| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeliha Bayram, Esra Akcabag, Gul Ozbey, Cahit Nacitarhan, Sebahat Ozdem, Cengiz Turkay, Sadi S Ozde. THE effect of P2X7 receptor activation on functional responses of human left internal mammary artery. Naunyn-Schmiedeberg's archives of pharmacology. 2024-09-03. PMID:39225832. |
long-term (60 min) incubation with specific p2x7r agonist bz-atp caused significant reductions in relaxation responses of lima to atp and acetylcholine, which were reversed by selective p2x7r antagonists brilliant blue g or az11645373, whereas there were no changes in relaxation responses to endothelium-independent vasodilators isoprenaline, camp analog 8-br-camp, and nitric oxide donor sodium nitroprusside. |
2024-09-03 |
2024-09-05 |
human |
| Ramison Santos, Patrick Turck, Victor de Mello Palma, Fernanda Visioli, Vanessa Duarte Ortiz, Isabel Cristina Teixeira Proença, Tânia Regina G Fernandes, Elissa Fernandes, Silvio Tasca, Cristina Campos Carraro, Adriane Belló-Klein, Alex Sander da Rosa Araujo, Neelam Khaper, Alexandre Luz de Castr. MELATONIN IMPROVES NITRIC OXIDE BIOAVAILABILITY IN ISOPROTERENOL INDUCED MYOCARDIAL INJURY. Molecular and cellular endocrinology. 2024-05-26. PMID:38797355. |
melatonin improves nitric oxide bioavailability in isoproterenol induced myocardial injury. |
2024-05-26 |
2024-05-31 |
rat |
| Anthony M Mozzicato, Joakim A Bastrup, Jose L Sanchez Alonso, Jennifer van der Horst, Julia Gorelik, Per Mårten Hägglund, Thomas Jepp. Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation. The Biochemical journal. 2024-02-19. PMID:38373073. |
tubacin enhanced the β-adrenoceptor-mediated vasodilatation by isoprenaline when the endothelium was intact, but attenuated relaxations when the endothelium was denuded or nitric oxide production was inhibited. |
2024-02-19 |
2024-02-22 |
rat |
| Huiling Luan, Zhenhui Wang, Zhenzhen Zhang, Baohua Hou, Zhenzhen Liu, Lanping Yang, Mengmeng Yang, Yile Ma, Baobao Zhan. Brassica oleracea L. extract ameliorates isoproterenol- induced myocardial injury by regulating HIF-1α-mediated glycolysis. Fitoterapia. 2023-10-31. PMID:37907131. |
the effects of boe on myocardial cells were evaluated using isoproterenol (iso)-treated h9c2 cells and wistar rats, and the results revealed that boe could inhibit cardiomyocyte hypertrophy and reduce the levels of b-type natriuretic peptide, nitric oxide, reactive oxygen species, lactic acid, and pyruvic acid. |
2023-10-31 |
2023-11-08 |
rat |
| Hanaa M Khalaf, Ahlam M Abdalla, Amira F Ahmed, Asmaa Mohamed Abdel-Azi. Role of nitric oxide in mediating the cardioprotective effect of agomelatine against isoproterenol-induced myocardial injury in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 10. 2021-08-11. PMID:32399613. |
the present study aimed to explore the cardioprotective effect of ago on isoproterenol (iso)-induced myocardial injury in a rat model and determine the role of nitric oxide (no) in mediating this beneficial effect. |
2021-08-11 |
2023-08-13 |
rat |
| L Provitera, G Cavallaro, A Griggio, G Raffaeli, I Amodeo, S Gulden, D Lattuada, G Ercoli, C Lonati, A Tomaselli, F Mosca, E Villamo. Cyclic nucleotide-dependent relaxation in human umbilical vessels. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 70. issue 4. 2020-04-07. PMID:31741459. |
following precontraction with the thromboxane prostanoid (tp) receptor agonist u44069, concentration-response curves to the nitric oxide (no) donor sodium nitroprusside (snp), the soluble guanylate cyclase (sgc) stimulator bay 41-2272, the adenylate cyclase (ac) activator forskolin, the β-adrenergic receptor agonists isoproterenol (adrb1), salmeterol (adrb2), and brl37344 (adrb3), and the phosphodiesterase (pde) inhibitors milrinone (pde |
2020-04-07 |
2023-08-13 |
human |
| Faheem Sultan, Rajdeep Kaur, Arshad Hussain Mir, Ishfaq Maqbool, Milindmitra Lonare, Digvijay Singh, Satyavan Rampal, Javeed Ahmad Da. Rosuvastatin and retinoic acid may act as 'pleiotropic agents' against β-adrenergic agonist-induced acute myocardial injury through modulation of multiple signalling pathways. Chemico-biological interactions. vol 318. 2020-03-10. PMID:32007421. |
