| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ornella Manfra, Kathleen Van Craenenbroeck, Kamila Skieterska, Thomas Frimurer, Thue W Schwartz, Finn Olav Levy, Kjetil Wessel Andresse. Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25706089. |
we have previously found that the atypical antipsychotics clozapine and olanzapine inhibited g protein activation and, surprisingly, induced both internalization and lysosomal degradation of 5-ht7 receptors. |
2016-04-19 |
2023-08-13 |
human |
| Min Feng, Jun Gao, Nan Sui, Ming L. Effects of central activation of serotonin 5-HT2A/2C or dopamine D 2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test. Psychopharmacology. vol 232. issue 7. 2016-02-29. PMID:25288514. |
acute administration of clozapine (a gold standard of atypical antipsychotics) disrupts avoidance response in rodents, while repeated administration often causes a tolerance effect. |
2016-02-29 |
2023-08-13 |
Not clear |
| Shinichiro Nakajima, Hiroyoshi Takeuchi, Gagan Fervaha, Eric Plitman, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Yukiko Mihashi, Philip Gerretsen, Gary Remington, Benoit Mulsant, Ariel Graff-Guerrer. Comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the CATIE phase 2E data. Schizophrenia research. vol 161. issue 2-3. 2015-12-31. PMID:25556080. |
comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the catie phase 2e data. |
2015-12-31 |
2023-08-13 |
Not clear |
| Shinichiro Nakajima, Hiroyoshi Takeuchi, Gagan Fervaha, Eric Plitman, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Yukiko Mihashi, Philip Gerretsen, Gary Remington, Benoit Mulsant, Ariel Graff-Guerrer. Comparative efficacy between clozapine and other atypical antipsychotics on depressive symptoms in patients with schizophrenia: analysis of the CATIE phase 2E data. Schizophrenia research. vol 161. issue 2-3. 2015-12-31. PMID:25556080. |
the comparative antidepressant effects of clozapine and other atypical antipsychotics for schizophrenia remain elusive, leading us to examine this question using the data from the clinical antipsychotic trials of intervention effectiveness phase 2e. |
2015-12-31 |
2023-08-13 |
Not clear |
| Donovan M Ashby, Christopher C Lapish, Anthony G Phillip. Stability of avoidance behaviour following repeated intermittent treatment with clozapine, olanzapine or D,L-govadine. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25325293. |
we sought to compare d,l-govadine with two atypical antipsychotics, clozapine and olanzapine, on repeated conditioned avoidance responding (car), a task that has recently been utilized to model the effects of repeated antipsychotic treatment. |
2015-09-03 |
2023-08-13 |
rat |
| Elcin Ozcelik-Eroglu, Aygun Ertugrul, Kader Karli Oguz, Arzu Ceylan Has, Sevilay Karahan, Mumin Kazim Yazic. Effect of clozapine on white matter integrity in patients with schizophrenia: a diffusion tensor imaging study. Psychiatry research. vol 223. issue 3. 2014-11-17. PMID:25012780. |
an increase in fa following 12 weeks of treatment with clozapine suggests that this treatment alters white matter microstructural integrity in patients with schizophrenia previously treated with typical and/or atypical antipsychotics and, in some locations, reverses a previous deficit. |
2014-11-17 |
2023-08-13 |
Not clear |
| b' Zofia Rog\\xc3\\xb3\\xc5\\xb. Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy. Pharmacological reports : PR. vol 65. issue 6. 2014-10-14. PMID:24553002.' |
combined treatment of rats with all studied atypical antipsychotics (olanzapine, risperidone, clozapine and quetiapine) and antidepressants (citalopram, fluoxetine and fluvoxamine) increased the extracellular level of dopamine in the prefrontal cortex compared to a respective drug given alone; in addition, a combination of olanzapine or quetiapine plus fluoxetine or fluvoxamine increased the levels of dopamine and noradrenaline. |
2014-10-14 |
2023-08-12 |
rat |
| Mohamed M El-Seweidy, Nermin Abdel Hamid Sadik, Marwa M Malek, Rawia S Ami. Chronic effects of clozapine administration on insulin resistance in rats: evidence for adverse metabolic effects. Pathology, research and practice. vol 210. issue 1. 2014-09-10. PMID:24176172. |
chronic treatment with the atypical antipsychotics clozapine has been associated with an increased risk for deterioration of glucose homeostasis, leading to hyperglycemia and insulin resistance diabetes. |
2014-09-10 |
2023-08-12 |
rat |
| Jun Cai, Wen Zhang, Zhenghui Yi, Weihong Lu, Zhiguo Wu, Jun Chen, Shunying Yu, Yiru Fang, Chen Zhan. Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. Psychopharmacology. vol 230. issue 1. 2014-06-10. PMID:23660601. |
clinical observations indicate that atypical antipsychotics, especially clozapine, induce obsessive-compulsive (oc) symptoms in schizophrenia patients. |
2014-06-10 |
2023-08-12 |
Not clear |
| Bo-Jian Wu, Hsing-Kang Chen, Shin-Min Le. Do atypical antipsychotics really enhance smoking reduction more than typical ones?: the effects of antipsychotics on smoking reduction in patients with schizophrenia. Journal of clinical psychopharmacology. vol 33. issue 3. 2013-11-07. PMID:23609378. |
the 95% confidence intervals of the estimated means of change in the cpd and ftnd scores did not contain zero only among subjects on tas or clozapine.these findings suggest that tas and clozapine enhance smoking reduction compared with nonclozapine atypical antipsychotics in schizophrenic patients. |
