| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C G Campbell, F J Seidler, T A Slotki. Chlorpyrifos interferes with cell development in rat brain regions. Brain research bulletin. vol 43. issue 2. 1997-09-05. PMID:9222531. |
this effect was not seen at 1 mg/kg, a dose that did not compromise survival or growth, nor was there any adverse effect at either dose in the forebrain, despite the fact that both brainstem and forebrain possess comparable cholinergic projections. |
1997-09-05 |
2023-08-12 |
rat |
| C G Campbell, F J Seidler, T A Slotki. Chlorpyrifos interferes with cell development in rat brain regions. Brain research bulletin. vol 43. issue 2. 1997-09-05. PMID:9222531. |
although regions rich in cholinergic projections, such as brainstem and forebrain, may be more affected than noncholinergic regions (cerebellum), the maturational timetable of each region (brainstem earliest, forebrain intermediate, cerebellum last) appears to be more important in setting the window of vulnerability. |
1997-09-05 |
2023-08-12 |
rat |
| C J Maclean, H F Baker, A Fine, R M Ridle. The distribution of p75 neurotrophin receptor-immunoreactive cells in the forebrain of the common marmoset (Callithrix jacchus). Brain research bulletin. vol 43. issue 2. 1997-09-05. PMID:9222533. |
the p75-immunoreactive forebrain cells appear to correspond to choline acetyltransferase-immunoreactive (i.e., cholinergic) neurones. |
1997-09-05 |
2023-08-12 |
marmoset |
| B Kolb, G Gorny, S Côte, A Ribeiro-da-Silva, A C Cuell. Nerve growth factor stimulates growth of cortical pyramidal neurons in young adult rats. Brain research. vol 751. issue 2. 1997-09-02. PMID:9099817. |
these findings indicated that, besides its known effects on forebrain cholinergic neurons, ngf produces a very generalized synaptic re-modeling involving the cells responsible for the major output of the cerebral cortex in the intact adult brain. |
1997-09-02 |
2023-08-12 |
rat |
| X Song, F J Seidler, J L Saleh, J Zhang, S Padilla, T A Slotki. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicology and applied pharmacology. vol 145. issue 1. 1997-08-08. PMID:9221834. |
in the current study, neonatal rats were exposed to apparently subtoxic doses of chlorpyrifos (no weight loss, no mortality) either on postnatal days 1-4 or on postnatal days 11-14, and the effects on components of the adenylyl cyclase cascade were evaluated in brain regions that are enriched (forebrain) or sparse (cerebellum) in cholinergic innervation, as well as in a nonneural tissue (heart). |
1997-08-08 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
pharmacological modulation of alzheimer's beta-amyloid precursor protein levels in the csf of rats with forebrain cholinergic system lesions. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
abnormal deposition and accumulation of alzheimer's amyloid beta-protein (a beta) and degeneration of forebrain cholinergic neurons are among the principal features of alzheimer's disease. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
studies in rat model systems have shown that forebrain cholinergic deficits are accompanied by induction of cortical beta-amyloid precursor protein (beta-app) mrnas and increased levels of secreted beta-app in the csf. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
in different experiments, rats with lesions of the forebrain cholinergic system received injections of vehicle, a muscarinic receptor antagonist scopolamine, or one of two cholinesterase inhibitors - diisopropyl phosphorofluoridate (dfp) or phenserine. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
the cholinesterase inhibitors were administered to determine whether the forebrain cholinergic system lesion-induced increases in csf beta-app could be reduced by cholinergic augmentation. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
phenserine, a novel, reversible acetyl-selective cholinesterase inhibitor, significantly decreased the levels of secreted beta-app in the csf of forebrain cholinergic system-lesioned rats whereas dfp, a relatively non-specific cholinesterase inhibitor, failed to affect csf levels of secreted beta-app. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
