| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V K Shukla, S K Garg, S K Kulkarn. GABAergic, dopaminergic and cholinergic interaction in tremorine-induced tremors in mice. Methods and findings in experimental and clinical pharmacology. vol 10. issue 1. 1988-05-16. PMID:2895827. |
the modification of the protective effect of anticholinergic and dopaminergic agents by gabaergic agents has been explained on the basis of neurotransmitter interaction. |
1988-05-16 |
2023-08-11 |
mouse |
| R Dal Toso, O Giorgi, C Soranzo, G Kirschner, G Ferrari, M Favaron, D Benvegnù, D Presti, S Vicini, G Toffan. Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 3. 1988-04-14. PMID:3346717. |
in particular the development, i.e., neurotransmitter uptake characteristics, and survival of dopaminergic and gabaergic neurons in fetal mouse (e13)-dissociated mesencephalic cells cultured in serum-free, hormone-supplemented medium have been assessed as a function of culture time and cell density. |
1988-04-14 |
2023-08-11 |
mouse |
| R Dal Toso, O Giorgi, C Soranzo, G Kirschner, G Ferrari, M Favaron, D Benvegnù, D Presti, S Vicini, G Toffan. Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 3. 1988-04-14. PMID:3346717. |
in particular, bovine striatal extracts contain activity capable of increasing high-affinity neurotransmitter uptake parameters and cell survival of at least the dopaminergic and gabaergic neurons present in the culture system. |
1988-04-14 |
2023-08-11 |
mouse |
| B Eichelma. Toward a rational pharmacotherapy for aggressive and violent behavior. Hospital & community psychiatry. vol 39. issue 1. 1988-03-10. PMID:2828219. |
a substantial body of research with both animals and humans demonstrates that pharmacologic modulation of three neurotransmitter systems (the gabaergic, the noradrenergic, and the serotonergic) and electrical stimulation of regions of the brain produce marked alterations in aggressive and violent behavior. |
1988-03-10 |
2023-08-11 |
Not clear |
| K Bizière, J P Chambo. [Animal models of epilepsy and experimental seizures]. Revue neurologique. vol 143. issue 5. 1987-10-28. PMID:3116633. |
alterations in several neurotransmitter systems have been reported in susceptible strains as compared to resistant strains, such as modifications in noradrenergic, serotoninergic, gabaergic or glutamatergic transmissions, but no single abnormal parameter can unequivocally be correlated to seizure susceptibility. |
1987-10-28 |
2023-08-11 |
mouse |
| C R Houser, A B Harris, J E Vaugh. Time course of the reduction of GABA terminals in a model of focal epilepsy: a glutamic acid decarboxylase immunocytochemical study. Brain research. vol 383. issue 1-2. 1986-12-10. PMID:3094829. |
immunocytochemical localization of glutamic acid decarboxylase (gad), the synthesizing enzyme for the neurotransmitter gamma-aminobutyric acid (gaba), has been used to study the time course of the decrease in putative gabaergic synaptic terminals that occurs in an alumina gel-induced model of focal epilepsy. |
1986-12-10 |
2023-08-11 |
monkey |
| J M Lauder, V K Han, P Henderson, T Verdoorn, A C Towl. Prenatal ontogeny of the GABAergic system in the rat brain: an immunocytochemical study. Neuroscience. vol 19. issue 2. 1986-12-04. PMID:3022187. |
the early differentiation of the gabaergic system could indicate a trophic role for gaba in early brain development, possibly involving receptors for this neurotransmitter or related substances. |
1986-12-04 |
2023-08-11 |
rat |
| V K Shukla, S K Garg, V S Mathur, S K Kulkarn. GABAergic, dopaminergic and cholinergic interactions in perphenazine-induced catatonia in rats. Archives internationales de pharmacodynamie et de therapie. vol 278. issue 2. 1986-03-28. PMID:3938209. |
the protective effect of gabaergic agonists and gaba antagonist and its modification by anticholinergic and dopaminergic agents has been explained on the basis of neurotransmitter interaction. |
1986-03-28 |
2023-08-11 |
rat |
| P Madtes, A Kyritsis, G J Chade. Neurotransmitter systems in morphologically undifferentiated human Y-79 retinoblastoma cells: studies of GABAergic, glycinergic, and beta-adrenergic systems. Journal of neurochemistry. vol 45. issue 6. 1985-12-16. PMID:2865336. |
neurotransmitter systems in morphologically undifferentiated human y-79 retinoblastoma cells: studies of gabaergic, glycinergic, and beta-adrenergic systems. |
1985-12-16 |
2023-08-11 |
human |
| A J Beitz, A A Larso. Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA. European journal of pharmacology. vol 114. issue 2. 1985-11-21. PMID:2995078. |
pipecolic acid (pa) is an alicyclic amino acid and putative neurotransmitter which may modulate gabaergic transmission in the central nervous system. |
1985-11-21 |
2023-08-11 |
mouse |
| C Tanaka, K Taniyam. Substance P provoked gamma-aminobutyric acid release from the myenteric plexus of the guinea-pig small intestine. The Journal of physiology. vol 362. 1985-09-12. PMID:2410602. |
bicuculline (10(-6) m) inhibited the release of [3h]ach evoked by substance p (10(-9) m) by 68.1 +/- 4.6% (n = 5), thereby suggesting that the substance p-evoked ach release is partly mediated through the endogenous gaba released by substance p. these results provide evidence for the neurotransmitter role of gaba and a possible excitatory role of substance p on the gabaergic neurones in the myenteric plexus of the guinea-pig small intestine. |
