| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuan-Wei Peng, Allison Klotz, Arcan Guven, Unnati Kapadnis, Shobha Ravipaty, Vladimir Tolstikov, Vijetha Vemulapalli, Leonardo O Rodrigues, Hongyan Li, Mark D Kellogg, Farah Kausar, Linda Rees, Rangaprasad Sarangarajan, Birgitt Schüle, William Langston, Paula Narain, Niven R Narain, Michael A Kiebis. Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson's disease biomarker panel. Scientific reports. vol 14. issue 1. 2024-05-01. PMID:38693432. |
parkinson's disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor symptoms with a degree of misdiagnosis. |
2024-05-01 |
2024-05-04 |
Not clear |
| Xia-Yin Cao, Yi Liu, Jia-Shuo Kan, Xin-Xing Huang, Piniel Alphayo Kambey, Can-Tang Zhang, Jin Ga. Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression. Brain research bulletin. 2024-04-30. PMID:38688414. |
parkinson's disease (pd) is a severe neurodegenerative disease associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-04-30 |
2024-05-03 |
Not clear |
| Kajal Sharma, Shivani Chib, Aniket Gupta, Randhir Singh, Rishabh Chalotr. Interplay between α-synuclein and parkin genes: Insights of Parkinson's disease. Molecular biology reports. vol 51. issue 1. 2024-04-29. PMID:38683365. |
parkinson's disease (pd) is a complex and debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2024-04-29 |
2024-05-02 |
Not clear |
| Irene H Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Lura, Omnia Shadad, Erika Fernandez-Vizarra, Cèlia Painous, Alexandra Pérez-Soriano, Yaroslau Compta, Laura Molina-Porcel, Guido Alves, Ole-Bjørn Tysnes, Christian Dölle, Gonzalo S Nido, Charalampos Tzouli. Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease. Nature communications. vol 15. issue 1. 2024-04-29. PMID:38684731. |
in contrast, the non-ci deficient (nci-pd) subtype exhibits no evidence of mitochondrial impairment outside the dopaminergic substantia nigra and has a predilection for a tremor dominant phenotype. |
2024-04-29 |
2024-05-03 |
Not clear |
| Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Domin. Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-25. PMID:38664405. |
in immunohistochemical techniques and multi-channel fluorescence studies, gingipain antigens were abundant in dopaminergic neurons in the substantia nigra of both pd and neurologically normal control brains. |
2024-04-25 |
2024-04-28 |
Not clear |
| Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Domin. Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-25. PMID:38664405. |
these data suggest that gingipains localize in dopaminergic neurons in the substantia nigra and interact with alpha-synuclein. |
2024-04-25 |
2024-04-28 |
Not clear |
| Sheng Li, Yanbing Liu, Sen Lu, Jiayi Xu, Xiaokun Liu, Di Yang, Yuxuan Yang, Lin Hou, Ning L. A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress. Molecular and cellular biochemistry. 2024-04-16. PMID:38625515. |
parkinson's disease (pd) is an aging-associated neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of lewy bodies containing α-synuclein within these neurons. |
2024-04-16 |
2024-04-18 |
Not clear |
| Hideaki Matsui, Ryosuke Takahash. Current trends in basic research on Parkinson's disease: from mitochondria, lysosome to α-synuclein. Journal of neural transmission (Vienna, Austria : 1996). 2024-04-13. PMID:38613675. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and other brain regions. |
2024-04-13 |
2024-04-16 |
Not clear |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Che. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells. Biological & pharmaceutical bulletin. vol 47. issue 4. 2024-04-10. PMID:38599826. |
parkinson's disease (pd) is a common neurodegenerative disease with progressive loss of dopaminergic neurons in substantia nigra and the presence of α-synuclein-immunoreactive inclusions. |
2024-04-10 |
2024-04-13 |
human |
| Junwon Choi, Sun Wha Park, Hyunji Lee, Do Hyun Kim, Sung Won Ki. Human Nasal Inferior Turbinate-Derived Neural Stem Cells Improve the Niche of Substantia Nigra Par Compacta in a Parkinson's Disease Model by Modulating Hippo Signaling. Tissue engineering and regenerative medicine. 2024-04-10. PMID:38600296. |
