| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Christina Alves Peixot. Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-07-23. PMID:39042202. |
our data also showed that semaglutide increased the serotonin (5-ht) and serotonin transporter (5-htt) and glutamatergic receptors in the hippocampus. |
2024-07-23 |
2024-07-25 |
mouse |
| Allison K Warner, Lauren Iskander, Kristen Allen, Isabella Quatela, Hannah Borrelli, Benjamin D Sach. The Effects of Brain Serotonin Deficiency on the Behavioral and Neurogenesis-Promoting Effects of Voluntary Exercise in Tryptophan Hydroxylase 2 (R439H) Knock-in Mice. Neuropharmacology. 2024-07-15. PMID:39009217. |
one neurotransmitter that has been implicated in both antidepressant-like effects and the regulation of hippocampal neurogenesis is serotonin (5-ht). |
2024-07-15 |
2024-07-18 |
mouse |
| Allison K Warner, Lauren Iskander, Kristen Allen, Isabella Quatela, Hannah Borrelli, Benjamin D Sach. The Effects of Brain Serotonin Deficiency on the Behavioral and Neurogenesis-Promoting Effects of Voluntary Exercise in Tryptophan Hydroxylase 2 (R439H) Knock-in Mice. Neuropharmacology. 2024-07-15. PMID:39009217. |
however, genetic reductions in 5-ht synthesis did not significantly impact exercise-induced alterations in cellular proliferation or immature neuron production in the hippocampus in either sex. |
2024-07-15 |
2024-07-18 |
mouse |
| Liesl Maria Fernandes E Mendonça, Arun Bhimrao Joshi, Anant Bhandarkar, Shamshad Shaikh, Samantha Fernandes, Himanshu Joshi, Shrinivas Josh. Potential anxiolytic therapeutics from Hybanthus enneaspermus (L.) F. Muell. - mitigate anxiety by plausibly modulating the GABA Neurochemistry international. 2024-07-13. PMID:39002759. |
monoamines (serotonin, noradrenaline, dopamine), gamma-aminobutyric acid (gaba), and glutamate were quantified in the different regions of rats' brain (cortex, hippocampus, pons, medulla oblongata, cerebellum). |
2024-07-13 |
2024-07-16 |
rat |
| Aldo R Tejeda-Martínez, Ana R Ramos-Molina, Patricia A Brand-Rubalcava, Mario E Flores-Sot. Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review. Medicine. vol 103. issue 28. 2024-07-12. PMID:38996114. |
disorders such as anxiety, depression, schizophrenia, epilepsy, sexual disorders, and eating disorders, have been closely linked to variations in 5-ht concentrations and modifications in brain structures, including the raphe nuclei (rn), prefrontal cortex, basal ganglia, hippocampus, and hypothalamus, among others. |
2024-07-12 |
2024-07-15 |
Not clear |
| B Boamah, C Morse, S Siciliano, N Hogan, M Hecker, M Hanson, P Campbell, R Peters, A N Al-Dissi, T D Olver, L Webe. Impaired memory in Sprague-Dawley rats exposed to complex groundwater mixtures of contaminants is associated with reduced cranial blood flow and hippocampal neurotoxicity. Neurotoxicology. 2024-07-11. PMID:38992737. |
a significant reduction in hippocampal serotonin levels was observed in groundwater-exposed rats relative to that in the control group. |
2024-07-11 |
2024-07-14 |
rat |
| Earric Lee, Tuuli A Nissinen, Laura Ylä-Outinen, Aaro Jalkanen, Jari E Karppinen, Victoria Jeanne Vieira-Potter, Arto Lipponen, Sira Karvine. Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise. Frontiers in neuroscience. vol 18. 2024-07-10. PMID:38983274. |
estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise. |
2024-07-10 |
2024-07-12 |
Not clear |
| Yunkwon Nam, Sujin Kim, Yong Ho Park, Byeong-Hyeon Kim, Soo Jung Shin, Seol Hwa Leem, Hyun Ha Park, Gukhwa Jung, Jeongbeen Lee, Hyung-Gun Kim, Doo-Han Yoo, Hak Su Kim, Minho Moo. Investigating the impact of environmental enrichment on proteome and neurotransmitter-related profiles in an animal model of Alzheimer's disease. Aging cell. 2024-07-02. PMID:38952076. |
