| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruri Okubo, Motohiro Okada, Eishi Motomur. Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia. Biomolecules. vol 14. issue 9. 2024-09-28. PMID:39334894. |
however, neither typical nor atypical antipsychotics, other than clozapine, have been effective in addressing negative symptoms and cognitive impairments, which are indices for the prognostic and disability outcomes of schizophrenia. |
2024-09-28 |
2024-10-01 |
Not clear |
| Foteini Vartzoka, Maria Anastasia Parlantza, Petros A Tarantilis, Nikolaos Pitsika. Co-administration of sub-effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats. Phytotherapy research : PTR. 2024-07-20. PMID:39031890. |
the present study was designed to evaluate the efficacy of the joint administration of sub-effective doses of crocins with those of the atypical antipsychotics clozapine and risperidone in alleviating nonspatial recognition and emotional memory deficits induced either by ketamine (3 mg/kg) or mk-801 (0.1 mg/kg) in the rat. |
2024-07-20 |
2024-07-24 |
rat |
| Janusz Rybakowsk. Sixty years of recurrence prevention in mood disorders. Psychiatria polska. vol 58. issue 2. 2024-07-14. PMID:39003507. |
since the mid-1990s, 2nd generation of mood-stabilizing drugs has been introduced, including some atypical antipsychotics (clozapine, olanzapine, quetiapine, aripiprazole, risperidone) and anticonvulsant drug, lamotrigine, showing prophylactic activity in bipolar mood disorder. |
2024-07-14 |
2024-07-16 |
Not clear |
| Júlio César Menezes Vieira, Edna Afonso Reis, Augusto Afonso Guerra, Helian Nunes de Oliveira, Cristina Mariano Rua. Comparative effectiveness of clozapine and non-clozapine atypical antipsychotics provided by the Brazilian National Health System in adults with schizophrenia. Frontiers in psychiatry. vol 15. 2024-07-04. PMID:38962057. |
comparative effectiveness of clozapine and non-clozapine atypical antipsychotics provided by the brazilian national health system in adults with schizophrenia. |
2024-07-04 |
2024-07-10 |
Not clear |
| Júlio César Menezes Vieira, Edna Afonso Reis, Augusto Afonso Guerra, Helian Nunes de Oliveira, Cristina Mariano Rua. Comparative effectiveness of clozapine and non-clozapine atypical antipsychotics provided by the Brazilian National Health System in adults with schizophrenia. Frontiers in psychiatry. vol 15. 2024-07-04. PMID:38962057. |
we aimed to assess the survival of patients with schizophrenia using clozapine compared with non-clozapine atypical antipsychotics provided by the brazilian national health system using real-world data. |
2024-07-04 |
2024-07-10 |
Not clear |
| Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S O'Connell, Ole A Andreassen, Espen Molde. Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data. CNS drugs. 2024-04-18. PMID:38635089. |
we aimed to investigate potential rapid drug metabolism underlying low dose-adjusted serum concentration (cd) of non-clozapine atypical antipsychotics preceding clozapine treatment. |
2024-04-18 |
2024-04-20 |
Not clear |
| Merve Direktor, Peter Gass, Dragos Int. Understanding the therapeutic action of antipsychotics: from molecular to cellular targets with focus on the islands of Calleja. The international journal of neuropsychopharmacology. 2024-04-17. PMID:38629703. |
here we discuss results suggesting a main role of the islands of calleja, still poorly studied gabaergic granule cell clusters in the ventral striatum, as cellular targets of several innovative atypical antipsychotics (clozapine, cariprazine and xanomeline/emraclidine) effective in treating also negative symptoms of schizophrenia. |
2024-04-17 |
2024-04-19 |
Not clear |
| Chunlei Gao, Tongpei Zhou, Sihan Liu, Chenyang Miao, Jingting Feng, Yifan Ding, Yanni L. Revealing receptor-ligand interactions of atypical antipsychotic drugs and screening anti-schizophrenia ingredients in Magnolia officinalis based on 5-HTR2A-SNAP-Tag/CMC and DRD2-SNAP-Tag/CMC models. Journal of chromatography. A. vol 1720. 2024-03-05. PMID:38442497. |
binding assays showed that the effects of three atypical antipsychotics (including clozapine, olanzapine, and quetiapine) on 5-htr2a were stronger than their effects on drd2. |
2024-03-05 |
2024-03-08 |
Not clear |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759688. |
considering the expressions of gaba-b and iii-mglu receptors (localised in the presynaptic regions), the activation of gaba-b and iii-mglu receptors can explain the distinct therapeutic advantages of clozapine in schizophrenia or trs associated with n-methyl-d-aspartate (nmda) receptor disturbance compared with other atypical antipsychotics via the inhibition of the persistent tonic hyperactivation of thalamocortical glutamatergic transmission in the prefrontal cortex. |
2023-09-28 |
2023-10-07 |
Not clear |
