| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
deletion studies demonstrated that the last c-terminal 30 amino acids (amino acids (aa) 288 to aa 317, deleted in i kappa b alpha delta 3), including most of the pest domain, were dispensable for i kappa b alpha function. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
however, deletions from aa 261 to 317 or aa 269 to 317 (i kappa b alpha delta 1 and i kappa b alpha delta 2 respectively), lacked the ability to dissociate nf-kappa b/dna complexes in vitro and were unable to inhibit nf-kappa b dependent transcription. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
moreover, i kappa b alpha delta 1 and i kappa b alpha delta 2 mutants were resistant to inducer-mediated degradation. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
analysis of i kappa b alpha deletions in the presence of protein synthesis inhibitors revealed that, independently of stimulation, i kappa b alpha delta 1 and i kappa b alpha delta 2 had a half-life four times shorter than wild type i kappa b alpha and the interaction of i kappa b alpha delta 1 and i kappa b alpha delta 2 with p65 was dramatically decreased in vivo as measured by co-immunoprecipitation. |
1996-07-01 |
2023-08-12 |
human |
| P Beauparlant, R Lin, J Hiscot. The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631876. |
interestingly, protease inhibitors which blocked inducer-mediated degradation of i kappa b alpha also stabilized the turnover of i kappa b alpha delta 1 and i kappa b alpha delta 2. |
1996-07-01 |
2023-08-12 |
human |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
judging by the amplitudes of accho currents generated, the levels of functional receptor expression were: alpha beta gamma delta > alpha beta delta > alpha beta gamma > alpha gamma delta. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
the alpha beta gamma delta and alpha beta delta acchor subtypes were strongly blocked by 5ht, whereas the alpha beta gamma receptor was blocked only slightly. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
the order of blocking potency of acchors by 5ht was: alpha beta delta > alpha beta gamma delta > alpha beta gamma. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
blockage of alpha beta gamma delta and alpha beta delta receptors by 5ht was voltage-dependent, and the voltage dependence was abolished when the delta subunit was omitted. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| C M Rzepczyk, S Stamatiou, K Anderson, A Stowers, Q Cheng, A Saul, A Allworth, J McCormack, M Whitby, C Olive, G Lawrenc. Experimental human Plasmodium falciparum infections: longitudinal analysis of lymphocyte responses with particular reference to gamma delta T cells. Scandinavian journal of immunology. vol 43. issue 2. 1996-07-01. PMID:8633202. |
numbers of gamma delta and alpha beta t cells and nk cells declined markedly during infection to reach minimum values 12-13 days post-infection when the patients were ill. |
1996-07-01 |
2023-08-12 |
human |
| K P Kearse, J P Roberts, D L Wiest, A Singe. Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 17. issue 12. 1996-06-28. PMID:8634066. |
most lymphocytes of the t cell lineage develop along the cd4/cd8 pathway and express antigen receptors on their surfaces consisting of clonotypic alpha beta chains associated with invariant cd3- gamma delta epsilon components and sigma chains, collectively referred to as the t cell antigen receptor complex (tcr). |
1996-06-28 |
2023-08-12 |
Not clear |
| E Szomolanyi-Tsuda, R M Wels. T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice. The Journal of experimental medicine. vol 183. issue 2. 1996-06-27. PMID:8627153. |
sera from pyv-infected t cell receptor (tcr) alpha beta knockout or tcr alpha beta gamma delta knockout mice contained igg2a antibodies to pyv. |
1996-06-27 |
2023-08-12 |
mouse |
| H Nakano, T Yamazaki, S Miyatake, N Nozaki, A Kikuchi, T Sait. Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex. The Journal of biological chemistry. vol 271. issue 11. 1996-06-24. PMID:8626450. |
