| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoki Ito, Rieko Miki, Naoya Kawada, Masaaki Yoshida, Yoshinori Kobayash. Nobiletin-rich kososan, a Kampo formula, prevents the onset of apathy-like behavior and neuroinflammation in sickness behavior mouse model induced by increasing doses of lipopolysaccharide. Neuroscience. 2024-12-07. PMID:39645074. |
nks and paro significantly increased the anti-inflammatory milieu in the hippocampus and prefrontal cortex (pfc), as well as brain microglia, of lps-injected mice. |
2024-12-07 |
2024-12-10 |
mouse |
| Jae-Won Jung, Yukiori Goto, Young-A Le. Dopamine-mediated behavioral alterations following exposure to a social video in socially isolated mice during the developmental period. Behavioral neuroscience. 2024-12-05. PMID:39636608. |
furthermore, the sve group exhibited elevated levels of tyrosine hydroxylase and dopamine transporter in key social cognition regions-namely the prefrontal cortex, retrosplenial cortex, and hippocampus. |
2024-12-05 |
2024-12-08 |
mouse |
| Piper Schneider, Danielle Goldbaum, Ansh Agarwal, Ashton Taylor, Peyton Sundberg, Eliot L Gardner, Robert Ranaldi, Zhi-Bing You, Ewa Gala. Region-specific neuroadaptations of CRF1 and CRF2 expression following heroin exposure in female rats. Pharmacology, biochemistry, and behavior. 2024-12-03. PMID:39626795. |
heroin-treated rats showed a significant decrease in crf1 receptor protein expression in the ventral tegmental area (vta) and an increase in the nucleus accumbens (nac) but no changes in the prefrontal cortex (pfc), insula, dorsal striatum (dstr), dorsal hippocampus (dhippo), anterior hypothalamus (hypth), amygdala, or substantia nigra (sn) as compared to saline-treated rats. |
2024-12-03 |
2024-12-06 |
rat |
| Łukasz Gąsior, Bartłomiej Pochwat, Monika Zaręba-Kozioł, Jakub Włodarczyk, Andreas Martin Grabrucker, Bernadeta Szewczy. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacological reports : PR. 2024-12-02. PMID:39623245. |
to investigate these mechanisms, we examined proteomic changes in the prefrontal cortex (pfc) and hippocampus (hp) of rats, two critical brain regions implicated in the pathophysiology of depression. |
2024-12-02 |
2024-12-06 |
rat |
| Ahmed S Al-Shami, Medhat Haroun, Amina E Essawy, Nermine Moussa, Heba-Tallah Abd Elrahim Abd Elkade. Early-life bisphenol A exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: Involvement of NMDAR/PSD-95-PTEN/AKT signaling pathway. Neurotoxicology. 2024-12-01. PMID:39617347. |
notably, neurotransmitter levels such as dopamine, serotonin, and gamma-aminobutyric acid, levels of postsynaptic density protein 95 and camp response element-binding protein, as well as mrna levels of n-methyl-d-aspartate receptor subunits, fluctuated between reduction and elevation in the pfc and hippocampus. |
2024-12-01 |
2024-12-06 |
rat |
| Edurne Urquizu, Selma Paratusic, Júlia Goyenechea, Cristian Gómez-Canela, Berta Fumàs, David Pubill, Demetrio Raldúa, Jordi Camarasa, Elena Escubedo, Raúl López-Arna. Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596313. |
our results demonstrated that the model showed increased lipid peroxidation, downregulation of antioxidant enzymes and astrogliosis in the mouse hippocampus (hp) and prefrontal cortex (pfc), brain areas involved in cognitive functions. |
2024-11-27 |
2024-11-29 |
mouse |
| Evan J Ciacciarelli, Scott D Dunn, Taqdees Gohar, T Joseph Sloand, Mark Niedringhaus, Elizabeth A Wes. Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task. Neurobiology of learning and memory. 2024-11-25. PMID:39586458. |
the prefrontal cortex and its connections with thalamic subregions are thought to mediate specific aspects of working memory, including engaging with the hippocampus to mediate memory retrieval. |
2024-11-25 |
2024-11-28 |
Not clear |
| Juliete Tavares, Alfaete Vieira Oliveira, Tyciane de Souza Nascimento, Jessica Maria Pessoa Gomes, Ana Caroline Barros Parente, Jessica Rabelo Bezerra, Mac Dionys Rodrigues da Costa, Mayara Sandrielly Soares de Aguiar, Tiago Lima Sampaio, Francisco Arnaldo Viana Lima, Glauce Socorro de Barros Viana, Geanne Matos de Andrad. Aqueous extract of Spirulina exerts neuroprotection in an experimental model of Alzheimer sporadic disease in mice induced by Streptozotocin. Metabolic brain disease. vol 40. issue 1. 2024-11-20. PMID:39565401. |