myocardial injury with isoproterenol resulted in increased cardiac mass, decreased r-wave amplitude, increased qrs and qt durations; elevated levels of cardiac markers like ctni, ck-mb, alt and ast; increased lipid peroxidation, protein carbonylation and tissue nitric oxide levels; decreased endogenous antioxidants like sod, cat, gr, gst, gpx and total antioxidant activity; increased inflammatory markers like tnf-α and il-6; decreased the mrna expression of nrf2 and bcl-2; increased the mrna expression of bax, enos and inos genes. |
2020-03-10 |
2023-08-13 |
rat |
| Donald E. Smith, Alan David Kaye, Chang J. Feng, Bin Kang, Philip J. Kadowitz, Bobby Dean Nossama. Comparative Effects of N(omega)-L-Nitro-L-Arginine Methyl Ester and N(omega)-L-Nitro-L-Arginine Benzyl Ester in the Mesenteric Circulation of the Rat. American journal of therapeutics. vol 3. issue 4. 2019-11-20. PMID:11862266. |
comparative effects of the nitric oxide (no) synthase inhibitors, n(omega)-l-nitro-l-arginine methyl ester, and n(omega)-l-nitro-l-arginine benzyl ester on baseline arterial tone and on vasodilator responses to acetylcholine, isoproterenol, prostaglandin e(1), histamine, and nitroglycerin were investigated in the isolated mesenteric vascular bed of the rat. |
2019-11-20 |
2023-08-12 |
rat |
| Shuyu Zhan, Baoyue Ding, Yu-Er Ruan, Xuan Huang, Guoqiang Liu, Xiaoqing Lv, Xiong Huang, Mingjuan Li, Ninghua Jiang, Qing Sha. A simple blood microdialysis in freely-moving rats for pharmacokinetic-pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate. Journal of pharmaceutical and biomedical analysis. vol 154. 2018-09-18. PMID:29529491. |
in this study, a simple blood microdialysis sampling system in freely-moving rats was established for simultaneous study of pk and pd of shengmai injection (smi) effect on inducing real-time nitric oxide (no) release on isoproterenol (iso) induced myocardial ischemia rats. |
2018-09-18 |
2023-08-13 |
rat |
| Yingguang Shan, Dandan Wang, Ran Li, Congxin Huan. Molsidomine Attenuates Ventricular Electrical Remodeling and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation Through the NO/cGMP/PKG Pathway. Journal of cardiovascular pharmacology. vol 68. issue 5. 2017-11-27. PMID:27482866. |
this study investigated the effects and associated underlying mechanisms of molsidomine, a nitric oxide (no) donor, on cardiac electrical remodeling and ventricular tachycardias (vts) induced by chronic isoprenaline (iso) stimulation in rats. |
2017-11-27 |
2023-08-13 |
rat |
| K K Chaudagar, C Viczenczova, B Szeiffova Bacova, T Egan Benova, M Barancik, N Tribulov. Modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive Wistar rats. Physiological research. vol 65 Suppl 1. 2017-04-07. PMID:27643932. |
modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive wistar rats. |
2017-04-07 |
2023-08-13 |
rat |
| K K Chaudagar, C Viczenczova, B Szeiffova Bacova, T Egan Benova, M Barancik, N Tribulov. Modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive Wistar rats. Physiological research. vol 65 Suppl 1. 2017-04-07. PMID:27643932. |
we aimed to explore the effects of melatonin and n-3 polyunsaturated fatty acids (pufa) supplementation on plasma and aortic nitric oxide (no) levels in isoproterenol (iso) affected spontaneously hypertensive (shr) and wistar rats. |
2017-04-07 |
2023-08-13 |
rat |
| Mingli Zhong, Hongmin Zhou, Chaoliang Long, Yanfang Zhang, Wenyu Cui, Hao Zhang, Hai Wan. Natakalim Ameliorates Isoproterenol-Induced Chronic Heart Failure by Protecting against Endothelial Dysfunction. Pharmacology. vol 98. issue 3-4. 2017-03-16. PMID:27174236. |
mechanistically, natakalim attenuates the elevation of plasma nitric oxide (no) level and inducible no synthase in cardiac tissue induced by isoproterenol. |
2017-03-16 |
2023-08-13 |
rat |
