| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Li. Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism. Journal of neuroinflammation. vol 21. issue 1. 2024-10-19. PMID:39425203. |
at the cellular level, plx5622 restores the morphology and/or number of microglia in the somatosensory cortex, striatum, and hippocampal ca1 regions of the two models. |
2024-10-19 |
2024-10-21 |
mouse |
| Luping Liu, Tianxiang Li, Jinlong Chang, Xiaojiao Xia, Jun J. Microglia inversely regulate the level of perineuronal nets with the treatment of lipopolysaccharide and valproic acid. Neuroscience letters. 2024-09-20. PMID:39304021. |
specifically, 1 day or 3 days after a single dose of lipopolysaccharide (lps, 0.25 mg/kg) increased the density of microglia and further reduced the density of pnns in both hippocampus ca1 and visual cortex. |
2024-09-20 |
2024-09-23 |
mouse |
| Kang-In Lee, Min-Soo Kim, Heung Joo Yuk, Yousang Jo, Hye Jin Kim, Jieun Kim, Hyungjun Kim, Ju-Young Shin, Donghwan Kim, Ki-Sun Par. Alleviating depressive-like behavior in DSS-induced colitis mice: Exploring naringin and poncirin from Poncirus trifoliata extracts. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-21. PMID:38772154. |
in the cornu ammonis 1 (ca1) and dentate gyrus (dg) regions of the hippocampus, pt controlled the neuroinflammatory responses of proliferated microglia. |
2024-05-21 |
2024-05-27 |
mouse |
| Valeria Cogut, Maaike Goris, Aukje Jansma, Marrit van der Staaij, Robert H Hennin. Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction. Frontiers in neuroanatomy. vol 18. 2024-05-01. PMID:38686173. |
concurrently, the ca1 region of the hippocampus showed persistent morphological changes in microglia, characterized by reduced cell branching, decreased cell complexity and altered shape. |
2024-05-01 |
2024-05-03 |
mouse |
| Dae Won Kim, Tae-Kyeong Lee, Ji Hyeon Ahn, Se-Ran Yang, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang, Joon Ha Par. Porphyran Attenuates Neuronal Loss in the Hippocampal CA1 Subregion Induced by Ischemia and Reperfusion in Gerbils by Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation. Marine drugs. vol 22. issue 4. 2024-04-26. PMID:38667787. |
the pretreatment with 50 mg/kg of porphyran significantly suppressed the ir-induced activation and proliferation of microglia in the ca1 subregion. |
2024-04-26 |
2024-04-28 |
Not clear |
| Austin Ferro, Anosha Arshad, Leah Boyd, Tess Stanley, Adrian Berisha, Uma Vrudhula, Adrian M Gomez, Jeremy C Borniger, Lucas Cheadl. The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617238. |
at the cellular level, microglia contacted fewer, but larger, excitatory synapses in ca1 in the absence of fn14, suggesting that these brain-resident immune cells may dampen neuronal activity by modifying synaptic inputs onto pyr neurons. |
2024-04-15 |
2024-04-17 |
mouse |
| Assunta Virtuoso, Christos Galanis, Maximilian Lenz, Michele Papa, Andreas Vlacho. Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397023. |
in the present study, we mechanically induced a schaffer collateral lesion (scl) in mouse entorhino-hippocampal slice cultures to investigate glial behavior, i.e., microglia and astrocytes, under metalloproteinases (mmps) modulation in the lesioned area, ca3, and the denervated region, ca1. |
2024-02-24 |
2024-02-26 |
mouse |
| Shiva Zeini, Nahid Davoodian, Seyed Abdollah Mousav. Gamma-oryzanol attenuates lipopolysaccharide-induced cognitive impairment by modulation of hippocampal inflammatory response and glial activation in mice. Journal of neuroimmunology. vol 387. 2024-01-26. PMID:38278081. |
also, neuronal loss, microglia, and astrocyte densities were evaluated in the ca1 and ca3 hippocampus. |
2024-01-26 |
2024-01-29 |
mouse |
| Shiva Zeini, Nahid Davoodian, Seyed Abdollah Mousav. Gamma-oryzanol attenuates lipopolysaccharide-induced cognitive impairment by modulation of hippocampal inflammatory response and glial activation in mice. Journal of neuroimmunology. vol 387. 2024-01-26. PMID:38278081. |
this behavioral improvement was accompanied by a significant reduction in the number of microglia and astrocytes in the ca1 and ca3 hippocampus. |
2024-01-26 |
2024-01-29 |
mouse |
| Changran Niu, Xinpei Yue, Juan Ji An, Robert Bass, Haifei Xu, Baoji X. Genetic Dissection of BDNF and TrkB Expression in Glial Cells. Biomolecules. vol 14. issue 1. 2024-01-23. PMID:38254691. |