spi treatment protected against gsh increase in the prefrontal cortex and hippocampus, and inhibited ache activity in the prefrontal cortex. |
2024-11-20 |
2024-11-23 |
mouse |
| D Kunčická, N Cmarková, S Ondráčková, D Kačer, D Rodriguez, K Valeš, J Svoboda, H Brožka, A Stuchlí. Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA. Physiological research. vol 73. issue 5. 2024-11-19. PMID:39560195. |
next, homovanillic acid and 5-hydroxyindoleacetic acid, metabolites of dopamine and serotonin, respectively, were quantified in the rats' prefrontal cortex, striatum, and hippocampus. |
2024-11-19 |
2024-11-22 |
rat |
| Jing Jiang, Stefania Ferraro, Youjin Zhao, Baolin Wu, Jinping Lin, Taolin Chen, Jin Gao, Lei L. Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity. Psychoradiology. vol 4. 2024-11-18. PMID:39554694. |
these functional magnetic resonance imaging (mri) studies highlight the (i) shared hypoactivation in the prefrontal cortex during cognitive and emotional processing in mdd and ptsd; (ii) higher activation in fear processing regions including amygdala, hippocampus, and insula in ptsd compared to mdd; and (iii) distinct functional deficits in brain regions involved in fear and reward processing in patients with ptsd + mdd relative to those with ptsd alone. |
2024-11-18 |
2024-11-22 |
Not clear |
| Sandra Bonfante, Martins Back Netto, Aloir Neri de Oliveira Junior, Khiany Mathias, Richard Simon Machado, Larissa Joaquim, Taina Cidreira, Marina Goulart da Silva, Guilherme Cabreira Daros, Lucinéia Gainski Danielski, Fernanda Gava, Isabela da Silva Lemos, Rafaela Tezza Matiola, Emily Córneo, Josiane Somariva Prophiro, Rafael Mariano de Bitencourt, Carlos Henrique Rocha Catalão, Jaqueline da Silva Generoso, Emílio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation. Metabolic brain disease. vol 40. issue 1. 2024-11-13. PMID:39535569. |
in an experimental tibial fracture (tf) model, we aimed to understand the role of the nlr family pyrin domain containing 3 (nlrp3) on oxidative stress and mitochondrial dysfunction as mechanisms underlying pocd in aged and adult rats. adult or aged male wistar rats were subjected to the tf model and received intracerebroventricular saline or mcc950 (140 ng/kg), a specific small-molecule inhibitor that selectively blocks activation of the nlrp3 inflammasome. we followed the control (sham) and tf groups treated with mcc950 or saline for seven days to determine cognitive function and survival. the prefrontal cortex and hippocampus were isolated for nlrp3 evaluation, cytokine analysis, oxidative stress measurements, myeloperoxidase activity, nitric oxide formation, mitochondrial respiratory chain enzymes, and succinate dehydrogenase (sdh) activity. |
2024-11-13 |
2024-11-17 |
rat |
| Sandra Bonfante, Martins Back Netto, Aloir Neri de Oliveira Junior, Khiany Mathias, Richard Simon Machado, Larissa Joaquim, Taina Cidreira, Marina Goulart da Silva, Guilherme Cabreira Daros, Lucinéia Gainski Danielski, Fernanda Gava, Isabela da Silva Lemos, Rafaela Tezza Matiola, Emily Córneo, Josiane Somariva Prophiro, Rafael Mariano de Bitencourt, Carlos Henrique Rocha Catalão, Jaqueline da Silva Generoso, Emílio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation. Metabolic brain disease. vol 40. issue 1. 2024-11-13. PMID:39535569. |
seven days after tf induction, nlrp3 levels increased in the hippocampus and prefrontal cortex in both ages, showed an enhancement in aged rats compared to adults, and experienced a reversal with mcc950 administration. the administration of mcc950 restored memory, il-1β and il-10 levels, nitrite/nitrate, lipid peroxidation in the hippocampus and prefrontal cortex, and preserved catalase activity in the prefrontal cortex in aged rats. |
2024-11-13 |
2024-11-17 |
rat |
| Ryota Araki, Ayami Kita, Takeshi Yab. Decreased Brain pH Underlies Behavioral and Brain Abnormalities Induced by Chronic Exposure to Glucocorticoids in Mice. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-10. PMID:39522977. |