| Soumitra Das, Annie Itrat, Mary Elizabeth Trejo Hernandez, Rasish Subedi, Thusanth Jogarajah, Sreshatha Vashist, Nikitha Daggal. Clozapine-induced eosinophilia: A case report. SAGE open medical case reports. vol 11. 2023-09-05. PMID:37667744. |
clozapine is one of the best atypical antipsychotics and is highly effective in treating treatment-resistant schizophrenia. |
2023-09-05 |
2023-09-07 |
Not clear |
| Janusz K Rybakowsk. Application of Antipsychotic Drugs in Mood Disorders. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979224. |
the second-generation, so-called atypical antipsychotics (sgas), such as clozapine, risperidone, olanzapine, and quetiapine, have antimanic activity and are also effective for the maintenance treatment of bipolar disorder. |
2023-03-29 |
2023-08-14 |
human |
| Kouji Fukuyama, Eishi Motomura, Takashi Shiroyama, Motohiro Okad. Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-26. PMID:35219120. |
these results suggest that effects of subchronic lurasidone administration on astroglial l-glutamate release, 5-ht receptor, and intracellular signalling are similar to vortioxetine and different from mood-stabilising atypical antipsychotics, clozapine. |
2022-02-26 |
2023-08-13 |
Not clear |
| Mina Y George, Esther T Menze, Ahmed Esmat, Mariane G Tadros, Ebtehal El-Demerdas. Naringin treatment improved main clozapine-induced adverse effects in rats; emphasis on weight gain, metabolic abnormalities, and agranulocytosis. Drug development research. vol 82. issue 7. 2021-11-15. PMID:33537987. |
among them, clozapine is one of the atypical antipsychotics prescribed in schizophrenia wing to its blocking effect on dopamine (d2) and serotonin (5-ht |
2021-11-15 |
2023-08-13 |
rat |
| Leslie Citrome, Jan Volavk. Specific Anti-hostility Effects of Atypical Antipsychotics in Persons with Schizophrenia: From Clozapine to Cariprazine. Harvard review of psychiatry. vol 29. issue 1. 2021-10-25. PMID:33417374. |
specific anti-hostility effects of atypical antipsychotics in persons with schizophrenia: from clozapine to cariprazine. |
2021-10-25 |
2023-08-13 |
Not clear |
| Rohn Nahmias, David Pison, Areef Kassam, Dennis Anderso. Slow your role: How slowing clozapine titration can prevent recurrent NMS. Schizophrenia research. vol 218. 2021-06-17. PMID:31973998. |
in this case report, we discuss the importance of identifying atypical nms in patients treated with typical and atypical antipsychotics, and propose that successful treatment of these patients may be possible with slower and gradual titration of clozapine. |
2021-06-17 |
2023-08-13 |
Not clear |
| Chengfang Zhang, Xiaodan Wang, Chengping Hu, Wenhua Ding, Han Li, Meng Wu, Manji Hu, Qiang Wang, Xirong Su. The effect of prohibiting outside food during COVID-19 pandemic on the body weight of schizophrenic patients taking olanzapine or clozapine: a retrospective self-controlled study. Annals of palliative medicine. vol 10. issue 5. 2021-06-11. PMID:33894724. |
olanzapine and clozapine are atypical antipsychotics (aaps) with the greatest risk of weight gain, and changes in feeding behavior are among the most important underlying mechanisms. |
2021-06-11 |
2023-08-13 |
Not clear |
| Gulshan Begum, Stanley Nkemjika, Olaniyi Olayinka, Tolu Olupona, Ayodeji Jolayem. Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review. Cureus. vol 13. issue 3. 2021-04-29. PMID:33907647. |
we suggest that clozapine augmentation therapy could be an approach in treatment-resistant vocal tics among schizophrenic patients who are refractory to atypical antipsychotics. |
2021-04-29 |
2023-08-13 |
Not clear |
| Karun Badwal, Shangwe A Kiliaki, Sagar B Dugani, Sandeep R Pagal. Psychosis Management in Lewy Body Dementia: A Comprehensive Clinical Approach. Journal of geriatric psychiatry and neurology. 2021-01-19. PMID:33461372. |
if addition of pharmacological agents is required, consideration should be given to acetylcholinesterase inhibitors, pimavanserin and atypical antipsychotics such as quetiapine or clozapine. |
2021-01-19 |
2023-08-13 |
Not clear |
| Mehran Zarghami, Seyed Davood Hoseini, Arash Kazemi, Forouzan Elyas. Concurrent Hepatotoxicity and Neutropenia Induced by Clozapine. Archives of Iranian medicine. vol 23. issue 2. 2021-01-06. PMID:32061077. |
clozapine is known as one of the atypical antipsychotics which is placed in the second line of medical treatment for schizophrenia due to its hematologic complications. |
2021-01-06 |
2023-08-13 |
Not clear |
| Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Fabio Tascedda, Filippo Drago, Filippo Carac. Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia. Pharmaceuticals (Basel, Switzerland). vol 13. issue 12. 2020-12-29. PMID:33322693. |
opposite to haloperidol, second-generation antipsychotics (or atypical antipsychotics) such as risperidone, clozapine, and olanzapine exert a strong antioxidant activity in experimental models of schizophrenia by rescuing the antioxidant system, with an increase in superoxide dismutase and glutathione (gsh) serum levels. |
2020-12-29 |
2023-08-13 |
Not clear |