squamous cell carcinoma]. Arkhiv patologii. vol 77. issue 5. 2016-05-26. PMID:26978018. |
to investigate the specific features of the expression of matrix metalloproteinases 2 and 9 (mmp-2, mmp-9), tissue inhibitor of metalloptoteinase 2 (timp-2), urokinase-type plasminogen activator (upa), and angiotensin-converting enzyme (ace) in cervical squamous cell carcinoma (cscc). |
2016-05-26 |
2023-08-13 |
Not clear |
| Ying Liu, Zev Carrey, Wilbert S Aronow, Daruish Alaie, Richard L Petrillo, William H Frishma. The Role of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Postangioplasty Restenosis. American journal of therapeutics. vol 22. issue 4. 2016-04-05. PMID:23782765. |
stimulation of the renin-angiotensin system has been shown to cause vascular smooth muscle migration, matrix deposition, and endothelial dysfunction, which are possible causes of postangioplasty restenosis, suggesting that the use of angiotensin-converting enzyme (ace) inhibitors and/or angiotensin receptor blockers might ameliorate or prevent restenosis. |
2016-04-05 |
2023-08-12 |
human |
| Luciana B Kuntze, Raquel C Antonio, Tatiane C Izidoro-Toledo, Cesar A Meschiari, Jose E Tanus-Santos, Raquel F Gerlac. Captopril and lisinopril only inhibit matrix metalloproteinase-2 (MMP-2) activity at millimolar concentrations. Basic & clinical pharmacology & toxicology. vol 114. issue 3. 2015-09-28. PMID:25767848. |
matrix metalloproteinase-2 (mmp-2) shares structural similarities with the angiotensin-converting enzyme (ace). |
2015-09-28 |
2023-08-13 |
human |
| Robert J Baranello, Krishna L Bharani, Vasudevaraju Padmaraju, Nipun Chopra, Debomoy K Lahiri, Nigel H Greig, Miguel A Pappolla, Kumar Sambamurt. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Current Alzheimer research. vol 12. issue 1. 2015-08-28. PMID:25523424. |
several candidate enzymes, including insulin-degrading enzyme (ide), neprilysin (nep), endothelin-converting enzyme (ece), angiotensin converting enzyme (ace), plasmin, and matrix metalloproteinases (mmps) have been identified and some have even been successfully evaluated in animal models. |
2015-08-28 |
2023-08-13 |
Not clear |
| John S K Kauwe, Matthew H Bailey, Perry G Ridge, Rachel Perry, Mark E Wadsworth, Kaitlyn L Hoyt, Lyndsay A Staley, Celeste M Karch, Oscar Harari, Carlos Cruchaga, Benjamin J Ainscough, Kelly Bales, Eve H Pickering, Sarah Bertelsen, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. PLoS genetics. vol 10. issue 10. 2015-06-30. PMID:25340798. |
we identified genetic associations with csf levels of 5 proteins (angiotensin-converting enzyme (ace), chemokine (c-c motif) ligand 2 (ccl2), chemokine (c-c motif) ligand 4 (ccl4), interleukin 6 receptor (il6r) and matrix metalloproteinase-3 (mmp3)) with study-wide significant p-values (p<1.46×10-10) and significant, consistent evidence for association in both the knight adrc and the adni samples. |
2015-06-30 |
2023-08-13 |
human |
| Conor V Dolan, Johanna M de Kort, Toos C E M van Beijsterveldt, Meike Bartels, Dorret I Boomsm. GE covariance through phenotype to environment transmission: an assessment in longitudinal twin data and application to childhood anxiety. Behavior genetics. vol 44. issue 3. 2015-04-06. PMID:24789102. |
we investigated misspecification, and found that fitting the standard ace simplex to covariance matrices generated by an ae simplex with phenotype to e transmission produces the particular result of a rank 1 c (common environment) covariance matrix with positive transmission, and a rank 1 d (dominance) matrix given negative transmission. |
2015-04-06 |
2023-08-13 |
Not clear |
| Hong Fang, Wei Chen, Yang Gao, Yi Shen, Ming Lu. Molecular mechanisms associated with Angiotensin-converting enzyme-inhibitory peptide activity on vascular extracellular matrix remodeling. Cardiology. vol 127. issue 4. 2014-12-03. PMID:24480854. |
this paper aimed to investigate the molecular mechanisms associated with angiotensin-converting enzyme (ace)-inhibitory peptide activity involved in vascular extracellular matrix (ecm) remodeling. |
2014-12-03 |
2023-08-12 |
Not clear |
| Shinji Takai, Denan Jin, Daisuke Yamamoto, Zhong-Lian Li, Yoshinori Otsuki, Mizuo Miyazak. Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice. Journal of pharmacological sciences. vol 123. issue 2. 2014-05-13. PMID:24096831. |