2013-11-07 |
2023-08-12 |
human |
| N M W J de Bruin, M van Drimmelen, M Kops, J van Elk, M Middelveld-van de Wetering, I Schwienbache. Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats. Behavioural brain research. vol 244. 2013-09-30. PMID:23384714. |
then, we investigated whether the atypical antipsychotics risperidone and clozapine and the 5-hydroxytryptamine6 (5-ht6) antagonist gsk-742457 could reverse the pcp-induced deficits. |
2013-09-30 |
2023-08-12 |
rat |
| Baldeep Kumar, Ajay Prakash, Rakesh K Sewal, Bikash Medhi, Manish Mod. Drug therapy in autism: a present and future perspective. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406740. |
there are classes of different pharmacological agents which are found to be effective in improving behavioral symptoms of asd such as neurotransmitter reuptake inhibitors (fluoxetine), tricyclic antidepressants (imipramine), anticonvulsants (lamotrigine), atypical antipsychotics (clozapine), acetylcholinesterase inhibitors (rivastigmine), etc. |
2013-07-16 |
2023-08-12 |
Not clear |
| J A Allen, P N Yadav, V Setola, M Farrell, B L Rot. Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo. Translational psychiatry. vol 1. 2013-04-04. PMID:22832607. |
interestingly, genetic deletion of cav-1 rendered the atypical antipsychotics clozapine and olanzapine and the 5-ht(2a)-selective antagonist m100907 ineffective at normalizing pcp-induced disruption of ppi. |
2013-04-04 |
2023-08-12 |
mouse |
| Marco Innamorati, Stefano Baratta, Cristina Di Vittorio, David Lester, Paolo Girardi, Maurizio Pompili, Mario Amor. Atypical antipsychotics in the treatment of depressive and psychotic symptoms in patients with chronic schizophrenia: a naturalistic study. Schizophrenia research and treatment. vol 2013. 2013-02-13. PMID:23401771. |
the aim of this naturalistic study was to investigate whether treatment with clozapine and other atypical antipsychotics for at least 2 years was associated with a reduction in psychotic and depressive symptoms and an improvement in chronic schizophrenia patients' awareness of their illness. |
2013-02-13 |
2023-08-12 |
Not clear |
| Marco Innamorati, Stefano Baratta, Cristina Di Vittorio, David Lester, Paolo Girardi, Maurizio Pompili, Mario Amor. Atypical antipsychotics in the treatment of depressive and psychotic symptoms in patients with chronic schizophrenia: a naturalistic study. Schizophrenia research and treatment. vol 2013. 2013-02-13. PMID:23401771. |
at the follow-up, patients treated with other atypical antipsychotics reported a greater reduction in depression than patients treated with clozapine, but not when limiting the analyses to those with clinically relevant depression. |
2013-02-13 |
2023-08-12 |
Not clear |
| István Gacsályi, Katalin Nagy, Katalin Pallagi, György Lévay, László G Hársing, Krisztina Móricz, Szabolcs Kertész, Péter Varga, József Haller, Gábor Gigler, Gábor Szénási, József Barkóczy, Judit Bíró, Michael Spedding, Ferenc A Anton. Egis-11150: a candidate antipsychotic compound with procognitive efficacy in rodents. Neuropharmacology. vol 64. 2013-02-11. PMID:22824189. |
the introduction of atypical antipsychotics such as risperidone, olanzapine and clozapine has obviated this problem, but none of the current drugs seem to improve the cognitive deficits accompanying schizophrenia. |
2013-02-11 |
2023-08-12 |
mouse |
| Azizah Attard, David M Taylo. Comparative effectiveness of atypical antipsychotics in schizophrenia: what have real-world trials taught us? CNS drugs. vol 26. issue 6. 2012-10-29. PMID:22668246. |
efficacy studies have already shown the unique effectiveness of clozapine, and suggested improved outcomes for olanzapine compared with some atypical antipsychotics and a reduced tendency to produce acute and chronic movement disorders for atypical compared with typical drugs. |
2012-10-29 |
2023-08-12 |
Not clear |
| Philippe Huot, Tom H Johnston, Naomi P Visanji, Tayyeba Darr, Donna Pires, Lili-Naz Hazrati, Jonathan M Brotchie, Susan H Fo. Increased levels of 5-HT1A receptor binding in ventral visual pathways in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 6. 2012-10-25. PMID:22419526. |
the atypical antipsychotics clozapine and quetiapine, which have affinity for 5-ht(2a) and 5-ht(1a) receptors, are effective against visual hallucinations in pd. |
2012-10-25 |
2023-08-12 |
human |
| Matthew J Fell, Jason S Katner, Kurt Rasmussen, Alexander Nikolayev, Ming-Shang Kuo, David L G Nelson, Kenneth W Perry, Kjell A Svensso. Typical and atypical antipsychotic drugs increase extracellular histamine levels in the rat medial prefrontal cortex: contribution of histamine h(1) receptor blockade. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22629251. |
atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics. |
2012-10-02 |
2023-08-12 |
rat |
| Georges Vauquelin, Sophie Bostoen, Patrick Vanderheyden, Philip Seema. Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism. Naunyn-Schmiedeberg's archives of pharmacology. vol 385. issue 4. 2012-07-10. PMID:22331262. |
fast dissociation of clozapine, the prototype of the "atypical antipsychotics", has been evidenced by distinct radioligand binding approaches both on cell membranes and intact cells. |
2012-07-10 |
2023-08-12 |
Not clear |