| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Faulkner, Gitte M Knudsen, Vibe G Frokjaer, David Erritzo. Cigarette Smoking is Associated with Levels of the Serotonin Transporter in the Brain: A [11C]DASB PET Study. The international journal of neuropsychopharmacology. 2025-04-21. PMID:40258113. |
preclinical work suggests that chronic nicotine/tobacco use is associated with reductions in serotonin within the hippocampus, yet no research has yet shown an association of smoking behaviours and alterations in brain serotonin in humans in vivo. |
2025-04-21 |
2025-04-24 |
Not clear |
| Meng Xu, Wanggao Li, Xiaosong Hu, Jiachao Zhan. Arecoline Alleviates Depression via Gut-Brain Axis Modulation, Neurotransmitter Balance, Neuroplasticity Enhancement, and Inflammation Reduction in CUMS Mice. Journal of agricultural and food chemistry. 2025-04-21. PMID:40257350. |
mechanistically, arecoline restored serotonin and norepinephrine levels in the brain and serum, reduced pro-inflammatory markers such as il-1β and lps in both serum and colon, and enhanced hippocampal neuroplasticity through increased bdnf and psd-95 expression. |
2025-04-21 |
2025-04-23 |
mouse |
| Haitham S Mohammed, Dalia H Ahmed, Yasser A Khadrawy, Noha G Madia. Neuroprotection in pentylenetetrazol kindling rat model: A synergistic approach with eugenol and photobiomodulation. Brain research. 2025-04-14. PMID:40228569. |
the study also evaluated cortical and hippocampal levels of brain-derived neurotrophic factor (bdnf), oxidative stress markers (mda, no, and gsh), activities of acetylcholinesterase (ache) and na + k + -atpase, and monoamine neurotransmitters (da, 5-ht, and ne). |
2025-04-14 |
2025-04-17 |
rat |
| Hager Adel Saad, Mahmoud Marzouk, Hla Abdelrahman, Nasrollah Moradiko. Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications. Progress in brain research. vol 291. 2025-04-13. PMID:40222781. |
this dysregulation is linked to persistent neuroinflammation, oxidative stress, and neurotransmitter imbalances involving dopamine and serotonin, impairing neuroplasticity and leading to structural changes in critical brain areas, such as the hippocampus and prefrontal cortex. |
2025-04-13 |
2025-04-16 |
Not clear |
| Zhitao Hou, Jindi Ma, Xian Zhang, Liying Song, Yan Li, Xiaochen Song, Xinying Hu, Dongdong Li, Changyuan He, Yuefeng Sun, Hongbo Cai, Jing Che. Electroacupuncture's Impact on the Hippocampal RAGE/LRP1 Receptor System in SAMP8 Mice. Advanced biology. 2025-04-08. PMID:40195915. |
ea at zusanli (st36) and baihui (gv20) improved cognitive performance, reduced hippocampal neuronal degeneration, elevated cerebrospinal fluid dopamine, norepinephrine, serotonin, and 5-hydroxyindoleacetic acid, and decreased aβ42 levels. |
2025-04-08 |
2025-04-10 |
mouse |
| Han Wang, Ji-Tao Li, De-Nong Liu, Xian-Qiang Zhang, Meng Sun, Chen-Chen Zhang, Tian-Mei Si, Yun-Ai S. Environmental enrichment improves deficits in hippocampal neuroplasticity and cognition in prenatally aripiprazole-exposed mouse offspring. Translational psychiatry. vol 15. issue 1. 2025-03-28. PMID:40148276. |
in addition, lower concentrations of dopamine and higher concentrations of serotonin in the hippocampus were detected in aripiprazole-exposed mice via hplc with electrochemical detection. |
2025-03-28 |
2025-03-30 |
mouse |
