| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghadda. Reduced presynaptic dopamine activity in adolescent dorsal striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23358239. |
we combined molecular and dynamic indices of dopamine neurotransmission to assess dopamine function in adolescent rats in two functionally distinct striatal subregions: nucleus accumbens (nac) and dorsal striatum (ds). |
2014-01-24 |
2023-08-12 |
rat |
| Mary Kay Lobo, Samir Zaman, Diane M Damez-Werno, Ja Wook Koo, Rosemary C Bagot, Jennifer A DiNieri, Alexandria Nugent, Eric Finkel, Dipesh Chaudhury, Ramesh Chandra, Efrain Riberio, Jacqui Rabkin, Ezekiell Mouzon, Roger Cachope, Joseph F Cheer, Ming-Hu Han, David M Dietz, David W Self, Yasmin L Hurd, Vincent Vialou, Eric J Nestle. ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 47. 2014-01-21. PMID:24259563. |
we make use of fluorescent reporter bac transgenic mice to evaluate induction of Δfosb in dopamine receptor 1 (d1) enriched and dopamine receptor 2 (d2) enriched msns in ventral striatum, nucleus accumbens (nac) shell and core, and in dorsal striatum (dstr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. |
2014-01-21 |
2023-08-12 |
mouse |
| Edgardo Falcon, Angela Ozburn, Shibani Mukherjee, Kole Roybal, Colleen A McClun. Differential regulation of the period genes in striatal regions following cocaine exposure. PloS one. vol 8. issue 6. 2014-01-16. PMID:23776671. |
thus, we wanted to determine the effects of chronic cocaine on the expression of several circadian genes in the nucleus accumbens (nac) and caudate putamen (cp), regions of the brain known to be involved in the behavioral responses to drugs of abuse. |
2014-01-16 |
2023-08-12 |
mouse |
| F Saint-Preux, L R Bores, I Tulloch, B Ladenheim, R Kim, P K Thanos, N D Volkow, J L Cade. Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience. vol 243. 2013-12-17. PMID:23562942. |
chronic exposure to either nicotine or meth caused significant decreases in the expression of fosb, fra1, and fra2 in the nucleus accumbens (nac) but not in the dorsal striatum whereas the drug combination increased fra2 expression in both structures. |
2013-12-17 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Xia Li, Jie Li, Xiao-Qing Peng, Rui Song, József Gaál, Eliot L Gardne. Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats. Addiction biology. vol 18. issue 4. 2013-10-29. PMID:22913325. |
here, we report that systemic or local administration of sb-277011a, a highly selective d3 r antagonist, into the nac (core and shell) or the cea, but not the dorsal striatum or basolateral amygdala, significantly inhibits expression of incubation of cocaine craving in rats after 2-30 days of withdrawal from previous cocaine self-administration but had no effect on sucrose-seeking behavior in rats after 10-30 days of withdrawal. |
2013-10-29 |
2023-08-12 |
rat |
| Taehyun Kim, David J Hinton, Sandy Johng, Jia Bei Wang, Doo-Sup Cho. Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum. Behavioural brain research. vol 244. 2013-09-30. PMID:23376703. |
our results indicated that a single injection of l-thp increased active phosphorylated forms of pka, akt and erk in the caudate-putamen (cpu), but not in the nucleus accumbens (nac), of alcohol naïve mice. |
2013-09-30 |
2023-08-12 |
mouse |
| Carine Chassain, Guy Bielicki, Carole Carcenac, Anne-Claire Ronsin, Jean-Pierre Renou, Marc Savasta, Franck Duri. Does MPTP intoxication in mice induce metabolite changes in the nucleus accumbens? A ¹H nuclear MRS study. NMR in biomedicine. vol 26. issue 3. 2013-08-20. PMID:23059905. |
in vivo spectra were acquired for a voxel (8 μl) in the dorsal striatum, and in the nac (1.56 μl). |
2013-08-20 |
2023-08-12 |
mouse |
| Carine Chassain, Guy Bielicki, Carole Carcenac, Anne-Claire Ronsin, Jean-Pierre Renou, Marc Savasta, Franck Duri. Does MPTP intoxication in mice induce metabolite changes in the nucleus accumbens? A ¹H nuclear MRS study. NMR in biomedicine. vol 26. issue 3. 2013-08-20. PMID:23059905. |
the glu, gln and gaba concentrations obtained in the basal state were higher in the nac of mptp-intoxicated mice which have the higher dopamine denervation in the ventral tegmental area (vta) and in the dorsal striatum. |
2013-08-20 |
2023-08-12 |
mouse |
| Shanna L Resendez, Mackenzie Dome, Gwen Gormley, Dena Franco, Natalie Nevárez, Arif A Hamid, Brandon J Aragon. μ-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699524. |
within this circuitry, μ-opioid receptors (mors) modulate naturally rewarding behavior in an anatomically segregated manner; mors located throughout the striatum (dorsal striatum, nac core, and the entire nac shell) are implicated in general motivational processes, whereas those located specifically within the dorsomedial nac shell mediate positive hedonics (and are referred to as a "hedonic hotspot"). |
2013-08-09 |
2023-08-12 |
Not clear |
| Shanna L Resendez, Mackenzie Dome, Gwen Gormley, Dena Franco, Natalie Nevárez, Arif A Hamid, Brandon J Aragon. μ-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699524. |
