| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sachiko Tanaka, Akihiro Tsuchida, Yuji Kiuchi, Katsuji Oguchi, Satoshi Numazawa, Takemi Yoshid. GABAergic modulation of hippocampal glutamatergic neurons: an in vivo microdialysis study. European journal of pharmacology. vol 465. issue 1-2. 2003-07-21. PMID:12650834. |
these results suggest that gaba modulates depolarization-evoked glutamate release in the hippocampus by inhibiting ca(2+) entry into neurons, an effect mediated by presynaptic gaba(b) receptors. |
2003-07-21 |
2023-08-12 |
rat |
| P M Thomas, J P Phillips, N Delanty, W T O'Conno. Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus. Epilepsy research. vol 54. issue 1. 2003-07-21. PMID:12742599. |
elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus. |
2003-07-21 |
2023-08-12 |
human |
| P M Thomas, J P Phillips, N Delanty, W T O'Conno. Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus. Epilepsy research. vol 54. issue 1. 2003-07-21. PMID:12742599. |
in two cases, spontaneously vigorous hippocampal epileptiform activity (ea) was identified; basal dialysate levels for hippocampal glutamate, aspartate, and gamma-aminobutyric acid ranged from approximately 23- to 84-fold, 19- to 33-fold and 10- to 34-fold higher, respectively, compared to the two cases of minimal hippocampal ea. |
2003-07-21 |
2023-08-12 |
human |
| Jimmy de Melo, Xiangguo Qiu, Guoyan Du, Leah Cristante, David D Eisensta. Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. The Journal of comparative neurology. vol 461. issue 2. 2003-07-16. PMID:12724837. |
the correlation of dlx2 with gaba expression in the mouse retina closely mirrors the relationship of dlx2 to gabaergic neuronal differentiation in the embryonic forebrain, including neocortex, olfactory bulb and hippocampus, signifying a conservation of function of dlx genes in the developing central nervous system. |
2003-07-16 |
2023-08-12 |
mouse |
| Bjarne W Kristensen, Jens Noraberg, Jens Zimme. The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures. Brain research. vol 973. issue 2. 2003-07-16. PMID:12738075. |
the potential neuroprotective effects of the gaba(a) receptor agonists thip (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and muscimol, and the selective glur5 kainate receptor agonist atpa ((rs)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid), which activates gabaergic interneurons, were examined in hippocampal slice cultures exposed to n-methyl-d-aspartate (nmda). |
2003-07-16 |
2023-08-12 |
Not clear |
| Bjarne W Kristensen, Jens Noraberg, Jens Zimme. The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures. Brain research. vol 973. issue 2. 2003-07-16. PMID:12738075. |
the results demonstrate that direct gaba(a) agonism can mediate neuroprotection in the hippocampus in vitro as previously suggested in vivo. |
2003-07-16 |
2023-08-12 |
Not clear |
| Laurent Groc, Bengt Gustafsson, Eric Hans. Early establishment of multiple release site connectivity between interneurons and pyramidal neurons in the developing hippocampus. The European journal of neuroscience. vol 17. issue 9. 2003-07-16. PMID:12752787. |
here we examine the development of connectivity between gamma-aminobutyric acid (gaba)ergic interneurons and ca1 pyramidal neurons in the hippocampus. |
2003-07-16 |
2023-08-12 |
Not clear |
| I E Holopainen, H B Laure. Neuronal activity regulates GABAA receptor subunit expression in organotypic hippocampal slice cultures. Neuroscience. vol 118. issue 4. 2003-07-11. PMID:12732242. |
the postnatal expression of gaba(a) receptor subunit mrnas in the rat brain, including the hippocampus, exhibits a unique temporal and regional developmental profile in vivo, which may be altered by external stimuli. |
2003-07-11 |
2023-08-12 |
rat |
| I E Holopainen, H B Laure. Neuronal activity regulates GABAA receptor subunit expression in organotypic hippocampal slice cultures. Neuroscience. vol 118. issue 4. 2003-07-11. PMID:12732242. |
using the in situ hybridization technique we have now studied the in vitro expression of alpha1,alpha2, alpha 4, alpha 5, beta 1, beta 3, gamma 2, and gamma 3 subunit mrnas of gaba(a) receptors in organotypic hippocampal slices cultured for 7 days. |
2003-07-11 |
2023-08-12 |
rat |
| Indrani Choudhury-Mukherjee, Hilary A Schenck, Sylvia Cechova, Thomas N Pajewski, Jaideep Kapur, Jeffrey Ellena, David S Cafiso, Milton L Brow. Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. Journal of medicinal chemistry. vol 46. issue 12. 2003-07-11. PMID:12773053. |