these results suggest that the levels of secreted beta-app in the csf can be pharmacologically modulated but that this modulation is dependent upon the status of the forebrain cholinergic system and the pharmacological properties of the drugs used to influence it. |
1997-08-05 |
2023-08-12 |
rat |
| C M Portas, M Thakkar, D G Rainnie, R W Greene, R W McCarle. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat. Neuroscience. vol 79. issue 1. 1997-08-04. PMID:9178878. |
there is considerable evidence to suggest that the activity of forebrain and mesopontine cholinergic neurons is intimately involved in electroencephalographic arousal. |
1997-08-04 |
2023-08-12 |
cat |
| G N Akoev, N I Chalisov. Role of neurotrophic factors in adaptational processes of the nervous system. Neuroscience and behavioral physiology. vol 27. issue 3. 1997-07-31. PMID:9194051. |
in the brain, ngf does not affect adrenergic neurons, as it does in the periphery, but acts on cholinergic neurons in the basal part of the forebrain. |
1997-07-31 |
2023-08-12 |
rat |
| D L Tikhonravov, K B Shapovalova, T A Dyubkachev. Effects of microinjection of scopolamine into the neostriatum of rats on performance of a food conditioned reflex at different levels of fixation. Neuroscience and behavioral physiology. vol 27. issue 3. 1997-07-31. PMID:9194073. |
the cholinergic system of the caudate nucleus either takes no part in realizing the well-fixed conditioned reflex movement response and/or other forebrain structures are involved in the reflex, compensating for the disturbance in neostriatal cholinergic function. |
1997-07-31 |
2023-08-12 |
rat |
| D G Xu, R G Korneluk, K Tamai, N Wigle, A Hakim, A Mackenzie, G S Robertso. Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system. The Journal of comparative neurology. vol 382. issue 2. 1997-07-21. PMID:9183692. |
in the forebrain, immunoreactive neurons were detected in the cortex, the hippocampus (pyramidal cells, dentate granule cells, and interneurons), the striatum (cholinergic interneurons), the basal forebrain (ventral pallidum, medial septal nucleus, and diagonal band), the thalamus (lateral and ventral nuclei), the habenula, the globus pallidus, and the entopenduncular nucleus. |
1997-07-21 |
2023-08-12 |
rat |
| F A Abdulla, M Calaminici, J A Gray, J D Stephenson, J D Sinde. Behavioural specificity of neocortical grafts of fetal basal forebrain tissue after unilateral lesion of the nucleus basalis with alpha-amino-3-OH-4-isoxozole propionic acid (AMPA). Brain research bulletin. vol 42. issue 6. 1997-07-18. PMID:9128913. |
the previous articles in this series [4,9] have shown that unilateral ampa lesions of the nucleus basalis magnocellularis (nbm) produced widespread morphological and functional changes to the forebrain cholinergic projection system that could be reversed by transplants of fetal cholinergic tissue. |
1997-07-18 |
2023-08-12 |
Not clear |
| S Shoham, P J Norris, W A Baker, P C Emso. Nitric oxide synthase in ventral forebrain grafts and in early ventral forebrain development. Brain research. Developmental brain research. vol 99. issue 2. 1997-06-16. PMID:9125469. |
an additional neurotransmitter, nitric oxide (no), is synthesized by a subset of cholinergic neurons in rat ventral forebrain. |
1997-06-16 |
2023-08-12 |
rat |
| J Clos, E Dico. Two peptides derived from the nerve growth factor precursor enhance cholinergic enzyme activities in vivo. Brain research. Developmental brain research. vol 99. issue 2. 1997-06-16. PMID:9125482. |
these data suggest a physiological role for the two propeptides derived from the prongf in the development of forebrain cholinergic neurons. |
1997-06-16 |
2023-08-12 |
rat |
| G Grigoryan, H Hodges, S Mitchell, J D Sinden, J A Gra. 6-OHDA lesions of the nucleus accumbens accentuate memory deficits in animals with lesions to the forebrain cholinergic projection system: effects of nicotine administration on learning and memory in the water maze. Neurobiology of learning and memory. vol 65. issue 2. 1997-05-30. PMID:8833103. |
6-ohda lesions of the nucleus accumbens accentuate memory deficits in animals with lesions to the forebrain cholinergic projection system: effects of nicotine administration on learning and memory in the water maze. |
1997-05-30 |
2023-08-12 |
Not clear |