| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G X Xie, K Jones, S J Peroutka, P P Palme. Detection of mRNAs and alternatively spliced transcripts of dopamine receptors in rat peripheral sensory and sympathetic ganglia. Brain research. vol 785. issue 1. 1998-05-29. PMID:9526064. |
these results are useful in further studying the roles of dopamine and the effects of dopaminergic agents in the peripheral nervous system. |
1998-05-29 |
2023-08-12 |
rat |
| A Colzi, K Turner, A J Lee. Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 64. issue 5. 1998-05-28. PMID:9598668. |
to determine whether continuous waking day dopaminergic stimulation with the dopamine agonist apomorphine can reduce levodopa induced dyskinesias in parkinson's disease |
1998-05-28 |
2023-08-12 |
Not clear |
| S J Cragg, C Holmes, C R Hawkey, S A Greenfiel. Dopamine is released spontaneously from developing midbrain neurons in organotypic culture. Neuroscience. vol 84. issue 2. 1998-05-22. PMID:9539208. |
moreover, elevations in the extracellular concentrations of dopamine were markedly more prolonged in these and other developing systems than in axon terminal regions in mature striatum in which dopaminergic innervation is fully established. |
1998-05-22 |
2023-08-12 |
Not clear |
| M G Murer, G Dziewczapolski, L B Menalled, M C García, Y Agid, O Gershanik, R Raisman-Vozar. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Annals of neurology. vol 43. issue 5. 1998-05-21. PMID:9585350. |
we have evaluated the effects of a 6-month oral levodopa treatment on several dopaminergic markers, in rats with moderate or severe 6-hydroxydopamine-induced lesions of mesencephalic dopamine neurons and sham-lesioned animals. |
1998-05-21 |
2023-08-12 |
rat |
| L Fard. Brain imaging of schizophrenia--the dopamine hypothesis. Schizophrenia research. vol 28. issue 2-3. 1998-05-14. PMID:9468350. |
the dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. |
1998-05-14 |
2023-08-12 |
Not clear |
| A Kishore, T G Nygaard, R de la Fuente-Fernandez, A B Naini, M Schulzer, E Mak, T J Ruth, D B Calne, B J Snow, A J Stoess. Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography. Neurology. vol 50. issue 4. 1998-05-07. PMID:9566390. |
we tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (drd) have increased dopamine d2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. |
1998-05-07 |
2023-08-12 |
human |
| F Blandini, J T Greenamyr. Prospects of glutamate antagonists in the therapy of Parkinson's disease. Fundamental & clinical pharmacology. vol 12. issue 1. 1998-05-06. PMID:9523179. |
degeneration of dopamine nigral neurons and striatal dopaminergic denervation cause a cascade of functional modifications in the activity of basal ganglia nuclei. |
1998-05-06 |
2023-08-12 |
Not clear |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, A J DeMaggio, P Milbury, W R Matson, M P Rathbon. Altered guanosine and guanine concentrations in rabbit striatum following increased dopamine turnover. Brain research bulletin. vol 45. issue 3. 1998-05-05. PMID:9510422. |
because of the neurotrophic properties of guanosine and guanine, changes in striatal concentrations of these purines secondary to increased dopamine (da) turnover may have relevance for survival of remaining dopaminergic neurons in parkinson's disease (pd). |
1998-05-05 |
2023-08-12 |
rabbit |
| B J Morris, C S Simpson, S Mundell, K Maceachern, H M Johnston, A M Nola. Dynamic changes in NADPH-diaphorase staining reflect activity of nitric oxide synthase: evidence for a dopaminergic regulation of striatal nitric oxide release. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517430. |
these results therefore provide strong evidence that the nadph-diaphorase reaction can be used to monitor nos activity at a cellular level of resolution, and reveal a dopaminergic regulation of nos activity in the striatum mediated by d1-like and d2-like dopamine receptors. |
1998-05-05 |
2023-08-12 |
rat |
| O Saucedo-Cardenas, J D Quintana-Hau, W D Le, M P Smidt, J J Cox, F De Mayo, J P Burbach, O M Conneel. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520484. |
here we demonstrate that nurr1 functions at the later stages of dopamine cell development to drive differentiation of ventral mesencephalic late dopaminergic precursor neurons. |
1998-05-01 |
2023-08-12 |
mouse |
| M F Beal, R T Matthews, A Tieleman, C W Shult. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain research. vol 783. issue 1. 1998-04-30. PMID:9479058. |
