| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B J Del Buono, F W Luscinskas, E R Simon. Preparation and characterization of plasma membrane vesicles from human polymorphonuclear leukocytes. Journal of cellular physiology. vol 141. issue 3. 1990-01-24. PMID:2592431. |
the resultant cavitate was freed of undisrupted cells and nuclei and then centrifuged through discontinuous isotonic/isoosmotic percoll gradients, which resolved four fractions: alpha (intact azurophilic granules), beta (intact specific granules), gamma (membrane vesicles), and delta (cytosol). |
1990-01-24 |
2023-08-11 |
human |
| J B Winfiel. Stress proteins, arthritis, and autoimmunity. Arthritis and rheumatism. vol 32. issue 12. 1990-01-22. PMID:2688657. |
a great deal of work remains to be done in this area, including (a) generation and propagation of specifically reactive t cell clones, (b) molecular delineation of the immune recognition elements and critical epitopes shared by microbial stress proteins and host proteins, (c) definition of the relative contribution of alpha beta and gamma delta tcrs to t cell reactivity to stress proteins, and (d) clarification of the circumstances that enable persistent t cell autoreactivity to stress proteins. |
1990-01-22 |
2023-08-11 |
rat |
| C Geisler, J Kuhlmann, B Rubi. Assembly, intracellular processing, and expression at the cell surface of the human alpha beta T cell receptor/CD3 complex. Function of the CD3-zeta chain. Journal of immunology (Baltimore, Md. : 1950). vol 143. issue 12. 1990-01-19. PMID:2531776. |
the tcr/cd3 complex is a multimeric protein complex composed of a minimum of seven transmembrane chains (tcr alpha beta-cd3 gamma delta epsilon zeta 2). |
1990-01-19 |
2023-08-11 |
human |
| C Geisler, J Kuhlmann, B Rubi. Assembly, intracellular processing, and expression at the cell surface of the human alpha beta T cell receptor/CD3 complex. Function of the CD3-zeta chain. Journal of immunology (Baltimore, Md. : 1950). vol 143. issue 12. 1990-01-19. PMID:2531776. |
the results indicate that: 1) cd3-zeta is required for the cell surface expression of the tcr/cd3 complex; 2) the pentameric form (tcr alpha beta-cd3 gamma delta epsilon) of the tcr/cd3 complex and single tcr chains associated with cd3 (tcr alpha-cd3 gamma delta epsilon and tcr beta-cd3 gamma delta epsilon) are produced in the endoplasmic reticulum in the absence of cd3-zeta; 3) the cd3-zeta does not associate with tcr alpha-cd3 gamma delta epsilon or tcr beta-cd3 gamma delta epsilon complexes; 4) cd3-zeta associate with the pentameric form of the tcr/cd3 complex in the endoplasmic reticulum to form the heptameric complex (tcr alpha beta-cd3 gamma delta epsilon----tcr alpha beta-cd3 gamma delta epsilon 2); and 5) cd3-zeta is required for the export of the tcr/cd3 complex from the endoplasmic reticulum to the golgi apparatus for subsequent processing. |
1990-01-19 |
2023-08-11 |
human |
| R Civitelli, S L Teitelbaum, K A Hruska, D L Lace. IL-1 activates the Na+/H+ antiport in a murine T cell. Journal of immunology (Baltimore, Md. : 1950). vol 143. issue 12. 1990-01-19. PMID:2556473. |
exposure to hril-1 alpha (120 pm) leads to an early, sustained intracellular alkalinization (delta ph = + 0.09 +/- 0.03) that plateaus within 20 min. |
1990-01-19 |
2023-08-11 |
human |
| T Tsurimoto, B Stillma. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. The EMBO journal. vol 8. issue 12. 1990-01-11. PMID:2573521. |
multiple replication factors augment dna synthesis by the two eukaryotic dna polymerases, alpha and delta. |
1990-01-11 |
2023-08-11 |
Not clear |
| T Tsurimoto, B Stillma. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. The EMBO journal. vol 8. issue 12. 1990-01-11. PMID:2573521. |
dna synthesis by two eukaryotic dna polymerases, alpha and delta, was studied using a single-strand m13 dna template primed at a unique site. |
1990-01-11 |
2023-08-11 |
Not clear |
| T Tsurimoto, B Stillma. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. The EMBO journal. vol 8. issue 12. 1990-01-11. PMID:2573521. |
in the presence of low amounts of either dna polymerase alpha or delta, dna synthesis was limited and short dna strands of approximately 100 bases were produced. |
1990-01-11 |
2023-08-11 |
Not clear |
| T Tsurimoto, B Stillma. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. The EMBO journal. vol 8. issue 12. 1990-01-11. PMID:2573521. |
the differential effects of these three replication factors on dna polymerases alpha and delta is consistent with the model that the polymerases function at the replication fork on the lagging and leading strand templates respectively. |
