| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H T Chan. Noradrenergic innervation of the substantia innominata: a light and electron microscopic analysis of dopamine beta-hydroxylase immunoreactive elements in the rat. Experimental neurology. vol 104. issue 2. 1989-06-06. PMID:2707360. |
noradrenergic input to the rat substantia innominata (si) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (dbh), the synthetic enzyme for noradrenaline. |
1989-06-06 |
2023-08-11 |
rat |
| R A Browning, D R Wade, M Marcinczyk, G L Long, P C Job. Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat. The Journal of pharmacology and experimental therapeutics. vol 249. issue 1. 1989-06-01. PMID:2709332. |
two markers for noradrenergic neurons: 1) desmethylimipramine sensitive norepinephrine (ne) uptake and 2) dopamine beta-hydroxylase activity were compared in various brain regions of normal and genetically epilepsy-prone rats (gepr). |
1989-06-01 |
2023-08-11 |
rat |
| A Hirose, M Sasa, Y Ohno, S Takaor. Inhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus. Japanese journal of pharmacology. vol 48. issue 4. 1989-05-30. PMID:2907593. |
electrophysiological studies using reserpine-treated cats were carried out to elucidate the effects of l-threo-3,4-dihydroxyphenylserine (l-threo-dops) on the noradrenergic pathway from the locus coeruleus (lc) to the caudate nucleus (cn) neurons, which were activated by iontophoretically applied bromocriptine, a dopamine d-2 receptor agonist. |
1989-05-30 |
2023-08-11 |
Not clear |
| W E Blumberg, P R Desai, L Powers, J H Freedman, J J Villafranc. X-ray absorption spectroscopic study of the active copper sites in dopamine beta-hydroxylase. The Journal of biological chemistry. vol 264. issue 11. 1989-05-18. PMID:2703478. |
x-ray absorption spectroscopy has been used to investigate the local environment of the copper sites in bovine dopamine beta-hydroylase, the enzyme that catalyzes the conversion of dopamine to norepinephrine in the adrenal medulla and noradrenergic nerve cells. |
1989-05-18 |
2023-08-11 |
cattle |
| A J Man in 't Veld, F Boomsma, A H van den Meiracker, C Julien, J Lenders, M A Schalekam. d,l-threo-3,4-dihydroxyphenylserine restores sympathetic control and cures orthostatic hypotension in dopamine beta-hydroxylase deficiency. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 6. issue 4. 1989-05-18. PMID:3149290. |
in this orthostatic syndrome the functional integrity of the sympathetic noradrenergic neuron is probably intact, but dopamine instead of noradrenaline is released as the neurotransmitter. |
1989-05-18 |
2023-08-11 |
Not clear |
| R J Bicknell, B G Zhao, C Chapman, R P Heavens, D J Sirinathsinghj. Opioid inhibition of secretion from oxytocin and vasopressin nerve terminals following selective depletion of neurohypophysial catecholamines. Neuroscience letters. vol 93. issue 2-3. 1989-05-16. PMID:3241653. |
the enhancement of oxt secretion was not significantly altered in neurohypophyses depleted of greater than 90% of noradrenaline content by prior lesion of the ventral noradrenergic tract, or depleted of greater than 90% of both noradrenaline and dopamine content by prior reserpine treatment. |
1989-05-16 |
2023-08-11 |
Not clear |
| C Pifl, L Pichler, W Kobinger, O Hornykiewic. The dopamine autoreceptor agonist, B-HT 920, preferentially reduces brain dopamine release in vivo: biochemical indices of brain dopamine, noradrenaline and serotonin in ventriculocisternal perfusates in the cat. European journal of pharmacology. vol 153. issue 1. 1989-03-03. PMID:2463928. |