the onset of pd is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2024-04-10 |
2024-04-13 |
human |
| Robert Coukos, Dimitri Krain. Key genes and convergent pathogenic mechanisms in Parkinson disease. Nature reviews. Neuroscience. 2024-04-10. PMID:38600347. |
parkinson disease (pd) is a neurodegenerative disorder marked by the preferential dysfunction and death of dopaminergic neurons in the substantia nigra. |
2024-04-10 |
2024-04-13 |
Not clear |
| Zsoka Varga, Jiri Keller, Simon Daniel Robinson, Tereza Serranova, Jiri Nepozitek, David Zogala, Jiri Trnka, Evzen Ruzicka, Karel Sonka, Petr Duse. Whole brain pattern of iron accumulation in REM sleep behavior disorder. Human brain mapping. vol 45. issue 5. 2024-04-09. PMID:38590155. |
dopaminergic degeneration in the substantia nigra is paralleled by susceptibility increase, mainly in nigrosome 1. |
2024-04-09 |
2024-04-11 |
Not clear |
| Rou Gu, Jianyu Pan, Maher Un Nisa Awan, Xiaowei Sun, Fang Yan, Liping Bai, Jie Ba. The major histocompatibility complex participates in Parkinson's disease. Pharmacological research. 2024-04-07. PMID:38583689. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and the aggregation of alpha-synuclein (α-syn). |
2024-04-07 |
2024-04-10 |
Not clear |
| Ya-Shi Wu, Wen-Han Zheng, Tai-Hang Liu, Yan Sun, Yu-Ting Xu, Li-Zhen Shao, Qin-Yu Cai, Ya Qin Tan. Joint-tissue integrative analysis identifies high-risk genes for Parkinson's disease. Frontiers in neuroscience. vol 18. 2024-04-05. PMID:38576865. |
the loss of dopaminergic neurons in the substantia nigra and the abnormal accumulation of synuclein proteins and neurotransmitters in lewy bodies constitute the primary symptoms of parkinson's disease (pd). |
2024-04-05 |
2024-04-07 |
Not clear |
| Thomas Paß, Konrad M Ricke, Pierre Hofmann, Roy S Chowdhury, Yu Nie, Patrick Chinnery, Heike Endepols, Bernd Neumaier, André Carvalho, Lionel Rigoux, Sophie M Steculorum, Julien Prudent, Trine Riemer, Markus Aswendt, Birgit Liss, Bent Brachvogel, Rudolf J Wiesne. Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons. Brain : a journal of neurology. 2024-04-04. PMID:38574200. |
degeneration of dopaminergic neurons in the substantia nigra and their striatal axon terminals causes cardinal motor symptoms of parkinson's disease. |
2024-04-04 |
2024-04-07 |
mouse |
| Tomaz Rus, Anka Cuderman, Dejan Georgie. Parkinsonism Associated With Traumatic Hemorrhage in Substantia Nigra: Role of Presynaptic Dopaminergic Imaging. Neurology. vol 102. issue 9. 2024-04-04. PMID:38574327. |
parkinsonism associated with traumatic hemorrhage in substantia nigra: role of presynaptic dopaminergic imaging. |
2024-04-04 |
2024-04-07 |
Not clear |
| Mingxue Song, Yalong Qiang, Shuai Wang, Shan Shan, Liwen Zhang, Caipei Liu, Fuyong Song, Xiulan Zha. High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway. Ecotoxicology and environmental safety. vol 276. 2024-04-04. PMID:38574648. |
high-fat diet exacerbates 1-bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway. |
2024-04-04 |
2024-04-07 |
mouse |
| Priyadarshi Prajjwal, Nikhil Deep Kolanu, Yeruva Bheemeswara Reddy, Aneeqa Ahmed, Mohammed Dheyaa Marsool Marsool, Krupanagram Santoshi, Himani Harshad Pattani, Jobby John, Kiran Kishor Chandrasekar, Omniat Amir Hussi. Association of Parkinson's disease to Parkinson's plus syndromes, Lewy body dementia, and Alzheimer's dementia. Health science reports. vol 7. issue 4. 2024-04-02. PMID:38562616. |
it is caused by the death of dopaminergic neurons, particularly in the substantia nigra. |
2024-04-02 |
2024-04-04 |
Not clear |
| Juan U Mascotte-Cruz, Arturo Vera, Lorenzo Leija, Francisco E Lopez-Salas, Michael Gradzielski, Joachim Koetz, Bismark Gatica-García, C P Rodríguez-Oviedo, Irais E Valenzuela-Arzeta, Lourdes Escobedo, David Reyes-Corona, M E Gutierrez-Castillo, Minerva Maldonado-Berny, Armando J Espadas-Alvarez, Carlos E Orozco-Barrios, Daniel Martinez-Fon. Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation. Discover nano. vol 19. issue 1. 2024-04-02. PMID:38564106. |
focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation. |
2024-04-02 |
2024-04-04 |
rat |