coenzyme q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (mptp) induced loss of striatal dopamine and dopaminergic axons in aged mice. |
1998-04-30 |
2023-08-12 |
mouse |
| M F Beal, R T Matthews, A Tieleman, C W Shult. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain research. vol 783. issue 1. 1998-04-30. PMID:9479058. |
our results indicate that coq10 can attenuate the mptp-induced loss of striatal dopamine and dopaminergic axons in aged mice and suggest that coq10 may be useful in the treatment of parkinson's disease. |
1998-04-30 |
2023-08-12 |
mouse |
| P Allard, M Norlé. Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503281. |
previous findings regarding reduced csf hva in suicidal depression and indications of striatal dopaminergic biochemical and receptor changes in depression seem, according to the present study, not to be reflected by alterations in density or affinity of dopamine uptake sites in depressed suicide victims. |
1998-04-29 |
2023-08-12 |
Not clear |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
although cocaine induced similar profiles of dopamine overflow in the two mesolimbic areas, in the nucleus accumbens the latency of the dopaminergic response was shorter (three- to four-fold) during both initiation and termination of the cocaine self-administration session than in the amygdala. |
1998-04-24 |
2023-08-12 |
rat |
| K Kannari, T Maeda, M Matsunaga, T Sud. [Reduction of apomorphine-induced rotation in rats with additional destruction of the pedunculopontine nucleus contralateral to the unilateral nigrostriatal lesion]. No to shinkei = Brain and nerve. vol 50. issue 1. 1998-04-21. PMID:9493196. |
pedunculopontine nucleus (ppn) has been proposed to be one of the responsible sites for dopamine agonist induced contraversive rotation in rats with unilateral dopaminergic denervation. |
1998-04-21 |
2023-08-12 |
rat |
| F Pellicer, I Buendía-Roldán, V C Pallares-Trujill. Self-mutilation in the Lesch-Nyhan syndrome: a corporal consciousness problem?--a new hypothesis. Medical hypotheses. vol 50. issue 1. 1998-04-14. PMID:9488181. |
as a consequence, a decrease in dopamine synthesis during gestation and the early postnatal period could occur, producing a functional dopaminergic denervation of the d1 receptors, located on the prefrontal cortex, specifically in the cingulum bundle projections. |
1998-04-14 |
2023-08-12 |
Not clear |
| G Radnikow, U Misgel. Dopamine D1 receptors facilitate GABAA synaptic currents in the rat substantia nigra pars reticulata. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 6. 1998-04-13. PMID:9482788. |
we conclude that dopamine released from dendrites of dopaminergic neurons enhances gaba release in the pars reticulata of the substantia nigra through d1 receptors presumably located on striatonigral afferents. |
1998-04-13 |
2023-08-12 |
rat |
| U Muthane, T C Yasha, S K Shanka. Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India. Annals of neurology. vol 43. issue 3. 1998-04-10. PMID:9506543. |
despite a low number of melanized nigral neurons in the brains from india, individuals function normally and have dopamine levels comparable with their western counterparts, suggesting that it is not the absolute number of melanized nigral neurons but the percent loss of nigral neurons that results in dopaminergic deficiency in pd. |
1998-04-10 |
2023-08-12 |
human |
| C Rosenblad, A Martinez-Serrano, A Björklun. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience. vol 82. issue 1. 1998-04-09. PMID:9483509. |
in the control group the lesion induced a 75-90% reduction of the dopaminergic innervation in the dorsolateral striatum (assessed by [3h]n-[1-(2-benzo(b)thiopenyl)cyclohexyl]piperidine-labelled dopamine uptake sites), and an approximately 50% reduction in the number of tyrosine hydroxylase-positive cell bodies in the central part of the substantia nigra, accompanied by a significant impairment in spontaneous motor behaviour, as assessed by a forelimb stepping test. |
1998-04-09 |
2023-08-12 |
rat |
| Y Itzhak, C Gandia, P L Huang, S F Al. Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495865. |
methamphetamine (meth) is a powerful psychostimulant that produces dopaminergic neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity and dopamine transporter (dat) binding sites in the nigrostriatal system. |
1998-04-09 |
2023-08-12 |
mouse |