| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Chen, A Tucker, B A Wallac. Solution structure of a parallel left-handed double-helical gramicidin-A determined by 2D 1H NMR. Journal of molecular biology. vol 264. issue 4. 1997-01-14. PMID:8980684. |
chi 2 angles were determined using d alpha beta(i,i), dn beta(i,i), d beta delta(i,i), dn gamma(i,i) and d alpha gamma(i,i). |
1997-01-14 |
2023-08-12 |
Not clear |
| R L Papke, M Bencherif, P Lippiell. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. Neuroscience letters. vol 213. issue 3. 1997-01-10. PMID:8873149. |
choline was a full agonist for alpha 7, but a hydroxyl group was strongly non-permissive for other receptor subtypes (alpha 1 beta 1 gamma delta, alpha 3 beta 4, alpha 3 beta 2, and alpha 4 beta 2). |
1997-01-10 |
2023-08-12 |
xenopus_laevis |
| D X Fu, S M Sin. Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor. The Journal of biological chemistry. vol 271. issue 49. 1997-01-09. PMID:8940161. |
in the beta and gamma subunits, p136g prevented assembly of higher order heteroligomers, whereas in the alpha and delta subunits, p136g prevented transport of assembled pentamers to the cell surface. |
1997-01-09 |
2023-08-12 |
Not clear |
| H J Caruncho, I Liste, C Pesold, F Impagnatiello, A Guidotti, J L Labandeira-Garci. Semiquantitative immunocytochemical analysis of GABAA receptor subunit expression in the rat neostriatum. Receptors & channels. vol 4. issue 2. 1997-01-08. PMID:8865360. |
the results indicate that the subunits studied can be classified into three groups on the basis of their labelling density in the striatum: alpha 1 and alpha 3 (labelling density of less than 100 gold particles per 1000 microns2), gamma 2 and delta (between 100 and 200 particles per 1000 microns2), and alpha 2 and beta 2/3 (more than 300 particles per 1000 microns2). |
1997-01-08 |
2023-08-12 |
rat |
| H J Caruncho, I Liste, C Pesold, F Impagnatiello, A Guidotti, J L Labandeira-Garci. Semiquantitative immunocytochemical analysis of GABAA receptor subunit expression in the rat neostriatum. Receptors & channels. vol 4. issue 2. 1997-01-08. PMID:8865360. |
the alpha 2 and delta subunits did not show significant regional differences in abundance. |
1997-01-08 |
2023-08-12 |
rat |
| A G Engel, K Ohno, M Milone, H L Wang, S Nakano, C Bouzat, J N Pruitt, D O Hutchinson, J M Brengman, N Bren, J P Sieb, S M Sin. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872460. |
mutations in genes encoding the epsilon, delta, beta and alpha subunits of the end plate acetylcholine (ach) receptor (achr) are described and functionally characterized in three slow-channel congenital myasthenic syndrome patients. |
1997-01-08 |
2023-08-12 |
Not clear |
| A G Engel, K Ohno, M Milone, H L Wang, S Nakano, C Bouzat, J N Pruitt, D O Hutchinson, J M Brengman, N Bren, J P Sieb, S M Sin. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872460. |
genetic analysis revealed heterozygous mutations: epsilon l269f and delta q267e in patient 1, beta v266m in patient 2, and alpha n217k in patient 3 that were not detected in 100 normal controls. |
1997-01-08 |
2023-08-12 |
Not clear |
| A G Engel, K Ohno, M Milone, H L Wang, S Nakano, C Bouzat, J N Pruitt, D O Hutchinson, J M Brengman, N Bren, J P Sieb, S M Sin. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872460. |
epsilon l269f, delta q267e and beta v266m occur in the second and alpha n217k in the first transmembrane domain of achr subunits; all have been postulated to contribute to the lining of the upper half of the channel lumen and all but delta q267e are positioned toward the channel lumen, and introduce an enlarged side chain. |
1997-01-08 |
2023-08-12 |
Not clear |
| A G Engel, K Ohno, M Milone, H L Wang, S Nakano, C Bouzat, J N Pruitt, D O Hutchinson, J M Brengman, N Bren, J P Sieb, S M Sin. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Human molecular genetics. vol 5. issue 9. 1997-01-08. PMID:8872460. |
epsilon l269f, beta v266m, and alpha n217k slow the rate of channel closure in the presence of ach and increase apparent affinity for ach; epsilon l269f and alpha n217k enhance desensitization, and epsilon l269f and beta v266m cause pathologic channel openings in the absence of ach, rendering the channel leaky, delta q267e has none of these effects and is therefore a rare polymorphism or a benign mutation. |
