| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Carlos Ledesma, Marta Rodríguez-Arias, Ana L Gavito, Ana M Sánchez-Pérez, José Viña, Dina Medina Vera, Fernando Rodríguez de Fonseca, José Miñarr. Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:32043730. |
previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (etoh) exposure could be due to endocannabinoid system (ecs) alterations. |
2021-10-05 |
2023-08-13 |
mouse |
| Elba Arango, Allison Toriello, Zoila Rosario, Gail Coope. Increasing Prevalence of Ketamine in Drivers in New York City Including the Identification of 2-Fluoro-Deschloroketamine. Journal of analytical toxicology. vol 45. issue 8. 2021-09-20. PMID:34050644. |
the most common drug classes detected in addition to ketamine were cannabinoids (38%), ethanol (32%), benzodiazepines (26%), cocaine (19%) and amphetamines/3,4-methylenedioxymethamphetamine (15%). |
2021-09-20 |
2023-08-13 |
human |
| Oswald Boa-Amponsem, Chengjin Zhang, Derek Burton, Kevin P Williams, Gregory J Col. Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor-Dependent Mechanism. Alcoholism, clinical and experimental research. vol 44. issue 7. 2021-09-07. PMID:32472575. |
ethanol and cannabinoids regulate zebrafish gabaergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor-dependent mechanism. |
2021-09-07 |
2023-08-13 |
zebrafish |
| Juan Suárez, Sophia Khom, Francisco Alén, Luis A Natividad, Florence P Varodayan, Reesha R Patel, Dean Kirson, Rocío Arco, Antonio Ballesta, Michal Bajo, Leticia Rubio, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Marisa Robert. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31339221. |
the increase in ethanol self-administration was associated with (a) reductions in levels of the endocannabinoids n-arachidonoylethanolomine and 2-arachidonoylglycerol in the cea, (b) increased amygdalar gene expression of cannabinoid type-1 receptor (cb1), n-acyl phosphatidylethanolamine phospholipase d (nape-pld), fatty acid amid hydrolase (faah), (c) decreased amygdalar gene expression of ionotropic ampa (glua2 and glua4) and metabotropic (mglu3) glutamate receptors, and (d) increased glutamatergic receptor function. |
2021-08-11 |
2023-08-13 |
Not clear |
| L Sanchez-Marin, A L Gavito, J Decara, A Pastor, E Castilla-Ortega, J Suarez, R de la Torre, F J Pavon, F Rodriguez de Fonseca, A Serran. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 33. 2021-08-10. PMID:32057593. |
impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. |
2021-08-10 |
2023-08-13 |
rat |
| Chulhun Park, Jieyu Zuo, Vijay Somayaji, Beom-Jin Lee, Raimar Löbenber. Development of a novel cannabinoid-loaded microemulsion towards an improved stability and transdermal delivery. International journal of pharmaceutics. vol 604. 2021-07-27. PMID:34087415. |
pseudo-ternary phase diagrams were constructed by formulation of cannabinoids with capryol® 90 as oil phase, tween® 80, solutol® hs15, procetyl® aws, and cremophor® rh40 as surfactants, ethanol as cosurfactant, and distilled water as the aqueous phase. |
2021-07-27 |
2023-08-13 |
Not clear |
| Carol A Gianessi, Stephanie M Groman, Summer L Thompson, Ming Jiang, Mario van der Stelt, Jane R Taylo. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31056846. |
the endocannabinoid system plays a critical role in habit learning and in ethanol self-administration, but the role of this neuromodulatory system in the expression of habitual alcohol seeking is unknown. |
2021-06-24 |
2023-08-13 |
mouse |
| Carol A Gianessi, Stephanie M Groman, Summer L Thompson, Ming Jiang, Mario van der Stelt, Jane R Taylo. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31056846. |
we found that administration of the novel diacyl glycerol lipase inhibitor do34, which decreases the biosynthesis of the endocannabinoid 2-arachidonoyl glycerol (2-ag), reduced habitual responding for ethanol and ethanol approach behaviors. |
2021-06-24 |
2023-08-13 |
mouse |
| Carol A Gianessi, Stephanie M Groman, Summer L Thompson, Ming Jiang, Mario van der Stelt, Jane R Taylo. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31056846. |
moreover, administration of the endocannabinoid transport inhibitor am404 or the cannabinoid receptor type 1 antagonist am251 produced similar reductions in habitual responding for ethanol and ethanol approach behaviors. |
2021-06-24 |
2023-08-13 |
mouse |
| Carol A Gianessi, Stephanie M Groman, Summer L Thompson, Ming Jiang, Mario van der Stelt, Jane R Taylo. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31056846. |
these results demonstrate an important role for endocannabinoid signaling in the motivation to seek ethanol, in ethanol-motivated habits, and suggest that pharmacological manipulations of endocannabinoid signaling could be effective therapeutics for treating alcohol use disorder. |
2021-06-24 |
2023-08-13 |
mouse |
| Michael Notaras, Aiman Lodhi, Estibaliz Barrio-Alonso, Careen Foord, Tori Rodrick, Drew Jones, Haoyun Fang, David Greening, Dilek Cola. Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids. Molecular psychiatry. 2021-06-23. PMID:34158620. |