| Han Wang, Ji-Tao Li, De-Nong Liu, Xian-Qiang Zhang, Meng Sun, Chen-Chen Zhang, Tian-Mei Si, Yun-Ai S. Environmental enrichment improves deficits in hippocampal neuroplasticity and cognition in prenatally aripiprazole-exposed mouse offspring. Translational psychiatry. vol 15. issue 1. 2025-03-28. PMID:40148276. |
our results provide insight into the long-term negative effects of early-life exposure to aripiprazole on hippocampal plasticity and behavior, which may be related to disturbances in the dopamine and serotonin transmitter systems. |
2025-03-28 |
2025-03-30 |
mouse |
| Xiaolin Fan, Hong Wang, Xiaoqiang Lv, Qi Wang, Boya Yu, Xiao Li, Liang Li, Yuhao Zhang, Ning Ma, Qing Lu, Airong Qian, Junhong Ga. The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury. Brain sciences. vol 15. issue 3. 2025-03-28. PMID:40149758. |
the pcreb/bdnf pathway in the hippocampus is involved in the therapeutic effect of selective 5-ht reuptake inhibitors in adult male rats exposed to blast traumatic brain injury. |
2025-03-28 |
2025-03-30 |
rat |
| Xiaolin Fan, Hong Wang, Xiaoqiang Lv, Qi Wang, Boya Yu, Xiao Li, Liang Li, Yuhao Zhang, Ning Ma, Qing Lu, Airong Qian, Junhong Ga. The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury. Brain sciences. vol 15. issue 3. 2025-03-28. PMID:40149758. |
ssris have been shown to significantly alleviate depression-like behaviors in animal models of traumatic brain injury (tbi) by increasing serotonin (5-ht) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2025-03-28 |
2025-03-30 |
rat |
| Yi-Wei Hu, Jian Liu, Zi-Han Qiu, Xiao-Ying Li, Juan Li, Li Chen, Tao Wang, Xin-Feng Wang, Zhong-Jie Feng, Wan-Ting Bai, Yuan Guo, Li Zhan. Effects of astrocytes in the dorsal hippocampus on anxiety-like and depressive-like behaviors in hemiparkinsonian rats. Behavioural brain research. 2025-03-27. PMID:40147794. |
chemogenetic activation of dhipp as only decreased da level in the ventral hippocampus (vhipp) in sham-operated rats, while inhibition of dhipp as increased 5-hydroxytryptamine (5-ht) levels in the medial prefrontal cortex (mpfc) and vhipp in sham-operated rats and also in the amygdala, mpfc, lateral habenula, dhipp and vhipp in the lesioned rats. |
2025-03-27 |
2025-03-30 |
rat |
| Yanqin Luo, Ning Jiang, Yiwen Zhang, Yongzhi Zhao, Fang Chen, Xueyan Li, Meng Qiang, Guirong Zeng, Qinghu He, Xinmin Liu, Chunhui Sha. Chronic unpredictable mild stress induces anxiety-like behavior in female C57BL/6N mice, accompanied by alterations in inflammation and the kynurenine pathway of tryptophan metabolism. Frontiers in neuroscience. vol 19. 2025-03-13. PMID:40078708. |
regarding tryptophan metabolism, after 3-4 weeks of cums, serotonin (5-ht) levels in the hippocampus of the mice began to decrease. |
2025-03-13 |
2025-03-15 |
mouse |
| Yan Yan, Ni Zhao, Jiaying Liu, Shengmei Zhang, Yinjie Zhang, Xuemei Qin, Kefeng Zhai, Chenhui D. Ziziphi Spinosae Semen Flavonoid Ameliorates Hypothalamic Metabolism and Modulates Gut Microbiota in Chronic Restraint Stress-Induced Anxiety-like Behavior in Mice. Foods (Basel, Switzerland). vol 14. issue 5. 2025-03-13. PMID:40077533. |
zssf was prepared using microporous resin chromatography, and seven compounds were determined by uplc-ms. zssf treatment dramatically reduced anxiety-like behaviors, exerted sedative-hypnotic effects, increased hippocampal 5-ht and 5-htp, and enhanced intestinal barrier function through inhibiting colon zo-1, claudin-1, and occludin expression and reducing tnf-α, il-6, and il-1β levels. |
2025-03-13 |
2025-03-15 |
mouse |
