| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregorio Segovia, Almudena G Yagüe, José M García-Verdugo, Francisco Mor. Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750477. |
after the housing period, rats were stereotaxically implanted with guide-cannulas to accommodate microdialysis probes in the ca3 area of the hippocampus and the extracellular concentrations of glutamate and gaba were determined. |
2006-09-05 |
2023-08-12 |
rat |
| Gregorio Segovia, Almudena G Yagüe, José M García-Verdugo, Francisco Mor. Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750477. |
these results suggest that enriched housing conditions change both neurogenesis in the dentate gyrus and glutamate and gaba levels in the ca3 area of the hippocampus of aged rats. |
2006-09-05 |
2023-08-12 |
rat |
| Cheng Xiao, Yan Gu, Chun-Yi Zhou, Lang Wang, Min-Min Zhang, Di-Yun Rua. Pb2+ impairs GABAergic synaptic transmission in rat hippocampal slices: a possible involvement of presynaptic calcium channels. Brain research. vol 1088. issue 1. 2006-08-25. PMID:16630593. |
in the present study, we examined the effects of pb2+ on gaba(a)-receptor-mediated inhibitory postsynaptic currents (ipscs), recorded on ca1 pyramidal neurons in rat hippocampal slices, using whole-cell patch clamp recording. |
2006-08-25 |
2023-08-12 |
rat |
| Cheng Xiao, Yan Gu, Chun-Yi Zhou, Lang Wang, Min-Min Zhang, Di-Yun Rua. Pb2+ impairs GABAergic synaptic transmission in rat hippocampal slices: a possible involvement of presynaptic calcium channels. Brain research. vol 1088. issue 1. 2006-08-25. PMID:16630593. |
this study provided electrophysiological evidence from developing hippocampal slices to support that pb2+ inhibited action potential-dependent gaba release by inhibiting presynaptic vgcc, which might be a mechanism for pb2+ -induced cognitive deficit. |
2006-08-25 |
2023-08-12 |
rat |
| Tih-Shih Lee, Lars Petter Bjørnsen, Carlos Paz, Jung H Kim, Susan S Spencer, Dennis D Spencer, Tore Eid, Nihal C de Laneroll. GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16456667. |
the study aimed to determine the relationship of gaba transporter expression to known patterns of hippocampal hyperexcitability and extracellular gaba levels. |
2006-08-24 |
2023-08-12 |
human |
| Tih-Shih Lee, Lars Petter Bjørnsen, Carlos Paz, Jung H Kim, Susan S Spencer, Dennis D Spencer, Tore Eid, Nihal C de Laneroll. GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16456667. |
the reduction in gat-1 around granule cells in the sclerotic hippocampus could explain the prolonged gaba responses in this region. |
2006-08-24 |
2023-08-12 |
human |
| Tih-Shih Lee, Lars Petter Bjørnsen, Carlos Paz, Jung H Kim, Susan S Spencer, Dennis D Spencer, Tore Eid, Nihal C de Laneroll. GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. Acta neuropathologica. vol 111. issue 4. 2006-08-24. PMID:16456667. |
the increased gat-3 expression in astrocytes in regions of relative neuronal sparing in the sclerotic hippocampus may be related to the overall low levels of extracellular gaba observed in the sclerotic hippocampus and their increased excitability. |
2006-08-24 |
2023-08-12 |
human |
| Maria Pytel, Katarzyna Mercik, Jerzy W Mozrzyma. Interaction between cyclodextrin and neuronal membrane results in modulation of GABA(A) receptor conformational transitions. British journal of pharmacology. vol 148. issue 4. 2006-08-16. PMID:16702996. |
to reliably resolve the kinetics of conformational transitions, currents were elicited by ultrafast gamma-aminobutyric acid (gaba) applications to outside-out patches from rat cultured hippocampal neurons. |
2006-08-16 |
2023-08-12 |
rat |
| Mariangela Serra, Maria Cristina Mostallino, Giuseppe Talani, Maria Giuseppina Pisu, Mario Carta, Maria Luisa Mura, Ivan Floris, Elisabetta Maciocco, Enrico Sanna, Giovanni Biggi. Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function. Journal of neurochemistry. vol 98. issue 1. 2006-08-16. PMID:16805802. |
moreover, ethanol increased the amplitude of gaba(a) receptor-mediated miniature inhibitory postsynaptic currents recorded from ca1 pyramidal neurones with greater potency in hippocampal slices prepared from socially isolated rats than in those from group-housed rats, an effect inhibited by finasteride. |
2006-08-16 |
2023-08-12 |
rat |
| Mariangela Serra, Maria Cristina Mostallino, Giuseppe Talani, Maria Giuseppina Pisu, Mario Carta, Maria Luisa Mura, Ivan Floris, Elisabetta Maciocco, Enrico Sanna, Giovanni Biggi. Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function. Journal of neurochemistry. vol 98. issue 1. 2006-08-16. PMID:16805802. |
the amounts of the alpha(4) and delta subunits of the gaba(a) receptor in the hippocampus were increased in isolated rats as were gaba(a) receptor-mediated tonic inhibitory currents in granule cells of the dentate gyrus. |
2006-08-16 |
2023-08-12 |