furthermore, neurotransmitter-related analyses showed an increase in acetylcholine and serotonin concentrations as well as a decrease in polyamine concentration in the frontal cortex and hippocampus of 5xfad mice raised under ee conditions. |
2024-07-02 |
2024-07-04 |
mouse |
| Xingfang Zhang, Yajun Qiao, Mengyuan Wang, Xinxin Liang, Lixin Wei, Ming Zhang, Hongtao Bi, Tingting Ga. Study of the immune disorder and metabolic dysregulation underlying mental abnormalities caused by exposure to narrow confined spaces. Brain research. 2024-06-30. PMID:38945470. |
we measured lower hippocampal brain-derived neurotrophic factor levels and cortical monoamine neurotransmitters (5-ht and ne) in the stressed group. |
2024-06-30 |
2024-07-03 |
mouse |
| Nian-Sheng Tzeng, Jing-Yi Chung, Chen-Cheng Lin, Pao-Yun Cheng, Yia-Ping Li. Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related Depression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931384. |
tissue levels of serotonin (5-ht) and its metabolite 5-hiaa were measured in the hippocampus, the amygdala, and the prefrontal cortex. |
2024-06-27 |
2024-06-29 |
rat |
| Nian-Sheng Tzeng, Jing-Yi Chung, Chen-Cheng Lin, Pao-Yun Cheng, Yia-Ping Li. Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related Depression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931384. |
efflux levels of 5-ht, dopamine (da), and norepinephrine (ne) were detected in the hippocampus by brain dialysis. |
2024-06-27 |
2024-06-29 |
rat |
| Nian-Sheng Tzeng, Jing-Yi Chung, Chen-Cheng Lin, Pao-Yun Cheng, Yia-Ping Li. Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related Depression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931384. |
our results showed (i) increased immobility time in the fst for the ir rats as compared to the social controls, which could not be reversed by the buspirone administration; (ii) ir-induced fst immobility in rats receiving buspirone was corrected by the 8-oh-dpat; and (iii) ir-induced reduction in hippocampal 5-ht levels can be reversed by the buspirone administration. |
2024-06-27 |
2024-06-29 |
rat |
| Xiaolei Yang, Hongjie Li, Chao Yang, Jie G. Supplementation with stigma maydis polysaccharide attenuates autism-like behaviors and improves gut function in valproic acid-induced autism model male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-06-26. PMID:38923604. |
furthermore, the expression levels of neurotransmitters (substance p, enkephalin, vasoactive intestinal peptide, and 5-hydroxytryptamine) in the hippocampal tissues were altered after smps treatment. |
2024-06-26 |
2024-06-29 |
rat |
| Mengyu Zhang, Xin Qian, Ziwei Wei, Kai Chen, Hongqun Ding, Junhai Jia, Ying Li, Siyu Liu, Kun Yang, Jia Wang, Huanxin Chen, Weining Zhan. Micro-infusion of 5-HT1a receptor antagonists into the ventral subiculum ameliorate MK-801 induced schizophrenia-like behavior in rats. Neuroscience. 2024-06-23. PMID:38909674. |
recent studies have shown that the 5-ht1a receptor (5-ht1ar) in the central 5-ht (serotonergic) system is involved in the pathophysiology of schizophrenia through its various receptors, and the dysfunction of the ventral hippocampus may be a key causative factor in schizophrenia. |
2024-06-23 |
2024-06-26 |
rat |
| Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Francis-Oliveira, Emily Cruvinel, Thainá Soares Franchin, Tania Marcourakis, Henning Ulrich, Roberto De Pasqual. Serotonergic Neuromodulation of Synaptic Plasticity. Neuropharmacology. 2024-06-14. PMID:38876308. |
