| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Delini-Stul. Baclofen-induced modification of conditioned discriminative avoidance behaviour and contraversive turning in the rat. European journal of pharmacology. vol 46. issue 3. 1978-02-18. PMID:563331. |
after alpha-methyltyrosine, baclofen like haloperidol, produced a marked increase in avoidance response failures suggesting an additional inhibitory effect of the compound on dopaminergic transmission. |
1978-02-18 |
2023-08-11 |
rat |
| D J Albert, S E Richmon. Reactivity and aggression in the rat: induction by alpha-adrenergic blocking agents injected ventral to anterior septum but not into lateral septum. Journal of comparative and physiological psychology. vol 91. issue 4. 1977-10-14. PMID:19511. |
the results showed that transmitter blocking agents reproduced the effect of the local anesthetic only in the region ventral to the anterior septum and that alpha-adrenergic (phentolamine, tolazoline), but not beta-adrenergic (propranolol, hydralazine), cholinergic (atropine, hyocine), or dopaminergic (haloperidol) blocking agents were effective. |
1977-10-14 |
2023-08-11 |
rat |
| R Dunstan, D M Jackso. The effect of apomorphine and clonidine on locomotor activity in mice after long term treatment with haloperidol. Clinical and experimental pharmacology & physiology. vol 4. issue 2. 1977-09-22. PMID:195762. |
the data suggest that there is a change in the functional responsiveness of both adrenergic and dopaminergic receptors after withdrawal from long term haloperidol treatment. |
1977-09-22 |
2023-08-11 |
mouse |
| S E Vizi, A Rónai, L Hársing, J Knol. Inhibitory effect of dopamine on acetylcholine release from caudate nucleus. Polish journal of pharmacology and pharmacy. vol 29. issue 3. 1977-09-22. PMID:887499. |
the parkinson-syndrome induced by drugs which depress dopaminergic function either by reducing the output of dopamine, such as reserpine, or by antagonizing its action on da receptors, as for instance haloperidol or chlorpromazine, can be attributed to the augmented release of ach from caudate cholinergic nerve terminals and a consequent increase of cholinergic outflow from caudate nucleus. |
1977-09-22 |
2023-08-11 |
Not clear |
| R Horowski, H J Grä. Influence of dopaminergic agonists and antagonists on serum prolactin concentrations in the rat. Neuroendocrinology. vol 22. issue 3. 1977-09-22. PMID:1028957. |
inhibitors of dopaminergic neurotransmission, such as reserpine (res), given alone or combined with alpha-methyl-p-tyrosine (alpha-mpt)or ro 4-4602, as well as haloperidol (hal) and sulpiride (sul), induced highly elevated serum prolactin (prl) concentrations in intact rats. |
1977-09-22 |
2023-08-11 |
rat |
| A A Duto. [Effects of catecholaminergic substances on the circular reaction caused by stimulation of the caudate nucleus]. Farmakologiia i toksikologiia. vol 39. issue 5. 1977-09-17. PMID:1028579. |
the influence of stimulators (l-dopa and apomorphine) and of inhibitors (chlorpromazine and haloperidol) of the dopaminergic systems on the circular reaction arising during high-frequency (30 puls/sec) stimulation of the caudate nucleus was studied in chronic experiments with freely moving cats carrying preliminarily implanted electrodes. |
1977-09-17 |
2023-08-11 |
Not clear |
| G Gianutsos, K E Moor. Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol or clozapine. Life sciences. vol 20. issue 9. 1977-08-12. PMID:875633. |
dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol or clozapine. |
1977-08-12 |
2023-08-11 |
Not clear |
| D P Henry, W Aoi, M H Weinberge. The effects of dopamine on renin release in vitro. Endocrinology. vol 101. issue 1. 1977-07-29. PMID:16742. |
dopamine-induced renin release was not inhibited by the presence of the alpha-adrenergic antagonist, phentolamine (9 x 10(-4)m), the dopaminergic antagonist, haloperidol (5 x 10(-5)m) or the neural uptake inhibitor, cocaine (1 x 10(-5)m). |
1977-07-29 |
2023-08-11 |
rat |
| T G Heffner, M J Zigmond, E M Stricke. Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats. The Journal of pharmacology and experimental therapeutics. vol 201. issue 2. 1977-06-30. PMID:859104. |
doses of d-amphetamine that increased the conversion of 3h-tyrosine to 3h-dopamine in the brain were found to decrease food intake, an effect that was reduced by the systemic administration of the dopaminergic antagonists alpha-methyltyrosine, haloperidol or spiroperidol. |
1977-06-30 |
2023-08-11 |
rat |
| A Carlsson, W Kehr, M Lindqvis. Agonist--antagonist interaction on dopamine receptors in brain, as reflected in the rates of tyrosine and tryptophan hydroxylation. Journal of neural transmission. vol 40. issue 2. 1977-06-22. PMID:323424. |