1990-01-11 |
2023-08-11 |
Not clear |
| A Winoto, D Baltimor. Alpha beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers. Cell. vol 59. issue 4. 1990-01-05. PMID:2582491. |
t cells expressing either the alpha beta or gamma delta antigen receptor (tcr) are distinct cell lineages. |
1990-01-05 |
2023-08-11 |
Not clear |
| A Winoto, D Baltimor. Alpha beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers. Cell. vol 59. issue 4. 1990-01-05. PMID:2582491. |
the single locus encoding the tcr alpha and delta genes requires special regulation to avoid alpha gene expression in gamma delta t cells. |
1990-01-05 |
2023-08-11 |
Not clear |
| A Winoto, D Baltimor. Alpha beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers. Cell. vol 59. issue 4. 1990-01-05. PMID:2582491. |
we show here that the minimal alpha enhancer is active in the gamma delta t cell lineage but gains alpha beta lineage specificity through negative cis-acting elements 3' of the c alpha gene that silence the enhancer in gamma delta t cells. |
1990-01-05 |
2023-08-11 |
Not clear |
| S J Korsmeyer, R D Hockett, E A McGuire, G Nune. Human delta T cell receptor: rearrangement, deletion, and translocation. Princess Takamatsu symposia. vol 19. 1990-01-04. PMID:2978616. |
individual t cells express the cd3 molecule in association with alternative gamma delta or alpha beta heterodimeric t cell receptors (tcr). |
1990-01-04 |
2023-08-11 |
human |
| S J Korsmeyer, R D Hockett, E A McGuire, G Nune. Human delta T cell receptor: rearrangement, deletion, and translocation. Princess Takamatsu symposia. vol 19. 1990-01-04. PMID:2978616. |
the delta tcr, used in one type of t cell is located within the alpha tcr gene used in quite another cell. |
1990-01-04 |
2023-08-11 |
human |
| S J Korsmeyer, R D Hockett, E A McGuire, G Nune. Human delta T cell receptor: rearrangement, deletion, and translocation. Princess Takamatsu symposia. vol 19. 1990-01-04. PMID:2978616. |
t cell precursors and occasional gamma delta t cells in humans possess an unexpected 2.0 kb mrna in which a tandemly repeated motif, t early alpha (tea), has been spliced to the constant (c alpha) region. |
1990-01-04 |
2023-08-11 |
human |
| S J Korsmeyer, R D Hockett, E A McGuire, G Nune. Human delta T cell receptor: rearrangement, deletion, and translocation. Princess Takamatsu symposia. vol 19. 1990-01-04. PMID:2978616. |
moreover, pre t cells within this group indicate that delta tcr rearrangement can occur prior to the activation of gamma, beta, and alpha loci. |
1990-01-04 |
2023-08-11 |
human |
| S Takeshita, M Toda, H Yamagish. Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus. The EMBO journal. vol 8. issue 11. 1989-12-29. PMID:2583098. |
we find that the frequency of circular dna clones carrying germline delta sequences is lower than that of j alpha probe-positive clones, possibly related to increasing 5' distance from the most upstream j alpha segment. |
1989-12-29 |
2023-08-11 |
mouse |
| Y Kaneko, G Frizzera, T Shikano, H Kobayashi, N Maseki, M Sakura. Chromosomal and immunophenotypic patterns in T cell acute lymphoblastic leukemia (T ALL) and lymphoblastic lymphoma (LBL). Leukemia. vol 3. issue 12. 1989-12-29. PMID:2586183. |
we found translocations involving 14q11, 7q35, or 7p15, where t cell receptor alpha and delta, beta, and gamma subunit genes reside, in 20 patients (40%). |
1989-12-29 |
2023-08-11 |
Not clear |
| I S Park, H Y Koh, J K Park, S D Par. Two different mechanisms are involved for the bleomycin-induced DNA repair synthesis in permeabilized HeLa cells. Biochemical and biophysical research communications. vol 164. issue 3. 1989-12-28. PMID:2480115. |
bleomycin-induced dna repair synthesis in the permeabilized hela cells was sensitive to aphidicolin, an inhibitor of dna polymerase alpha and delta, and to dideoxythymidine triphosphate (ddttp), a specific inhibitor of dna polymerase beta. |
1989-12-28 |
2023-08-11 |
Not clear |
| Nomenclature of the Fc receptors. IUIS subcommittee on nomenclature. Bulletin of the World Health Organization. vol 67. issue 4. 1989-12-21. PMID:2805222. |
subtypes of receptors are denoted by capital roman numerals, such as: fc gamma ri, ii and iii: fc receptors for igg on macrophages/monocytes and lymphocytes (numerals are in the order of affinity for igg); fc alpha r, fc mu r and fc delta r: fc receptors for iga, igm and igd; fc epsilon ri: high-affinity receptors for ige on mast cells and basophils; fc epsilon rii: low-affinity receptors for ige on lymphocytes, macrophages, and activated eosinophils. |
1989-12-21 |
2023-08-11 |
mouse |