b-ht 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4h-thiazolo[4,5-d]azepine), a candidate for selective dopamine (da) autoreceptor agonist activity, was tested for its interactions with biochemical parameters of brain dopaminergic, noradrenergic and serotoninergic systems as measured in ventriculocisternal perfusates of chloralose-anaesthetized cats. |
1989-03-03 |
2023-08-11 |
cat |
| J H Kordower, J R Sladek, M S Fiandaca, G Y Bing, D M Gas. Tyrosine hydroxylase-immunoreactive somata within the primate subfornical organ: species specificity. Brain research. vol 461. issue 2. 1988-12-21. PMID:2902903. |
cebus monkeys displayed dopamine beta hydroxylase and phenylethanolamine-n-methyltransferase- immunoreactive neurons within established noradrenergic and adrenergic nuclei respectively, but not within the sfo, suggesting that the neurons which are immunoreactive for th in this region contain dopamine. |
1988-12-21 |
2023-08-11 |
rat |
| J M Woulfe, A W Hrycyshyn, B A Flumerfel. Collateral axonal projections from the A1 noradrenergic cell group to the paraventricular nucleus and bed nucleus of the stria terminalis in the rat. Experimental neurology. vol 102. issue 1. 1988-12-07. PMID:2846338. |
immunohistochemical labeling of medullary neurons containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine n-methyltransferase was used to reveal the anatomical location of a1 noradrenergic neurons within the ventrolateral medulla. |
1988-12-07 |
2023-08-11 |
rat |
| W Verslegers, M Van den Kerchove, R Crols, W De Potter, B Appel, A Lowentha. Methanol intoxication. Parkinsonism and decreased Met-enkephalin levels due to putaminal necrosis. Acta neurologica Belgica. vol 88. issue 3. 1988-11-21. PMID:3176874. |
an alteration of the central noradrenergic activity and the opioid system can be assumed because of increased dopamine beta-hydroxylase (d beta h) activity and decreased methionine-enkephalin (met-enk) levels in the cerebrospinal fluid (csf). |
1988-11-21 |
2023-08-11 |
Not clear |
| C Burle. [Stress and feeding behavior]. Annales d'endocrinologie. vol 49. issue 2. 1988-10-25. PMID:3421663. |
in the brain, both aminergic and peptidergic systems were concerned; the stress-induced hyperphagia required the functionality of the dopamine, dorsal noradrenergic bundle and endogenous opioids of the central nervous system. |
1988-10-25 |
2023-08-11 |
Not clear |
| I J Kopin, J H White, K Bankiewic. A new approach to biochemical evaluation of brain dopamine metabolism. Cellular and molecular neurobiology. vol 8. issue 2. 1988-10-06. PMID:3044592. |
because hva is derived in part from dopamine formed in noradrenergic neurons, plasma levels and urinary excretion rates of hva do not adequately reflect solely metabolism of brain dopamine. |
1988-10-06 |
2023-08-11 |
monkey |
| I J Kopin, J H White, K Bankiewic. A new approach to biochemical evaluation of brain dopamine metabolism. Cellular and molecular neurobiology. vol 8. issue 2. 1988-10-06. PMID:3044592. |
by measuring the levels of methoxy-hydroxyphenylglycol (mhpg) in plasma or of urinary norepinephrine metabolites (total mhpg in monkeys; the sum of total mhpg and vanillyl mandelic acid (vma) in humans) along with hva, it is possible to estimate the degree of impairment by debrisoquin of hva formation from noradrenergic neuronal dopamine and thereby better assess brain dopamine metabolism. |
1988-10-06 |
2023-08-11 |
monkey |
| R E Powers, R G Struble, M F Casanova, D T O'Connor, C A Kitt, D L Pric. Innervation of human hippocampus by noradrenergic systems: normal anatomy and structural abnormalities in aging and in Alzheimer's disease. Neuroscience. vol 25. issue 2. 1988-09-01. PMID:3399052. |
immunocytochemical studies, using an antibody directed against human dopamine beta-hydroxylase, identified an extensive plexus of noradrenergic axons/terminals in normal human hippocampus. |