thus, mors within the dorsal striatum mediate partner preference formation via impairment of mating, whereas those in the dorsomedial nac shell appear to mediate pair bond formation through the positive hedonics associated with mating. |
2013-08-09 |
2023-08-12 |
Not clear |
| Ya Xu, Xiu-Fang Lv, Cai-Lian Cui, Fei-Fei Ge, Yi-Jing Li, Hao-Lin Zhan. Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory. Brain research bulletin. vol 89. issue 1-2. 2013-06-06. PMID:22776695. |
our results showed that, in rats that had undergone morphine conditioning, after testing (expression phase) perk1/2 in the nac shell but not the nac core or the adjacent caudate putamen was specifically increased. |
2013-06-06 |
2023-08-12 |
rat |
| Florence R M Theberge, Charles L Pickens, Evan Goldart, Sanya Fanous, Bruce T Hope, Qing-Rong Liu, Yavin Shaha. Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22790874. |
we investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (bdnf) and methyl-cpg binding protein 2 (mecp2) signaling and mu opioid receptor (mor) expression in nucleus accumbens (nac), dorsal striatum (ds), and medial prefrontal cortex (mpfc). |
2013-05-10 |
2023-08-12 |
rat |
| M L Perreault, A Hasbi, M Alijaniaram, B F O'Dowd, S R Georg. Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats. Neuroscience. vol 225. 2013-04-16. PMID:22986162. |
in adult rat striatum the dopamine d1-d2 receptor heteromer is expressed selectively in a subset of medium spiny neurons (msns) that coexpress the dopamine d1 and d2 receptors (d1r and d2r) as well as dynorphin (dyn) and enkephalin (enk), with higher coexpression in nucleus accumbens (nac) and much lower in the caudate putamen (cp). |
2013-04-16 |
2023-08-12 |
rat |
| Ming-Lei Guo, Bing Xue, Dao-Zhong Jin, Zhen-Guo Liu, Eugene E Fibuch, Li-Min Mao, John Q Wan. Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22884934. |
we found that acute systemic injection of amph had a minimal effect on protein levels of npas4 in the caudate putamen (cpu) and nucleus accumbens (nac), while amph readily increased protein products of the immediate early gene c-fos in these regions. |
2012-12-20 |
2023-08-12 |
rat |
| Kayo Nishizawa, Ryoji Fukabori, Kana Okada, Nobuyuki Kai, Motokazu Uchigashima, Masahiko Watanabe, Akira Shiota, Masatsugu Ueda, Yuji Tsutsui, Kazuto Kobayash. Striatal indirect pathway contributes to selection accuracy of learned motor actions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015433. |
the dorsal striatum, which contains the dorsolateral striatum (dls) and dorsomedial striatum (dms), integrates the acquisition and implementation of instrumental learning in cooperation with the nucleus accumbens (nac). |
2012-12-10 |
2023-08-12 |
rat |
| Brad A Grueter, Patrick E Rothwell, Robert C Malenk. Integrating synaptic plasticity and striatal circuit function in addiction. Current opinion in neurobiology. vol 22. issue 3. 2012-11-19. PMID:22000687. |
these synaptic adaptations include changes in the nucleus accumbens (nac), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use. |
2012-11-19 |
2023-08-12 |
Not clear |
| J Luigjes, W van den Brink, M Feenstra, P van den Munckhof, P R Schuurman, R Schippers, A Mazaheri, T J De Vries, D Deny. Deep brain stimulation in addiction: a review of potential brain targets. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21931318. |
we found 7 animal studies targeting six different brain areas: nucleus accumbens (nac), subthalamic nucleus (stn), dorsal striatum, lateral habenula, medial prefrontal cortex (mpfc) and hypothalamus, and 11 human studies targeting two different target areas: nac and stn. |
2012-11-07 |
2023-08-12 |
human |
| Marek Schwendt, Carmela M Reichel, Ronald E Se. Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479593. |
synaptosomes from the medial pfc, nucleus accumbens (nac), and the dorsal striatum (dstr) were isolated and labeled with membrane-impermeable biotin in order to measure surface mglur2/3 and mglur7 receptors. |
2012-11-05 |
2023-08-12 |
rat |
| Diane Damez-Werno, Quincey LaPlant, HaoSheng Sun, Kimberly N Scobie, David M Dietz, Ian M Walker, Ja Wook Koo, Vincent F Vialou, Ezekiell Mouzon, Scott J Russo, Eric J Nestle. Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 30. 2012-10-29. PMID:22836260. |
Δfosb, a fosb gene product, is induced in nucleus accumbens (nac) and caudate-putamen (cpu) by repeated exposure to drugs of abuse such as cocaine. |
2012-10-29 |
2023-08-12 |
rat |
| Dorothy J Yamamoto, Nancy R Zahnise. Differences in rat dorsal striatal NMDA and AMPA receptors following acute and repeated cocaine-induced locomotor activation. PloS one. vol 7. issue 5. 2012-09-27. PMID:22655064. |
three areas involved in the development and expression of locomotor sensitization were investigated: the ventral tegmental area (vta), nucleus accumbens (nac) and dorsal striatum (dstr). |
2012-09-27 |
2023-08-12 |
rat |