| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
we showed that chemical agents or sirna inhibiting the activity of atm, cdk2 and p70s6k kinases blocked degradation of delta np63 alpha in hnscc cells after cisplatin exposure. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
site-specific mutagenesis of delta np63 alpha residues targeted for phosphorylation by atm, cdk2 or p70s6k led to dramatic modulation of delta np63 alpha degradation. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
finally, we demonstrated that the delta np63 alpha protein is a target for direct in vitro phosphorylation by atm, cdk2 or p70s6k. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
our results implicate specific kinases, and target phosphorylation sites in the degradation of delta np63 alpha following dna damage. |
2008-11-03 |
2023-08-12 |
human |
| Lisa Y Pang, Ted R Hup. Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18797190. |
protein kinases coordinately regulate the p53: delta np63 alpha axis after dna damage. |
2008-11-03 |
2023-08-12 |
Not clear |
| Takashi Akiyama, Takeshi Okino, Hiroshi Konishi, Yoji Wani, Kenji Notohara, Choutatsu Tsukayama, Tsukasa Tsunoda, Taizo Tasaka, Yuji Masaki, Takashi Sugihara, Yoshito Sadahir. CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients. Pathology international. vol 58. issue 10. 2008-10-30. PMID:18801082. |
immunohistochemistry and genetics suggested that three cases were of alpha beta t-cell origin and two cases were of gamma delta t-cell origin. |
2008-10-30 |
2023-08-12 |
Not clear |
| Gerald J Obermair, Petronel Tuluc, Bernhard E Fluche. Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Current opinion in pharmacology. vol 8. issue 3. 2008-10-28. PMID:18329337. |
a multitude of studies in heterologous cells demonstrated that coexpression of the pore-forming alpha(1) subunits with auxiliary alpha(2)delta and beta subunits promotes membrane expression and modulates the biophysical channel properties. |
2008-10-28 |
2023-08-12 |
Not clear |
| Gerald J Obermair, Petronel Tuluc, Bernhard E Fluche. Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Current opinion in pharmacology. vol 8. issue 3. 2008-10-28. PMID:18329337. |
whether these specific functions in muscle indicate similar roles of alpha(2)delta and beta subunits as functional modulator and structural organizer, respectively, in neurons is being discussed. |
2008-10-28 |
2023-08-12 |
Not clear |
| G S Coyne, D A Kenny, S Childs, J M Sreenan, S M Water. Dietary n-3 polyunsaturated fatty acids alter the expression of genes involved in prostaglandin biosynthesis in the bovine uterus. Theriogenology. vol 70. issue 5. 2008-10-28. PMID:18582926. |
expression of mrna for prostaglandin e synthase (pges) and peroxisome proliferator-activated receptors, ppar alpha and delta was increased (p<0.05) while mrna expression of phospholipase a(2) (pla(2)) was decreased (p=0.06) in the high pufa endometrial tissues. |
2008-10-28 |
2023-08-12 |
cattle |
| Tatsuo Yamamot. [Mechanisms of the development of neuropathic pain and its treatment]. Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association. vol 77. issue 3. 2008-10-28. PMID:18800643. |
alpha 2 delta subunit blockers, such as gabapentin and pregabalin, may reduce the release of neurotransmitter and elicit analgesic effect in the treatment of neuropathic pain. |
2008-10-28 |
2023-08-12 |
Not clear |
| Takeshi Tomita, Taketomo Kido, Reiko Kurotani, Shun-Ichiro Iemura, Esta Sterneck, Tohru Natsume, Charles Vinson, Shioko Kimur. CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. The Journal of biological chemistry. vol 283. issue 37. 2008-10-23. PMID:18632661. |
caatt/enhancer-binding proteins alpha and delta interact with nkx2-1 to synergistically activate mouse secretoglobin 3a2 gene expression. |
2008-10-23 |
2023-08-12 |
mouse |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