1988-09-01 |
2023-08-11 |
human |
| A Man in 't Veld, F Boomsma, J Lenders, A vd Meiracker, C Julien, J Tulen, P Moleman, T Thien, S Lamberts, M Schalekam. Patients with congenital dopamine beta-hydroxylase deficiency. A lesson in catecholamine physiology. American journal of hypertension. vol 1. issue 3 Pt 1. 1988-08-22. PMID:3291893. |
studies in this novel syndrome showed evidence for the peripheral production of dopamine from sympathetic nerve terminals noradrenergic in nature. |
1988-08-22 |
2023-08-11 |
Not clear |
| R S Mansbach, C Harrod, S M Hoffmann, M A Nader, Z Lei, J M Witkin, J E Barret. Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding. The Journal of pharmacology and experimental therapeutics. vol 246. issue 1. 1988-08-17. PMID:2455786. |
neurochemical analyses on samples of cerebrospinal fluid after administration of several doses of each compound were performed for the dopamine metabolites homovanillic acid (hva) and dihydroxyphenylacetic acid (dopac), the noradrenergic metabolite 3-methoxy-4-hydroxyphenylethylene glycol (mhpg) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa). |
1988-08-17 |
2023-08-11 |
Not clear |
| I J Kopin, J A Oliver, R J Polinsk. Relationship between urinary excretion of homovanillic acid and norepinephrine metabolites in normal subjects and patients with orthostatic hypotension. Life sciences. vol 43. issue 2. 1988-08-17. PMID:3393060. |
the regression line relating excretion of the dopamine and norepinephrine metabolites suggests that about one third of dopamine formed in noradrenergic neurons is converted to norepinephrine and the remainder metabolized, mainly to hva. |
1988-08-17 |
2023-08-11 |
human |
| K Taghzouti, H Simon, D Hervé, G Blanc, J M Studler, J Glowinski, M LeMoal, J P Tassi. Behavioural deficits induced by an electrolytic lesion of the rat ventral mesencephalic tegmentum are corrected by a superimposed lesion of the dorsal noradrenergic system. Brain research. vol 440. issue 1. 1988-05-27. PMID:3129124. |
when a specific 6-hydroxy dopamine (6-ohda) destruction of the dorsal noradrenergic (na) ascending pathway was superimposed to an electrolytic lesion of the vmt, animals recovered a normal locomotor activity and the possibility to alternate. |
1988-05-27 |
2023-08-11 |
rat |
| R Freedman, L E Adler, G A Gerhardt, M Waldo, N Baker, G M Rose, C Drebing, H Nagamoto, P Bickford-Wimer, R Frank. Neurobiological studies of sensory gating in schizophrenia. Schizophrenia bulletin. vol 13. issue 4. 1988-03-31. PMID:2894074. |
the measurement of this deficit in human subjects and the exploration of its neurobiology in animals has produced evidence about several issues in the pathophysiology of schizophrenia: (1) the role of dopamine in improvement of sensory function in schizophrenic patients treated with neuroleptic drugs, (2) the interaction between familial or genetic deficits in sensory functioning in schizophrenic patients and possible abnormalities in dopamine metabolism, and (3) a mechanism by which noradrenergic hyperactivity in mania and other psychiatric illnesses might mimic some pathophysiological deficits in schizophrenia. |
1988-03-31 |
2023-08-11 |
human |
| C R Clark, G M Geffen, L B Geffe. Catecholamines and attention. I: Animal and clinical studies. Neuroscience and biobehavioral reviews. vol 11. issue 4. 1988-03-28. PMID:3325864. |
of particular interest are the catecholamine projections to the cerebral cortex from the reticular formation, namely the dopamine neurons of the ventral tegmentum of the midbrain and the noradrenergic neurons of the locus coeruleus in the upper pons. |
1988-03-28 |
2023-08-11 |
human |