| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalcin, Kiarash Shamardani, Abigail Rogers, Rebecca Mancusi, Kathryn R Taylor, Yoon Seok Kim, Pamelyn J Woo, Alexandre Ravel, Eva Tatlock, Charu Ramakrishnan, Alberto E Ayala-Sarmiento, David Rincon Fernandez Pacheco, La'Akea Siverts, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng, Joshua J Breunig, Karl Deisseroth, Michelle Monj. Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386427. |
here, we demonstrate that the activity of cholinergic midbrain neurons modulates both healthy opc and malignant dmg proliferation in a circuit-specific manner at sites of long-range cholinergic projections. |
2024-10-10 |
2024-10-12 |
mouse |
| Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalcin, Kiarash Shamardani, Abigail Rogers, Rebecca Mancusi, Kathryn R Taylor, Yoon Seok Kim, Pamelyn J Woo, Alexandre Ravel, Eva Tatlock, Charu Ramakrishnan, Alberto E Ayala-Sarmiento, David Rincon Fernandez Pacheco, La'Akea Siverts, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng, Joshua J Breunig, Karl Deisseroth, Michelle Monj. Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386427. |
optogenetic stimulation of the cholinergic pedunculopontine nucleus (ppn) promotes glioma growth in pons, while stimulation of the laterodorsal tegmentum nucleus (ldt) facilitates proliferation in thalamus, consistent with the predominant projection patterns of each cholinergic midbrain nucleus. |
2024-10-10 |
2024-10-12 |
mouse |
| Mireia Medrano, Wissal Allaoui, Ra'fat Ehab Salim Haddad, Leila Makrini-Maleville, Emmanuel Valjent, Ilse Smolders, Viktória Kormos, Balázs Gaszner, Dimitri De Bunde. Neuromedin U Neurons in the Edinger-Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response. Neurochemical research. 2024-09-12. PMID:39266897. |
the edinger-westphal nucleus (ew) is a midbrain nucleus composed of a preganglionic, cholinergic subpopulation and a densely clustered peptidergic subpopulation (ewcp). |
2024-09-12 |
2024-09-15 |
mouse |
| Chao Zhang, R Michael Burge. Cholinergic modulation in the vertebrate auditory pathway. Frontiers in cellular neuroscience. vol 18. 2024-07-04. PMID:38962512. |
despite its apparent ubiquity in auditory circuitry, investigation of the roles of this cholinergic network has been mainly focused on the inner ear or forebrain structures, while less attention has been directed at regions between the cochlear nuclei and midbrain. |
2024-07-04 |
2024-07-10 |
Not clear |
| Chao Zhang, R Michael Burge. Cholinergic modulation in the vertebrate auditory pathway. Frontiers in cellular neuroscience. vol 18. 2024-07-04. PMID:38962512. |
in this review, we highlight what is known about cholinergic function throughout the auditory system from the ear to the cortex, but with a particular emphasis on brainstem and midbrain auditory centers. |
2024-07-04 |
2024-07-10 |
Not clear |
| William A Noftz, Emily E Echols, Nichole L Beebe, Jeffrey G Mellott, Brett R Schofiel. Differential cholinergic innervation of lemniscal versus non-lemniscal regions of the inferior colliculus. Journal of chemical neuroanatomy. 2024-06-24. PMID:38914378. |
the inferior colliculus (ic), a midbrain hub for integration of auditory information, receives dense cholinergic input that could modulate nearly all aspects of hearing. |
2024-06-24 |
2024-06-27 |
mouse |
| Qiying Ye, Jeremiah Nunez, Xiaobing Zhan. Multiple cholinergic receptor subtypes coordinate dual modulation of acetylcholine on anterior and posterior paraventricular thalamic neurons. Journal of neurochemistry. 2024-04-25. PMID:38664195. |
although acetylcholine (ach) neurons of the midbrain were reported to send projections to pvt, little is known about how cholinergic signaling regulates pvt neurons. |
2024-04-25 |
2024-04-28 |
mouse |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
in particular, nerve growth factor (ngf) plays an important role in the survival and function of cholinergic neurons while brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity and the maintenance of midbrain dopaminergic and cholinergic neurons. |
2023-08-30 |
2023-09-07 |
Not clear |
| Eric J Nunes, Nii A Addy, P Jeffrey Conn, Daniel J Foste. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. Annual review of pharmacology and toxicology. 2023-08-08. PMID:37552895. |
the activity of midbrain da neurons and da release patterns in terminal regions are tightly regulated by cholinergic neurons found in both the striatum and the hindbrain. |