the study objective was to predict the regioselectivity in the reaction of hydrogen addition onto azahydro[60]fullerene c 59h n+1 n ( n = 0-4) systems using a new reactivity indicator termed general-purpose reactivity indicator, xi delta nalpha (kappa), proposed by anderson et al. |
2008-10-21 |
2023-08-12 |
Not clear |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
because xi delta nalpha (kappa) combines the information from the electrostatic potential and the fukui function, this indicator is a two-parameter model that depends on the atomic charges and fukui values calculated. |
2008-10-21 |
2023-08-12 |
Not clear |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
comparisons with traditional indicators show that the application of xi delta nalpha (kappa) performs much better for predicting reactivity in the aza[60]fullerene derivatives studied. |
2008-10-21 |
2023-08-12 |
Not clear |
| Yael M Cycowicz, Bruce Luber, Timothy Spellman, Sarah H Lisanb. Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates. Clinical EEG and neuroscience. vol 39. issue 3. 2008-10-21. PMID:18751564. |
eeg power within four frequencies (delta, theta, alpha and beta) was calculated. |
2008-10-21 |
2023-08-12 |
monkey |
| Yoko Araya, Jun-Ichi Kasuga, Kenji Toyota, Yuko Hirakawa, Takuji Oyama, Makoto Makishima, Kosuke Morikawa, Yuichi Hashimoto, Hiroyuki Miyach. Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands. Chemical & pharmaceutical bulletin. vol 56. issue 9. 2008-10-21. PMID:18758120. |
based on the result of x-ray crystallographic analysis of our peroxisome proliferator-activated receptor alpha and delta (pparalpha/delta) co-agonist complexed with human ppar ligand binding domain (lbd), we designed and synthesized an optically active fluorescent pparalpha/delta co-agonist, which has a pyrene unit incorporated directly at the hydrophobic tail part of the structure as a fluorophore. |
2008-10-21 |
2023-08-12 |
human |
| Jennifer A Hunt, Stephen R Petteway, Philip Scuderi, Valery Novokhatn. Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin. Thrombosis and haemostasis. vol 100. issue 3. 2008-10-17. PMID:18766256. |
additionally, delta[k2-k5]pm was rapidly inhibited by alpha(2)-antiplasmin (1.1+/-0.1 x 10(7) m(-1) s(-1)) and alpha(2)-macroglobulin (7.6+/-0.6 x 10(5) m(-1) s(-1)). |
2008-10-17 |
2023-08-12 |
human |
| Michael A Rogawski, Carl W Bazi. New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590620. |
new molecular targets for antiepileptic drugs: alpha(2)delta, sv2a, and k(v)7/kcnq/m potassium channels. |
2008-10-09 |
2023-08-12 |
Not clear |
| Michael A Rogawski, Carl W Bazi. New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590620. |
here, we describe three of these targets: alpha(2)delta, auxiliary subunits of voltage-gated calcium channels through which the gabapentinoids gabapentin and pregabalin exert their anticonvulsant and analgesic actions; sv2a, a ubiquitous synaptic vesicle glycoprotein that may prepare vesicles for fusion and serves as the target for levetiracetam and its analog brivaracetam (which is currently in late-stage clinical development); and k(v)7/kcnq/m potassium channels that mediate the m-current, which acts a brake on repetitive firing and burst generation and serves as the target for the investigational aeds retigabine and ica-105665. |
2008-10-09 |
2023-08-12 |
Not clear |
| Emmanuel Bissé, Christine Schaeffer, Agnès Hovasse, Sabine Preisler-Adams, Thomas Epting, Manfred Baumstark, Alain Van Dorsselaer, Jürgen Horst, Heinrich Wielan. Haemoglobin Noah Mehmet Oeztuerk (alpha(2) delta(2)143 (H21)His-->Tyr: A novel delta-chain variant in the 2,3-DPG binding site. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 871. issue 1. 2008-10-06. PMID:18644751. |
haemoglobin noah mehmet oeztuerk (alpha(2) delta(2)143 (h21)his-->tyr: a novel delta-chain variant in the 2,3-dpg binding site. |
2008-10-06 |
2023-08-12 |
Not clear |