further, compound 1 was used at a concentration of 1 mm and slightly enhanced gaba(a) current in hippocampal neurons at 10 microm. |
2003-07-11 |
2023-08-12 |
Not clear |
| Christiane Halbsguth, Oliver Meissner, Hanns Häberlei. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site. Planta medica. vol 69. issue 4. 2003-07-10. PMID:12709895. |
to confirm the modulatory activity of the protoberberine type 2 alkaloids on living cells, gaba a receptor binding studies were performed by fluorescence correlation spectroscopy (fcs) using hippocampal neurons and the fluorescently labelled ligand, muscimol-alexa (mu-alexa). |
2003-07-10 |
2023-08-12 |
Not clear |
| S Katsurabayashi, H Kubota, N Tokutomi, N Akaik. A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons. Neuropharmacology. vol 44. issue 8. 2003-07-08. PMID:12763095. |
this provides another potential mechanism whereby 5-ht can modulate gaba release and hence the excitability of hippocampal neurons. |
2003-07-08 |
2023-08-12 |
Not clear |
| Akiva S Cohen, Dean D Lin, Gerald L Quirk, Douglas A Coulte. Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology. The European journal of neuroscience. vol 17. issue 8. 2003-07-03. PMID:12752378. |
dentate granule cell gaba(a) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology. |
2003-07-03 |
2023-08-12 |
Not clear |
| Bin Lin, Amy C Arai, Gary Lynch, Christine M Gal. Integrins regulate NMDA receptor-mediated synaptic currents. Journal of neurophysiology. vol 89. issue 5. 2003-07-02. PMID:12740418. |
excitatory postsynaptic currents (epscs) were recorded with whole cell clamp from hippocampal slices in which ampa-type glutamate receptors and gaba(a) receptors were pharmacologically blocked. |
2003-07-02 |
2023-08-12 |
Not clear |
| Naoaki Saito, Yasuhito Shira. Protein kinase C gamma (PKC gamma): function of neuron specific isotype. Journal of biochemistry. vol 132. issue 5. 2003-07-01. PMID:12417016. |
pkc gamma deficient mice (i) have modified long term potentiation (ltp) in hippocampus, (ii) exhibit mild deficits in spatial and contextual learning (iii) exhibit impaired motor coordination due to persistent multiple innervations of climbing fibers on purkinje cells, (iv) show attenuation of opioid receptor activation, and (v) show decreased effects of ethanol on type a of gamma-aminobutyric acid (gaba) receptor. |
2003-07-01 |
2023-08-12 |
mouse |
| Alexey Semyanov, Matthew C Walker, Dimitri M Kullman. GABA uptake regulates cortical excitability via cell type-specific tonic inhibition. Nature neuroscience. vol 6. issue 5. 2003-07-01. PMID:12679782. |
we show that, in the presence of intact gaba uptake, guinea pig hippocampal interneurons, but not pyramidal cells, express a tonic gaba(a) receptor-mediated conductance. |
2003-07-01 |
2023-08-12 |
Not clear |
| G Ben-Yaakov, H Gola. Cell proliferation in response to GABA in postnatal hippocampal slice culture. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711353. |
cell proliferation in response to gaba in postnatal hippocampal slice culture. |
2003-07-01 |
2023-08-12 |
Not clear |
| G Ben-Yaakov, H Gola. Cell proliferation in response to GABA in postnatal hippocampal slice culture. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711353. |
using 5 days postnatal hippocampus, we tested gaba effects on growth into an incision made in ca1 and the possibility that this response to gaba is mediated via gaba(a)-receptor. |
2003-07-01 |
2023-08-12 |
Not clear |
| G Ben-Yaakov, H Gola. Cell proliferation in response to GABA in postnatal hippocampal slice culture. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 3. 2003-07-01. PMID:12711353. |
these results suggest that gaba can promote growth in postnatal hippocampal tissue. |
2003-07-01 |
2023-08-12 |
Not clear |
| X Wang, J Wu, H Xiao, Y Sh. [Effects of fenvalerate and phoxim insecticides on glutamate and gamma-aminobutyric acid immunoreactive cells in the central nervous system of rats]. Wei sheng yan jiu = Journal of hygiene research. vol 29. issue 1. 2003-07-01. PMID:12725027. |
the results showed that the total number, percentage of positive area and integral optical density of glu immunoreactive cells in cerebral cortex, hippocampus and striate exhibited a characteristic decrease in the groups fed with fenvalerate and fenvalerate plus phoxim, while those of gaba were enhanced to certain extents. |
2003-07-01 |
2023-08-12 |
rat |