| Sanghoon Kim, Edward Pajarillo, Alexis Digman, Itunu Ajayi, Deok-Soo Son, Michael Aschner, Eunsook Le. Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice. Neurotoxicology. 2025-03-08. PMID:40057281. |
neurotransmitters, including da, serotonin (5-ht), norepinephrine (ne), and glutamate, were analyzed in different brain regions, such as the striatum, midbrain, cortex, hippocampus, and cerebellum. |
2025-03-08 |
2025-03-12 |
mouse |
| Ali Azargoonjahrom. Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment. Brain imaging and behavior. 2025-03-04. PMID:40035916. |
tryptophan has been shown to improve cognitive functions, but whether these benefits emanate from changes in hippocampal structure or other mechanisms like enhanced serotonin pathways remains unclear. |
2025-03-04 |
2025-03-06 |
Not clear |
| Yanqin Luo, Yiwen Zhang, Yongzhi Zhao, Fang Chen, Xueyan Li, Xinmin Liu, Muhammad Zulqarnain Shakir, Ning Jiang, Chunhui Sha. Chronic Unpredictable Mild Stress-Induced Anxiety is Linked to Inflammatory Responses and Disruptions in Tryptophan Metabolism in Male C57BL/6N Mice. Behavioural brain research. 2025-02-25. PMID:39999912. |
in terms of tryptophan metabolism, 5-ht content in the hippocampus of the mice began to decrease after 3 weeks of cums, while the levels of neuroprotective kynurenic acid (kyna) continued to rise. |
2025-02-25 |
2025-02-28 |
mouse |
| Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Veronica Ghiglieri, Paolo Calabres. Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease. Current neuropharmacology. 2025-02-24. PMID:39988779. |
since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-ht) and dopamine (da) transmission is essential for regulating synaptic plasticity in the striatum (str), prefrontal cortex (pfc), and hippocampus (hpc).. |
2025-02-24 |
2025-02-26 |
Not clear |
| Naozumi Araragi, Markus Petermann, Mototaka Suzuki, Matthew Larkum, Valentina Mosienko, Michael Bader, Natalia Alenina, Friederike Klempi. Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of Mice. ACS chemical neuroscience. 2025-02-12. PMID:39937171. |
the dentate gyrus of the hippocampus is targeted by axons from serotonin raphe neurons, where the neurotransmitter modulates adult neurogenesis and antidepressant action, and mediates the neurogenic effect of running. |
2025-02-12 |
2025-02-14 |
mouse |
| Havizur Rahman, Kusnandar Anggadiredja, Lucy Sasongk. Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis. Toxicology reports. vol 14. 2025-02-06. PMID:39911318. |
the mechanism studies revealed significant correlation between spt vs. serotonin in the hippocampus, and spt vs. serotonin, cortisol, nf-κb in the prefrontal cortex. |
2025-02-06 |
2025-02-08 |
rat |
| Havizur Rahman, Kusnandar Anggadiredja, Lucy Sasongk. Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis. Toxicology reports. vol 14. 2025-02-06. PMID:39911318. |
meanwhile, fst was significantly correlated with serotonin in the hippocampus and the prefrontal cortex, while in the prefrontal cortex it was significantly correlated with cortisol, nf-κb, and il-6. |
2025-02-06 |
2025-02-08 |
rat |
| Havizur Rahman, Kusnandar Anggadiredja, Lucy Sasongk. Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis. Toxicology reports. vol 14. 2025-02-06. PMID:39911318. |
based on the afore-mentioned results, it was found that lactulose improved fst by targeting serotonin in the hippocampus. |
2025-02-06 |
2025-02-08 |
rat |