1985-09-12 |
2023-08-11 |
Not clear |
| A M Sillito, T E Salt, J A Kem. Modulatory and inhibitory processes in the visual cortex. Vision research. vol 25. issue 3. 1985-08-26. PMID:2862740. |
the functional role of three putative neurotransmitter systems in the visual cortex is compared; the gabaergic inhibitory interneurons, the interneurones containing somatostatin and the cholinergic input originating from the nucleus basalis of meynert (nbm). |
1985-08-26 |
2023-08-11 |
Not clear |
| J M Gerhart, J S Hong, H A Tilso. Studies on the mechanism of chlordecone-induced tremor in rats. Neurotoxicology. vol 6. issue 1. 1985-06-18. PMID:2581196. |
although no one neurotransmitter system appears necessary for tremor, the serotonergic, gabaergic, and cholinergic systems appear to contribute to chlordecone-induced tremor. |
1985-06-18 |
2023-08-11 |
rat |
| B Sadasivudu, M Swam. Possible occurrence of ornithine-omega-aminotransferase in GABAergic neurons. Neurochemical research. vol 9. issue 11. 1985-03-08. PMID:6521820. |
the specific precursors for neurotransmitter pools of glutamate giving rise to gaba in gabaergic neurons and nerve endings have not been clearly established. |
1985-03-08 |
2023-08-12 |
rat |
| M Poisson, F Huguet, A Savattier, F Bakri-Logeais, G Narciss. A new type of anticonvulsant, stiripentol. Pharmacological profile and neurochemical study. Arzneimittel-Forschung. vol 34. issue 2. 1984-06-11. PMID:6326778. |
these findings suggest that the anticonvulsant activity of stiripentol involves two aspects of the gabaergic mechanism in which the metabolic transamination and synaptosomal uptake of this neurotransmitter are inhibited. |
1984-06-11 |
2023-08-12 |
rat |
| S J Enna, J P Gallaghe. Biochemical and electrophysiological characteristics of mammalian GABA receptors. International review of neurobiology. vol 24. 1984-02-14. PMID:6317597. |
also, anatomically, there appear to be two different types of receptors, those located postsynaptically on the soma or dendrites of a neighboring cell and those found presynaptically on gabaergic and other neurotransmitter terminals. |
1984-02-14 |
2023-08-12 |
Not clear |
| M Ikeda, T Dohi, A Tsujimot. Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics. Anesthesiology. vol 58. issue 6. 1983-07-08. PMID:6859579. |
these results suggest that local anesthetics reduce gabaergic activities by inhibiting the release of the neurotransmitter from the nerve terminals, and that inhibition of the gaba system may be involved in the mechanism of local anesthetic-induced convulsions. |
1983-07-08 |
2023-08-12 |
rat |
| J P Loeffler, E Desaulles, B A Demeneix, P Felt. Electrophysiological study with K+- and Ca2+-sensitive micropipettes of GABA receptors in the rat neurointermediate lobe in vitro. Neuroscience letters. vol 34. issue 3. 1983-04-21. PMID:6298674. |
the possible distribution of receptors and role of gabaergic synapses in modulating neurotransmitter and hormone release by the nil are discussed. |
1983-04-21 |
2023-08-12 |
rat |
| S C Fung, Y C Kong, D M La. Prenatal development of gabaergic, glycinergic, and dopaminergic neurons in the rabbit retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 11. 1983-01-07. PMID:6292378. |
the main findings from our studies on the emergence and maturation of neurotransmitter systems in the rabbit retina are that, during normal development: (1) the commitments for certain neurons to become gabaergic, glycinergic, or dopaminergic are made prenatally; the maturation of these neurons, however, occurs postnatally; (2) specific accumulations of exogenously supplied transmitters by presumed retinal neurons were first observed autoradiographically around embryonic day 22 (e22) for gamma-aminobutyric acid (gaba), e25 for glycine, and e27 for dopamine, suggesting that putative gabaergic, glycinergic, and dopaminergic neurons are determined phenotypically at least by these days; (3) based upon the three transmitter-specific properties--uptake, synthesis, and release--the uptake property is generally the first to emerge, while the appearance of the other properties follows a precise and distinct temporal pattern for each of the transmitters studied; (4) for gabaergic and glycinergic systems, the emergence of k+-stimulated, ca2+-dependent release mechanisms occurs many days after the first appearance of the uptake properties; in contrast, the mechanisms for dopamine uptake and release emerge at about the same time; and (5) by our criteria, putative gabaergic and glycinergic amacrine cells are mature between postnatal day 10 (p10) and p12, around the time when the eyes first open and direction-selective ganglion cells can first be recorded; however, the dopaminergic neurons probably are not mature until about p24. |
1983-01-07 |
2023-08-12 |
rabbit |
| V E Pettorossi, D Troiani, L Petrosin. Diazepam enhances cerebellar inhibition on vestibular neurons. Acta oto-laryngologica. vol 93. issue 5-6. 1982-09-24. PMID:7102294. |
gaba being the neurotransmitter released by purkinje cells evidence is provided for a diazepam potentiation of the gabaergic mechanism at the level of vestibular system. |
1982-09-24 |
2023-08-12 |
Not clear |