2023-08-08 |
2023-08-16 |
Not clear |
| Julia T Kwapiszewski, Luis M Rivera-Perez, Michael T Robert. Cholinergic Boutons are Distributed Along the Dendrites and Somata of VIP Neurons in the Inferior Colliculus. Journal of the Association for Research in Otolaryngology : JARO. 2023-01-10. PMID:36627519. |
cholinergic signaling shapes sound processing and plasticity in the inferior colliculus (ic), the midbrain hub of the central auditory system, but how cholinergic terminals contact and influence individual neuron types in the ic remains largely unknown. |
2023-01-10 |
2023-08-14 |
Not clear |
| Wei-Li Kuan, Maha Alfaidi, Catherine B Horne, Benjamin Vallin, Sarah Fox, Shaline V Fazal, Caroline H Williams-Gray, Roger A Barke. Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain. Brain pathology (Zurich, Switzerland). 2022-11-02. PMID:36321260. |
our data demonstrated that a non-selective, transvascular delivery of α-synuclein pffs led to a time-dependent loss of specific populations of midbrain (but not olfactory) dopaminergic neurons, medullary (but not pontine) cholinergic neurons, and brainstem serotonergic neurons. |
2022-11-02 |
2023-08-14 |
rat |
| Nadine K Gut, Juan Mena-Segovi. Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility. Trends in neurosciences. 2022-05-09. PMID:35534340. |
midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility. |
2022-05-09 |
2023-08-13 |
Not clear |
| William A Noftz, Nichole L Beebe, Jeffrey G Mellott, Brett R Schofiel. Dense cholinergic projections to auditory and multisensory nuclei of the intercollicular midbrain. Hearing research. vol 411. 2021-11-30. PMID:34564033. |
dense cholinergic projections to auditory and multisensory nuclei of the intercollicular midbrain. |
2021-11-30 |
2023-08-13 |
rat |
| Luis M Rivera-Perez, Julia T Kwapiszewski, Michael T Robert. α Frontiers in neural circuits. vol 15. 2021-11-20. PMID:34434092. |
α the inferior colliculus (ic), the midbrain hub of the central auditory system, receives extensive cholinergic input from the pontomesencephalic tegmentum. |
2021-11-20 |
2023-08-13 |
mouse |
| Avery F McGuirt, Michael R Post, Irena Pigulevskiy, David Sulzer, Ori J Lieberma. Coordinated Postnatal Maturation of Striatal Cholinergic Interneurons and Dopamine Release Dynamics in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 16. 2021-11-19. PMID:33664134. |
its tonically active cholinergic interneuron (chi) is an integral regulator of the synaptic activity of other striatal neurons, as well as afferent axonal projections of midbrain dopamine (da) neurons; however, little is known about its development. |
2021-11-19 |
2023-08-13 |
mouse |
| Margherita Zaupa, Seyedeh Maryam Alavi Naini, Maroun Abi Younes, Erika Bullier, Erik R Duboué, Hervé Le Corronc, Hédi Soula, Sebastien Wolf, Raphaël Candelier, Pascal Legendre, Marnie E Halpern, Jean-Marie Mangin, Elim Hon. Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Current biology : CB. vol 31. issue 21. 2021-11-11. PMID:34529937. |
the evolutionarily conserved forebrain to midbrain habenulo-interpeduncular nucleus (hb-ipn) pathway consists of cholinergic and non-cholinergic neurons, which mediate different aversive behaviors. |
2021-11-11 |
2023-08-13 |
Not clear |
| Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K Gut, Bakhtawer Khan, Juan Mena-Segovi. Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33907215. |
whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. |
2021-10-14 |
2023-08-13 |
rat |
| Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K Gut, Bakhtawer Khan, Juan Mena-Segovi. Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33907215. |
the cholinergic midbrain is involved in a wide range of motor and cognitive processes. |
2021-10-14 |
2023-08-13 |
rat |
| Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K Gut, Bakhtawer Khan, Juan Mena-Segovi. Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33907215. |
cholinergic neurons of the pedunculopontine (ppn) and laterodorsal tegmental nucleus (ldt) send long-ranging axonal projections that target sensorimotor and limbic areas in the thalamus, the dopaminergic midbrain and the striatal complex following a topographical gradient, where they influence a range of functions including attention, reinforcement learning and action-selection. |
2021-10-14 |
2023-08-13 |
rat |