through a comparative analysis across three main forebrain structures-the hippocampus, amygdala, and prefrontal cortex, this review discusses the actions of 5-ht on synaptic plasticity, offering insights into its role as a neuromodulator involved in emotional and cognitive functions. |
2024-06-14 |
2024-06-17 |
Not clear |
| Walaa G Abdelhamid, Noha A Mowaad, Gihan F Asaad, Asmaa F Galal, Sarah S Mohammed, Olfat E Mostafa, Doaa R Sadek, Lobna A Elkhate. The potential protective effect of Camellia Sinensis in mitigating monosodium glutamate-induced neurotoxicity: biochemical and histological study in male albino rats. Metabolic brain disease. 2024-06-13. PMID:38869783. |
msg administration resulted in significant neurotoxicity in rats that was revealed by the significant reduction of serum concentration of glutathione peroxidase (gpx) and nitric oxide (no), and the significant elevation of total antioxidant capacity (tac) accompanied by the significant reduction of levels of serum monoamines (dopamine, serotonin, and norepinephrine) and histological changes in the hippocampus area ca1, dentate gyrus, and cerebellar cortex and positive immunohistochemical staining of glial fibrillary acidic proteins (gfap) and calretinin. |
2024-06-13 |
2024-06-15 |
rat |
| Salma A El-Marasy, Mona M AbouSamra, Passant E Moustafa, Hoda B Mabrok, Omar A Ahmed-Farid, Asmaa F Galal, Hadir Farou. Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway. Scientific reports. vol 14. issue 1. 2024-06-12. PMID:38866877. |
they also reduced cortical and hippocampal 5-hydroxyindoeacetic acid, 3,4-dihydroxy-phenylacetic acid, malondialdehyde, nlr family pyrin domain containing-3 (nlrp3) and interleukin-1beta content while raised serotonin, nor-epinephrine, dopamine and glutathione level. |
2024-06-12 |
2024-06-15 |
rat |
| Sergio Mena, Allison Cruikshank, Janet Best, H F Nijhout, Michael C Reed, Parastoo Hashem. Modulation of serotonin transporter expression by escitalopram under inflammation. Communications biology. vol 7. issue 1. 2024-06-08. PMID:38851804. |
in this work, we create a theoretical hippocampal model incorporating escitalopram's pharmacokinetics, pharmacodynamics (competitive and non-competitive inhibition, and serotonin transporter (sert) internalization), inflammation, and receptor dynamics. |
2024-06-08 |
2024-06-11 |
mouse |
| Xiaofei Xu, Jingde Li, Mingjun Liu, Baoyan Zhan. Neuroprotective effect of Marrubiin against MPTP induced experimental Parkinson's disease in Male Wistar Rats. Toxicology mechanisms and methods. 2024-06-07. PMID:38847585. |
after marrubiin treatment, rats were trained, and tested for behavioral analyses like cognitive performance, open field test, rotarod test, grip strength test, beam walking test, the status of body weight, and striatal levels of neurotransmitters like dopamine, norepinephrine, serotonin, dopac, homovanillic acid, 5-hydroxy indole acetic acid, the status of oxidative stress markers like lpo, protein carbonyl content (pcc), xanthine oxidase (xo), and status of antioxidant enzyme levels like sod, cat, gpx in the striatum and hippocampal tissues, status of neuroinflammatory markers like tnf-α, il1β, il-6, and status of histological architecture in brain striatum were also analyzed. |
2024-06-07 |
2024-06-10 |
rat |
| Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Ha. Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice. Pakistan journal of pharmaceutical sciences. vol 37. issue 2(Special). 2024-06-01. PMID:38822547. |
the levels of dopamine, 5-hydroxytryptamine and the expression of postsynaptic density protein 95, brain-derived neurotrophic factor in hippocampus were assayed. |
2024-06-01 |
2024-06-03 |
mouse |