t cell antigen receptor (tcr)-cd3 complex is composed of six different subunits: tcr alpha and tcr beta and cd3 gamma, cd3 delta, cd3 epsilon, and cd3 eta. |
1996-06-24 |
2023-08-12 |
Not clear |
| N Nakaigawa, S Hirai, K Mizuno, T Shuin, M Hosaka, S Ohn. Differential effects of overexpression of PKC alpha and PKC delta/epsilon on cellular E2F activity in late G1 phase. Biochemical and biophysical research communications. vol 222. issue 1. 1996-06-24. PMID:8630081. |
overexpression of pkc alpha inhibited e2f activity while the overexpression of pkc delta or pkc epsilon enhanced it, suggesting that these pkc isozymes play different roles in the regulation of e2f activity. |
1996-06-24 |
2023-08-12 |
rat |
| D A Grahame, E DeMol. Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri. The Journal of biological chemistry. vol 271. issue 14. 1996-06-21. PMID:8626532. |
catalysis of acetyl-coa synthesis was lost in parallel with the loss of the intact beta subunit; however, no decrease in activity was detected in any of three partial reactions found to be catalyzed by distinct protein components of the proteolyzed acds complex: (a) co dehydrogenase, catalyzed by the alpha epsilon component, (b) ch3-h4pteridine:cob(i)amide-protein methyltransferase, catalyzed by the intact gamma subunit and fragments of the delta subunit, and (c) acetyltransferase, catalyzed by a truncated form of the beta subunit. |
1996-06-21 |
2023-08-12 |
Not clear |
| Y Ikeuchi, T Nishizaki, T Matsuoka, K Sumikaw. Arachidonic acid potentiates ACh receptor currents by protein kinase C activation but not by receptor phosphorylation. Biochemical and biophysical research communications. vol 221. issue 3. 1996-06-21. PMID:8630027. |
furthermore, arachidonic acid-evoked current depression was blocked in mutant ach receptors with pkc phosphorylation site deletions on the alpha and delta subunits, but the long-lasting potentiation effect remained. |
1996-06-21 |
2023-08-12 |
xenopus_laevis |
| W M Jones, B Walcheck, M A Jutil. Generation of a new gamma delta T cell-specific monoclonal antibody (GD3.5). Biochemical comparisons of GD3.5 antigen with the previously described Workshop Cluster 1 (WC1) family. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 10. 1996-06-20. PMID:8621913. |
facs analysis indicated that gd3.5ag is expressed on approximately 90% of the peripheral blood gamma delta t cell population and gd3.5 specifically stained gamma delta t cells and not alpha beta t cells, b cells, neutrophils, or monocytes. |
1996-06-20 |
2023-08-12 |
Not clear |
| M C Verschuren, C J van Bergen, E J van Gastel-Mol, A J Bogers, J J van Donge. A DNA binding protein in human thymocytes recognizes the T cell receptor-delta-deleting element psi J alpha. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 10. 1996-06-20. PMID:8621917. |
the tcr is a heterodimeric molecule composed of either gamma delta or alpha beta chains. |
1996-06-20 |
2023-08-12 |
human |
| M C Verschuren, C J van Bergen, E J van Gastel-Mol, A J Bogers, J J van Donge. A DNA binding protein in human thymocytes recognizes the T cell receptor-delta-deleting element psi J alpha. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 10. 1996-06-20. PMID:8621917. |
the differentiation mechanisms that force thymocytes into the gamma delta alpha beta lineage are poorly understood, but rearrangement processes in the tcr-delta alpha locus are likely to play an important role. |
1996-06-20 |
2023-08-12 |
human |
| M C Verschuren, C J van Bergen, E J van Gastel-Mol, A J Bogers, J J van Donge. A DNA binding protein in human thymocytes recognizes the T cell receptor-delta-deleting element psi J alpha. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 10. 1996-06-20. PMID:8621917. |
the tcr-delta gene complex is flanked by the delta-deleting elements delta rec and psi j alpha, which are assumed to delete the tcr-delta gene before v alpha-j alpha rearrangement. |
1996-06-20 |
2023-08-12 |
human |