rat |
| Jozsef Somogy. Functional significance of co-localization of GABA and Glu in nerve terminals: a hypothesis. Current topics in medicinal chemistry. vol 6. issue 10. 2006-08-11. PMID:16787271. |
experimental data have been accumulating which demonstrate; i) gaba-immunoreactivity in and gaba-release from constitutively gluergic hippocampal mossy fibre terminals, ii) plasticity of the gabaergic phenotype of constitutively gluergic granule cells of the dentate gyrus, iii) expression of gaba(a) receptor gamma(3) subunit in the mossy fibre termination zone in the ca3 subfield, iv) co-labeling of terminals for gaba and glu in the retina, brain stem and spinal cord, and v) functional compatibility of vesicular glu (vglut3) and gaba (viaat) transporters. |
2006-08-11 |
2023-08-12 |
Not clear |
| Rafael Gutiérrez, Uwe Heineman. Co-existence of GABA and Glu in the hippocampal granule cells: implications for epilepsy. Current topics in medicinal chemistry. vol 6. issue 10. 2006-08-11. PMID:16787272. |
co-existence of gaba and glu in the hippocampal granule cells: implications for epilepsy. |
2006-08-11 |
2023-08-12 |
Not clear |
| Hazem Elsersy, Javier Mixco, Huaxin Sheng, Robert D Pearlstein, David S Warne. Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection. Anesthesiology. vol 105. issue 1. 2006-08-11. PMID:16809998. |
the authors hypothesized that this is attributable to interaction with the gamma-aminobutyric acid type a (gabaa) receptor resulting in altered time to onset of ischemic hippocampal depolarization. |
2006-08-11 |
2023-08-12 |
rat |
| Jingyi Ma, L Stan Leun. Limbic system participates in mediating the effects of general anesthetics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16205783. |
in a previous study, we reported that inactivation of the medial septum or the hippocampus by muscimol, a gaba(a) receptor agonist, potentiated the effects of a general anesthetic. |
2006-08-07 |
2023-08-12 |
rat |
| Mitsuyoshi Shimane, Kaori Miyagawa, Masao Sugawar. Detection of gamma-aminobutyric acid-induced glutamate release in acute mouse hippocampal slices with a patch sensor. Analytical biochemistry. vol 353. issue 1. 2006-08-01. PMID:16620752. |
gamma-aminobutyric acid (gaba)-stimulated release of l-glutamate from various neuronal regions of acute mouse hippocampal slices was detected with a patch sensor that responds to l-glutamate at the sub-micromolar level. |
2006-08-01 |
2023-08-12 |
mouse |
| Lucas de Oliveira Alvares, Bruna Pasqualini Genro, Ricardo Vaz Breda, Michele Franzen Pedroso, Jaderson Costa Da Costa, Jorge Alberto Quillfeld. AM251, a selective antagonist of the CB1 receptor, inhibits the induction of long-term potentiation and induces retrograde amnesia in rats. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16464439. |
endocannabinoids are one of the endogenous systems that modulate this plasticity event: the activation of hippocampal cb1 receptors may inhibit local gaba release. |
2006-07-31 |
2023-08-12 |
rat |
| E Palma, M Amici, F Sobrero, G Spinelli, S Di Angelantonio, D Ragozzino, A Mascia, C Scoppetta, V Esposito, R Miledi, F Euseb. Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 22. 2006-07-26. PMID:16709666. |
anomalous levels of cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make gaba excitatory. |
2006-07-26 |
2023-08-12 |
human |
| E Palma, M Amici, F Sobrero, G Spinelli, S Di Angelantonio, D Ragozzino, A Mascia, C Scoppetta, V Esposito, R Miledi, F Euseb. Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 22. 2006-07-26. PMID:16709666. |
the gaba currents elicited in oocytes injected with membranes from the subiculum had a more depolarized reversal potential (e(gaba)) compared with the hippocampus proper or the neocortex. |
2006-07-26 |
2023-08-12 |
human |
| E Palma, M Amici, F Sobrero, G Spinelli, S Di Angelantonio, D Ragozzino, A Mascia, C Scoppetta, V Esposito, R Miledi, F Euseb. Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 22. 2006-07-26. PMID:16709666. |
the nkcc1 blocker bumetanide or a temperature decrease of 10 degrees c shifted the gaba-current e(gaba) more negative in oocytes injected with membranes from tle hippocampal subiculum, matching the e(gaba) of tl neocortex-injected oocytes. |
2006-07-26 |
2023-08-12 |
human |
| E Palma, M Amici, F Sobrero, G Spinelli, S Di Angelantonio, D Ragozzino, A Mascia, C Scoppetta, V Esposito, R Miledi, F Euseb. Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 22. 2006-07-26. PMID:16709666. |
we conclude that the anomalous expression of both cl(-) transporters, nkcc1 and kcc2 [corrected] in tle hippocampal subiculum probably causes altered cl(-) transport in the "epileptic" neurons, as revealed in the microtransplanted xenopus oocytes, and renders gaba aberrantly "exciting," a feature that may contribute to the precipitation of epileptic seizures. |
2006-07-26 |
2023-08-12 |
human |