to clarify the matrix metalloproteinase (mmp)-9 inhibitory effect of an angiotensin-converting enzyme (ace) inhibitor in vivo, we evaluated the effect of an ace inhibitor against elastase-induced abdominal aortic aneurysm (aaa) progression in mice. |
2014-05-13 |
2023-08-12 |
mouse |
| Zohreh Rahimi, Ziba Rahimi, Amir Aghaei, Asad Vaisi-Raygan. AT2R -1332 G:A polymorphism and its interaction with AT1R 1166 A:C, ACE I/D and MMP-9 -1562 C:T polymorphisms: risk factors for susceptibility to preeclampsia. Gene. vol 538. issue 1. 2014-04-11. PMID:24440243. |
also, the interaction of this polymorphism with angiotensin type 1 receptor (at1r) 1166 a:c, angiotensin converting enzyme insertion/deletion (ace i/d) and also with matrix metalloproteinase-9 (mmp-9) -1562 c:t polymorphism was investigated. |
2014-04-11 |
2023-08-12 |
Not clear |
| Joshua A Day, Seth M Cohe. Investigating the selectivity of metalloenzyme inhibitors. Journal of medicinal chemistry. vol 56. issue 20. 2014-03-10. PMID:24074025. |
a panel of metalloenzymes, including carbonic anhydrase (hcaii), several matrix metalloproteinases (mmps), angiotensin converting enzyme (ace), histone deacetylase (hdac-2), and tyrosinase (ty), was selected based on their clinical importance for a range of pathologies. |
2014-03-10 |
2023-08-12 |
Not clear |
| María Gabriela Morales, Daniel Cabrera, Carlos Céspedes, Carlos P Vio, Yaneisi Vazquez, Enrique Brandan, Claudio Cabello-Verrugi. Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2). Cell and tissue research. vol 353. issue 1. 2014-02-11. PMID:23673415. |
the renin-angiotensin system (ras), through angiotensin ii and the angiotensin-converting enzyme (ace), is involved in the genesis and progression of fibrotic diseases characterized by the replacement of normal tissue by an accumulation of an extracellular matrix (ecm). |
2014-02-11 |
2023-08-12 |
mouse |
| Ya-dong Yuan, Ying Zhang, Chang-hong Su. [Association of genetic polymorphisms of angiotensin converting enzyme and matrix metallo proteinase-1 with idiopathic pulmonary fibrosis]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 36. issue 1. 2014-01-09. PMID:23537541. |
to investigate the correlation between angiotensin converting enzyme (ace) and matrix metallo proteinase (mmp)-1 gene polymorphisms and the risk of idiopathic pulmonary fibrosis (ipf) in a han chinese population from hebei province. |
2014-01-09 |
2023-08-12 |
Not clear |
| João Vicente Maggioni Franquni, Andrews Marques do Nascimento, Eweliny Miranda de Lima, Girlândia Alexandre Brasil, Otávio Arruda Heringer, Karla Oliveira Dos Santos Cassaro, Thony Vinicius Pita da Cunha, Carlos Musso, Maria Carmen L F Silva Santos, Ieda Carneiro Kalil, Denise Coutinho Endringer, Giovanna Assis Pereirra Boëchat, Nazaré Souza Bissoli, Tadeu Uggere de Andrad. Nandrolone decanoate determines cardiac remodelling and injury by an imbalance in cardiac inflammatory cytokines and ACE activity, blunting of the Bezold-Jarisch reflex, resulting in the development of hypertension. Steroids. vol 78. issue 3. 2013-07-25. PMID:23287648. |
cardiac inflammatory cytokine levels and angiotensin-converting enzyme (ace) activity were studied as well the biomarker of cardiac lesion, troponin i. deca group showed enhancement of matrix type i collagen deposition (p < 0.01) and cardiac ace activity (p < 0.01) compared with the cont. |
2013-07-25 |
2023-08-12 |
rat |
| Iban Sagardia, Rubén H Roa-Ureta, Carlos Bal. A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides. Food chemistry. vol 136. issue 3-4. 2013-05-17. PMID:23194537. |
due to its good predictive capability, this model could be used as a tool for identifying and prioritizing the potential ace inhibitory peptides present in a complex matrix. |
2013-05-17 |
2023-08-12 |
Not clear |
| Alessandra Bernadete Trovó de Marqu. Genetic polymorphisms and endometriosis: contribution of genes that regulate vascular function and tissue remodeling. Revista da Associacao Medica Brasileira (1992). vol 58. issue 5. 2013-05-07. PMID:23090236. |
this review presents a detailed description of the contribution of genetic polymorphisms in genes that regulate vascular function and tissue remodeling in endometriosis (alpha 2-hs glycoprotein [ahsg], epidermal growth factor receptor [egfr], vascular endothelial growth factor [vegf], endostatin, plasminogen activator inhibitor 1 [pai-1], angiotensin i-converting enzyme [ace], and matrix metalloproteinases [mmps]). |
2013-05-07 |
2023-08-12 |
Not clear |