1997-01-08 |
2023-08-12 |
Not clear |
| K Holmbäck, M J Danton, T T Suh, C C Daugherty, J L Dege. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. The EMBO journal. vol 15. issue 21. 1997-01-08. PMID:8918453. |
however, both gamma delta 5-fibrinogen binding to alpha iib beta 3 and platelet aggregation were highly defective. |
1997-01-08 |
2023-08-12 |
mouse |
| K Holmbäck, M J Danton, T T Suh, C C Daugherty, J L Dege. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. The EMBO journal. vol 15. issue 21. 1997-01-08. PMID:8918453. |
remarkably, another alpha iib beta 3-dependent process, clot retraction, was unaffected by the gamma delta 5 mutation. |
1997-01-08 |
2023-08-12 |
mouse |
| B T Bäckström, E Milia, A Peter, B Jaureguiberry, C T Baldari, E Palme. A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. Immunity. vol 5. issue 5. 1997-01-08. PMID:8934571. |
mutant alphabeta tcrs were generated by replacing domains of the alpha and beta chain constant regions with homologous domains from tcr delta and gamma chains, respectively. |
1997-01-08 |
2023-08-12 |
Not clear |
| B T Bäckström, E Milia, A Peter, B Jaureguiberry, C T Baldari, E Palme. A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. Immunity. vol 5. issue 5. 1997-01-08. PMID:8934571. |
chimeric tcrs in which the alpha chain contains tcr delta chain sequences within the connecting peptide domain are unresponsive to alloantigens and superantigens, and have defective interactions with the cd3/zeta complex. |
1997-01-08 |
2023-08-12 |
Not clear |
| C Beh. [Immunopathology of malaria: emergence of a new T-lymphocyte reactivity]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 190. issue 4. 1997-01-07. PMID:8952887. |
studies investigating the role of gamma delta t cells have been conducted in different mice model where alpha beta t cells have been eliminated. |
1997-01-07 |
2023-08-12 |
mouse |
| C A Gurnett, M De Waard, K P Campbel. Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron. vol 16. issue 2. 1997-01-06. PMID:8789958. |
dual function of the voltage-dependent ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. |
1997-01-06 |
2023-08-12 |
xenopus_laevis |
| C A Gurnett, M De Waard, K P Campbel. Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron. vol 16. issue 2. 1997-01-06. PMID:8789958. |
voltage-dependent ca2+ channels are modulated by complex interactions with the alpha 2 delta subunit. |
1997-01-06 |
2023-08-12 |
xenopus_laevis |
| C A Gurnett, M De Waard, K P Campbel. Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron. vol 16. issue 2. 1997-01-06. PMID:8789958. |
in vitro translation was used to demonstrate a single transmembrane topology of the alpha 2 delta subunit in which all but the transmembrane sequence and 5 carboxy-terminal amino acids are extracellular. |
1997-01-06 |
2023-08-12 |
xenopus_laevis |
| C A Gurnett, M De Waard, K P Campbel. Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron. vol 16. issue 2. 1997-01-06. PMID:8789958. |
the glycosylated extra-cellular domain is required for current stimulation, as shown by coexpression of truncated alpha 2 delta subunits with alpha 1a and beta 4 subunits in xenopus oocytes and deglycosylation with peptide-n-glycosidase f. however, coexpression of the transmembrane domain-containing delta subunit reduced the stimulatory effects of full-length alpha 2 delta subunits and substitution of a different transmembrane domain resulted in a loss of current stimulation. |
1997-01-06 |
2023-08-12 |
xenopus_laevis |
| C A Gurnett, M De Waard, K P Campbel. Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron. vol 16. issue 2. 1997-01-06. PMID:8789958. |
these results support a model whereby the alpha 2 delta transmembrane domain mediates subunit interactions and the glycosylated extracellular domain enhances current amplitude. |
1997-01-06 |
2023-08-12 |
xenopus_laevis |
| R S Petralia, Y X Wang, H M Zhao, R J Wenthol. Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus. The Journal of comparative neurology. vol 372. issue 3. 1997-01-06. PMID:8873866. |
staining of the postsynaptic density and membrane of the granule cell-parallel fiber/cartwheel cell spins synapse was most prevalent with delta 1/2 and mglur1 alpha antibodies. |
1997-01-06 |
2023-08-12 |
Not clear |