All Relations between hippocampus and serotonin

Publication Sentence Publish Date Extraction Date Species
Walaa G Abdelhamid, Noha A Mowaad, Gihan F Asaad, Asmaa F Galal, Sarah S Mohammed, Olfat E Mostafa, Doaa R Sadek, Lobna A Elkhate. The potential protective effect of Camellia Sinensis in mitigating monosodium glutamate-induced neurotoxicity: biochemical and histological study in male albino rats. Metabolic brain disease. 2024-06-13. PMID:38869783. msg administration resulted in significant neurotoxicity in rats that was revealed by the significant reduction of serum concentration of glutathione peroxidase (gpx) and nitric oxide (no), and the significant elevation of total antioxidant capacity (tac) accompanied by the significant reduction of levels of serum monoamines (dopamine, serotonin, and norepinephrine) and histological changes in the hippocampus area ca1, dentate gyrus, and cerebellar cortex and positive immunohistochemical staining of glial fibrillary acidic proteins (gfap) and calretinin. 2024-06-13 2024-06-15 rat
Salma A El-Marasy, Mona M AbouSamra, Passant E Moustafa, Hoda B Mabrok, Omar A Ahmed-Farid, Asmaa F Galal, Hadir Farou. Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway. Scientific reports. vol 14. issue 1. 2024-06-12. PMID:38866877. they also reduced cortical and hippocampal 5-hydroxyindoeacetic acid, 3,4-dihydroxy-phenylacetic acid, malondialdehyde, nlr family pyrin domain containing-3 (nlrp3) and interleukin-1beta content while raised serotonin, nor-epinephrine, dopamine and glutathione level. 2024-06-12 2024-06-15 rat
Sergio Mena, Allison Cruikshank, Janet Best, H F Nijhout, Michael C Reed, Parastoo Hashem. Modulation of serotonin transporter expression by escitalopram under inflammation. Communications biology. vol 7. issue 1. 2024-06-08. PMID:38851804. in this work, we create a theoretical hippocampal model incorporating escitalopram's pharmacokinetics, pharmacodynamics (competitive and non-competitive inhibition, and serotonin transporter (sert) internalization), inflammation, and receptor dynamics. 2024-06-08 2024-06-11 mouse
Xiaofei Xu, Jingde Li, Mingjun Liu, Baoyan Zhan. Neuroprotective effect of Marrubiin against MPTP induced experimental Parkinson's disease in Male Wistar Rats. Toxicology mechanisms and methods. 2024-06-07. PMID:38847585. after marrubiin treatment, rats were trained, and tested for behavioral analyses like cognitive performance, open field test, rotarod test, grip strength test, beam walking test, the status of body weight, and striatal levels of neurotransmitters like dopamine, norepinephrine, serotonin, dopac, homovanillic acid, 5-hydroxy indole acetic acid, the status of oxidative stress markers like lpo, protein carbonyl content (pcc), xanthine oxidase (xo), and status of antioxidant enzyme levels like sod, cat, gpx in the striatum and hippocampal tissues, status of neuroinflammatory markers like tnf-α, il1β, il-6, and status of histological architecture in brain striatum were also analyzed. 2024-06-07 2024-06-10 rat
Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Ha. Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice. Pakistan journal of pharmaceutical sciences. vol 37. issue 2(Special). 2024-06-01. PMID:38822547. the levels of dopamine, 5-hydroxytryptamine and the expression of postsynaptic density protein 95, brain-derived neurotrophic factor in hippocampus were assayed. 2024-06-01 2024-06-03 mouse
Huilin Zhang, Xiaohan Zhang, Xue Jia, Wei Zheng, Jie He, Zhenhua Wang, Tian Wang, Bing Ha. Hydroxysafflor yellow A ameliorates depression-like behavior in Parkinson's disease mice. Pakistan journal of pharmaceutical sciences. vol 37. issue 2(Special). 2024-06-01. PMID:38822547. hydroxysafflor yellow a attenuated the injury of nerve and elevated contents of dopamine, 5-hydroxytryptamine in hippocampus. 2024-06-01 2024-06-03 mouse
Rida Nisar, Aimen Inamullah, Asad Ullah Faiz Ghalib, Hareem Nisar, Alireza Sarkaki, Asia Afzal, Maryam Tariq, Zehra Batool, Saida Haide. Geraniol mitigates anxiety-like behaviors in rats by reducing oxidative stress, repairing impaired hippocampal neurotransmission, and normalizing brain cortical-EEG wave patterns after a single electric foot-shock exposure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-05-25. PMID:38795639. however, the treatment with geraniol and diazepam normalized cortical-eeg wave pattern and hippocampal serotonin and catecholamines profile which was also reflected by reduced anxious behavior and normalized antioxidant levels. 2024-05-25 2024-05-31 rat
Anri Hirai, Chitoku Toda, Yared Beyene Yohannes, Nimako Collins, Mai Tamba, Kei Nomiyama, Akifumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenak. Role of brain monoamines in acetamiprid-induced anxiety-like behavior. Toxicology. 2024-05-23. PMID:38782113. further, significant correlations were found between behavioral test results and hippocampal serotonin and striatal dopamine concentrations, as well as between dopamine and serotonin concentrations, in the exposed group. 2024-05-23 2024-05-27 mouse