| Noha I Hussien, Ayman M Mous. Could nitric oxide be a mediator of action of oxytocin on myocardial injury in rats? (Biochemical, histological and immunohistochemical study). General physiology and biophysics. vol 35. issue 3. 2016-09-13. PMID:27226256. |
the aim of our study was to investigate the possible protective effect of ot on the biochemical, histological and immunohistochemical changes of mi induced by isoprenaline (iso) in adult male albino rats and studying the possible role of nitric oxide (no) in its action. |
2016-09-13 |
2023-08-13 |
rat |
| Eva Kralova, Gabriel Doka, Lenka Pivackova, Jasna Srankova, Kristina Kuracinova, Pavol Janega, Pavel Babal, Jan Klimas, Peter Krene. l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy. Basic & clinical pharmacology & toxicology. vol 117. issue 4. 2016-06-14. PMID:25865156. |
in view of previously reported increased capacity for nitric oxide production, we suggested that l-arginine (arg), the nitric oxide synthase (nos) substrate, supplementation would improve cardiac function in isoproterenol (iso)-induced heart failure. |
2016-06-14 |
2023-08-13 |
rat |
| Zhi-Jie Yue, Peng-Tao Xu, Bo Jiao, Hui Chang, Zhen Song, Man-Jiang Xie, Zhi-Bin Y. Nitric Oxide Protects L-Type Calcium Channel of Cardiomyocyte during Long-Term Isoproterenol Stimulation in Tail-Suspended Rats. BioMed research international. vol 2015. 2016-04-14. PMID:26167497. |
nitric oxide protects l-type calcium channel of cardiomyocyte during long-term isoproterenol stimulation in tail-suspended rats. |
2016-04-14 |
2023-08-13 |
rat |
| Zhi-Jie Yue, Peng-Tao Xu, Bo Jiao, Hui Chang, Zhen Song, Man-Jiang Xie, Zhi-Bin Y. Nitric Oxide Protects L-Type Calcium Channel of Cardiomyocyte during Long-Term Isoproterenol Stimulation in Tail-Suspended Rats. BioMed research international. vol 2015. 2016-04-14. PMID:26167497. |
the aim of this study was to investigate the effects of nitric oxide (no) and reactive oxygen species (ros) on l-type calcium channel (ltcc) gating properties of cardiomyocytes during long-term isoproterenol (iso) stimulation. |
2016-04-14 |
2023-08-13 |
rat |
| Giacomo Cavallaro, Else Bijker, Eveline Strackx, Johan S H Vles, Danilo Gavilanes, Eduardo Villamo. Age-related changes and effects of mild hypothermia on carotid artery reactivity in newborn rats. CNS & neurological disorders drug targets. vol 14. issue 1. 2016-01-22. PMID:25613514. |
hypothermia did not significantly affect the contractions induced by kcl and u46619, nor the relaxations induced by acetylcholine (ach), the nitric oxide (no) donor sodium nitroprusside (snp), the no-independent stimulator of soluble guanylate cyclase (sgc) bay 41-2272, the β -adrenoceptor agonist isoproterenol, the adenylate cyclase activator forskolin, and acute hypoxia (po2 3 kpa). |
2016-01-22 |
2023-08-13 |
rat |
| Allison Hempenstall, Gary D Grant, Shailendra Anoopkumar-Dukie, Peter J Johnso. Pyocyanin inhibits both nitric oxide-dependent and -independent relaxation in porcine coronary arteries. Clinical and experimental pharmacology & physiology. vol 42. issue 2. 2015-09-22. PMID:25399964. |
pyocyanin (0.1-10 μmol/l) significantly inhibited endothelium-dependent relaxations evoked by neurokinin a. pyocyanin also inhibited relaxations evoked by diethylamine nitric oxide (a nitric oxide donor), forskolin (an adenylate cyclase activator), dibuytyryl-camp (a camp analogue), 8-bromo-cgmp (a cgmp analogue) and p1075 (a katp channel activator), but not isoprenaline (β-adrenoceceptor agonist). |
2015-09-22 |
2023-08-13 |
Not clear |
| Ana P Davel, Jamaira A Victorio, Maria A Delbin, Livia E Fukuda, Luciana V Rosson. Enhanced endothelium-dependent relaxation of rat pulmonary artery following β-adrenergic overstimulation: involvement of the NO/cGMP/VASP pathway. Life sciences. vol 125. 2015-05-04. PMID:25640757. |
the aim of this study was to investigate whether β-adrenoceptor (β-ar) overstimulation induced by in vivo treatment with isoproterenol (iso) alters vascular reactivity and nitric oxide (no) production and signaling in pulmonary arteries. |
2015-05-04 |
2023-08-13 |
rat |