in tandem experiments conducted in parallel, we modeled exposure to opiates (μ-opioid agonist endomorphin), cannabinoids (win 55,212-2), alcohol (ethanol), smoking (nicotine), chronic stress (human cortisol), and maternal immune activation (human interleukin-17a; il17a). |
2021-06-23 |
2023-08-13 |
human |
| Xiaochen Liu, Dingang Zhang, Xiaoru Dong, Rongzhe Zhu, Yonghong Ye, Liliang Li, Yan Jian. Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis. Molecular and cellular biochemistry. vol 474. issue 1-2. 2021-05-17. PMID:32681290. |
in addition, ethanol abuse caused an imbalance in the endocannabinoid system and regulated two cannabinoid receptors (cb1r and cb2r) in the myocardium. |
2021-05-17 |
2023-08-13 |
mouse |
| Veronica M Piggott, Scott C Lloyd, James I Matchynski, Shane A Perrine, Alana C Cont. Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-11. PMID:33917316. |
based on these data we conclude that the effects of combined traumatic stress and chronic ethanol exposure on the cannabinoid system in reward pathway regions are driven by cie exposure and that traumatic stress affects the cannabinoid components in limbic regions, warranting future investigation of neurotherapeutic treatment to attenuate these effects. |
2021-05-11 |
2023-08-13 |
mouse |
| Kuntheavy Ing Lorenzini, François Girardi. Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients. Liver international : official journal of the International Association for the Study of the Liver. vol 40. issue 1. 2021-03-23. PMID:31654604. |
we discussed the pharmacokinetics (pks) and pharmacodynamics (pd) of currently prescribed direct antiviral agents (nsa5 inhibitors: daclatasvir, elbasvir, ledipasvir, pibrentasvir, velpatasvir; ns5b inhibitor: sofosbuvir; ns3/4a protease inhibitors: glecaprevir, grazoprevir, voxilaprevir) and most common substances of abuse (opioids: buprenorphine, fentanyl, heroin, methadone, morphine, oxycodone; stimulants: amphetamines, cathinones, cocaine; cannabinoids; ethanol). |
2021-03-23 |
2023-08-13 |
Not clear |
| Kuntheavy Ing Lorenzini, François Girardi. Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients. Liver international : official journal of the International Association for the Study of the Liver. vol 40. issue 1. 2021-03-23. PMID:31654604. |
based on pharmacological considerations, neither efficacy loss nor adverse drug event associated with detrimental interaction are expected with opioids, stimulants, cannabinoids and ethanol. |
2021-03-23 |
2023-08-13 |
Not clear |
| Masahiko Funada, Mika Takebayashi-Ohsawa, Ken-Ich Tomiyam. Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of central glutamate neurotransmission. Toxicology and applied pharmacology. vol 408. 2021-01-11. PMID:33068620. |
this study investigated the combined use of both synthetic cannabinoids and ethanol and their effect on motor coordination in mice in addition to examining the neurochemical changes in the cerebellum. |
2021-01-11 |
2023-08-13 |
mouse |
| Sara Peñasco, Irantzu Rico-Barrio, Nagore Puente, Christine J Fontaine, Almudena Ramos, Leire Reguero, Inmaculada Gerrikagoitia, Fernando Rodríguez de Fonseca, Juan Suarez, Sergio Barrondo, Xabier Aretxabala, Gontzal García Del Caño, Joan Sallés, Izaskun Elezgarai, Patrick C Nahirney, Brian R Christie, Pedro Grande. Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31569197. |
intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice. |
2020-12-28 |
2023-08-13 |
mouse |
| Sara Peñasco, Irantzu Rico-Barrio, Nagore Puente, Christine J Fontaine, Almudena Ramos, Leire Reguero, Inmaculada Gerrikagoitia, Fernando Rodríguez de Fonseca, Juan Suarez, Sergio Barrondo, Xabier Aretxabala, Gontzal García Del Caño, Joan Sallés, Izaskun Elezgarai, Patrick C Nahirney, Brian R Christie, Pedro Grande. Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31569197. |
binge drinking is a significant problem in adolescent populations, and because of the reciprocal interactions between ethanol (etoh) consumption and the endocannabinoid (ecb) system, we sought to determine if adolescent etoh intake altered the localization and function of the cannabinoid 1 (cb |
2020-12-28 |
2023-08-13 |
mouse |
| Maria Simakova, Ana Tobiasz, Ryan D Sullivan, Shivantika Bisen, Jose Duncan, J Pierce Sullivan, Steven Davison, Danielle L Tate, Stacey Barnett, Giancarlo Mari, Alex M Dopico, Anna N Bukiy. Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries. Journal of drug and alcohol research. vol 8. 2020-09-30. PMID:31057979. |
moreover, ethanol dilated fetal cerebral arteries via cannabinoid (cb) receptors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hada Fong-Ha Ieon. Commentary: Prenatal Ethanol Exposure Persistently Alters Endocannabinoid Signaling and Endocannabinioid-Mediated Excitatory Synaptic Plasticity in Ventral Tegmental Area Dopamine Neurons. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:29163039. |
commentary: prenatal ethanol exposure persistently alters endocannabinoid signaling and endocannabinioid-mediated excitatory synaptic plasticity in ventral tegmental area dopamine neurons. |
2020-09-29 |
2023-08-13 |
Not clear |