surprisingly, we found no bdnf- or trkb-expressing microglia in examined cns regions, including the somatomotor cortex, hippocampal ca1, and spinal cord. |
2024-01-23 |
2024-01-25 |
mouse |
| Xue-Jing Lv, Su-Su Lv, Guo-Hong Wang, Yue Chang, Ya-Qi Cai, Hui-Zhu Liu, Guang-Zhou Xu, Wen-Dong Xu, Yu-Qiu Zhan. Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia. Brain, behavior, and immunity. 2024-01-20. PMID:38244946. |
we found that rtn resulted in robust activation of astrocytes and microglia in the ca1 area of the vhpc (vca1). |
2024-01-20 |
2024-01-23 |
mouse |
| K Oberman, B L van Leeuwen, M Nabben, J E Villafranca, R G Schoemake. J147 affects cognition and anxiety after surgery in Zucker rats. Physiology & behavior. vol 273. 2023-11-26. PMID:37989448. |
surgery in zucker rats reduced exploration and increased anxiety in the open field test, impaired short-term spatial memory, induced a shift in circadian rhythm and increased plasma neutrophil gelatinase-associated lipocalin (ngal), microglia activity in the ca1 and blood brain barrier leakage. |
2023-11-26 |
2023-11-28 |
rat |
| Zhen Li, Meng-Xing Li, Yun-Peng Qin, Wei Tan. Electroacupuncture improves cognitive dysfunction in rats with Alzheimer's disease by regulating microglial cells. Zhen ci yan jiu = Acupuncture research. vol 48. issue 11. 2023-11-24. PMID:37984903. |
to observe the effect of electroacupuncture (ea) on microglia (mg), janus kinase-2 (jak2) and signal transducer and activator of transcription-3 (stat3) in hippocampal ca1 region of alzheimer's di-sease (ad) rats, so as to explore its mechanisms in the treatment of ad. |
2023-11-24 |
2023-11-28 |
rat |
| Juan Chen, Tao Wang, Yuting Zhou, Yiming Hong, Shiyong Zhang, Zhongtao Zhou, Ao Jiang, Danyang Li. Microglia trigger the structural plasticity of GABAergic neurons in the hippocampal CA1 region of a lipopolysaccharide-induced neuroinflammation model. Experimental neurology. 2023-10-08. PMID:37806513. |
microglia trigger the structural plasticity of gabaergic neurons in the hippocampal ca1 region of a lipopolysaccharide-induced neuroinflammation model. |
2023-10-08 |
2023-10-15 |
mouse |
| Shuo Zhao, Jinpeng Zhang, Yufeng Chen, Xinyuan Cui, Haiqing Liu, Ying Yan, Yuexiang Sun, Yongxiu Qi, Yuanyuan Li. The comprehensive mechanism underlying Schisandra polysaccharide in AD-like symptoms of Aβ25-35-induced rats based on hippocampal metabolomics and serum lipidomics techniques. Journal of pharmaceutical and biomedical analysis. vol 236. 2023-09-16. PMID:37716276. |
the pharmacodynamic results revealed that scp significantly improved the spatial learning and long-term memory function and the morphology of neurons in the hippocampal ca1 region, alleviated inflammatory damage and oxidative stress, inhibited the activation of microglia and astrocytes, and increased the proportion of mature neurons of ad-like symptoms of aβ25-35-induced rats. |
2023-09-16 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
we found that hpc decreased nlrp3 inflammasome in microglia and inhibited m1 polarization of microglia in ca1 after tgci. |
2023-09-08 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
additionally, the knockdown of p-mlkl by short hairpin rna (shrna) administration inhibited the activation of the nf-κb signaling pathway and reduced the formation of nlrp3 inflammasome, thus attenuating m1 polarization of microglia and decreasing the release of interleukin 1 beta (il-1β) and necrosis factor alpha (tnf-α) in ca1 post ischemia. |
2023-09-08 |
2023-10-07 |
rat |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |
| Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhan. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochemical research. 2023-07-25. PMID:37490197. |
ds also remarkably inhibited lps-induced neuroinflammation by suppressing microglia overactivation, pro-inflammatory cytok ine release (tnf-α and il-1β) and reducing neuronal loss in the ca1 and dg regions of the hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Gumaro Galindo-Paredes, Gonzalo Flores, Julio César Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. |
in the bla, cea and ca1, obx caused significant changes in glial cells, such as hypertrophy and hypotrophy in gfap-positive astrocytes and iba1-positive microglia, respectively. |
2023-06-30 |
2023-08-14 |
rat |