| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
t cells can be divided into two groups on the basis of the expression of either alpha beta or gamma delta t-cell receptors (tcrs). |
1996-01-19 |
2023-08-12 |
mouse |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
because the tcr delta chain locus lies within the larger tcr alpha chain locus, control of the utilization of these two receptors is important in t-cell development, specifically for determination of t-cell type: rearrangement of the alpha locus results in deletion of the delta coding segments and commitment to the alpha beta lineage. |
1996-01-19 |
2023-08-12 |
mouse |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
these lines demonstrate that utilization of the delta deleting elements occurs in alpha beta t cells of the spleen and thymus. |
1996-01-19 |
2023-08-12 |
mouse |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
these recombinations are rare in the gamma delta population, indicating that the machinery for utilization of delta deleting elements is functional in alpha beta t cells but absent in gamma delta t cells. |
1996-01-19 |
2023-08-12 |
mouse |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
furthermore, a discrete population of early thymocytes containing delta deleting element recombinations but not v alpha-to-j alpha rearrangements has been identified. |
1996-01-19 |
2023-08-12 |
mouse |
| J Shutter, J A Cain, S Ledbetter, M D Rogers, R D Hocket. A delta T-cell receptor deleting element transgenic reporter construct is rearranged in alpha beta but not gamma delta T-cell lineages. Molecular and cellular biology. vol 15. issue 12. 1996-01-19. PMID:8524269. |
these data are consistent with a model in which delta deletion contributes to the implementation of a signal by which the tcr alpha chain locus is rearranged and expressed and thus becomes an alpha beta t cell. |
1996-01-19 |
2023-08-12 |
mouse |
| Y Tatsumi, D Deluca, R Q Cron, J A Blueston. Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture. Thymus. vol 23. issue 3-4. 1996-01-19. PMID:8525502. |
fetal thymus organ culture system (ftoc), a well-known model used for the study of tcr alpha beta development, was employed to study tcr gamma delta cell development. |
1996-01-19 |
2023-08-12 |
Not clear |
| H Suwa, T Tanaka, F Kitamura, T Shiohara, K Kuida, M Miyasak. Dysregulated expression of the IL-2 receptor beta-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice. International immunology. vol 7. issue 9. 1996-01-18. PMID:7495752. |
however, the development of other lymphocyte subsets including conventional alpha beta tcr+ cells, gamma delta tcr+ cells and b cells remained apparently intact. |
1996-01-18 |
2023-08-12 |
mouse |
| C Lundqvist, V Baranov, S Hammarström, L Athlin, M L Hammarströ. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. International immunology. vol 7. issue 9. 1996-01-18. PMID:7495755. |
the thymocyte markers cd1a and cd1c as well as the nk cell marker cd56 were expressed on a fraction of tcr alpha beta and tcr gamma delta iel. |
1996-01-18 |
2023-08-12 |
human |
| C Lundqvist, V Baranov, S Hammarström, L Athlin, M L Hammarströ. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. International immunology. vol 7. issue 9. 1996-01-18. PMID:7495755. |
the distinct surface marker profiles of iel and epithelial cells along small and large intestine suggest functional regional specialization and are compatible with the hypothesis that tcr alpha beta iel participate in immune reactions to lumenal antigens while tcr gamma delta iel perform surveillance of the epithelium. |
1996-01-18 |
2023-08-12 |
human |
| Y Li, S A Newby, J V Johnston, K E Hellström, L Che. Protective immunity induced by B7/CD28-costimulated gamma delta T cells to the EL-4 lymphoma in allogenic athymic mice. Journal of immunology (Baltimore, Md. : 1950). vol 155. issue 12. 1996-01-18. PMID:7499857. |
furthermore, depletion of gamma delta t cells with a specific mab made possible the progressive growth of b7+ el-4 cells in 90% of athymic mice while depletion of alpha beta t cells allowed tumor growth in 50% of these mice. |
1996-01-18 |
2023-08-12 |
mouse |
| Y Li, S A Newby, J V Johnston, K E Hellström, L Che. Protective immunity induced by B7/CD28-costimulated gamma delta T cells to the EL-4 lymphoma in allogenic athymic mice. Journal of immunology (Baltimore, Md. : 1950). vol 155. issue 12. 1996-01-18. PMID:7499857. |
our data demonstrate that gamma delta t cells, and, to a less extent, extrathymic alpha beta t cells, mediate an immune response against b7+ el-4 cells in allogeneic athymic mice. |
1996-01-18 |
2023-08-12 |
mouse |
| A López-Girona, O Bachs, N Agel. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Biochemical and biophysical research communications. vol 217. issue 2. 1996-01-18. PMID:7503737. |
calmodulin is involved in the induction of dna polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. |
1996-01-18 |
2023-08-12 |
rat |
| A López-Girona, O Bachs, N Agel. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Biochemical and biophysical research communications. vol 217. issue 2. 1996-01-18. PMID:7503737. |
the results showed that the blockade of calmodulin by w13 produced an almost complete inhibition of dna polymerase delta activity whereas the activity of dna polymerase alpha was only partially inhibited. |
1996-01-18 |
2023-08-12 |
rat |
| A López-Girona, O Bachs, N Agel. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Biochemical and biophysical research communications. vol 217. issue 2. 1996-01-18. PMID:7503737. |
our data suggest that calmodulin might regulate dna replication through the control of the activities of dna polymerases alpha and delta and the expression of proliferating cell nuclear antigen. |
1996-01-18 |
2023-08-12 |
rat |
| S P Balk, J E Polischuk, C Probert, C Stevens, E Ebert, J She, C Terhorst, R S Blumber. Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. International immunology. vol 7. issue 8. 1996-01-17. PMID:7495730. |
thus, normal human iiel contain a tcr-cd3 complex that consists predominantly of zeta homodimers in association with the alpha beta tcr and cd3 gamma, delta and epsilon, similar to the majority of peripheral lymphocytes. |
1996-01-17 |
2023-08-12 |
mouse |
| E Gemmell, G J Seymou. Gamma delta T lymphocytes in human periodontal disease tissue. Journal of periodontology. vol 66. issue 9. 1996-01-17. PMID:7500244. |
in this study, a biotin-streptavidin peroxidase technique was used to determine the presence of t cells expressing alpha beta and gamma delta t cell receptors (tcr) in the inflammatory infiltrates of gingival tissue sections from gingivitis and adult periodontitis patients. |
1996-01-17 |
2023-08-12 |
human |
| J Mega, J R McGhee, H Kiyon. Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues. Advances in experimental medicine and biology. vol 371B. 1996-01-16. PMID:7502762. |
most interestingly, cd4-, cd8+ t cell subset contains both alpha beta tcr+ and gamma delta tcr+ t cells. |
1996-01-16 |
2023-08-12 |
Not clear |
| C C Chen, J Chang, W W Li. Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion. Neurochemistry international. vol 26. issue 5. 1996-01-11. PMID:7492943. |
the expression of pkc alpha and pkc delta in c6-glioma cells was more abundant than ng 108-15 cells, however, pkc epsilon in ng 108-15 was more abundant than c6-glioma cells in which pkc epsilon was almost undetectable. |
1996-01-11 |
2023-08-12 |
Not clear |
| C C Chen, J Chang, W W Li. Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion. Neurochemistry international. vol 26. issue 5. 1996-01-11. PMID:7492943. |
in this condition, the translocation of cpkc alpha, npkc delta and npkc epsilon induced by tpa still occurred, however, that of cpkc alpha was reduced more than in the normal condition. |
1996-01-11 |
2023-08-12 |
Not clear |