three weeks of cort treatment decreased ph in the prefrontal cortex (pfc), striatum, and hippocampus (hc), whereas intake of ph 9.0 drinking water increased ph in these brain regions. |
2024-11-10 |
2024-11-17 |
mouse |
| Shiva Hashemizadeh, Elham Alaee, Niloofar Aghajani, Hossein Azizi, Saeed Semnania. Atorvastatin facilitates extinction and prevents reinstatement of morphine-induced conditioned place preference in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 181. 2024-11-09. PMID:39520913. |
we found that atorvastatin 1 mg/kg attenuated morphine-seeking behaviors, and this attenuation of reinstatement was partly mediated by the upregulation of brain-derived neurotrophic factor (bdnf) in the prefrontal cortex (pfc) and hippocampus (hipp). |
2024-11-09 |
2024-11-17 |
rat |
| Xinlei Zhang, Lulu Wang, Chen Xu, Heng Wang, An Yan, Qingmeng Zheng, Ke Wang, Xiaomeng Qia. Intestinal dysbiosis causes spatial memory impairment in alcohol-exposed male mice by inducing neuroinflammation. Experimental neurology. 2024-11-03. PMID:39490622. |
by giving mice specific prebiotics (n = 16/group), we pointed out that increased endotoxin coming from gram negative bacteria such as lipopolysaccharides (lps) cross the bbb to activate microglia and inflammatory pathways in the prefrontal cortical (pfc) and hippocampus (hip), releasing inflammatory factors and resulting in neuroinflammation. |
2024-11-03 |
2024-11-06 |
mouse |
| YiShu Zhang, HaiChao Chen, JiaXin Cao, LiPing Gao, YuHong Jin. Maternal separation alters peripheral immune responses associated with IFN-γ and OT in mice. Peptides. 2024-11-01. PMID:39486747. |
additionally, maternal separation led to decreased levels of bdnf, igf2, and creb mrnas in the hippocampus, while levels in the prefrontal cortex (pfc) remained unaffected. |
2024-11-01 |
2024-11-05 |
mouse |
| Quentin Devignes, Kevin J Clancy, Boyu Ren, Yara Pollmann, Justin T Baker, Isabelle M Ross. Intrinsic functional connectivity of right dorsolateral prefrontal cortex and hippocampus subregions relates to emotional and sensory-perceptual properties of intrusive trauma memories. medRxiv : the preprint server for health sciences. 2024-11-01. PMID:39484280. |
intrinsic functional connectivity of right dorsolateral prefrontal cortex and hippocampus subregions relates to emotional and sensory-perceptual properties of intrusive trauma memories. |
2024-11-01 |
2024-11-03 |
Not clear |
| Quentin Devignes, Kevin J Clancy, Boyu Ren, Yara Pollmann, Justin T Baker, Isabelle M Ross. Intrinsic functional connectivity of right dorsolateral prefrontal cortex and hippocampus subregions relates to emotional and sensory-perceptual properties of intrusive trauma memories. medRxiv : the preprint server for health sciences. 2024-11-01. PMID:39484280. |
prior research links voluntary tr-im suppression to inhibitory control of the right dorsolateral prefrontal cortex (dlpfc) over the hippocampus (hpc). |
2024-11-01 |
2024-11-03 |
Not clear |
| Yue Guo, Feiyang Wei, Yue Lv, Hangsha Wu, Yafei Li, Rui Tang, Mingfang Zhao, Weihong Ge, Weifeng D. Spinosin improves anxiety disorders in mice with chronic restraint stress via the ERK1/2-CREB-BDNF pathway. International immunopharmacology. vol 143. issue Pt 2. 2024-10-30. PMID:39476570. |
additionally, spinosin normalized neurotransmitter levels and mitigated inflammation and neuronal damage in the hippocampus (hpc) and prefrontal cortex (pfc). |
2024-10-30 |
2024-11-02 |
mouse |
| Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Victor Silva Dias, Camila Pereira Medeiros, Fernanda Wickert, Nadja Schroder, Marcia Giovernardi, Renata Padilha Guede. Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring. Neuropharmacology. vol 262. 2024-10-25. PMID:39447736. |
behavioral tests assessed anxiety-like manifestations and social behavior, while neuroinflammatory and endocannabinoid markers were evaluated in the hypothalamus, prefrontal cortex (pfc) and hippocampus, as well as the biochemical profile in the plasma. |
2024-10-25 |
2024-10-28 |
rat |