Anri Hirai, Chitoku Toda, Yared Beyene Yohannes, Nimako Collins, Mai Tamba, Kei Nomiyama, Akifumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenak. Role of brain monoamines in acetamiprid-induced anxiety-like behavior. Toxicology. 2024-05-23. PMID:38782113. taken together, these results suggest that ace regulates ma levels, notably serotonin levels in the hippocampus and that rn plays an important role in ace-induced anxiety-like behavior. 2024-05-23 2024-05-27 mouse
Maurizio S Riga, Mercedes Pérez-Fernández, Lluis Miquel-Rio, Verónica Paz, Leticia Campa, Magdalena Martínez-Losa, Francisco J Esteban, Luis F Callado, Javier Meana, Francesc Artigas, Analía Bortolozzi, Manuel Álvarez-Dolad. Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype. Brain : a journal of neurology. 2024-05-20. PMID:38769595. additionally, it reduced extracellular serotonin concentration in the dorsal raphe nucleus and brain-derived neurotrophic factor expression in the hippocampus, two mdd-related brain areas beyond the pfc. 2024-05-20 2024-05-27 mouse
D Hen-Shoval, T Indig-Naimer, L Moshe, N M Kogan, H Zaidan, I Gaisler-Salomon, E Okun, R Mechoulam, G Shoval, G Zalsman, A Welle. Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression. Journal of psychiatric research. vol 175. 2024-05-05. PMID:38704981. the behavioral impact in wky rats coincided with reduced corticosterone serum levels, upregulated mrna expression of cannabinoid receptor 1, fatty acid amide hydrolase, and corticotropin-releasing hormone receptor 1, alongside downregulation of the serotonin transporter in the hippocampus. 2024-05-05 2024-05-08 rat
Sarah A Elfakharany, Samir S Eskaros, Nesrine M El Azhary, Doaa A Abdelmonsif, Teshreen M Zeitoun, Gamal A G Ammar, Youssef A Hate. Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress. Molecular neurobiology. 2024-05-04. PMID:38703343. prefrontal cortical and hippocampal serotonin levels, oxidative stress markers including malondialdehyde (mda), reduced glutathione (gsh) and glutathione peroxidase (gpx), tumor necrosis factor alpha (tnf-α) and caspase-3 were assessed. 2024-05-04 2024-05-07 rat
Sarah A Elfakharany, Samir S Eskaros, Nesrine M El Azhary, Doaa A Abdelmonsif, Teshreen M Zeitoun, Gamal A G Ammar, Youssef A Hate. Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress. Molecular neurobiology. 2024-05-04. PMID:38703343. the present study exhibited the neuroprotective role of senps in rats subjected to crs and proposed their antioxidant, anti-inflammatory and anti-apoptotic effects as the possible mechanism for increased prefrontal cortical and hippocampal serotonin level, ameliorated anxiety-like and depressive-like behaviors and improved prefrontal cortical and hippocampal histological architecture. 2024-05-04 2024-05-07 rat
Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. 2024-05-04 2024-05-07 mouse
Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkon. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behavioural brain research. 2024-04-30. PMID:38688411. in addition, stressed mice showed lower levels of tyrosine, dopamine, dopac, mhpg, kynurenine, kynurenic acid, and 5-hiaa levels but higher serotonin levels in the prefrontal cortex, not in the hippocampus. 2024-04-30 2024-05-03 mouse
Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. analysis of hippocampal transcriptomics suggested that hfpo-ta exposure would impair 5-ht generation and metabolic pathways. 2024-04-25 2024-04-28 mouse
Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. in keeping with this prediction, our findings confirmed that the levels of several neurotransmitters, including tryptophan (trp), 5-ht, 5-htp, and 5-hiaa, were all impaired by hfpo-ta exposure in the serum, colon, and hippocampus, as was the colonic and hippocampal expression of trp and 5-ht metabolism-related genes such as sert, mao-a, and ido. 2024-04-25 2024-04-28 mouse
Yan-Jia Luo, Hechen Bao, Andrew Crowther, Ya-Dong Li, Ze-Ka Chen, Dalton S Tart, Brent Asrican, Libo Zhang, Juan Son. Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. Cell reports. vol 43. issue 5. 2024-04-24. PMID:38656873. sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. 2024-04-24 2024-04-28 mouse
Su-Ting Jiang, Shu-Ying Lian, Yao-Huan Sun, Mei-Bo Pan, Bin Wang, Hui Wang, Jun Hua, Yi-Chen Wang, Qiu-Ling Wang, Yin-Feng Don. The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice. Experimental gerontology. 2024-04-13. PMID:38614224. pair housing increased hippocampal serotonin (5-ht), but treatment with l368,889 had no significant impact. 2024-04-13 2024-04-16 mouse
Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. whereas brain tissue levels of 5-ht and/or its metabolite 5-hiaa tended to decrease during continuous paroxetine, levels increased above controls after discontinuation, notably in hippocampus. 2024-04-12 2024-04-15 mouse