the interaction between apomorphine and haloperidol with respect to dopa formation appears to be largely explicable on the assumption of a competition between an agonist and an antagonist for dopaminergic receptors. |
1977-06-22 |
2023-08-11 |
rat |
| R Kuczenski, D Schmidt, N Leit. Amphetamine-haloperidol interactions in rat striatum: failure to correlate behavioral effects with dopaminergic and cholinergic dynamics. Brain research. vol 126. issue 1. 1977-06-22. PMID:558038. |
previous reports have suggested that the hyperactivity and stereotypy produced by amphetamine (amp) and the catalepsy produced by haloperidol (hal) are mediated by striatal dopaminergic mechanisms. |
1977-06-22 |
2023-08-11 |
rat |
| M J Bastie, N Vaysse, B Brenac, J P Pascal, A Ribe. Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. Gastroenterology. vol 72. issue 4 Pt 1. 1977-04-28. PMID:838228. |
dopaminergic agonists (dopamine, 2, 10, 50, and 250 mug; apomorphine, 1 mg; noradrenaline, 2, 20, and 200 mug), and inhibitors (haloperidol, 5 mg; pentamethonium, 500 mg; phenoxybenzamine, 15 mg, and atropine sulfate, 10 mg), were tested on isolated perfused canine pancreas; under basal conditions and under stimulation by a background of secretin (0.1, 0.5, and 10.0 clinical unit per hr), or of caerulein (1200 ng per hr). |
1977-04-28 |
2023-08-11 |
Not clear |
| J Bockaert, J P Tassin, A M Thierry, J Glowinski, J Premon. Characteristics of dopamine and beta-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases. Brain research. vol 122. issue 1. 1977-04-15. PMID:837225. |
in contrast, in all experiments, haloperidol had an higher affinity for the cerebral frontal cortex than for the striatal dopaminergic receptors. |
1977-04-15 |
2023-08-11 |
rat |
| J Bockaert, J P Tassin, A M Thierry, J Glowinski, J Premon. Characteristics of dopamine and beta-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases. Brain research. vol 122. issue 1. 1977-04-15. PMID:837225. |
thus, haloperidol was less effective than fluphenazine in blocking the striatal dopaminergic receptors, and equally potent than fluphenazine in inhibiting the frontal cerebral cortex dopamine sensitive adenylate cyclase. |
1977-04-15 |
2023-08-11 |
rat |
| B A Weissman, D F Johnso. Possible role of dopamine in diethylstilbestrol-elicited accumulation of cyclic AMP in incubated male rat hypothalamus. Neuroendocrinology. vol 21. issue 1. 1977-02-24. PMID:187977. |
pimozide and haloperidol, the dopaminergic antagonists, have been shown to effectively block diethylstilbestrol (des)-elicited [3h] adenosine 3', 5'-monophosphate (camp) accumulation in incubated hypothalami from immature male rats. |
1977-02-24 |
2023-08-11 |
rat |
| M H Van Woert, R Jutkowitz, D Rosenbaum, M B Bower. Gilles de la Tourette's syndrome: biochemical approaches. Research publications - Association for Research in Nervous and Mental Disease. vol 55. 1977-02-24. PMID:1070064. |
this supports the hypothesis that tourette symptoms are related to an increased firing of dopaminergic neurons in the central nervous system; haloperidol relieves these symptoms by blocking dopamine receptors. |
1977-02-24 |
2023-08-11 |
Not clear |
| L F Tseng, D A Brase, H H Lo. Dopaminergic influence on withdrawal jumping behavior in morphine-dependent mice. Research communications in chemical pathology and pharmacology. vol 15. issue 3. 1977-01-29. PMID:1033590. |
a cataleptic dose of the dopaminergic antagonist, haloperidol, does not block naloxone-precipitated jumping, but does significantly block the inhibition by apomorphine. |
1977-01-29 |
2023-08-11 |
mouse |
| B H Westerink, J Kor. Comparison of effects of drugs on dopamine metabolism in the substantia nigra and the corpus striatum of rat brain. European journal of pharmacology. vol 40. issue 1. 1977-01-28. PMID:991922. |
the influence of apomorphine, chloral hydrate, haloperidol, morphine, oxotremorine, pargyline, probenecid and promethazine on dopac and hva levels was studied in the substantia nigra (including the ventral tegmental dopaminergic regions) and corpus striatum of the rat brain. |
1977-01-28 |
2023-08-11 |
rat |
| J E Thornburg, K E Moor. Supersensitivity to dopaminergic agonists induced by haloperidol. National Institute on Drug Abuse research monograph series. issue 3. 1976-12-01. PMID:1241913. |
supersensitivity to dopaminergic agonists induced by haloperidol. |
1976-12-01 |
2023-08-11 |
mouse |
| W Keh. [Interactions of dopamine receptor agonists and antagonists with regard to dopamine synthesis and metabolism]. Arzneimittel-Forschung. vol 26. issue 6. 1976-11-01. PMID:9107. |
the functional antagonists haloperidol and d-amphetamine appear to have synergistic effects on dopaminergic neurons. |
1976-11-01 |
2023-08-11 |
rat |